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Original Articles

The Protective and Immunomodulatory Effects of Fucoidan Against 7,12-Dimethyl benz[a]anthracene-Induced Experimental Mammary Carcinogenesis Through the PD1/PDL1 Signaling Pathway in Rats

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Pages 1234-1244 | Received 08 Oct 2016, Accepted 28 Jul 2017, Published online: 18 Oct 2017

Keep up to date with the latest research on this topic with citation updates for this article.

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Muhammad Waheed Iqbal, Tahreem Riaz, Shahid Mahmood, Muhammad Bilal, Muhammad Faisal Manzoor, Sarmad Ahmad Qamar & Xianghui Qi. (2024) Fucoidan-based nanomaterial and its multifunctional role for pharmaceutical and biomedical applications. Critical Reviews in Food Science and Nutrition 64:2, pages 354-380.
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Ting Sun, Hui Liang, Meilan Xue, Ying Liu, Anjing Gong, Yushan Jiang, Yimin Qin, Jia Yang & Danyang Meng. (2020) Protective effect and mechanism of fucoidan on intestinal mucosal barrier function in NOD mice. Food and Agricultural Immunology 31:1, pages 939-953.
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Articles from other publishers (18)

Zhenzhen Deng, Suo Qishan, Quanbin Zhang, Jing Wang, Yang Yue, Lihua Geng & Ning Wu. (2024) Low molecular weight fucoidan LF2 improves the immunosuppressive tumor microenvironment and enhances the anti-pancreatic cancer activity of oxaliplatin. Biomedicine & Pharmacotherapy 173, pages 116360.
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Caixia Li, Yaping Liu, Mingzhi Yang, Haoyue Huang, Lulu Tang, Yufan Miao, Wenjie Li & Xing Li. (2024) Fucoidan ameliorates diabetic skeletal muscle atrophy through PI3K/Akt pathway. Journal of Functional Foods 114, pages 106076.
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Xi Huang, Si Li, Rong Ding, Yuan Li, Canlin Li & Rui Gu. (2023) Antitumor effects of polysaccharides from medicinal lower plants: A review. International Journal of Biological Macromolecules 252, pages 126313.
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Nikolay Zahariev, Plamen Katsarov, Paolina Lukova & Bissera Pilicheva. (2023) Novel Fucoidan Pharmaceutical Formulations and Their Potential Application in Oncology—A Review. Polymers 15:15, pages 3242.
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Emma J. Murphy, Gustavo Waltzer Fehrenbach, Ismin Zainol Abidin, Ciara Buckley, Therese Montgomery, Robert Pogue, Patrick Murray, Ian Major & Emanuele Rezoagli. (2023) Polysaccharides—Naturally Occurring Immune Modulators. Polymers 15:10, pages 2373.
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Jennifer Saliba, Chanez Manseur, Hugo Groult, Hussein Akil, Mona Tannoury, Danielle Troutaud, Thierry Maugard, Jean Feuillard, Ingrid Arnaudin & Chantal Jayat-Vignoles. (2023) Anti-Proliferative and Pro-Apoptotic vLMW Fucoidan Formulas Decrease PD-L1 Surface Expression in EBV Latency III and DLBCL Tumoral B-Cells by Decreasing Actin Network. Marine Drugs 21:2, pages 132.
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Simone E. M. Olsthoorn, Xi Wang, Berend Tillema, Tim Vanmierlo, Stefan Kraan, Pieter J. M. Leenen & Monique T. Mulder. (2021) Brown Seaweed Food Supplementation: Effects on Allergy and Inflammation and Its Consequences. Nutrients 13:8, pages 2613.
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Claudia Rita Corso, Natalia Mulinari Turin de Oliveira, Leonardo Moura Cordeiro, Karien Sauruk da Silva, Suzany Hellen da Silva Soczek, Virgilio Frota Rossato, Elizabeth Soares Fernandes & Daniele Maria-Ferreira. (2021) Polysaccharides with Antitumor Effect in Breast Cancer: A Systematic Review of Non-Clinical Studies. Nutrients 13:6, pages 2008.
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Wei-Ping Ma, Shu-Man Hu, Yan-Lai Xu, Hai-Hua Li, Xiao-Qing Ma, Bao-Hong Wei, Fu-Yu Li, Hua-Shi Guan, Guang-Li Yu, Ming Liu & Hong-Bing Liu. (2020) Haimufang decoction, a Chinese medicine formula for lung cancer, arrests cell cycle, stimulates apoptosis in NCI-H1975 cells, and induces M1 polarization in RAW 264.7 macrophage cells. BMC Complementary Medicine and Therapies 20:1.
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Samar M. Etman, Yosra S.R. Elnaggar & Ossama Y. Abdallah. (2020) “Fucoidan, a natural biopolymer in cancer combating: From edible algae to nanocarrier tailoring”. International Journal of Biological Macromolecules 147, pages 799-808.
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Samar M. Etman, Ossama Y. Abdallah & Yosra S.R. Elnaggar. (2020) Novel fucoidan based bioactive targeted nanoparticles from Undaria Pinnatifida for treatment of pancreatic cancer. International Journal of Biological Macromolecules 145, pages 390-401.
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Soraya Sajadimajd, Saeideh Momtaz, Pouya Haratipour, Fardous F. El-Senduny, Amin Iran Panah, Jafar Navabi, Zhaleh Soheilikhah, Mohammad Hosein Farzaei & Roja Rahimi. (2019) Molecular Mechanisms Underlying Cancer Preventive and Therapeutic Potential of Algal Polysaccharides. Current Pharmaceutical Design 25:11, pages 1210-1235.
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Haotian Ma, Huaye Xiong, Xiaoli Zhu, Chunli Ji, Jinai Xue, Runzhi Li, Baosheng Ge & Hongli Cui. (2019) Polysaccharide from Spirulina platensis ameliorates diphenoxylate-induced constipation symptoms in mice. International Journal of Biological Macromolecules 133, pages 1090-1101.
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Monika Corban, Mark Ambrose, Joanne Pagnon, Damien Stringer, Sam Karpiniec, Ahyoung Park, Raj Eri, J Fitton & Nuri Gueven. (2019) Pathway Analysis of Fucoidan Activity Using a Yeast Gene Deletion Library Screen. Marine Drugs 17:1, pages 54.
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Arumugam P.Arunkumar K., Sivakumar L.Murugan M.Murugan K.. (2019) Anticancer effect of fucoidan on cell proliferation, cell cycle progression, genetic damage and apoptotic cell death in HepG2 cancer cells. Toxicology Reports 6, pages 556-563.
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Sunyoung Park, Soyun Cho, Minji Kim, Ji Ung Park, Eui Cheol Jeong, Euno Choi, Jeong Hwan Park, Cheol Lee & Mee Soo Chang. (2018) Dermatofibrosarcoma protuberans: A retrospective study of clinicopathologic features and related Akt/mTOR, STAT3, ERK, cyclin D1, and PD-L1 expression. Journal of the American Academy of Dermatology 79:5, pages 843-852.
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Irina Bakunina, Oksana Chadova, Olesya Malyarenko & Svetlana Ermakova. (2018) The Effect of Fucoidan from the Brown Alga Fucus evanescence on the Activity of α-N-Acetylgalactosaminidase of Human Colon Carcinoma Cells. Marine Drugs 16:5, pages 155.
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Meilan Xue, Xinqiang Ji, Hui Liang, Ying Liu, Bing Wang, Lingling Sun & Weiwei Li. (2018) The effect of fucoidan on intestinal flora and intestinal barrier function in rats with breast cancer. Food & Function 9:2, pages 1214-1223.
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