381
Views
62
CrossRef citations to date
0
Altmetric
Original Articles

Cytotoxic Activity of Oleocanthal Isolated from Virgin Olive Oil on Human Melanoma Cells

, , , , , , , , , , , & show all
Pages 873-877 | Received 18 Jun 2015, Accepted 08 Feb 2016, Published online: 07 Jun 2016

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (3)

Marlene Costa, Vânia Costa, Margarida Lopes & Fátima Paiva-Martins. (2024) A biochemical perspective on the fate of virgin olive oil phenolic compounds in vivo. Critical Reviews in Food Science and Nutrition 64:5, pages 1403-1428.
Read now
Julián Lozano-Castellón, Anallely López-Yerena, José Fernando Rinaldi de Alvarenga, Jaume Romero del Castillo-Alba, Anna Vallverdú-Queralt, Elvira Escribano-Ferrer & Rosa M. Lamuela-Raventós. (2020) Health-promoting properties of oleocanthal and oleacein: Two secoiridoids from extra-virgin olive oil. Critical Reviews in Food Science and Nutrition 60:15, pages 2532-2548.
Read now
Vita Di Stefano & Maria Grazia Melilli. (2020) Effect of storage on quality parameters and phenolic content of Italian extra-virgin olive oils. Natural Product Research 34:1, pages 78-86.
Read now

Articles from other publishers (59)

Simone Filardo, Mattioli Roberto, Daniel Di Risola, Luciana Mosca, Marisa Di Pietro & Rosa Sessa. (2024) Olea europaea L-derived secoiridoids: Beneficial health effects and potential therapeutic approaches. Pharmacology & Therapeutics 254, pages 108595.
Crossref
María González-Rodríguez, Djedjiga Ait Edjoudi, Alfonso Cordero-Barreal, Mariam Farrag, María Varela-García, Carlos Torrijos-Pulpón, Clara Ruiz-Fernández, Maurizio Capuozzo, Alessandro Ottaiano, Francisca Lago, Jesús Pino, Yousof Farrag & Oreste Gualillo. (2023) Oleocanthal, an Antioxidant Phenolic Compound in Extra Virgin Olive Oil (EVOO): A Comprehensive Systematic Review of Its Potential in Inflammation and Cancer. Antioxidants 12:12, pages 2112.
Crossref
Raffaele Infante, Marco Infante, Donatella Pastore, Francesca Pacifici, Francesca Chiereghin, Gina Malatesta, Giulia Donadel, Manfredi Tesauro & David Della-Morte. (2023) An Appraisal of the Oleocanthal-Rich Extra Virgin Olive Oil (EVOO) and Its Potential Anticancer and Neuroprotective Properties. International Journal of Molecular Sciences 24:24, pages 17323.
Crossref
Mohammad Hossein Asgarshamsi, Mehrdad Mohammadpour Dehkordi, Seyed Mohamad Reza Nazifi & Krzysztof K. Zborowski. (2023) Theoretical Evaluation of Oleocanthal Reactive Centers. Current Drug Metabolism 24:11, pages 756-762.
Crossref
Doretta Cuffaro, Diana Pinto, Ana Margarida Silva, Andrea Bertolini, Simone Bertini, Alessandro Saba, Marco Macchia, Francisca Rodrigues & Maria Digiacomo. (2023) Insights into the Antioxidant/Antiradical Effects and In Vitro Intestinal Permeation of Oleocanthal and Its Metabolites Tyrosol and Oleocanthalic Acid. Molecules 28:13, pages 5150.
Crossref
Rizwan Ahmad, Aljawharah Alqathama, Mohammad Mahtab Alam, Muhammad Riaz, Ashraf N. Abdalla, Mohammed Aldholmi, Hamdi M. Al− Said, Fatema S. Aljishi, Ebtihal H. Althomali, Murtada M. Alabdullah, Nezar H. Altaweel, Ali F. Almubarak & Sami. S. Asghar. (2023) Biological quality and phytochemical profiling of olive fruits using gas chromatography–mass spectrometry (GCMS) analysis. Chemical and Biological Technologies in Agriculture 10:1.
Crossref
Doretta Cuffaro, Simone Bertini, Marco Macchia & Maria Digiacomo. (2023) Enhanced Nutraceutical Properties of Extra Virgin Olive Oil Extract by Olive Leaf Enrichment. Nutrients 15:5, pages 1073.
Crossref
Aikaterini Papakonstantinou, Petrina Koumarianou, Aimilia Rigakou, Panagiotis Diamantakos, Efseveia Frakolaki, Niki Vassilaki, Evangelia Chavdoula, Eleni Melliou, Prokopios Magiatis & Haralabia Boleti. (2022) New Affordable Methods for Large-Scale Isolation of Major Olive Secoiridoids and Systematic Comparative Study of Their Antiproliferative/Cytotoxic Effect on Multiple Cancer Cell Lines of Different Cancer Origins. International Journal of Molecular Sciences 24:1, pages 3.
Crossref
Lucía Melguizo-Rodríguez, Anabel González-Acedo, Rebeca Illescas-Montes, Enrique García-Recio, Javier Ramos-Torrecillas, Victor J. Costela-Ruiz & Olga García-Martínez. (2022) Biological effects of the olive tree and its derivatives on the skin. Food & Function 13:22, pages 11410-11424.
Crossref
Sara Peri, Jessica Ruzzolini, Silvia Urciuoli, Giampaolo Versienti, Alessio Biagioni, Elena Andreucci, Silvia Peppicelli, Francesca Bianchini, Andrea Bottari, Lido Calorini, Chiara Nediani, Lucia Magnelli & Laura Papucci. (2022) An Oleocanthal-Enriched EVO Oil Extract Induces the ROS Production in Gastric Cancer Cells and Potentiates the Effect of Chemotherapy. Antioxidants 11:9, pages 1762.
Crossref
Girish Rai & Sudhir Kumar Shekhar. 2022. Breast Cancer: Current Trends in Molecular Research. Breast Cancer: Current Trends in Molecular Research 196 218 .
Azra Kugić, Sanja Dabelić, Cvijeta Jakobušić Brala, Nina Dabelić & Monika Barbarić. (2022) Extra Virgin Olive Oil Secoiridoids Modulate the Metabolic Activity of Dacarbazine Pre-Treated and Treatment-Naive Melanoma Cells. Molecules 27:10, pages 3310.
Crossref
Jasmine Esposito Salsano, Maria Digiacomo, Doretta Cuffaro, Simone Bertini & Marco Macchia. (2022) Content Variations in Oleocanthalic Acid and Other Phenolic Compounds in Extra-Virgin Olive Oil during Storage. Foods 11:9, pages 1354.
Crossref
Elisa Rodríguez-Juan, Fernando Martínez Román, Alicia Sánchez-García, Juan Fernández-Bolaños & Aranzazu García-Borrego. (2021) From Low-Quality Olive Oils to Valuable Bioactive Compounds: Obtaining Oleacein and Oleocanthal from Olive Oils Intended for Refining. Journal of Agricultural and Food Chemistry 70:1, pages 333-342.
Crossref
Jasmine Esposito Salsano, Diana Pinto, Francisca Rodrigues, Alessandro Saba, Clementina Manera, Maria Digiacomo & Marco Macchia. (2022) Oleocanthalic acid from extra-virgin olive oil: Analysis, preparative isolation and radical scavenging activity. Journal of Food Composition and Analysis 105, pages 104160.
Crossref
Saitong Muneekaew, Yueh‐Han Huang & Meng-Jiy Wang. (2021) Selective Killing Effects of Atmospheric Pressure Plasma Jet on Human Melanoma and Lewis Lung Carcinoma Cells. Plasma Chemistry and Plasma Processing 41:6, pages 1613-1629.
Crossref
Daniela Gabbia, Sara Carpi, Samantha Sarcognato, Luana Cannella, Martina Colognesi, Michela Scaffidi, Beatrice Polini, Maria Digiacomo, Jasmine Esposito Salsano, Clementina Manera, Marco Macchia, Paola Nieri, Maria Carrara, Francesco Paolo Russo, Maria Guido & Sara De Martin. (2021) The Extra Virgin Olive Oil Polyphenol Oleocanthal Exerts Antifibrotic Effects in the Liver. Frontiers in Nutrition 8.
Crossref
Chrystalla Antoniou & Jonathon Hull. (2021) The Anti-cancer Effect of Olea europaea L. Products: a Review. Current Nutrition Reports 10:1, pages 99-124.
Crossref
Maria Rita Emma, Giuseppa Augello, Vita Di Stefano, Antonina Azzolina, Lydia Giannitrapani, Giuseppe Montalto, Melchiorre Cervello & Antonella Cusimano. (2021) Potential Uses of Olive Oil Secoiridoids for the Prevention and Treatment of Cancer: A Narrative Review of Preclinical Studies. International Journal of Molecular Sciences 22:3, pages 1234.
Crossref
Nehad M. Ayoub. 2021. Olives and Olive Oil in Health and Disease Prevention. Olives and Olive Oil in Health and Disease Prevention 661 669 .
Khalid A. El Sayed. 2021. Olives and Olive Oil in Health and Disease Prevention. Olives and Olive Oil in Health and Disease Prevention 681 691 .
Virginie Bottero & Judith A. Potashkin. (2020) A Comparison of Gene Expression Changes in the Blood of Individuals Consuming Diets Supplemented with Olives, Nuts or Long-Chain Omega-3 Fatty Acids. Nutrients 12:12, pages 3765.
Crossref
Mohamed Elamin Abdallah Mohamed Elamin Omer, Mohd Rizam Abu Bakar, Mohd Bakri Adam & Mohd Shafie Mustafa. (2020) Cure Models with Exponentiated Weibull Exponential Distribution for the Analysis of Melanoma Patients. Mathematics 8:11, pages 1926.
Crossref
Mohammed El Haouari, Juan E. Quintero & Juan A. Rosado. (2020) Anticancer molecular mechanisms of oleocanthal. Phytotherapy Research 34:11, pages 2820-2834.
Crossref
Francesca Costantini, Caterina Di Sano & Giovanna Barbieri. (2020) The Hydroxytyrosol Induces the Death for Apoptosis of Human Melanoma Cells. International Journal of Molecular Sciences 21:21, pages 8074.
Crossref
Nathiya Ranganathan & Gayathri Mahalingam. (2020) Validation of the antidiabetic potential of isolated and nanoemulsified endophytic fungal metabolite 2,4,6-triphenylaniline through AMPK activation pathway. Journal of Molecular Liquids 316, pages 113836.
Crossref
Antonio Francioso, Rodolfo Federico, Anna Maggiore, Mario Fontana, Alberto Boffi, Maria D’Erme & Luciana Mosca. (2020) Green Route for the Isolation and Purification of Hyrdoxytyrosol, Tyrosol, Oleacein and Oleocanthal from Extra Virgin Olive Oil. Molecules 25:16, pages 3654.
Crossref
Abu Bakar Siddique, Phillip C.S.R. Kilgore, Afsana Tajmim, Sitanshu S. Singh, Sharon A. Meyer, Seetharama D. Jois, Urska Cvek, Marjan Trutschl & Khalid A. El Sayed. (2020) (−)-Oleocanthal as a Dual c-MET-COX2 Inhibitor for the Control of Lung Cancer. Nutrients 12:6, pages 1749.
Crossref
Abu Bakar Siddique, Judy Ann King, Sharon A. Meyer, Khaldoun Abdelwahed, Belnaser Busnena & Khalid A. El Sayed. (2020) Safety Evaluations of Single Dose of the Olive Secoiridoid S-(−)-Oleocanthal in Swiss Albino Mice. Nutrients 12:2, pages 314.
Crossref
Paraskevi Kouka, Fotios Tekos, Zoi Papoutsaki, Panagiotis Stathopoulos, Maria Halabalaki, Maria Tsantarliotou, Ioannis Zervos, Charitini Nepka, Jyrki Liesivuori, Valerii N. Rakitskii, Aristidis Tsatsakis, Aristidis S. Veskoukis & Demetrios Kouretas. (2020) Olive oil with high polyphenolic content induces both beneficial and harmful alterations on rat redox status depending on the tissue. Toxicology Reports 7, pages 421-432.
Crossref
Alessandra Mazzocchi, Ludovica Leone, Carlo Agostoni & Isabella Pali-Schöll. (2019) The Secrets of the Mediterranean Diet. Does [Only] Olive Oil Matter?. Nutrients 11:12, pages 2941.
Crossref
Jelena Torić, Ana Karković Marković, Cvijeta Jakobušić Brala & Monika Barbarić. (2019) Anticancer effects of olive oil polyphenols and their combinations with anticancer drugs. Acta Pharmaceutica 69:4, pages 461-482.
Crossref
Sara Carpi, Egeria Scoditti, Marika Massaro, Beatrice Polini, Clementina Manera, Maria Digiacomo, Jasmine Esposito Salsano, Giulio Poli, Tiziano Tuccinardi, Stefano Doccini, Filippo Maria Santorelli, Maria Annunziata Carluccio, Marco Macchia, Martin Wabitsch, Raffaele De Caterina & Paola Nieri. (2019) The Extra-Virgin Olive Oil Polyphenols Oleocanthal and Oleacein Counteract Inflammation-Related Gene and miRNA Expression in Adipocytes by Attenuating NF-κB Activation. Nutrients 11:12, pages 2855.
Crossref
De Stefanis, Scimè, Accomazzo, Catti, Occhipinti, Bertea & Costelli. (2019) Anti-Proliferative Effects of an Extra-Virgin Olive Oil Extract Enriched in Ligstroside Aglycone and Oleocanthal on Human Liver Cancer Cell Lines. Cancers 11:11, pages 1640.
Crossref
Christos Papanikolaou, Eleni Melliou & Prokopios Magiatis. 2019. Functional Foods. Functional Foods.
Carlotta Malagoli, Marcella Malavolti, Francesca Farnetani, Caterina Longo, Tommaso Filippini, Giovanni Pellacani & Marco Vinceti. (2019) Food and Beverage Consumption and Melanoma Risk: A Population-Based Case-Control Study in Northern Italy. Nutrients 11:9, pages 2206.
Crossref
Gaforio, Visioli, Alarcón-de-la-Lastra, Castañer, Delgado-Rodríguez, Fitó, Hernández, Huertas, Martínez-González, Menendez, Osada, Papadaki, Parrón, Pereira, Rosillo, Sánchez-Quesada, Schwingshackl, Toledo & Tsatsakis. (2019) Virgin Olive Oil and Health: Summary of the III International Conference on Virgin Olive Oil and Health Consensus Report, JAEN (Spain) 2018. Nutrients 11:9, pages 2039.
Crossref
Limor Goren, George Zhang, Susmita Kaushik, Paul A. S. Breslin, Yi-Chieh Nancy Du & David A. Foster. (2019) (-)-Oleocanthal and (-)-oleocanthal-rich olive oils induce lysosomal membrane permeabilization in cancer cells. PLOS ONE 14:8, pages e0216024.
Crossref
Rabiatul Adawiyah Razali, Yogeswaran Lokanathan, Muhammad Dain Yazid, Ayu Suraya Ansari, Aminuddin Bin Saim & Ruszymah Bt Hj Idrus. (2019) Modulation of Epithelial to Mesenchymal Transition Signaling Pathways by Olea Europaea and Its Active Compounds. International Journal of Molecular Sciences 20:14, pages 3492.
Crossref
Giada Juli, Manuela Oliverio, Dina Bellizzi, Maria Eugenia Gallo Cantafio, Katia Grillone, Giuseppe Passarino, Carmela Colica, Monica Nardi, Marco Rossi, Antonio Procopio, Pierosandro Tagliaferri, Pierfrancesco Tassone & Nicola Amodio. (2019) Anti-tumor Activity and Epigenetic Impact of the Polyphenol Oleacein in Multiple Myeloma. Cancers 11:7, pages 990.
Crossref
Paloma Begines, David Biedermann, Kateřina Valentová, Lucie Petrásková, Helena Pelantová, Inés Maya, José G. Fernández-Bolaños & Vladimír Křen. (2019) Chemoenzymatic Synthesis and Radical Scavenging of Sulfated Hydroxytyrosol, Tyrosol, and Acetylated Derivatives. Journal of Agricultural and Food Chemistry 67:26, pages 7281-7288.
Crossref
Ilaria Peluso, Nagendra Sastry Yarla, Roberto Ambra, Gianni Pastore & George Perry. (2019) MAPK signalling pathway in cancers: Olive products as cancer preventive and therapeutic agents. Seminars in Cancer Biology 56, pages 185-195.
Crossref
Ana Karković Marković, Jelena Torić, Monika Barbarić & Cvijeta Jakobušić Brala. (2019) Hydroxytyrosol, Tyrosol and Derivatives and Their Potential Effects on Human Health. Molecules 24:10, pages 2001.
Crossref
Vera Francisco, Clara Ruiz-Fernández, Vicente Lahera, Francisca Lago, Jesús Pino, Leandros Skaltsounis, Miguel Angel González-Gay, Ali Mobasheri, Rodolfo Gómez, Morena Scotece & Oreste Gualillo. (2019) Natural Molecules for Healthy Lifestyles: Oleocanthal from Extra Virgin Olive Oil. Journal of Agricultural and Food Chemistry 67:14, pages 3845-3853.
Crossref
Marilena Celano, Valentina Maggisano, Saverio Massimo Lepore, Diego Russo & Stefania Bulotta. (2019) Secoiridoids of olive and derivatives as potential coadjuvant drugs in cancer: A critical analysis of experimental studies. Pharmacological Research 142, pages 77-86.
Crossref
R. Diez-Bello, I. Jardin, J.J. Lopez, M. El Haouari, J. Ortega-Vidal, J. Altarejos, G.M. Salido, S. Salido & J.A. Rosado. (2019) (−)‑Oleocanthal inhibits proliferation and migration by modulating Ca2+ entry through TRPC6 in breast cancer cells. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1866:3, pages 474-485.
Crossref
Juan Manuel Segura Palacios, Nuria Blázquez Sánchez, Francisco Rivas Ruiz, Miguel Aguilar Bernier, Belén Ramírez López, María Encarnación Fernández Sánchez & Magdalena de Troya Martín. (2019) Topical treatment with oleocanthal extract in reducing inflammatory reactions after photodynamic therapy: a prospective quasi-experimental pilot study. Complementary Therapies in Medicine 42, pages 298-301.
Crossref
Rabiatul Adawiyah Razali, Nik Ahmad Hafiz Nik Ahmad Eid, Turkambigai Jayaraman, Muhammad Asyrafi Amir Hassan, Nabilah Qistina Azlan, Nur Farhana Ismail, Nur Qisya Afifah Veronica Sainik, Muhammad Dain Yazid, Yogeswaran Lokanathan, Aminuddin Bin Saim & Ruszymah Bt Hj Idrus. (2018) The potential of Olea europaea extracts to prevent TGFβ1-induced epithelial to mesenchymal transition in human nasal respiratory epithelial cells. BMC Complementary and Alternative Medicine 18:1.
Crossref
Michela Palla, Maria Digiacomo, Caterina Cristani, Simone Bertini, Manuela Giovannetti, Marco Macchia, Clementina Manera & Monica Agnolucci. (2018) Composition of health-promoting phenolic compounds in two extra virgin olive oils and diversity of associated yeasts. Journal of Food Composition and Analysis 74, pages 27-33.
Crossref
Beatrice Polini, Maria Digiacomo, Sara Carpi, Simone Bertini, Francesca Gado, Giuseppe Saccomanni, Marco Macchia, Paola Nieri, Clementina Manera & Stefano Fogli. (2018) Oleocanthal and oleacein contribute to the in vitro therapeutic potential of extra virgin oil-derived extracts in non-melanoma skin cancer. Toxicology in Vitro 52, pages 243-250.
Crossref
M. Crespo, Joao Tomé-Carneiro, Alberto Dávalos & Francesco Visioli. (2018) Pharma-Nutritional Properties of Olive Oil Phenols. Transfer of New Findings to Human Nutrition. Foods 7:6, pages 90.
Crossref
Kok-Lun Pang & Kok-Yong Chin. (2018) The Biological Activities of Oleocanthal from a Molecular Perspective. Nutrients 10:5, pages 570.
Crossref
Luca Lombardo, Filomena Grasso, Francesca Lanciano, Stefania Loria & Emanuela Monetti. 2018. 41 77 .
Mehmet İbrahim Tuğlu, Işıl Aydemir, Pınar Kılıçarslan Sönmez, Tahir Buran & Mesut Mete. (2017) The Effects of Medicinal Plants on Cancer Cell Lines and Efficacy of Experimental Animal Model. International Journal of Secondary Metabolite, pages 49-59.
Crossref
María Losada-Echeberría, María Herranz-López, Vicente Micol & Enrique Barrajón-Catalán. (2017) Polyphenols as Promising Drugs against Main Breast Cancer Signatures. Antioxidants 6:4, pages 88.
Crossref
Nehad M. Ayoub, Abu Bakar Siddique, Hassan Y. Ebrahim, Mohamed M. Mohyeldin & Khalid A. El Sayed. (2017) The olive oil phenolic (-)-oleocanthal modulates estrogen receptor expression in luminal breast cancer in vitro and in vivo and synergizes with tamoxifen treatment. European Journal of Pharmacology 810, pages 100-111.
Crossref
Antonella Cusimano, Daniele Balasus, Antonina Azzolina, Giuseppa Augello, Maria R. Emma, Caterina Di Sano, Roberto Gramignoli, Stephen C. Strom, James A. Mccubrey, Giuseppe Montalto & Melchiorre Cervello. (2017) Oleocanthal exerts antitumor effects on human liver and colon cancer cells through ROS generation. International Journal of Oncology 51:2, pages 533-544.
Crossref
Chryssoula Drouza, Anthi Dieronitou, Ioanna Hadjiadamou & Marios Stylianou. (2017) Investigation of Phenols Activity in Early Stage Oxidation of Edible Oils by Electron Paramagnetic Resonance and 19 F NMR Spectroscopies Using Novel Lipid Vanadium Complexes As Radical Initiators . Journal of Agricultural and Food Chemistry 65:24, pages 4942-4951.
Crossref
Lisa Parkinson & Sara Cicerale. (2016) The Health Benefiting Mechanisms of Virgin Olive Oil Phenolic Compounds. Molecules 21:12, pages 1734.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.