Advanced search
Publication Cover
Nutrition and Cancer Volume 64, 2012 - Issue 7
Submit an article Journal homepage
426
Views
27
CrossRef citations to date
0
Altmetric
Original Articles

Cytotoxicity of Ascorbic Acid in a Human Colorectal Adenocarcinoma Cell Line (WiDr): In Vitro and In Vivo Studies

Ana Catarina Mamede Biophysics Unit, Institute of Biomedical Research on Light and Image (IBILI), Faculty of Medicine, University of Coimbra, Coimbra, Portugal; CICS-UBI, Health Sciences Research Centre, University of Beira Interior, Covilhã, Portugal; Centre of Investigation on Environment, Genetics and Oncobiology, Faculty of Medicine, University of Coimbra, Coimbra, Portugal
,
Ana Salomé Pires Biophysics Unit, Institute of Biomedical Research on Light and Image (IBILI), Faculty of Medicine, University of Coimbra, Coimbra, Portugal; Faculty of Sciences and Technology, University of Coimbra, Coimbra, Portugal
,
Ana Margarida Abrantes Biophysics Unit, Institute of Biomedical Research on Light and Image (IBILI), Faculty of Medicine, University of Coimbra, Coimbra, Portugal; Centre of Investigation on Environment, Genetics and Oncobiology, Faculty of Medicine, University of Coimbra, Coimbra, Portugal
,
Sónia Dorilde Tavares Biophysics Unit, Institute of Biomedical Research on Light and Image (IBILI), Faculty of Medicine, University of Coimbra, Coimbra, Portugal; Centre of Investigation on Environment, Genetics and Oncobiology, Faculty of Medicine, University of Coimbra, Coimbra, Portugal; Faculty of Sciences and Technology, University of Coimbra, Coimbra, Portugal
,
Ana Cristina Gonçalves Centre of Investigation on Environment, Genetics and Oncobiology, Faculty of Medicine, University of Coimbra, Coimbra, Portugal; Applied Molecular Biology and Hematology Group, Faculty of Medicine, University of Coimbra, Coimbra, Portugal
,
João Eduardo Casalta-Lopes Biophysics Unit, Institute of Biomedical Research on Light and Image (IBILI), Faculty of Medicine, University of Coimbra, Coimbra, Portugal
,
Ana Bela Sarmento-Ribeiro Centre of Investigation on Environment, Genetics and Oncobiology, Faculty of Medicine, University of Coimbra, Coimbra, Portugal; Applied Molecular Biology and Hematology Group, Faculty of Medicine, University of Coimbra, Coimbra, Portugal
,
Jorge Manuel Maia Faculty of Sciences, University of Beira Interior, Covilhã, Portugal
&
Maria Filomena Botelho Biophysics Unit, Institute of Biomedical Research on Light and Image (IBILI), Faculty of Medicine, University of Coimbra, Coimbra, Portugal; Centre of Investigation on Environment, Genetics and Oncobiology, Faculty of Medicine, University of Coimbra, Coimbra, Portugal
 show all
Pages 1049-1057 | Received 18 Apr 2012, Accepted 13 Jul 2012, Published online: 13 Sep 2012

Citations (27)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (2)

Ana Filipa Brito, Marina Ribeiro, Ana Margarida Abrantes, Ana Catarina Mamede, Mafalda Laranjo, João Eduardo Casalta-Lopes, Ana Cristina Gonçalves, Ana Bela Sarmento-Ribeiro, José Guilherme Tralhão & Maria Filomena Botelho. (2016) New Approach for Treatment of Primary Liver Tumors: The Role of Quercetin. Nutrition and Cancer 68:2, pages 250-266.
Read now
P.-L. Lam, S. H.-L. Kok, Z.-X. Bian, K.-H. Lam, R. Gambari, K. K.-H. Lee & C.-H. Chui. (2014) Microencapsulation-protected l-ascorbic acid for the application of human epithelial HaCaT cell proliferation. Journal of Microencapsulation 31:8, pages 754-758.
Read now

Articles from other publishers (25)

Thomas Kietzmann. (2023) Vitamin C: From nutrition to oxygen sensing and epigenetics. Redox Biology 63, pages 102753.
Crossref
Zijie Luo, Gervase Ng, Yingzhu Zhou, Cyrille Boyer & Rona Chandrawati. (2022) Polymeric Amines Induce Nitric Oxide Release from S ‐Nitrosothiols . Small 19:13.
Crossref
Rui Jiang, Yang Sui, Jingru Hong, Manabu Niimi, Qiaojing Yan, Zhuheng Shi & Jian Yao. (2023) The Combined Administration of Vitamin C and Copper Induces a Systemic Oxidative Stress and Kidney Injury. Biomolecules 13:1, pages 143.
Crossref
Eduarda Santos de Santana, Leila Bastos Leal, Luzia Abílio da Silva, Irla Carla de França Barbosa, Cristiane Moutinho Lagos de Melo, Dayane Kelly Dias do Nascimento Santos & Jeymesson Raphael Cardoso Vieira. (2023) Association of Rhizophora mangle and ascorbic acid in hydrogels: Evaluation of cytotoxic and immunomodulatory effects. Brazilian Journal of Pharmaceutical Sciences 59.
Crossref
Franziska Böttger, Andrea Vallés-Martí, Loraine Cahn & Connie R. Jimenez. (2021) High-dose intravenous vitamin C, a promising multi-targeting agent in the treatment of cancer. Journal of Experimental & Clinical Cancer Research 40:1.
Crossref
Anna Zasowska-Nowak, Piotr Jan Nowak & Aleksandra Ciałkowska-Rysz. (2021) High-Dose Vitamin C in Advanced-Stage Cancer Patients. Nutrients 13:3, pages 735.
Crossref
Ali Ghanem, Anna Maria Melzer, Esther Zaal, Laura Neises, Danny Baltissen, Omar Matar, Hannah Glennemeier-Marke, Fadi Almouhanna, Jannick Theobald, Mohamed A. Abu el Maaty, Celia Berkers & Stefan Wölfl. (2021) Ascorbate kills breast cancer cells by rewiring metabolism via redox imbalance and energy crisis. Free Radical Biology and Medicine 163, pages 196-209.
Crossref
Edgar Tavares-da-Silva, Eurico Pereira, Ana S. Pires, Ana R. Neves, Catarina Braz-Guilherme, Inês A. Marques, Ana M. Abrantes, Ana C. Gonçalves, Francisco Caramelo, Rafael Silva-Teixeira, Fernando Mendes, Arnaldo Figueiredo & Maria Filomena Botelho. (2021) Cold Atmospheric Plasma, a Novel Approach against Bladder Cancer, with Higher Sensitivity for the High-Grade Cell Line. Biology 10:1, pages 41.
Crossref
Caigui Lin, Jiyang Dong, Zhiliang Wei, Kian-Kai Cheng, Jie Li, Song You, Yueyue Liu, Xiaomin Wang & Zhong Chen. (2020) 1 H NMR-Based Metabolic Profiles Delineate the Anticancer Effect of Vitamin C and Oxaliplatin on Hepatocellular Carcinoma Cells . Journal of Proteome Research 19:2, pages 781-793.
Crossref
M. R. Faustova, E. D. Nikolskaya, M. D. Mollaev, M. B. Sokol, A. I. Zabolotsky, O. A. Zhunina, M. V. Fomicheva, V. I. Schvets, A. V. Lobanov & N. G. Yabbarov. (2020) Polymer particles containing Fe-based metalloporphyrin as a highly efficient stimulator of reactive oxygen species formation in vitro and in vivo. Russian Chemical Bulletin 68:12, pages 2216-2224.
Crossref
Yan Huang, Na He, Qi Kang, Dazhong Shen, Xiaoyan Wang, Yunqing Wang & Lingxin Chen. (2019) A carbon dot-based fluorescent nanoprobe for the associated detection of iron ions and the determination of the fluctuation of ascorbic acid induced by hypoxia in cells and in vivo . The Analyst 144:22, pages 6609-6616.
Crossref
Anitra C. Carr & John Cook. (2018) Intravenous Vitamin C for Cancer Therapy – Identifying the Current Gaps in Our Knowledge. Frontiers in Physiology 9.
Crossref
Ana S. Pires, Cláudia R. Marques, João C. Encarnação, Ana M. Abrantes, Inês A. Marques, Mafalda Laranjo, Rui Oliveira, João E. Casalta-Lopes, Ana C. Gonçalves, Ana B. Sarmento-Ribeiro & Maria F. Botelho. (2018) Ascorbic Acid Chemosensitizes Colorectal Cancer Cells and Synergistically Inhibits Tumor Growth. Frontiers in Physiology 9.
Crossref
M. Elisa Silva Serra, Dina Murtinho, Zênis N. da Rocha, Ana Salomé Pires, João Gabriel Baptista, Ana Margarida Abrantes, Mafalda Laranjo, João Eduardo Casalta-Lopes, Maria Filomena Botelho, Alberto A.C.C. Pais, Sandra C.C. Nunes, Hugh D. Burrows & Telma Costa. (2017) Dibrominated camphoric acid derived salen complexes: Synthesis, characterization and cytotoxic activity. Polyhedron 137, pages 147-156.
Crossref
Suresh Acharya, Timo D. Stark, Seung Tack Oh, Songhee Jeon, Sok Cheon Pak, Mina Kim, Jinyoung Hur, Toshiaki Matsutomo, Thomas Hofmann, Rodney A. Hill & Onesmo B. Balemba. (2017) (2 R ,3 S ,2″ R ,3″ R )-Manniflavanone Protects Proliferating Skeletal Muscle Cells against Oxidative Stress and Stimulates Myotube Formation . Journal of Agricultural and Food Chemistry 65:18, pages 3636-3646.
Crossref
Jorge Carrapita, Ana Margarida Abrantes, Sofia Campelos, Ana Cristina Gonçalves, Dulce Cardoso, Ana Bela Sarmento-Ribeiro, Clara Rocha, Jorge Nunes Santos, Maria Filomena Botelho, José Guilherme Tralhão, Olivier Farges & Jorge Maciel Barbosa. (2016) Impact of splenic artery ligation after major hepatectomy on liver function, regeneration and viability. Scientific Reports 6:1.
Crossref
A. C. Mamede, S. Guerra, M. Laranjo, K. Santos, M. J. Carvalho, T. Carvalheiro, P. Moura, A. Paiva, A. M. Abrantes, C. J. Maia & M. F. Botelho. (2016) Oxidative Stress, DNA, Cell Cycle/Cell Cycle Associated Proteins and Multidrug Resistance Proteins: Targets of Human Amniotic Membrane in Hepatocellular Carcinoma. Pathology & Oncology Research 22:4, pages 689-697.
Crossref
Fernando Mendes, Tiago Sales, Cátia Domingues, Susann Schugk, Ana Margarida Abrantes, Ana Cristina Gonçalves, Ricardo Teixo, Rita Silva, João Casalta-Lopes, Clara Rocha, Mafalda Laranjo, Paulo César Simões, Ana Bela Sarmento Ribeiro, Maria Filomena Botelho & Manuel Santos Rosa. (2015) Effects of X-radiation on lung cancer cells: the interplay between oxidative stress and P53 levels. Medical Oncology 32:12.
Crossref
Xiaohong Pan, Xiaoting Wang, Liyong Wang, Kehua Xu, Fanpeng Kong & Bo Tang. (2015) Near-Infrared Fluorescence Probe for Monitoring the Metabolic Products of Vitamin C in HepG2 Cells under Normoxia and Hypoxia. Analytical Chemistry 87:14, pages 7092-7097.
Crossref
Dina Murtinho, Zênis N. da Rocha, Ana Salomé Pires, Roberto P. Jiménez, Ana Margarida Abrantes, Mafalda Laranjo, Ana Catarina Mamede, João Eduardo Casalta‐Lopes, Maria Filomena Botelho, Alberto A. C. C. Pais, Sandra C. C. Nunes, Hugh D. Burrows, Telma Costa & M. Elisa Silva Serra. (2015) Synthesis, characterization and assessment of the cytotoxic activity of Cu(II), Fe(III) and Mn(III) complexes of camphoric acid‐derived salen ligands. Applied Organometallic Chemistry 29:7, pages 425-432.
Crossref
Ana R. GomesAna M. AbrantesAna F. BritoMafalda LaranjoJoão E. Casalta-LopesAna C. GonçalvesAna B. Sarmento-RibeiroMaria F. BotelhoJosé G. Tralhão. (2015) Influence of P53 on the radiotherapy response of hepatocellular carcinoma. Clinical and Molecular Hepatology 21:3, pages 257.
Crossref
Elizabeth J. Campbell & Gabi U. Dachs. (2014) Current Limitations of Murine Models in Oncology for Ascorbate Research. Frontiers in Oncology 4.
Crossref
Ana Catarina Mamede, M. Laranjo, M. J. Carvalho, A. M. Abrantes, A. S. Pires, A. F. Brito, P. Moura, C. J. Maia & M. F. Botelho. (2014) Effect of Amniotic Membrane Proteins in Human Cancer Cell Lines: An Exploratory Study. The Journal of Membrane Biology 247:4, pages 357-360.
Crossref
Jungyeob Seoung, Young-Han Park, Chaechun Rhim & Sungju Kim. (2014) Current Possible Drug Therapies for Ovarian Cancer. Journal of Cancer Therapy 05:13, pages 1203-1214.
Crossref
A. C. Mamede, A. M. Abrantes, L. Pedrosa, J. E. Casalta-Lopes, A. S. Pires, R. J. Teixo, A. C. Gonçalves, A. B. Sarmento-Ribeiro, C. J. Maia & M. F. Botelho. (2013) Beyond the Limits of Oxygen: Effects of Hypoxia in a Hormone-Independent Prostate Cancer Cell Line. ISRN Oncology 2013, pages 1-8.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.