Cytotoxicity of Ascorbic Acid in a Human Colorectal Adenocarcinoma Cell Line (WiDr): In Vitro and In Vivo Studies

REFERENCES

• Winawer , S J . 2007 . The multidisciplinary management of gastrointestinal cancer. Colorectal cancer screening . Best Practice & Research. Clinical Gastroenterology , 21 : 1031 – 1048 .
   PubMed Web of Science ®Google Scholar
• Potter , J D . 1999 . Colorectal cancer: molecules and populations . Journal of the National Cancer Institute , 91 : 916 – 932 .
   PubMed Web of Science ®Google Scholar
• Center , M. M , Jemal , A and Ward , E . 2009 . International trends in colorectal cancer incidence rates . Cancer Epidemiology, Biomarkers & Prevention , 18 : 1688 – 1694 .
   PubMed Web of Science ®Google Scholar
• Lee , K W , Lee , H J , Surh , Y-J and Lee , C Y . 2003 . Vitamin C and cancer chemoprevention: reappraisal . American Journal of Clinical Nutrition , 78 : 1074 – 1078 .
   PubMed Web of Science ®Google Scholar
• Deutsch , J C . 2000 . Dehydroascorbic acid . Journal of Chromatography , 881 : 299 – 307 .
   PubMed Web of Science ®Google Scholar
• Iqbal , K , Khan , A and Khattak , M . 2004 . Biological Significance of ascorbic acid (vitamin c) in human health: a review . Pakistan Journal of Nutrition , 3 : 5 – 13 .
   Google Scholar
• Padayatty , S J , Katz , A , Wang , Y , Eck , P Kwon , O . 2003 . Vitamin C as an antioxidant: evaluation of its role in disease prevention . Journal of the American College of Nutrition , 22 : 18 – 35 .
   PubMed Web of Science ®Google Scholar
• Mamede , A , Tavares , S , Abrantes , A , Trindade , J Maia , J . 2011 . The role of vitamins in cancer Nutrition and Cancer , 63 : 479 – 494 .
   PubMed Web of Science ®Google Scholar
• Padayatty , S J and Levine , M . 2001 . New insights into the physiology and pharmacology of vitamin C . Canadian Medical Association Journal , 164 : 353 – 355 .
   PubMed Web of Science ®Google Scholar
• Li , Y and Schellhorn , H E . 2007 . New developments and novel therapeutic perspectives for vitamin C . The Journal of Nutrition , 137 : 2171 – 2184 .
   PubMed Web of Science ®Google Scholar
• Padayatty , S J and Levine , M . 2000 . Reevaluation of ascorbate in cancer treatment: emerging evidence, open minds and serendipity . Journal of the American College of Nutrition , 19 : 423 – 425 .
   PubMed Web of Science ®Google Scholar
• Padayatty , S J , Riordan , H D , Hewitt , S M , Katz , A and Hoffer , L J . 2006 . Intravenously administered vitamin C as cancer therapy: three cases . Canadian Medical Association Journal , 174 : 937 – 942 .
   PubMed Web of Science ®Google Scholar
• Chen , Q , Espey , M G , Krishna , M C , Mitchell , J B Corpe , C P . Pharmacologic ascorbic acid concentrations selectively kill cancer cells: action as a pro-drug to deliver hydrogen peroxide to tissues . Proceedings of the National Academy of Sciences of the United States of America , Vol. 102 , pp. 13604 – 13609 .
   Google Scholar
• Valko , M , Leibfritz , D , Moncol , J , Cronin , MTD. Mazur , M . 2007 . Free radicals and antioxidants in normal physiological functions and human disease . The International Journal of Biochemistry & Cell Biology , 39 : 44 – 84 .
   PubMed Web of Science ®Google Scholar
• Fruehauf , J P and Meyskens , F L . 2007 . Reactive oxygen species: a breath of life or death? . Clinical Cancer Research , 13 : 789 – 794 .
   PubMed Web of Science ®Google Scholar
• Orrenius , S , Gogvadze , V and Zhivotovsky , B . 2007 . Mitochondrial oxidative stress: implications for cell death . Annual Review of Pharmacology and Toxicology , 47 : 143 – 183 .
   PubMed Web of Science ®Google Scholar
• Valko , M. , Rhodes , C J , Moncol , J , Izakovic , M and Mazur , M . 2006 . Free radicals, metals and antioxidants in oxidative stress-induced cancer . Chemico-Biological Interactions , 160 : 1 – 40 .
   PubMed Web of Science ®Google Scholar
• Ozben , T . 2007 . Oxidative stress and apoptosis: impact on cancer therapy . Journal of Pharmaceutical Sciences , 96 : 2181 – 2196 .
   PubMed Web of Science ®Google Scholar
• Ames , B N , Shigenaga , M K and Hagen , T M . Oxidants, antioxidants, and the degenerative diseases of aging . Proceedings of the National Academy of Sciences of the United States of America , Vol. 90 , pp. 7915 – 7922 . 17
   Google Scholar
• Goodman , M , Bostick , R M , Dash , C , Flanders , W D and Mandel , J S . 2007 . Hypothesis: oxidative stress score as a combined measure of pro-oxidant and antioxidant exposures . Annals of Epidemiology , 17 : 394 – 399 .
   PubMed Web of Science ®Google Scholar
• Mosmann T . 1983 . Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays . Journal of Immunological Methods , 65 : 55 – 63 .
   PubMed Web of Science ®Google Scholar
• Casalta-Lopes , J , Abrantes , AM , Laranjo , M , Rio , J Gonçalves , AC . 2011 . Efflux pumps modulation in colorectal adenocarcinoma cell lines: the role of nuclear medicine . Journal of Cancer Therapy , 2 : 408 – 417 .
   Google Scholar
• Aubry , J-P , Blaecke , A , Lecoanet-Henchoz , S , Jeannin , P Herbault , N . 1999 . Annexin V used for measuring apoptosis in the early events of cellular cytotoxicity . Cytometry , 37 : 197 – 204 .
   PubMedGoogle Scholar
• Abrantes , A M , Serra , M E , Gonçalves , A C , Rio , J Oliveiros , B . 2010 . Hypoxia-induced redox alterations and their correlation with 99mTc-MIBI and 99mTc-HL-91 uptake in colon cancer cells . Nuclear Medicine and Biology , 37 : 125 – 132 .
   PubMed Web of Science ®Google Scholar
• Halliwell , B and Whiteman , M . 2004 . Measuring reactive species and oxidative damage in vivo and in cell culture: how should you do it and what do the results mean? . British Journal of Pharmacology , 142 : 231 – 255 .
   PubMed Web of Science ®Google Scholar
• Zhao , H , Joseph , J , Fales , HM , Sokoloski , EA Levine , RL . Detection and characterization of the product of hydroethidine and intracellular superoxide by HPLC and limitations of fluorescence . Proceedings of the National Academy of Sciences of the United States of America , Vol. 102 , pp. 5727 – 5732 .
   Google Scholar
• O’Connor , J E , Kimler , B F , Morgan , M C and Tempas , K J . 1988 . A flow cytometric assay for intracellular nonprotein thiols using mercury orange . Cytometry , 9 : 529 – 532 .
   PubMedGoogle Scholar
• Yao , J , Jiang , Z , Duan , W , Huang , J Zhang , L . 2008 . Involvement of mitochondrial pathway in triptolide-induced cytotoxicity in human normal liver L-02 cells . Biological & Pharmaceutical Bulletin , 31 : 592 – 597 .
   PubMed Web of Science ®Google Scholar
• Dagrosa , M . 2003 . Experimental application of boron neutron capture therapy to undifferentiated thyroid carcinoma1 . International Journal of Radiation OncologyBiologyPhysics , 57 : 1084 – 1092 .
   Web of Science ®Google Scholar
• Arrigoni , O and De Tullio , M C . 2002 . Ascorbic acid: much more than just an antioxidant . Biochimica et Biophysica Acta , 1569 : 1 – 9 .
   PubMed Web of Science ®Google Scholar
• Giommarelli , C , Corti , A , Supino , R , Favini , E Paolicchi , A . 2008 . Cellular response to oxidative stress and ascorbic acid in melanoma cells overexpressing gamma-glutamyltransferase . European Journal of Cancer , 44 : 750 – 759 .
   PubMed Web of Science ®Google Scholar
• Rumsey , S C , Kwon , O , Xu , G W , Burant , C F Simpson , I . 1997 . Glucose transporter isoforms GLUT1 and GLUT3 transport dehydroascorbic acid . The Journal of Biological Chemistry , 272 : 18982 – 18989 .
   PubMed Web of Science ®Google Scholar
• Verrax , J and Calderon , P B . 2009 . Pharmacologic concentrations of ascorbate are achieved by parenteral administration and exhibit antitumoral effects . Free Radical Biology & Medicine , 47 : 32 – 40 .
   PubMed Web of Science ®Google Scholar
• Yeom , C-H , Lee , G , Park , JH , Yu , J Park , S . 2009 . High dose concentration administration of ascorbic acid inhibits tumor growth in BALB/C mice implanted with sarcoma 180 cancer cells via the restriction of angiogenesis . Journal of Translational Medicine , 7 : 70
   PubMed Web of Science ®Google Scholar