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Review Article

Cancer Cell Signaling Pathways Targeted by Spice-Derived Nutraceuticals

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Pages 173-197 | Received 27 Jul 2011, Accepted 20 Jun 2011, Published online: 09 Dec 2011

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Vijay P. Kale, Patrick J. Gilhooley, Sangita Phadtare, Ali Nabavizadeh & Manoj K. Pandey. 2018. Role of Nutraceuticals in Chemoresistance to Cancer. Role of Nutraceuticals in Chemoresistance to Cancer 151 167 .
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Manoj K. Pandey, Subash C. Gupta, Ali Nabavizadeh & Bharat B. Aggarwal. (2017) Regulation of cell signaling pathways by dietary agents for cancer prevention and treatment. Seminars in Cancer Biology 46, pages 158-181.
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Nagisa Nosrati, Marica Bakovic & Gopinadhan Paliyath. (2017) Molecular Mechanisms and Pathways as Targets for Cancer Prevention and Progression with Dietary Compounds. International Journal of Molecular Sciences 18:10, pages 2050.
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A.G.M. Mostofa, Md Kamal Hossain, Debasish Basak & Muhammad Shahdaat Bin Sayeed. (2017) Thymoquinone as a Potential Adjuvant Therapy for Cancer Treatment: Evidence from Preclinical Studies. Frontiers in Pharmacology 8.
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Greeshma Gopalan, Bhandara Purayil Dhanya, Jayaram Saranya, Thankappan Remadevi Reshmitha, Thekke Veettil Baiju, Murugan Thulasi Meenu, Mangalam S. Nair, Prakasan Nisha & Kokkuvayil Vasu Radhakrishnan. (2017) Metal-Free trans -Aziridination of Zerumbone: Synthesis and Biological Evaluation of Aziridine Derivatives of Zerumbone . European Journal of Organic Chemistry 2017:21, pages 3072-3077.
Crossref
Ajaikumar B Kunnumakkara, Devivasha Bordoloi, Ganesan Padmavathi, Javadi Monisha, Nand Kishor Roy, Sahdeo Prasad & Bharat B Aggarwal. (2017) Curcumin, the golden nutraceutical: multitargeting for multiple chronic diseases. British Journal of Pharmacology 174:11, pages 1325-1348.
Crossref
Khalid El Bairi, Mounir Ouzir, Najda Agnieszka & Loubna Khalki. (2017) Anticancer potential of Trigonella foenum graecum: Cellular and molecular targets. Biomedicine & Pharmacotherapy 90, pages 479-491.
Crossref
Haseeb Zubair, Shafquat Azim, Aamir Ahmad, Mohammad Khan, Girijesh Patel, Seema Singh & Ajay Singh. (2017) Cancer Chemoprevention by Phytochemicals: Nature’s Healing Touch. Molecules 22:3, pages 395.
Crossref
Hugo W. Huth, Daniel M. Santos, Humberto D. Gravina, Jarbas M. Resende, Alfredo M. Goes, Maria Elena De Lima & Catherine Ropert. (2017) Upregulation of p38 pathway accelerates proliferation and migration of MDA-MB-231 breast cancer cells. Oncology Reports 37:4, pages 2497-2505.
Crossref
B. P. Dhanya, Greeshma Gopalan, T. R. Reshmitha, J. Saranya, P. Sharathna, I. G. Shibi, P. Nisha & K. V. Radhakrishnan. (2017) Synthesis and in vitro evaluation of zerumbone pendant derivatives: potent candidates for anti-diabetic and anti-proliferative activities. New Journal of Chemistry 41:15, pages 6960-6964.
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Bangrong Cai, Aimei Liao, Kyung-Ku Lee, Jae-Sam Ban, Hyun-Sam Yang, Young Jun Im & ChangJu Chun. (2016) Design, synthesis of methotrexate-diosgenin conjugates and biological evaluation of their effect on methotrexate transport-resistant cells. Steroids 116, pages 45-51.
Crossref
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László Hackler, Béla Ózsvári, Márió Gyuris, Péter Sipos, Gabriella Fábián, Eszter Molnár, Annamária Marton, Nóra Faragó, József Mihály, Lajos István Nagy, Tibor Szénási, Andrea Diron, Árpád Párducz, Iván Kanizsai & László G. Puskás. (2016) The Curcumin Analog C-150, Influencing NF-κB, UPR and Akt/Notch Pathways Has Potent Anticancer Activity In Vitro and In Vivo. PLOS ONE 11:3, pages e0149832.
Crossref
Shih-Min Hsia, Wei-Hwa Lee, Gow-Chin Yen & Chi-Hao Wu. (2016) Capsaicin, an active ingredient from chilli peppers, attenuates glycative stress and restores sRAGE levels in diabetic rats. Journal of Functional Foods 21, pages 406-417.
Crossref
Mario Pulido-Moran, Jorge Moreno-Fernandez, Cesar Ramirez-Tortosa & MCarmen Ramirez-Tortosa. (2016) Curcumin and Health. Molecules 21:3, pages 264.
Crossref
Andrea Martínez-Herrera, Amaury Pozos-Guillén, Socorro Ruiz-Rodríguez, Arturo Garrocho-Rangel, Antonio Vértiz-Hernández & Diana María Escobar-García. (2016) Effect of 4-Allyl-1-hydroxy-2-methoxybenzene (Eugenol) on Inflammatory and Apoptosis Processes in Dental Pulp Fibroblasts. Mediators of Inflammation 2016, pages 1-7.
Crossref
Mafalda Jesus, Ana P. J. Martins, Eugenia Gallardo & Samuel Silvestre. (2016) Diosgenin: Recent Highlights on Pharmacology and Analytical Methodology. Journal of Analytical Methods in Chemistry 2016, pages 1-16.
Crossref
Swati Pund, Amita Joshi & Vandana Patravale. 2016. Nutraceuticals. Nutraceuticals 481 534 .
György Dormán, Beáta Flachner, István Hajdú & Csaba D. András. 2016. Nutraceuticals. Nutraceuticals 263 286 .
Ana Clara Aprotosoaie, Irina-Iuliana Costache & Anca Miron. 2016. Drug Discovery from Mother Nature. Drug Discovery from Mother Nature 247 267 .
Nicola Amodio, Eugenio Morelli, Agnese Barone & Pierfrancesco Tassone. 2016. Molecular Targets and Strategies in Cancer Prevention. Molecular Targets and Strategies in Cancer Prevention 37 60 .
Mei-Ling Chan, Jui-Wei Liang, Lih-Ching Hsu, Wei-Ling Chang, Shoei-Sheng Lee & Jih-Hwa Guh. (2015) Zerumbone, a ginger sesquiterpene, induces apoptosis and autophagy in human hormone-refractory prostate cancers through tubulin binding and crosstalk between endoplasmic reticulum stress and mitochondrial insult. Naunyn-Schmiedeberg's Archives of Pharmacology 388:11, pages 1223-1236.
Crossref
Paul B. Yaffe, Melanie R. Power Coombs, Carolyn D. Doucette, Mark Walsh & David W. Hoskin. (2015) Piperine, an alkaloid from black pepper, inhibits growth of human colon cancer cells via G1 arrest and apoptosis triggered by endoplasmic reticulum stress. Molecular Carcinogenesis 54:10, pages 1070-1085.
Crossref
Sanguine Byun, Semi Lim, Ji Young Mun, Ki Hyun Kim, Timothy R. Ramadhar, Lee Farrand, Seung Ho Shin, N.R. Thimmegowda, Hyong Joo Lee, David A. Frank, Jon Clardy, Sam W. Lee & Ki Won Lee. (2015) Identification of a Dual Inhibitor of Janus Kinase 2 (JAK2) and p70 Ribosomal S6 Kinase1 (S6K1) Pathways. Journal of Biological Chemistry 290:39, pages 23553-23562.
Crossref
Yassine Chtourou, Bakhta Aouey, Mohammed Kebieche & Hamadi Fetoui. (2015) Protective role of naringin against cisplatin induced oxidative stress, inflammatory response and apoptosis in rat striatum via suppressing ROS-mediated NF-κB and P53 signaling pathways. Chemico-Biological Interactions 239, pages 76-86.
Crossref
Johanna M. Gostner, Kathrin Becker, Florian Ueberall & Dietmar Fuchs. (2015) The good and bad of antioxidant foods: An immunological perspective. Food and Chemical Toxicology 80, pages 72-79.
Crossref
Yan He, Yuan Yue, Xi Zheng, Kun Zhang, Shaohua Chen & Zhiyun Du. (2015) Curcumin, Inflammation, and Chronic Diseases: How Are They Linked?. Molecules 20:5, pages 9183-9213.
Crossref
Antonino CarboneManoj K Pandey & Bharat B Aggarwal. 2015. Hodgkin And Non-Hodgkin Lymphomas Seen Through Their Microenvironment: Impact on Diagnosis, Prognosis and Innovative Therapy (Volume 1). Hodgkin And Non-Hodgkin Lymphomas Seen Through Their Microenvironment: Impact on Diagnosis, Prognosis and Innovative Therapy (Volume 1) 110 126 .
Andrew J. McLachlan & Stephen J. Clarke. 2015. Phytotherapies. Phytotherapies 536 553 .
Jeannette E. FergusonRobert A. Orlando. (2015) Curcumin Reduces Cytotoxicity of 5-Fluorouracil Treatment in Human Breast Cancer Cells. Journal of Medicinal Food 18:4, pages 497-502.
Crossref
Aamir Ahmad, Kevin Ginnebaugh, Yiwei Li, Subhash Padhye & Fazlul Sarkar. (2015) Molecular Targets of Naturopathy in Cancer Research: Bridge to Modern Medicine. Nutrients 7:1, pages 321-334.
Crossref
Samarjit Jana, Kartick Patra, Gopeswar Mukherjee, Shamee Bhattacharjee & Deba Prasad Mandal. (2015) Antitumor potential of anethole singly and in combination with cyclophosphamide in murine Sarcoma-180 transplantable tumor model. RSC Advances 5:70, pages 56549-56559.
Crossref
Johannah NM, Renny RM, Gopakumar G, Balu Maliakel, Sureshkumar D & Krishnakumar IM. (2015) Beyond the flavour: a de-flavoured polyphenol rich extract of clove buds (Syzygium aromaticum L) as a novel dietary antioxidant ingredient. Food & Function 6:10, pages 3373-3382.
Crossref
Shinjini Singh, Amit Kumar Tyagi, Sasha Raman, Jiamin Huang, Lokesh Deb, Qaisar Manzoor, Arfaa Sajid, LiXin Yang, Jagnyeswar Ratha, Sahdeo Prasad & Bharat B. Aggarwal. 2015. Multi-Targeted Approach to Treatment of Cancer. Multi-Targeted Approach to Treatment of Cancer 19 56 .
Donna M. Raditic & Joseph W. Bartges. (2014) Evidence-based Integrative Medicine in Clinical Veterinary Oncology. Veterinary Clinics of North America: Small Animal Practice 44:5, pages 831-853.
Crossref
Ogunc Meral, Merve Alpay, Gorkem Kismali, Funda Kosova, Dilek Ulker Cakir, Mert Pekcan, Serbulent Yigit & Tevhide Sel. (2014) Capsaicin inhibits cell proliferation by cytochrome c release in gastric cancer cells. Tumor Biology 35:7, pages 6485-6492.
Crossref
Luís Moreira GonçalvesInês Maria ValenteJosé António Rodrigues. (2014) An Overview on Cardamonin. Journal of Medicinal Food 17:6, pages 633-640.
Crossref
Kodappully Sivaraman Siveen, Sakshi Sikka, Rohit Surana, Xiaoyun Dai, Jingwen Zhang, Alan Prem Kumar, Benny K.H. Tan, Gautam Sethi & Anupam Bishayee. (2014) Targeting the STAT3 signaling pathway in cancer: Role of synthetic and natural inhibitors. Biochimica et Biophysica Acta (BBA) - Reviews on Cancer 1845:2, pages 136-154.
Crossref
Donald Craig Willcox, Giovanni Scapagnini & Bradley J. Willcox. (2014) Healthy aging diets other than the Mediterranean: A focus on the Okinawan diet. Mechanisms of Ageing and Development 136-137, pages 148-162.
Crossref
Sakshi Sikka, Muthu K. Shanmugam, Radhamani Kannaiyan, Rohit Surana, Eun Myoung Shin, Alan Prem Kumar, Gautam Sethi & Kwang Seok Ahn. (2013) Suppression of essential pro-inflammatory signaling pathways by natural agents for the therapy of Multiple Myeloma. Phytochemistry Reviews 13:1, pages 79-106.
Crossref
B. N. Singh, Harikesh Bahadur Singh, A. Singh, Alim H. Naqvi & Braj Raj Singh. (2014) Dietary phytochemicals alter epigenetic events and signaling pathways for inhibition of metastasis cascade. Cancer and Metastasis Reviews 33:1, pages 41-85.
Crossref
K.R. Ajish, B.P. Dhanya, Nayana Joseph, M. Priya Rani, K.G. Raghu, V.P. Vineetha & K.V. Radhakrishnan. (2014) Synthesis of novel zerumbone derivatives via regioselective palladium catalyzed decarboxylative coupling reaction: a new class of α-glucosidase inhibitors. Tetrahedron Letters 55:3, pages 665-670.
Crossref
Carolin Cornelius, Antonio Graziano, Rosario Perrotta, Rosanna Di Paola, Salvatore Cuzzocrea, Edward J. Calabrese & Vittorio Calabrese. 2014. Inflammation, Advancing Age and Nutrition. Inflammation, Advancing Age and Nutrition 309 321 .
Paulo Vilar-Saavedra & Barbara E. Kitchell. 2014. Skin Cancer. Skin Cancer 499 514 .
Chung S. Yang, Hong Wang & Bing Hu. (2013) Combination of Chemopreventive Agents in Nanoparticles for Cancer Prevention. Cancer Prevention Research 6:10, pages 1011-1014.
Crossref
Allan Lançon, Jean-Jacques Michaille & Norbert Latruffe. (2013) Effects of dietary phytophenols on the expression of microRNAs involved in mammalian cell homeostasis. Journal of the Science of Food and Agriculture 93:13, pages 3155-3164.
Crossref
Jianling Sun, Guolan Gao, YuLian Gao, liJuan Xiong, Xiaoying Li, Jihong Guo & Yueming Zhang. (2013) Experimental Research on the In Vitro Antitumor Effects of Crataegus sanguinea. Cell Biochemistry and Biophysics 67:1, pages 207-213.
Crossref
Rutugandha Paranjpe, Sushma R. Gundala, N. Lakshminarayana, Arpana Sagwal, Ghazia Asif, Anjali Pandey & Ritu Aneja. (2013) Piper betel leaf extract: anticancer benefits and bio-guided fractionation to identify active principles for prostate cancer management. Carcinogenesis 34:7, pages 1558-1566.
Crossref
S. Curic, Y. Wu, B. Shan, C. Schaaf, D. Utpadel, M. Lange, D. Kuhlen, M. J. Perone, E. Arzt, G. K. Stalla & U. Renner. (2013) Curcumin acts anti-proliferative and pro-apoptotic in human meningiomas. Journal of Neuro-Oncology 113:3, pages 385-396.
Crossref
Y.B. Shaik-Dasthagirisaheb, G. Varvara, G. Murmura, A. Saggini, A. Caraffa, P. Antinolfi, S. Tetè, M. Rosati, E. Cianchetti, E. Toniato, L. Speranza, A. Pantalone, R. Saggini, L.M. Di Tommaso, P. Conti, T.C. Theoharides & F. Pandolfi. (2013) Inhibitor Effect of Antioxidant Flavonoids Quercitin, and Capsaicin in Mast Cell Inflammation. European Journal of Inflammation 11:2, pages 353-357.
Crossref
Kyung-Soo Chun, Eun-Hee Kim, Sooyeon Lee & Ki Baik Hahm. (2013) Chemoprevention of Gastrointestinal Cancer: The Reality and the Dream. Gut and Liver 7:2, pages 137-149.
Crossref
SUSAN J. ZUNINO, DAVID H. STORMS, JOHN W. NEWMAN, THERESA L. PEDERSEN, CARL L. KEEN & JONATHAN M. DUCORE. (2013) Oral or parenteral administration of curcumin does not prevent the growth of high-risk t(4;11) acute lymphoblastic leukemia cells engrafted into a NOD/SCID mouse model. International Journal of Oncology 42:2, pages 741-748.
Crossref
June K. Dunnick & Abraham Nyska. (2012) The Toxicity and Pathology of Selected Dietary Herbal Medicines. Toxicologic Pathology 41:2, pages 374-386.
Crossref
André Wirries, Ann-Kristin Schubert, René Zimmermann, Samir Jabari, Steffen Ruchholtz & Nahed El-Najjar. (2013) Thymoquinone accelerates osteoblast differentiation and activates bone morphogenetic protein-2 and ERK pathway. International Immunopharmacology 15:2, pages 381-386.
Crossref
Nagi B. Kumar, Medha Dhurandhar, Bharat Aggarwal, Shrikant Anant, Kenyon Daniel, Gary Deng, Julie Djeu, Jinhui Dou, Ernest Hawk, B. Jayaram, Libin Jia, Rajendra Joshi, Madhuri Kararala, Devarajan Karunagaran, Omer Kucuk, Lalit Kumar, Mokenge Malafa, G. J. Samathanam, Fazlul Sarkar, Maqsood Siddiqi, Rana P. Singh, Anil Srivastava & Jeffrey D. White. (2012) Proceedings of the I ndo‐ U.S. bilateral workshop on accelerating botanicals/biologics agent development research for cancer chemoprevention, treatment, and survival . Cancer Medicine 2:1, pages 108-115.
Crossref
Susana González-Reyes, Silvia Guzmán-Beltrán, Omar Noel Medina-Campos & José Pedraza-Chaverri. (2013) Curcumin Pretreatment Induces Nrf2 and an Antioxidant Response and Prevents Hemin-Induced Toxicity in Primary Cultures of Cerebellar Granule Neurons of Rats. Oxidative Medicine and Cellular Longevity 2013, pages 1-14.
Crossref
Wanying Zhang, Jie Liao, Haonan Li, Allison Yang, Sanjay K. Srivastava & Guang-Yu Yang. 2013. Role of Capsaicin in Oxidative Stress and Cancer. Role of Capsaicin in Oxidative Stress and Cancer 89 106 .
Bernd Nilius & Giovanni Appendino. 2013. Reviews of Physiology, Biochemistry and Pharmacology, Vol. 164. Reviews of Physiology, Biochemistry and Pharmacology, Vol. 164 1 76 .
Nasser M Al-Daghri, Majed S Alokail, Khalid M Alkharfy, Abdul Khader Mohammed, Sherif H Abd-Alrahman, Sobhy M Yakout, Osama E Amer & Soundararajan Krishnaswamy. (2012) Fenugreek extract as an inducer of cellular death via autophagy in human T lymphoma Jurkat cells. BMC Complementary and Alternative Medicine 12:1.
Crossref
Zhi-Heng He, Grace Gar-Lee Yue, Clara Bik-San Lau, Wei Ge & Paul Pui-Hay But. (2012) Antiangiogenic Effects and Mechanisms of trans -Ethyl p -Methoxycinnamate from Kaempferia galanga L. . Journal of Agricultural and Food Chemistry 60:45, pages 11309-11317.
Crossref
Naveen Kumar Vishvakarma, Anjani Kumar, Ajay Kumar, Shiva Kant, Alok Chandra Bharti & Sukh Mahendra Singh. (2012) Myelopotentiating effect of curcumin in tumor-bearing host: Role of bone marrow resident macrophages. Toxicology and Applied Pharmacology 263:1, pages 111-121.
Crossref

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