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Review Article

Sucralose Non-Carcinogenicity: A Review of the Scientific and Regulatory Rationale

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Pages 1247-1261 | Received 09 Sep 2015, Accepted 20 Jun 2016, Published online: 21 Sep 2016

Keep up to date with the latest research on this topic with citation updates for this article.

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Tony Stankus. (2023) Reviews of Science for Science Librarians: Sucralose. Science & Technology Libraries 42:2, pages 149-154.
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Amelia G. Westmoreland, Tracey B. Schafer, Kendall E. Breland, Anna R. Beard & Todd Z. Osborne. (2024) Sucralose (C12H19Cl3O8) impact on microbial activity in estuarine and freshwater marsh soils. Environmental Monitoring and Assessment 196:5.
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Thaís Pasqualli, Pamella Eduardha E Chaves, Lavínia da Veiga Pereira, Élvio Adílio Serpa, Luís Flávio Souza de Oliveira & Michel Mansur Machado. (2020) Sucralose causes non‐selective CD4 and CD8 lymphotoxicity via probable regulation of the MAPK8/APTX/EID1 genes: An in vitro/in silico study. Clinical and Experimental Pharmacology and Physiology 47:10, pages 1751-1757.
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Andreas Eisenreich, Rainer Gürtler & Bernd Schäfer. (2020) Heating of food containing sucralose might result in the generation of potentially toxic chlorinated compounds. Food Chemistry 321, pages 126700.
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G.A. Chappell, S.J. Borghoff, L.L. Pham, C.L. Doepker & D.S. Wikoff. (2020) Lack of potential carcinogenicity for sucralose – Systematic evaluation and integration of mechanistic data into the totality of the evidence. Food and Chemical Toxicology 135, pages 110898.
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Adriana Hernández, Adriana Di Iorio, Jeffrey Lansdale & María Salazar. (2018) Characterization of the Types of Sweeteners Consumed in Honduras. Nutrients 10:3, pages 338.
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Szimonetta Lohner, Ingrid Toews & Joerg J. Meerpohl. (2017) Health outcomes of non-nutritive sweeteners: analysis of the research landscape. Nutrition Journal 16:1.
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Márcio Carocho, Patricia Morales & Isabel C.F.R. Ferreira. (2017) Sweeteners as food additives in the XXI century: A review of what is known, and what is to come. Food and Chemical Toxicology 107, pages 302-317.
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Bernadene A. Magnuson, Ashley Roberts & Earle R. Nestmann. (2017) Critical review of the current literature on the safety of sucralose. Food and Chemical Toxicology 106, pages 324-355.
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Fernando Aguilar, Riccardo Crebelli, Alessandro Di Domenico, Birgit Dusemund, Maria Jose Frutos, Pierre Galtier, David Gott, Ursula Gundert‐Remy, Claude Lambré, Jean‐Charles Leblanc, Oliver Lindtner, Peter Moldeus, Pasquale Mosesso, Dominique Parent‐Massin, Agneta Oskarsson, Ivan Stankovic, Ine Waalkens‐Berendsen, Rudolf Antonius Woutersen, Matthew Wright, Maged Younes, Laura Ciccolallo, Paolo Colombo, Federica Lodi & Alicja Mortensen. (2017) Statement on the validity of the conclusions of a mouse carcinogenicity study on sucralose (E 955) performed by the Ramazzini Institute. EFSA Journal 15:5.
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