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Original Articles

Luteolin Induces Apoptosis in BE Colorectal Cancer Cells by Downregulating Calpain, UHRF1, and DNMT1 Expressions

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Pages 1220-1227 | Received 28 May 2013, Accepted 27 Jul 2014, Published online: 10 Sep 2014

REFERENCES

  • Rossand JA and Kasum CM: Dietary flavonoids: bioavailability, metabolic effects, and safety. Annu Rev Nutr 22, 19–34, 2002.
  • Birt DF, Hendrich S, and Wang W: Dietary agents in cancer prevention: flavonoids and isoflavonoids. Pharmacol Ther 90, 157–177, 2001.
  • Yang CS, Landau JM, Huang MT, and Newmark HL: Inhibition of carcinogenesis by dietary polyphenolic compounds. Annu Rev Nutr 21, 381–406, 2001.
  • Seelinger G, Merfort I, Wolfle U, and Schempp CM: Anti-carcinogenic effects of the flavonoid luteolin. Molecules 13, 2628–2651, 2008.
  • Samy RP, Gopalakrishnakone P, and Ignacimuthu S: Anti-tumor promoting potential of luteolin against 7,12-dimethylbenz(a)anthracene-induced mammary tumors in rats. Chem Biol Interact 164, 1–14, 2006.
  • Chiang CT, Way TD, and Lin JK: Sensitizing HER2-overexpressing cancer cells to luteolin-induced apoptosis through suppressing p21(WAF1/CIP1) expression with rapamycin. Mol Cancer Ther 6, 2127–2138, 2007.
  • Selvendiran K, Koga H, Ueno T, Yoshida T, Maeyama M, et al.: Luteolin promotes degradation in signal transducer and activator of transcription 3 in human hepatoma cells: an implication for the antitumor potential of flavonoids. Cancer Res 66, 4826–4834, 2006.
  • Cantero G, Campanella C, Mateos S, and Cortes F: Topoisomerase II inhibition and high yield of endoreduplication induced by the flavonoids luteolin and quercetin. Mutagenesis 21, 321–325, 2006.
  • Kim JH, Lee EO, Lee HJ, Ku JS, Lee MH, et al.: Caspase activation and extracellular signal-regulated kinase/Akt inhibition were involved in luteolin-induced apoptosis in Lewis lung carcinoma cells. Ann N Y Acad Sci 1095, 598–611, 2007.
  • Huang YT, Hwang JJ, Lee PP, Ke FC, Huang JH, et al.: Effects of luteolin and quercetin, inhibitors of tyrosine kinase, on cell growth and metastasis-associated properties in A431 cells overexpressing epidermal growth factor receptor. Br J Pharmacol 128, 999–1010, 1999.
  • Leloupand L and Wells A: Calpains as potential anti-cancer targets. Expert 15, 309–323, 2011.
  • Alhosin M, Sharif T, Mousli M, Etienne-Selloum N, Fuhrmann G, et al.: Down-regulation of UHRF1, associated with re-expression of tumor suppressor genes, is a common feature of natural compounds exhibiting anti-cancer properties. Journal of Experimental & Clinical Cancer Research 30, 41, 2011.
  • Geng Y, Gao Y, Ju H, and Yan F: Diagnostic and prognostic value of plasma and tissue UHRF1 in breast cancer patients. SO - Cancer Sci 2012. doi:101111/cas12052 (2012)
  • Y. Kofunato, K. Kumamoto, K. Saitou, S. Hayase, H. Okayama, et al.: UHRF1 expression is upregulated and associated with cellular proliferation in colorectal cancer. SO–Oncol Rep 28, 1997–2002 2012. doi:103892/or20122064
  • Jazirehi AR, Arle D, and Wenn PB: UHRF1: a master regulator in prostate cancer. Epigenomics 4, 251–252, 2012.
  • Sabatino L, Fucci A, Pancione M, Carafa V, Nebbioso A, et al.: UHRF1 coordinates peroxisome proliferator activated receptor gamma (PPARG) epigenetic silencing and mediates colorectal cancer progression. SO–Oncogene 2012. doi:101038/onc20123
  • Chang H, Mi MT, Gu YY, Yuan JL, Ling WH, et al.:. [Effects of flavonoids with different structures on proliferation of leukemia cell line HL-60]. Ai Zheng 26, 1309–1314, 2007.
  • Lim do Y, Jeong Y, Tyner AL, and Park JH: Induction of cell cycle arrest and apoptosis in HT-29 human colon cancer cells by the dietary compound luteolin. Am J Physiol Gastrointest Liver Physiol 292, G66–G75, 2007.
  • Leung HW, Wu CH, Lin CH, and Lee HZ: Luteolin induced DNA damage leading to human lung squamous carcinoma CH27 cell apoptosis. Eur J Pharmacol 508, 77–83, 2005.
  • Shi RX, Ong CN, and Shen HM: Luteolin sensitizes tumor necrosis factor-alpha-induced apoptosis in human tumor cells. Oncogene 23, 7712–7721, 2004.
  • Cain K, Bratton SB, and Cohen GM: The Apaf-1 apoptosome: a large caspase-activating complex. Biochimie 84, 203–214, 2002.
  • Viragand L and Szabo C: The therapeutic potential of poly(ADP-ribose) polymerase inhibitors. Pharmacol Rev 54, 375–429, 2002.
  • Mellgren RL: Evidence for participation of a calpain-like cysteine protease in cell cycle progression through late G1 phase. Biochem Biophys Res Commun 236, 555–558, 1997.
  • Joy J, Nalabothula N, Ghosh M, Popp O, Jochum M, et al.: Identification of calpain cleavage sites in the G1 cyclin-dependent kinase inhibitor p19(INK4d). Biol Chem 387, 329–335, 2006.
  • Je Ma C, Jung WJ, Lee KY, Kim YC, and Sung SH: Calpain inhibitory flavonoids isolated from Orostachys japonicus. J Enzyme Inhib Med Chem 24, 676–679, 2009.
  • Kim HJ, Lee JY, Kim SM, Park DA, Jin C, et al.: A new epicatechin gallate and calpain inhibitory activity from Orostachys japonicus. Fitoterapia 80, 73–76, 2009.
  • Xuand L and Deng X: Tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone induces phosphorylation of mu- and m-calpain in association with increased secretion, cell migration, and invasion. J Biol Chem 279, 53683–53690, 2004.
  • Xuand L and Deng X: Protein kinase Ciota promotes nicotine-induced migration and invasion of cancer cells via phosphorylation of micro- and m-calpains. J Biol Chem 281, 4457–4466, 2006.
  • Tien AL, Senbanerjee S, Kulkarni A, Mudbhary R, Goudreau B, et al.: UHRF1 depletion causes a G2/M arrest, activation of DNA damage response and apoptosis. Biochem 435, 175–185, 2012.
  • Fini L, Selgrad M, Fogliano V, Graziani G, Romano M, et al.: Annurca apple polyphenols have potent demethylating activity and can reactivate silenced tumor suppressor genes in colorectal cancer cells. J Nutr 137, 2622–2628, 2007.
  • Nandakumar V, Vaid M, and Katiyar SK: (-)-Epigallocatechin-3-gallate reactivates silenced tumor suppressor genes, Cip1/p21 and p16INK4a, by reducing DNA methylation and increasing histones acetylation in human skin cancer cells. Carcinogenesis 32, 537–544, 2011.
  • Achour M, Jacq X, Ronde P, Alhosin M, Charlot C, et al.: The interaction of the SRA domain of ICBP90 with a novel domain of DNMT1 is involved in the regulation of VEGF gene expression. Oncogene 27, 2187–2197, 2008.
  • Alhosin M, Abusnina A, Achour M, Sharif T, Muller C, et al.: Induction of apoptosis by thymoquinone in lymphoblastic leukemia Jurkat cells is mediated by a p73-dependent pathway which targets the epigenetic integrator UHRF1. SO - Biochem Pharmacol 79, 1251–1260, 2010.
  • Unoki M, Nishidate T, and Nakamura Y: ICBP90, an E2F-1 target, recruits HDAC1 and binds to methyl-CpG through its SRA domain. Oncogene 23, 7601–7610, 2004.
  • Chen Z, Knutson E, Kurosky A, and Albrecht T: Degradation of p21cip1 in cells productively infected with human cytomegalovirus. J Virol 75, 3613–3625, 2001.
  • Delmas C., Aragou N, Poussard S, Cottin P, Darbon JM, et al.: MAP kinase-dependent degradation of p27Kip1 by calpains in choroidal melanoma cells. Requirement of p27Kip1 nuclear export. J Biol Chem 278, 12443–12451, 2003.
  • Abusnina A, Keravis T, Yougbare I, Bronner C, and. Lugnier C:. Anti-proliferative effect of curcumin on melanoma cells is mediated by PDE1A inhibition that regulates the epigenetic integrator UHRF1. Mol Nutr Food Res 55, 1677–1689, 2011.
  • Wu B, Zhang Q, Shen W, and Zhu J: Anti-proliferative and chemosensitizing effects of luteolin on human gastric cancer AGS cell line. Mol Cell Biochem 313, 125–132, 2008.

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