310
Views
117
CrossRef citations to date
0
Altmetric
Original Articles

Ayurvedic Medicine Constituent Withaferin A Causes G2 and M Phase Cell Cycle Arrest in Human Breast Cancer Cells

, &
Pages 51-60 | Received 23 Jul 2008, Accepted 27 Jul 2008, Published online: 10 Nov 2008

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (8)

Pawan Kumar, Samudra P. Banik, Apurva Goel, Sanjoy Chakraborty, Manashi Bagchi & Debasis Bagchi. (2024) Revisiting the Multifaceted Therapeutic Potential of Withaferin A (WA), a Novel Steroidal Lactone, W-ferinAmax Ashwagandha, from Withania Somnifera (L) Dunal. Journal of the American Nutrition Association 43:2, pages 115-130.
Read now
Zhichao Xing, Anping Su, Li Mi, Yujie Zhang, Ting He, Yuxuan Qiu, Tao Wei, Zhihui Li, Jingqiang Zhu & Wenshuang Wu. (2023) Withaferin A: A Dietary Supplement with Promising Potential as an Anti-Tumor Therapeutic for Cancer Treatment - Pharmacology and Mechanisms. Drug Design, Development and Therapy 17, pages 2909-2929.
Read now
Vikrant Mehta, Harish Chander & Anjana Munshi. (2021) Mechanisms of Anti-Tumor Activity of Withania somnifera (Ashwagandha). Nutrition and Cancer 73:6, pages 914-926.
Read now
Deepa S. Mandlik (Ingawale)Ajay G. Namdeo. (2021) Pharmacological evaluation of Ashwagandha highlighting its healthcare claims, safety, and toxicity aspects. Journal of Dietary Supplements 18:2, pages 183-226.
Read now
Sambamurthy Chandrasekaran, Jalaja Veronica, Ravi Kumar Gundampati, Shyam Sundar & Radheshyam Maurya. (2016) Exploring the inhibitory activity of Withaferin-A against Pteridine reductase-1 of L. donovani. Journal of Enzyme Inhibition and Medicinal Chemistry 31:6, pages 1029-1037.
Read now
MK McKenna, BW Gachuki, SS Alhakeem, KN Oben, VM Rangnekar, RC Gupta & S Bondada. (2015) Anti-cancer activity of withaferin A in B-cell lymphoma. Cancer Biology & Therapy 16:7, pages 1088-1098.
Read now
Silvia D. Stan, Shivendra V. Singh, David C. Whitcomb & Randall E. Brand. (2014) Phenethyl Isothiocyanate Inhibits Proliferation and Induces Apoptosis in Pancreatic Cancer Cells In Vitro and in a MIAPaca2 Xenograft Animal Model. Nutrition and Cancer 66:4, pages 747-755.
Read now
Tooba Ghazanfari, Roya Yaraee, Batool Rahmati, Hoda Hakimzadeh, Jalaledin Shams & Mohammad-Reza Jalali-Nadoushan. (2011) In vitro cytotoxic effect of garlic extract on malignant and nonmalignant cell lines. Immunopharmacology and Immunotoxicology 33:4, pages 603-608.
Read now

Articles from other publishers (109)

Geetanjali Devabattula, Biswajit Panda, Rachana Yadav & Chandraiah Godugu. (2024) The Potential Pharmacological Effects of Natural Product Withaferin A in Cancer: Opportunities and Challenges for Clinical Translation. Planta Medica.
Crossref
Prathapan Abeesh & Chandrasekaran Guruvayoorappan. (2024) The Therapeutic Effects of Withaferin A against Cancer: Overview and Updates. Current Molecular Medicine 24:4, pages 404-418.
Crossref
Valentina Lerose, Maria Ponticelli, Nadia Benedetto, Vittorio Carlucci, Ludovica Lela, Nikolay T. Tzvetkov & Luigi Milella. (2024) Withania somnifera (L.) Dunal, a Potential Source of Phytochemicals for Treating Neurodegenerative Diseases: A Systematic Review. Plants 13:6, pages 771.
Crossref
Delia Maccioni, Danilo Falconieri, Elio Acquas, Sanjay Bhaskar Kasture, Benedetta Era, Antonella Fais, Emma Cocco & Andrea Maxia. (2024) Advances in Sardinian Withania somnifera (L.) Dunal crops through phytochemical and biological approaches. Industrial Crops and Products 208, pages 117887.
Crossref
Nuria Vilaboa & Richard Voellmy. (2023) Withaferin A and Celastrol Overwhelm Proteostasis. International Journal of Molecular Sciences 25:1, pages 367.
Crossref
Zhiruo Zhang, Yueying Yang, Yang Xu, Yang Liu, Hua Li & Lixia Chen. (2023) Molecular targets and mechanisms of anti-cancer effects of withanolides. Chemico-Biological Interactions 384, pages 110698.
Crossref
Eun‐Ryeong Hahm, Su‐Hyeong Kim & Shivendra V. Singh. (2023) Withaferin A inhibits breast cancer‐induced osteoclast differentiation. Molecular Carcinogenesis 62:7, pages 1051-1061.
Crossref
Rabea Parveen, Sradhanjali Mohapatra, Sayeed Ahmad & Syed Akhtar Husain. (2023) Amalgamation of Nanotechnology for Delivery of Bioactive Constituents in Solid Tumors. Current Drug Delivery 20:5, pages 457-482.
Crossref
Taghreed A. Majrashi, Saad Ali Alshehri, Abdulrhman Alsayari, Abdullatif Bin Muhsinah, Mohammad Alrouji, Asma M. Alshahrani, Anas Shamsi & Akhtar Atiya. (2023) Insight into the Biological Roles and Mechanisms of Phytochemicals in Different Types of Cancer: Targeting Cancer Therapeutics. Nutrients 15:7, pages 1704.
Crossref
Wencheng Gong, Xiaoya Zhao, Xiaoyu Tang, Long Gao, Yuan Sun & Jingyun Ma. (2023) Infectious Recombinant Senecavirus A Expressing p16INK4A Protein. International Journal of Molecular Sciences 24:7, pages 6139.
Crossref
Bentham Science Publisher Kavita, Naina Rajak, Praveen Kumar, Shikha Singh & Neha Garg. 2023. Bioactive Phytochemicals from Himalayas: A Phytotherapeutic Approach. Bioactive Phytochemicals from Himalayas: A Phytotherapeutic Approach 105 116 .
Suneel Kumar, Stephen O. Mathew, Ravindra Prasad Aharwal, Hardeep Singh Tulli, Chakrabhavi Dhananjaya Mohan, Gautam Sethi, Kwang-Seok Ahn, Kassidy Webber, Sardul Singh Sandhu & Anupam Bishayee. (2023) Withaferin A: A Pleiotropic Anticancer Agent from the Indian Medicinal Plant Withania somnifera (L.) Dunal. Pharmaceuticals 16:2, pages 160.
Crossref
Federica Sarno, Désirée Goubert, Emilie Logie, Martijn G. S. Rutten, Mihaly Koncz, Christophe Deben, Anita E. Niemarkt, Lucia Altucci, Pernette J. Verschure, Antal Kiss, Wim Vanden Berghe & Marianne G. Rots. (2022) Functional Validation of the Putative Oncogenic Activity of PLAU. Biomedicines 11:1, pages 102.
Crossref
Maushma Atteeq. (2022) Evaluating anticancer properties of Withaferin A—a potent phytochemical. Frontiers in Pharmacology 13.
Crossref
Muhammad Ayaz, Asif Nawaz, Sajjad Ahmad, Osama F. Mosa, Alashary Adam Eisa Hamdoon, Modawy Alnour Khalifa, Abdul Sadiq, Farhat Ullah, Abdul Wadood, Atul Kabra & H. C. Ananda Murthy. (2022) Underlying Anticancer Mechanisms and Synergistic Combinations of Phytochemicals with Cancer Chemotherapeutics: Potential Benefits and Risks. Journal of Food Quality 2022, pages 1-15.
Crossref
Devesh Tewari, Vikas Chander, Archana Dhyani, Sanjeev Sahu, Pawan Gupta, Pooja Patni, Lindsay S. Kalick & Anupam Bishayee. (2022) Withania somnifera (L.) Dunal: Phytochemistry, structure-activity relationship, and anticancer potential. Phytomedicine 98, pages 153949.
Crossref
Muhammad Idrees Khan, Abdelhakim Bouyahya, Naoufal E. L. Hachlafi, Naoual El Menyiy, Muhammad Akram, Sabira Sultana, Gokhan Zengin, Lilya Ponomareva, Mohammad Ali Shariati, Oluwafemi Adeleke Ojo, Stefano Dall’Acqua & Tobiloba Christiana Elebiyo. (2022) Anticancer properties of medicinal plants and their bioactive compounds against breast cancer: a review on recent investigations. Environmental Science and Pollution Research 29:17, pages 24411-24444.
Crossref
Vivek K. Kashyap, Godwin Peasah-Darkwah, Anupam Dhasmana, Meena Jaggi, Murali M. Yallapu & Subhash C. Chauhan. (2022) Withania somnifera: Progress towards a Pharmaceutical Agent for Immunomodulation and Cancer Therapeutics. Pharmaceutics 14:3, pages 611.
Crossref
Amiya Das, Pallavi Agarwal, Gaurav Kumar Jain, Geeta Aggarwal, Viney Lather & Deepti Pandita. (2022) Repurposing Drugs as Novel Triple-negative Breast Cancer Therapeutics. Anti-Cancer Agents in Medicinal Chemistry 22:3, pages 515-550.
Crossref
Priyanka Sekar, Raashmi Ravitchandirane, Sofia Khanam, Nethaji Muniraj & Ananda Vayaravel Cassinadane. (2022) Novel molecules as the emerging trends in cancer treatment: an update. Medical Oncology 39:2.
Crossref
Tahira Sultana, Mohammad K. Okla, Madiha Ahmed, Nosheen Akhtar, Abdulrahman Al-Hashimi, Hamada Abdelgawad & Ihsan-ul- Haq. (2021) Withaferin A: From Ancient Remedy to Potential Drug Candidate. Molecules 26:24, pages 7696.
Crossref
Sajida & Ashwini Prabhu. (2021) Anti-angiogenic, apoptotic and matrix metalloproteinase inhibitory activity of Withania somnifera (ashwagandha) on lung adenocarcinoma cells. Phytomedicine 90, pages 153639.
Crossref
Seema Dubey, Manohar Singh, Ariel Nelson & Dev Karan. (2021) A Perspective on Withania somnifera Modulating Antitumor Immunity in Targeting Prostate Cancer. Journal of Immunology Research 2021, pages 1-11.
Crossref
Kejun Xu, Hongyan Shi, Yongming Du & Jilan Ou. (2021) Withaferin A inhibits proliferation of human endometrial cancer cells via transforming growth factor-β (TGF-β) signalling. 3 Biotech 11:7.
Crossref
Rajib Das, Abdur Rauf, Saima Akhter, Mohammad Nazmul Islam, Talha Bin Emran, Saikat Mitra, Ishaq N. Khan & Mohammad S. Mubarak. (2021) Role of Withaferin A and Its Derivatives in the Management of Alzheimer’s Disease: Recent Trends and Future Perspectives. Molecules 26:12, pages 3696.
Crossref
Su-Hyeong Kim, Krishna B. Singh, Eun-Ryeong Hahm & Shivendra V. Singh. (2021) The Role of Forkhead Box Q1 Transcription Factor in Anticancer Effects of Withaferin A in Breast Cancer. Cancer Prevention Research 14:4, pages 421-432.
Crossref
Ruju Vashi, Bhoomika M. Patel & Ramesh K. Goyal. (2021) Keeping abreast about ashwagandha in breast cancer. Journal of Ethnopharmacology 269, pages 113759.
Crossref
Neetu Singh, S.S. Yadav, Amrender Singh Rao, Abhishek Nandal, Sanjiv Kumar, S.A. Ganaie & B. Narasihman. (2021) Review on anticancerous therapeutic potential of Withania somnifera (L.) Dunal. Journal of Ethnopharmacology 270, pages 113704.
Crossref
Harshini Mallipeddi, Anita Thyagarajan & Ravi P. Sahu. (2021) Implications of Withaferin-A for triple-negative breast cancer chemoprevention. Biomedicine & Pharmacotherapy 134, pages 111124.
Crossref
Liubov Koval, Nadezhda Zemskaya, Alexander Aliper, Alex Zhavoronkov & Alexey Moskalev. (2021) Evaluation of the geroprotective effects of withaferin A in Drosophila melanogaster. Aging 13:2, pages 1817-1841.
Crossref
Chen-Chu LinTsung-Ying YangHseuh-Ju LuChen-Kai WanShih-Lan HsuChun-Chi Wu. (2021) Attenuating role of withaferin A in the proliferation and migration of lung cancer cells via a p53‑miR‑27a/miR‑10b pathway. Oncology Letters 21:3.
Crossref
Eun‐Ryeong Hahm, Su‐Hyeong Kim, Krishna B. Singh & Shivendra V. Singh. (2020) RNA‐seq reveals novel cancer‐selective and disease subtype‐independent mechanistic targets of withaferin A in human breast cancer cells. Molecular Carcinogenesis 60:1, pages 3-14.
Crossref
Tapan Behl, Aditi Sharma, Lalit Sharma, Aayush Sehgal, Gokhan Zengin, Roxana Brata, Ovidiu Fratila & Simona Bungau. (2020) Exploring the Multifaceted Therapeutic Potential of Withaferin A and Its Derivatives. Biomedicines 8:12, pages 571.
Crossref
Muhammad Furqan Akhtar, Ammara Saleem, Azhar Rasul, Mirza Muhammad Faran Ashraf Baig, May Bin-Jumah & Mohamed M. Abdel Daim. (2020) Anticancer natural medicines: An overview of cell signaling and other targets of anticancer phytochemicals. European Journal of Pharmacology 888, pages 173488.
Crossref
Zsuzsanna Nagy, Belamy B. Cheung, Wing Tsang, Owen Tan, Mika Herath, Olivia C. Ciampa, Fatima Shadma, Daniel R. Carter & Glenn M. Marshall. (2020) Withaferin A activates TRIM16 for its anti-cancer activity in melanoma. Scientific Reports 10:1.
Crossref
Eun-Ryeong Hahm, Su-Hyeong Kim, Krishna B. Singh, Kamayani Singh & Shivendra V. Singh. (2020) A Comprehensive Review and Perspective on Anticancer Mechanisms of Withaferin A in Breast Cancer. Cancer Prevention Research 13:9, pages 721-734.
Crossref
Vishnu Sankar Sivasankarapillai, Reshmi Madhu Kumar Nair, Abbas Rahdar, Simona Bungau, Dana Carmen Zaha, Lotfi Aleya & Delia Mirela Tit. (2020) Overview of the anticancer activity of withaferin A, an active constituent of the Indian ginseng Withania somnifera. Environmental Science and Pollution Research 27:21, pages 26025-26035.
Crossref
Akash Saggam, Girish Tillu, Santosh Dixit, Preeti Chavan-Gautam, Swapnil Borse, Kalpana Joshi & Bhushan Patwardhan. (2020) Withania somnifera (L.) Dunal: A potential therapeutic adjuvant in cancer. Journal of Ethnopharmacology 255, pages 112759.
Crossref
Anissa Nofita Sari, Priyanshu Bhargava, Jaspreet Kaur Dhanjal, Jayarani F. Putri, Navaneethan Radhakrishnan, Seyad Shefrin, Yoshiyuki Ishida, Keiji Terao, Durai Sundar, Sunil C. Kaul & Renu Wadhwa. (2020) Combination of Withaferin-A and CAPE Provides Superior Anticancer Potency: Bioinformatics and Experimental Evidence to Their Molecular Targets and Mechanism of Action. Cancers 12:5, pages 1160.
Crossref
Behrouz Hassannia, Emilie Logie, Peter Vandenabeele, Tom Vanden Berghe & Wim Vanden Berghe. (2020) Withaferin A: From ayurvedic folk medicine to preclinical anti-cancer drug. Biochemical Pharmacology 173, pages 113602.
Crossref
Martin Dom, Wim Vanden Berghe & Xaveer Van Ostade. (2020) Broad-spectrum antitumor properties of Withaferin A: a proteomic perspective. RSC Medicinal Chemistry 11:1, pages 30-50.
Crossref
Qin Tang, Liwen Ren, Jinyi Liu, Wan Li, Xiangjin Zheng, Jinhua Wang & Guanhua Du. (2019) Withaferin A triggers G2/M arrest and intrinsic apoptosis in glioblastoma cells via ATF4‐ATF3‐CHOP axis. Cell Proliferation 53:1.
Crossref
Eun‐Ryeong Hahm, Joomin Lee, Terric Abella & Shivendra V. Singh. (2019) Withaferin A inhibits expression of ataxia telangiectasia and Rad3‐related kinase and enhances sensitivity of human breast cancer cells to cisplatin. Molecular Carcinogenesis 58:11, pages 2139-2148.
Crossref
Nethaji Muniraj, Sumit Siddharth & Dipali Sharma. (2019) Bioactive Compounds: Multi-Targeting Silver Bullets for Preventing and Treating Breast Cancer. Cancers 11:10, pages 1563.
Crossref
Fan Wang, Jinyi Zhao, Juan Bai, Kai Gao, Dongxiao Cui, Yuan Chen, Ying Song, Yanyan Jia & Aidong Wen. (2019) Liquid chromatography-tandem mass spectrometry to assess the pharmacokinetics and tissue distribution of withaferin A in rats. Journal of Chromatography B 1122-1123, pages 90-95.
Crossref
Anuradha Sehrawat, Suman K. Samanta, Eun-Ryeong Hahm, Claudette St. Croix, Simon Watkins & Shivendra V. Singh. (2019) Withaferin A-mediated apoptosis in breast cancer cells is associated with alterations in mitochondrial dynamics. Mitochondrion 47, pages 282-293.
Crossref
Farrukh Aqil, Radha Munagala, Ashish K. Agrawal & Ramesh Gupta. 2019. New Look to Phytomedicine. New Look to Phytomedicine 237 272 .
Elif Mertoğlu, Aslıhan Şengelen, Ezgi Kıyga & Evren Önay-Uçar. 2019. Heat Shock Proteins in Neuroscience. Heat Shock Proteins in Neuroscience 189 208 .
Zheyi Yan, Rui Guo, Lu Gan, Wayne Bond Lau, Xiaoming Cao, Jianli Zhao, Xinliang Ma, Theodore A. Christopher, Bernard L. Lopez & Yajing Wang. (2018) Withaferin A inhibits apoptosis via activated Akt-mediated inhibition of oxidative stress. Life Sciences 211, pages 91-101.
Crossref
Shima Aliebrahimi, Shideh Montasser Kouhsari, Seyed Shahriar Arab, Amir Shadboorestan & Seyed Nasser Ostad. (2018) Phytochemicals, withaferin A and carnosol, overcome pancreatic cancer stem cells as c-Met inhibitors. Biomedicine & Pharmacotherapy 106, pages 1527-1536.
Crossref
Shuxian Xia, Yinglei Miao & Side Liu. (2018) Withaferin A induces apoptosis by ROS-dependent mitochondrial dysfunction in human colorectal cancer cells. Biochemical and Biophysical Research Communications 503:4, pages 2363-2369.
Crossref
Suman K. Samanta, Joomin Lee, Eun‐Ryeong Hahm & Shivendra V. Singh. (2018) Peptidyl‐prolyl cis/trans isomerase Pin1 regulates withaferin A‐mediated cell cycle arrest in human breast cancer cells . Molecular Carcinogenesis 57:7, pages 936-946.
Crossref
Carlos Roberto Koscky Paier, Sarah Sant'Anna Maranhão, Teiliane Rodrigues Carneiro, Lídia Moreira Lima, Danilo Damasceno Rocha, Renan da Silva Santos, Kaio Moraes de Farias, Manoel Odorico de Moraes-Filho & Claudia Pessoa. (2018) Natural products as new antimitotic compounds for anticancer drug development. Clinics 73, pages e813s.
Crossref
Chiara Borsari, Antonio Quotadamo, Stefania Ferrari, Alberto Venturelli, Anabela Cordeiro-da-Silva, Nuno Santarem & Maria Paola Costi. 2018. Neglected Diseases: Extensive Space for Modern Drug Discovery. Neglected Diseases: Extensive Space for Modern Drug Discovery 39 95 .
G. S. Pavan Kumar Achar, B. T. Prabhakar, Suresh Rao, Thomas George, Soniya Abraham, Nicole Sequeira & Manjeshwar Shrinath Baliga. 2018. Anticancer plants: Properties and Application. Anticancer plants: Properties and Application 285 301 .
Leslie C. Sherwood, Farrukh Aqil, Manicka V. Vadhanam, Jeyaprakash Jeyabalan, Radha Munagala, David Hoetker, Sanjay Srivastava, Inder P. Singh, Scott Cambron, Martin O'Toole, Wendy Spencer, Lynn P. Parker & Ramesh C. Gupta. (2017) Development of a goat model for evaluation of withaferin A: Cervical implants for the treatment of cervical intraepithelial neoplasia. Experimental and Molecular Pathology 103:3, pages 320-329.
Crossref
Francesca Pistollato, Ruben Calderón Iglesias, Roberto Ruiz, Silvia Aparicio, Jorge Crespo, Luis Dzul Lopez, Francesca Giampieri & Maurizio Battino. (2017) The use of natural compounds for the targeting and chemoprevention of ovarian cancer. Cancer Letters 411, pages 191-200.
Crossref
Chunyan Zhang, Cuifang Chang, Weiming Zhao, Hang Gao, Qiwen Wang, Deming Li, Fuchun Zhang, Shifu Zhang & Cunshuan Xu. (2017) The novel protein C9orf116 promotes rat liver cell line BRL-3A proliferation. PLOS ONE 12:7, pages e0180607.
Crossref
Green Kim, Tae-Hyoun Kim, Eun-Ha Hwang, Kyu-Tae Chang, Jung Joo Hong & Jong-Hwan Park. (2017) Withaferin A inhibits the proliferation of gastric cancer cells by inducing G2/M cell cycle arrest and apoptosis. Oncology Letters 14:1, pages 416-422.
Crossref
Katarzyna Szarc vel Szic, Ken Declerck, René A.J. Crans, Jolien Diddens, David B. Scherf, Clarissa Gerhäuser & Wim Vanden Berghe. (2017) Epigenetic silencing of triple negative breast cancer hallmarks by Withaferin A. Oncotarget 8:25, pages 40434-40453.
Crossref
Chandra Sekhar Chirumamilla, Claudina Pérez-Novo, Xaveer Van Ostade & Wim Vanden Berghe. (2017) Molecular insights into cancer therapeutic effects of the dietary medicinal phytochemical withaferin A. Proceedings of the Nutrition Society 76:2, pages 96-105.
Crossref
Ramadevi Subramani & Rajkumar Lakshmanaswamy. 2017. Approaches to Understanding Breast Cancer. Approaches to Understanding Breast Cancer 231 274 .
Muzamil Ahmad & Nawab J. Dar. 2017. Sustained Energy for Enhanced Human Functions and Activity. Sustained Energy for Enhanced Human Functions and Activity 137 154 .
Sheikh Rayees & Fayaz Malik. 2017. Science of Ashwagandha: Preventive and Therapeutic Potentials. Science of Ashwagandha: Preventive and Therapeutic Potentials 81 103 .
Sunil C. Kaul, Yoshiyuki Ishida, Kazuya Tamura, Teruo Wada, Tomoko Iitsuka, Sukant Garg, Mijung Kim, Ran Gao, Shoichi Nakai, Youji Okamoto, Keiji Terao & Renu Wadhwa. (2016) Novel Methods to Generate Active Ingredients-Enriched Ashwagandha Leaves and Extracts. PLOS ONE 11:12, pages e0166945.
Crossref
Wenjuan Li, Chunjing Zhang, Hongyan Du, Vincent Huang, Brandi Sun, John P. Harris, Quitin Richardson, Xinggui Shen, Rong Jin, Guohong Li, Christopher G. Kevil, Xin Gu, Runhua Shi & Yunfeng Zhao. (2015) Withaferin A suppresses the up‐regulation of acetyl‐coA carboxylase 1 and skin tumor formation in a skin carcinogenesis mouse model. Molecular Carcinogenesis 55:11, pages 1739-1746.
Crossref
Shuichiro Okamoto, Takayuki Tsujioka, Shin‐ichiro Suemori, Jun‐ichiro Kida, Toshinori Kondo, Yumi Tohyama & Kaoru Tohyama. (2016) Withaferin A suppresses the growth of myelodysplasia and leukemia cell lines by inhibiting cell cycle progression. Cancer Science 107:9, pages 1302-1314.
Crossref
Sharad Verma, Sukriti Goyal, Salma Jamal, Aditi Singh & Abhinav Grover. (2016) Hsp90: Friends, clients and natural foes. Biochimie 127, pages 227-240.
Crossref
Zongwei Wang, Charlotta Dabrosin, Xin Yin, Mark M. Fuster, Alexandra Arreola, W. Kimryn Rathmell, Daniele Generali, Ganji P. Nagaraju, Bassel El-Rayes, Domenico Ribatti, Yi Charlie Chen, Kanya Honoki, Hiromasa Fujii, Alexandros G. Georgakilas, Somaira Nowsheen, Amedeo Amedei, Elena Niccolai, Amr Amin, S. Salman Ashraf, Bill Helferich, Xujuan Yang, Gunjan Guha, Dipita Bhakta, Maria Rosa Ciriolo, Katia Aquilano, Sophie Chen, Dorota Halicka, Sulma I. Mohammed, Asfar S. Azmi, Alan Bilsland, W. Nicol Keith & Lasse D. Jensen. (2015) Broad targeting of angiogenesis for cancer prevention and therapy. Seminars in Cancer Biology 35, pages S224-S243.
Crossref
Nawab John Dar, Abid Hamid & Muzamil Ahmad. (2015) Pharmacologic overview of Withania somnifera, the Indian Ginseng. Cellular and Molecular Life Sciences 72:23, pages 4445-4460.
Crossref
Joomin Lee, Eun-Ryeong Hahm, Adam I. Marcus & Shivendra V. Singh. (2015) Withaferin A inhibits experimental epithelial-mesenchymal transition in MCF-10A cells and suppresses vimentin protein level in vivo in breast tumors. Molecular Carcinogenesis 54:6, pages 417-429.
Crossref
Eun‐Ryeong Hahm, Joomin Lee & Shivendra V. Singh. (2013) Role of mitogen‐activated protein kinases and Mcl‐1 in apoptosis induction by withaferin A in human breast cancer cells. Molecular Carcinogenesis 53:11, pages 907-916.
Crossref
Sham S. Kakar, Mariusz Z. Ratajczak, Karen S. Powell, Mana Moghadamfalahi, Donald M. Miller, Surinder K. Batra & Sanjay K. Singh. (2014) Withaferin A Alone and in Combination with Cisplatin Suppresses Growth and Metastasis of Ovarian Cancer by Targeting Putative Cancer Stem Cells. PLoS ONE 9:9, pages e107596.
Crossref
Patrick T. Grogan, Jann N. Sarkaria, Barbara N. Timmermann & Mark S. Cohen. (2014) Oxidative cytotoxic agent withaferin A resensitizes temozolomide-resistant glioblastomas via MGMT depletion and induces apoptosis through Akt/mTOR pathway inhibitory modulation. Investigational New Drugs 32:4, pages 604-617.
Crossref
Amritpal Saroya. 2014. Herbal Drugs as Therapeutic Agents. Herbal Drugs as Therapeutic Agents 20 27 .
Lei Tao, Rong Fu, Xiaoping Wang, Jing Yao, Yuxin Zhou, Qinsheng Dai, Zhiyu Li, Na Lu & Weiyun Wang. (2014) LL-202, a newly synthesized flavonoid, inhibits tumor growth via inducing G2/M phase arrest and cell apoptosis in MCF-7 human breast cancer cells in vitro and in vivo. Toxicology Letters 228:1, pages 1-12.
Crossref
Ritu Arora, Clayton Yates, Bernard D. Gary, Steven McClellan, Ming Tan, Yaguang Xi, Eddie Reed, Gary A. Piazza, Laurie B. Owen & Windy Dean-Colomb. (2014) Panepoxydone Targets NF-kB and FOXM1 to Inhibit Proliferation, Induce Apoptosis and Reverse Epithelial to Mesenchymal Transition in Breast Cancer. PLoS ONE 9:6, pages e98370.
Crossref
Dhanir Tailor, Eun-Ryeong Hahm, Raosaheb K. Kale, Shivendra V. Singh & Rana P. Singh. (2014) Sodium butyrate induces DRP1-mediated mitochondrial fusion and apoptosis in human colorectal cancer cells. Mitochondrion 16, pages 55-64.
Crossref
Katarzyna Szarc vel Szic, Ken Op de Beeck, Dariusz Ratman, An Wouters, Ilse M. Beck, Ken Declerck, Karen Heyninck, Erik Fransen, Marc Bracke, Karolien De Bosscher, Filip Lardon, Guy Van Camp & Wim Vanden Berghe. (2014) Pharmacological Levels of Withaferin A (Withania somnifera) Trigger Clinically Relevant Anticancer Effects Specific to Triple Negative Breast Cancer Cells. PLoS ONE 9:2, pages e87850.
Crossref
Ju-Hee Kim & Song-Ja Kim. (2014) Overexpression of MicroRNA-25 by Withaferin A Induces Cyclooxygenase-2 Expression in Rabbit Articular Chondrocytes. Journal of Pharmacological Sciences 125:1, pages 83-90.
Crossref
Avani R. Vyas & Shivendra V. Singh. (2013) Molecular Targets and Mechanisms of Cancer Prevention and Treatment by Withaferin A, A Naturally Occurring Steroidal Lactone. The AAPS Journal 16:1, pages 1-10.
Crossref
Anu Rahal, Amit Kumar, Vivek Singh, Brijesh Yadav, Ruchi Tiwari, Sandip Chakraborty & Kuldeep Dhama. (2014) Oxidative Stress, Prooxidants, and Antioxidants: The Interplay. BioMed Research International 2014, pages 1-19.
Crossref
Marie L. Antony, Joomin Lee, Eun-Ryeong Hahm, Su-Hyeong Kim, Adam I. Marcus, Vandana Kumari, Xinhua Ji, Zhen Yang, Courtney L. Vowell, Peter Wipf, Guy T. Uechi, Nathan A. Yates, Guillermo Romero, Saumendra N. Sarkar & Shivendra V. Singh. (2014) Growth Arrest by the Antitumor Steroidal Lactone Withaferin A in Human Breast Cancer Cells Is Associated with Down-regulation and Covalent Binding at Cysteine 303 of β-Tubulin. Journal of Biological Chemistry 289:3, pages 1852-1865.
Crossref
Neelam S. Sangwan & Rajender Singh Sangwan. 2014. Applied Plant Cell Biology. Applied Plant Cell Biology 325 367 .
Zhen Yang, Anapatricia Garcia, Songli Xu, Doris R. Powell, Paula M. Vertino, Shivendra Singh & Adam I. Marcus. (2013) Withania somnifera Root Extract Inhibits Mammary Cancer Metastasis and Epithelial to Mesenchymal Transition. PLoS ONE 8:9, pages e75069.
Crossref
Kanika Patel, Ravi B Singh & Dinesh K Patel. (2013) Pharmacological and analytical aspects of withaferin A: A concise report of current scientific literature. Asian Pacific Journal of Reproduction 2:3, pages 238-243.
Crossref
Dada Patil, Manish Gautam, Sanjay Mishra, Suresh Karupothula, Sunil Gairola, Suresh Jadhav, Shrikrishna Pawar & Bhushan Patwardhan. (2013) Determination of withaferin A and withanolide A in mice plasma using high-performance liquid chromatography-tandem mass spectrometry: Application to pharmacokinetics after oral administration of Withania somnifera aqueous extract. Journal of Pharmaceutical and Biomedical Analysis 80, pages 203-212.
Crossref
Eun-Ryeong Hahm & Shivendra V. Singh. (2013) Withaferin A-induced apoptosis in human breast cancer cells is associated with suppression of inhibitor of apoptosis family protein expression. Cancer Letters 334:1, pages 101-108.
Crossref
Patrick T. Grogan, Kristina D. Sleder, Abbas K. Samadi, Huaping Zhang, Barbara N. Timmermann & Mark S. Cohen. (2012) Cytotoxicity of withaferin A in glioblastomas involves induction of an oxidative stress-mediated heat shock response while altering Akt/mTOR and MAPK signaling pathways. Investigational New Drugs 31:3, pages 545-557.
Crossref
Seon Min Woo, Kyoung-Jin Min & Taeg Kyu Kwon. (2013) Anti-cancer Effects and Molecular Mechanisms of Withaferin A. Journal of Life Science 23:3, pages 462-469.
Crossref
Wenjuan Li & Yunfeng Zhao. (2012) Withaferin A suppresses tumor promoter 12‐ O ‐tetradecanoylphorbol 13‐acetate‐induced decreases in isocitrate dehydrogenase 1 activity and mitochondrial function in skin epidermal JB 6 cells . Cancer Science 104:2, pages 143-148.
Crossref
Wim Vanden Berghe, Linde Sabbe, Mary Kaileh, Guy Haegeman & Karen Heyninck. (2012) Molecular insight in the multifunctional activities of Withaferin A. Biochemical Pharmacology 84:10, pages 1282-1291.
Crossref
Joomin Lee, Anuradha Sehrawat & Shivendra V. Singh. (2012) Withaferin A causes activation of Notch2 and Notch4 in human breast cancer cells. Breast Cancer Research and Treatment 136:1, pages 45-56.
Crossref
Xuan Zhang, Barbara Timmermann, Abbas K. Samadi & Mark S. Cohen. (2012) Withaferin A Induces Proteasome-Dependent Degradation of Breast Cancer Susceptibility Gene 1 and Heat Shock Factor 1 Proteins in Breast Cancer Cells. ISRN Biochemistry 2012, pages 1-6.
Crossref
Sham S. Kakar, Venkatakrishna R. Jala & Miranda Y. Fong. (2012) Synergistic cytotoxic action of cisplatin and withaferin A on ovarian cancer cell lines. Biochemical and Biophysical Research Communications 423:4, pages 819-825.
Crossref
Shui-er Zheng, Sang Xiong, Feng Lin, Guang-lei Qiao, Tao Feng, Zan Shen, Da-liu Min, Chun-ling Zhang & Yang Yao. (2012) Pirarubicin inhibits multidrug-resistant osteosarcoma cell proliferation through induction of G2/M phase cell cycle arrest. Acta Pharmacologica Sinica 33:6, pages 832-838.
Crossref
Danilo D. Rocha, Aruna Balgi, Ana Isabel V. Maia, Otilia D. Pessoa, Edilberto R. Silveira, Letícia V. Costa-Lotufo, Michel Roberge & Claudia Pessoa. (2011) Cell cycle arrest through inhibition of tubulin polymerization by withaphysalin F, a bioactive compound isolated from Acnistus arborescens. Investigational New Drugs 30:3, pages 959-966.
Crossref
Thomas Efferth & Henry Johannes Greten. (2012) In Silico Analysis of Microarray-Based Gene Expression Profiles Predicts Tumor Cell Response to Withanolides. Microarrays 1:1, pages 44-63.
Crossref
Xuan Zhang, Abbas K. Samadi, Katherine F. Roby, Barbara Timmermann & Mark S. Cohen. (2012) Inhibition of cell growth and induction of apoptosis in ovarian carcinoma cell lines CaOV3 and SKOV3 by natural withanolide Withaferin A. Gynecologic Oncology 124:3, pages 606-612.
Crossref
Paola Bargagna-Mohan, Riya R. Paranthan, Adel Hamza, Chang-Guo Zhan, Do-Min Lee, Kyung Bo Kim, Daniel L. Lau, Cidambi Srinivasan, Keiko Nakayama, Keiichi I. Nakayama, Harald Herrmann & Royce Mohan. (2012) Corneal Antifibrotic Switch Identified in Genetic and Pharmacological Deficiency of Vimentin. Journal of Biological Chemistry 287:2, pages 989-1006.
Crossref
Xuan Zhang, Ridhwi Mukerji, Abbas K Samadi & Mark S Cohen. (2011) Down-regulation of estrogen receptor-alpha and rearranged during transfection tyrosine kinase is associated with withaferin a-induced apoptosis in MCF-7 breast cancer cells. BMC Complementary and Alternative Medicine 11:1.
Crossref
Eun Sun Yang, Min Jung Choi, Jin Hee Kim, Kyeong Sook Choi & Taeg Kyu Kwon. (2011) Combination of withaferin A and X-ray irradiation enhances apoptosis in U937 cells. Toxicology in Vitro 25:8, pages 1803-1810.
Crossref
R. Munagala, H. Kausar, C. Munjal & R. C. Gupta. (2011) Withaferin A induces p53-dependent apoptosis by repression of HPV oncogenes and upregulation of tumor suppressor proteins in human cervical cancer cells. Carcinogenesis 32:11, pages 1697-1705.
Crossref
Eun-Ryeong Hahm, Michelle B. Moura, Eric E. Kelley, Bennett Van Houten, Sruti Shiva & Shivendra V. Singh. (2011) Withaferin A-Induced Apoptosis in Human Breast Cancer Cells Is Mediated by Reactive Oxygen Species. PLoS ONE 6:8, pages e23354.
Crossref
Eun‐Ryeong Hahm, Joomin Lee, Yi Huang & Shivendra V. Singh. (2011) Withaferin a suppresses estrogen receptor‐α expression in human breast cancer cells. Molecular Carcinogenesis 50:8, pages 614-624.
Crossref
Eun Sun Yang, Min Jung Choi, Jin Hee Kim, Kyeong Sook Choi & Taeg Kyu Kwon. (2011) Withaferin A enhances radiation-induced apoptosis in Caki cells through induction of reactive oxygen species, Bcl-2 downregulation and Akt inhibition. Chemico-Biological Interactions 190:1, pages 9-15.
Crossref
Addanki P. Kumar, Heather Graham, Craig Robson, Karthik Garapati & Rita Ghosh. 2011. Evidence-based Anticancer Materia Medica. Evidence-based Anticancer Materia Medica 1 36 .
J. Lee, E.-R. Hahm & S. V. Singh. (2010) Withaferin A inhibits activation of signal transducer and activator of transcription 3 in human breast cancer cells. Carcinogenesis 31:11, pages 1991-1998.
Crossref
S. Kumar, C. J. Seal, M. J. R. Howes, G. C. Kite & E. J. Okello. (2010) In vitro protective effects of Withania somnifera (L.) dunal root extract against hydrogen peroxide and β‐amyloid (1–42) ‐induced cytotoxicity in differentiated PC12 cells . Phytotherapy Research 24:10, pages 1567-1574.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.