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Original Articles

Luteolin Induces Apoptosis in BE Colorectal Cancer Cells by Downregulating Calpain, UHRF1, and DNMT1 Expressions

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Pages 1220-1227 | Received 28 May 2013, Accepted 27 Jul 2014, Published online: 10 Sep 2014

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Yelin Song, Jie Yu, LingLing Li, Lei Wang, Liangle Dong, Guangmin Xi, Yun Jing Lu & Zuowei Li. (2022) Luteolin impacts deoxyribonucleic acid repair by modulating the mitogen-activated protein kinase pathway in colorectal cancer. Bioengineered 13:4, pages 10998-11011.
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Busheng Xue, Jiansong Zhao, Penghui Feng, Jia Xing, Hongliang Wu & Yan Li. (2019) Epigenetic mechanism and target therapy of UHRF1 protein complex in malignancies. OncoTargets and Therapy 12, pages 549-559.
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Yijie You, Rong Wang, Naiyuan Shao, Feng Zhi & Yilin Yang. (2019) Luteolin suppresses tumor proliferation through inducing apoptosis and autophagy via MAPK activation in glioma. OncoTargets and Therapy 12, pages 2383-2396.
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Kellen Cristine Tjioe, Denise Tostes Oliveira & Julie Gavard. (2016) Luteolin Impacts on the DNA Damage Pathway in Oral Squamous Cell Carcinoma. Nutrition and Cancer 68:5, pages 838-847.
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Man Zhang, Rui Wang, Jie Tian, Mengqiu Song, Ran Zhao, Kangdong Liu, Feng Zhu, Jung‐Hyun Shim, Zigang Dong & Mee‐Hyun Lee. (2021) Targeting LIMK1 with luteolin inhibits the growth of lung cancer in vitro and in vivo . Journal of Cellular and Molecular Medicine 25:12, pages 5560-5571.
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Omeima Abdullah, Ziad Omran, Salman Hosawi, Ali Hamiche, Christian Bronner & Mahmoud Alhosin. (2021) Thymoquinone Is a Multitarget Single Epidrug That Inhibits the UHRF1 Protein Complex. Genes 12:5, pages 622.
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Chunsik Lee & Jong Kyong Kim. (2020) Chromatin regulators in retinoblastoma: Biological roles and therapeutic applications. Journal of Cellular Physiology 236:4, pages 2318-2332.
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Shizhao Li, Min Chen, Yuanyuan Li & Trygve O. Tollefsbol. (2019) Prenatal epigenetics diets play protective roles against environmental pollution. Clinical Epigenetics 11:1.
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Sravani Polepalli, Sophia M George, R Valli Sri Vidya, Gabriel Sunil Rodrigues, L. Ramachandra, Raghu Chandrashekar, Deepak Nayak M, Praveen P.N. Rao, Richard G. Pestell & Mahadev Rao. (2019) Role of UHRF1 in malignancy and its function as a therapeutic target for molecular docking towards the SRA domain. The International Journal of Biochemistry & Cell Biology 114, pages 105558.
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Qian Zuo, Renyi Wu, Xi Xiao, Caizhi Yang, Yuqing Yang, Chao Wang, Lizhu Lin & Ah‐Ng Kong. (2018) The dietary flavone luteolin epigenetically activates the Nrf2 pathway and blocks cell transformation in human colorectal cancer HCT116 cells. Journal of Cellular Biochemistry 119:11, pages 9573-9582.
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Guillermo Senisterra, Hugh Y. Zhu, Xiao Luo, Hailong Zhang, Guoliang Xun, Chunliang Lu, Wen Xiao, Taraneh Hajian, Peter Loppnau, Irene Chau, Fengling Li, Abdellah Allali-Hassani, Peter Atadja, Counde Oyang, En Li, Peter J. Brown, Cheryl H. Arrowsmith, Kehao Zhao, Zhengtian Yu & Masoud Vedadi. (2018) Discovery of Small-Molecule Antagonists of the H3K9me3 Binding to UHRF1 Tandem Tudor Domain. SLAS Discovery 23:9, pages 930-940.
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Leonardo Elia, Paolo Kunderfranco, Pierluigi Carullo, Marco Vacchiano, Floriana Maria Farina, Ignacio Fernando Hall, Stefano Mantero, Cristina Panico, Roberto Papait, Gianluigi Condorelli & Manuela Quintavalle. (2018) UHRF1 epigenetically orchestrates smooth muscle cell plasticity in arterial disease. Journal of Clinical Investigation 128:6, pages 2473-2486.
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Anna Palko-Labuz, Kamila Sroda-Pomianek, Anna Uryga, Edyta Kostrzewa-Suslow & Krystyna Michalak. (2017) Anticancer activity of baicalein and luteolin studied in colorectal adenocarcinoma LoVo cells and in drug-resistant LoVo/Dx cells. Biomedicine & Pharmacotherapy 88, pages 232-241.
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Harsimran Sidhu & Neena Capalash. (2017) UHRF1: The key regulator of epigenetics and molecular target for cancer therapeutics. Tumor Biology 39:2, pages 101042831769220.
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Mahmoud Alhosin, Ziad Omran, Mazin A. Zamzami, Abdulrahman L. Al-Malki, Hani Choudhry, Marc Mousli & Christian Bronner. (2016) Signalling pathways in UHRF1-dependent regulation of tumor suppressor genes in cancer. Journal of Experimental & Clinical Cancer Research 35:1.
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Rajnee Kanwal, Manish Datt, Xiaoqi Liu & Sanjay Gupta. (2016) Dietary Flavones as Dual Inhibitors of DNA Methyltransferases and Histone Methyltransferases. PLOS ONE 11:9, pages e0162956.
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Natthawan Kittiratphatthana, Veerapol Kukongviriyapan, Auemduan Prawan & Laddawan Senggunprai. (2016) Luteolin induces cholangiocarcinoma cell apoptosis through the mitochondrial-dependent pathway mediated by reactive oxygen species. Journal of Pharmacy and Pharmacology 68:9, pages 1184-1192.
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