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Reports

Absence of genotoxicity of the carcinogenic sulfated polysaccharides carrageenan and dextran sulfate in mammalian DNA repair and bacterial mutagenicity assays

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Pages 92-97 | Published online: 04 Aug 2009

References and notes

  • Hirono , I . 1980 . “Natural Carcinogenic Products of Plant Origin” . CRC Crit Rev Toxicol , 11 : 235 – 277 .
  • Williams , GM . 1983 . “Mechanisms of Action of Foodborne Carcinogens” . In Environmental Aspects of Cancer: The Role of Macro and Micro Components of Food , Edited by: Wynder , EL , Leveille , GA , Weisburger , JH and Livingston , GW . 83 – 100 . Westport, CT : Food and Nutrition Press Inc. .
  • Watanabe , K , Reddy , BS , Wong , CQ and Weisburger , JH . 1978 . “Effect of Dietary Undegraded Carrageenan on Colon Carcinogenesis in F344 Rats Treated With Azoxymethane or Methylnitrosourea” . Cancer Res , 38 : 4427 – 4430 .
  • Wakabayashi , K , Inagaki , T , Fujimoto , Y and Fukuda , Y . 1978 . “Induction by Degraded Carrageenan of Colorec‐tal Tumors in Rats” . Cancer Lett , 4 : 171 – 176 .
  • Hirono , I , Kuhara , K , Hosaka , S , Tomisawa , S and Golberg , L . 1981 . “Induction of Intestinal Tumors in Rats by Dextran Sulfate Sodium” . JNCI , 66 : 579 – 583 .
  • Weisburger , JH and Williams , GM . 1981 . “Carcinogen Testing: Current Problems and New Approaches” . Science , 214 : 401 – 407 .
  • Williams , GM . 1983 . “Genotoxic and Epigenetic Carcinogens: Their Identification and Significance” . Ann NY Acad Sci , 407 : 328 – 333 .
  • Williams , GM . 1983 . “Indices for Identification of Genotoxic and Epigenetic Carcinogens in Cell Culture” . In Application of Biological Markers to Carcinogen Testing , Edited by: Milman , HA and Sell , S . 165 – 176 . New York : Plenum Publishing Corp. .
  • International Agency for Research on Cancer . 1980 . “DNA Damage and Repair in Mammalian Cells (Report 7)” . In Long‐Term and Short‐Term Screening Assays for Carcinogens: A Critical Appraisal , 201 – 226 . Lyon : International Agency for Research on Cancer .
  • Mitchell , AD , Casciano , DA , Meltz , ML , Robinson , DE , San , RHC , Williams , GM and Von Halle , ES . 1983 . “Unscheduled DNA Synthesis Tests. A Report of the U.S. Environmental Protection Agency Gene‐Tox Program” . Mutat Res , 123 : 363 – 410 .
  • Williams , GM . 1976 . “Carcinogen‐Induced DNA Repair in Primary Rat Liver Cell Cultures: A Possible Screening Test for Chemical Carcinogens” . Cancer Lett , 1 : 231 – 236 .
  • Williams , GM . 1977 . “Detection of Chemical Carcinogens by Unscheduled DNA Synthesis in Rat Liver Primary Cell Cultures” . Cancer Res , 37 : 1845 – 1851 .
  • Freeman , HJ and San , RHC . 1980 . “Use of Unscheduled DNA Synthesis in Freshly Isolated Human Intestinal Mucosal Cells for Carcinogen Detection” . Cancer Res , 40 : 3155 – 3157 .
  • Mori , H , Ohbayashi , F , Sugie , S , Tanaka , T , Takahashi , M and Mori , N . 1984 . “Measurement of Unscheduled DNA Synthesis on Alkylating Carcinogens in Rat Intestinal Mucosal Cells From Different Sites” . J Toxicol Sci , 9 : 23 – 28 .
  • Williams , GM . 1980 . “The Detection of Chemical Mutagens/Carcinogens by DNA Repair and Mutagenesis in Liver Cultures” . In Chemical Mutagens 6 , Edited by: de Serres , FJ and Hollaender , A . 61 – 79 . New York : Plenum Publishing Corp. .
  • Ames , BN , McCann , J and Yamasaki , E . 1975 . “Methods for Detecting Carcinogens and Mutagens With the Salmonella/Mammalian Microsome Mutagenicity Test” . Mutat Res , 31 : 347 – 364 .
  • Yahagi , T , Nagao , M , Seino , Y , Matsushima , T , Sugimura , T and Okada , M . 1977 . “Mutagenicities of N‐Nitrosoamines on Salmonella” . Mutat Res , 48 : 121 – 130 .
  • Nagao , M , Yahagi , T , Kawachi , T , Sugimura , T , Kosuge , T , Tsuji , K , Wakabayashi , K , Mizusaki , S and Matsumoto , T . 1977 . “Comutagenic Action of Norharman and Harman” . Proc Jpn Acad , 53 : 95 – 98 .
  • Williams , GM . 1981 . “The Detection of Genotoxic Chemicals in the Hepatocyte Primary Culture/DNA Repair Test” . In Gann Monographs in Cancer Research, No. 27: Mutation, Promotion and Transformation , Edited by: Inui , N , Kuroki , T , Yamada , M and Heidelberger , C . 45 – 55 . Tokyo : University of Tokyo Press .
  • Williams , GM and Weisburger , JH . 1983 . “Risk Assessment of Dietary Carcinogens and Tumor Promoters” . In Diet Nutrition and Cancer From Basic Research to Policy Implications , Edited by: Roe , D . 203 – 219 . New York : Alan R. Liss, Inc. .
  • This work was supported by a grant‐in‐aid for fundamental scientific research from the Ministry of Education, Science and Culture of Japan (No. 57010020), and by U.S. Public Health Grant CA 17613 from the National Cancer Institute, Bethesda, MD.
  • We thank Albertina Swanson for her excellent technical assistance in performing the Salmonella/microsome mutagenesis test. We also thank Miss Judy Benvin, Miss Laura Karabaic, and Miss Robin Zak for typing the manuscript.

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