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Nutrition and Cancer Volume 6, 1985 - Issue 2
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Absence of genotoxicity of the carcinogenic sulfated polysaccharides carrageenan and dextran sulfate in mammalian DNA repair and bacterial mutagenicity assays

Hideki Mori Department of Pathology, Gifu University School of Medicine, Gifu, 500, Japan
,
Futoshi Ohbayashi Department of Pathology, Gifu University School of Medicine, Gifu, 500, Japan
,
Iwao Hirono Department of Carcinogenesis and Cancer Susceptibility, Institute of Medical Science, University of Tokyo, Tokyo, 180, Japan
,
Tomiko Shimada Cell Biology Section, Laboratory of Viral Oncogenesis, National Cancer Institute, Frederick, MD, 21701
&
Gary M. Williams Division of Pathology and Toxicology, Naylor Dana Institute for Disease Prevention, American Health Foundation, Valhalla, NY, 10595
Pages 92-97 | Published online: 04 Aug 2009

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Myra L. Weiner. (2014) Food additive carrageenan: Part II: A critical review of carrageenan in vivo safety studies. Critical Reviews in Toxicology 44:3, pages 244-269.
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James M. McKim. (2014) Food additive carrageenan: Part I: A critical review of carrageenan in vitro studies, potential pitfalls, and implications for human health and safety. Critical Reviews in Toxicology 44:3, pages 211-243.
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Samuel M. Cohen & Nobuyuki Ito. (2002) A Critical Review of the Toxicological Effects of Carrageenan and Processed Eucheuma Seaweed on the Gastrointestinal Tract. Critical Reviews in Toxicology 32:5, pages 413-444.
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Stephen Nicklin & Klara Miller. (1989) Intestinal uptake and immunological effects of carrageenan—current concepts. Food Additives & Contaminants 6:4, pages 425-436.
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Articles from other publishers (22)

Atsushi Hakura, Hajime Sui, Yuki Seki, Jiro Sonoda, Yusaku Yoshida, Hisayoshi Takagi, Shigeo Yokose, Tomonari Matsuda, Shoji Asakura & Takehiko Nohmi. (2023) DNA polymerase κ suppresses inflammation and inflammation-induced mutagenesis and carcinogenic potential in the colon of mice. Genes and Environment 45:1.
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Atsushi Hakura, Naoki Koyama, Yuki Seki, Jiro Sonoda & Shoji Asakura. (2022) o-Aminoazotoluene, 7,12-dimethylbenz[a]anthracene, and N-ethyl-N-nitrosourea, which are mutagenic but not carcinogenic in the colon, rapidly induce colonic tumors in mice with dextran sulfate sodium-induced colitis. Genes and Environment 44:1.
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Atsushi Hakura, Hajime Sui, Jiro Sonoda, Tomonari Matsuda & Takehiko Nohmi. (2019) DNA polymerase kappa counteracts inflammation‐induced mutagenesis in multiple organs of mice. Environmental and Molecular Mutagenesis 60:4, pages 320-330.
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Maged Younes, Peter Aggett, Fernando Aguilar, Riccardo Crebelli, Metka Filipič, Maria Jose Frutos, Pierre Galtier, David Gott, Ursula Gundert‐Remy, Gunter Georg Kuhnle, Claude Lambré, Jean‐Charles Leblanc, Inger Therese Lillegaard, Peter Moldeus, Alicja Mortensen, Agneta Oskarsson, Ivan Stankovic, Ine Waalkens‐Berendsen, Rudolf Antonius Woutersen, Matthew Wright, Leon Brimer, Oliver Lindtner, Pasquale Mosesso, Anna Christodoulidou, Sofia Ioannidou, Federica Lodi & Birgit Dusemund. (2018) Re‐evaluation of carrageenan (E 407) and processed Eucheuma seaweed (E 407a) as food additives. EFSA Journal 16:4.
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Yuhua Li, Lei Fan, Tianle Tang, Yuan Tang, Ming Xie, Xiaocong Zeng, Yang Sun & Qibing Mei. (2017) Modified apple polysaccharide prevents colitis through modulating IL-22 and IL-22BP expression. International Journal of Biological Macromolecules 103, pages 1217-1223.
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Aya M. Westbrook, Akos Szakmary & Robert H. Schiestl. (2016) RETRACTED ARTICLE: Mouse models of intestinal inflammation and cancer. Archives of Toxicology 90:9, pages 2109-2130.
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Monice M. Fiume, Bart Heldreth, Wilma F. Bergfeld, Donald V. Belsito, Ronald A. Hill, Curtis D. Klaassen, Daniel C. Liebler, James G. MarksJrJr, Ronald C. Shank, Thomas J. Slaga, Paul W. Snyder & F. Alan Andersen. (2016) Safety Assessment of Microbial Polysaccharide Gums as Used in Cosmetics. International Journal of Toxicology 35:1_suppl, pages 5S-49S.
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Jiro Sonoda, Yuki Seki, Atsushi Hakura & Satoru Hosokawa. (2015) Time course of the incidence/multiplicity and histopathological features of murine colonic dysplasia, adenoma and adenocarcinoma induced by benzo[<i>a</i>]pyrene and dextran sulfate sodium. Journal of Toxicologic Pathology 28:2, pages 109-120.
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George S. Wilson & Jacob George. (2014) Physical and chemical insults induce inflammation and gastrointestinal cancers. Cancer Letters 345:2, pages 190-195.
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P.P. Trivedi & G.B. Jena. (2013) Ulcerative colitis-induced hepatic damage in mice: Studies on inflammation, fibrosis, oxidative DNA damage and GST-P expression. Chemico-Biological Interactions 201:1-3, pages 19-30.
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Takuji Tanaka. (2012) Preclinical Cancer Chemoprevention Studies Using Animal Model of Inflammation-Associated Colorectal Carcinogenesis. Cancers 4:3, pages 673-700.
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Yuhua Li, Li Liu, Yinbo Niu, Juan Feng, Yang Sun, Xianghe Kong, Yongchun Chen, Xiaoyan Chen, Hongquan Gan, Shousong Cao & Qibing Mei. (2011) Modified apple polysaccharide prevents against tumorigenesis in a mouse model of colitis-associated colon cancer: role of galectin-3 and apoptosis in cancer prevention. European Journal of Nutrition 51:1, pages 107-117.
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Aya M. Westbrook, Akos Szakmary & Robert H. Schiestl. (2010) Mechanisms of intestinal inflammation and development of associated cancers: Lessons learned from mouse models. Mutation Research/Reviews in Mutation Research 705:1, pages 40-59.
Crossref
Aya M. Westbrook & Robert H. Schiestl. (2010) Atm -Deficient Mice Exhibit Increased Sensitivity to Dextran Sulfate Sodium–Induced Colitis Characterized by Elevated DNA Damage and Persistent Immune Activation . Cancer Research 70:5, pages 1875-1884.
Crossref
Aya M. Westbrook, Bo Wei, Jonathan Braun & Robert H. Schiestl. (2009) Intestinal Mucosal Inflammation Leads to Systemic Genotoxicity in Mice. Cancer Research 69:11, pages 4827-4834.
Crossref
Young-Shin Chung, Ki-Hwan Eum, Seon-A Choi, Se-Wook Oh, Sue-Nie Park, Young-Na Yum, Joo-Hwan Kim, Young-Rok Seo & Michael Lee. (2009) Genotoxicity Studies on Carrageenan: Short-term In Vitro Assays. Toxicological Research 25:1, pages 51-58.
Crossref
Hiroyuki Kohno, Rikako Suzuki, Shigeyuki Sugie & Takuji Tanaka. (2005) β‐ Catenin mutations in a mouse model of inflammation‐related colon carcinogenesis induced by 1,2‐dimethylhydrazine and dextran sodium sulfate . Cancer Science 96:2, pages 69-76.
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Joanne Tobacman. 2003. Reviews in Food and Nutrition Toxicity. Reviews in Food and Nutrition Toxicity 204 229 .
Gary M. Williams, Hideki Mori & Charlene A. McQueen. (1989) Structure-activity relationships in the rat hepatocyte DNA-repair test for 300 chemicals. Mutation Research/Reviews in Genetic Toxicology 221:3, pages 263-286.
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YIN-TAK WOO, DAVID Y. LAI, JOSEPH C. ARCOS & MARY F. ARGUS. 1988. Natural, Metal, Fiber, and Macromolecular Carcinogens. Natural, Metal, Fiber, and Macromolecular Carcinogens 3 616 .
Byron E. Butterworth, John Ashby, Edilberto Bermudez, Daniel Casciano, Jon Mirsalis, Gregory Probst & Gary Williams. (1987) A protocol and guide for the in vitro rat hepatocyte DNA-repair assay. Mutation Research/Genetic Toxicology 189:2, pages 113-121.
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BYRON E. BUTTERWORTH. 1987. The Isolated Hepatocyte. The Isolated Hepatocyte 241 264 .

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