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Antitumorigenic effect of a mammalian lignan precursor from flaxseed

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Pages 159-165 | Received 01 Dec 1995, Accepted 20 Mar 1996, Published online: 04 Aug 2009

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Pollyanna Francielli De Oliveira, Luis Fernando Leandro, Ricardo Andrade Furtado, Natália Helen Ferreira, Patrícia Mendonça Pauletti, Alba Regina Barbosa Araújo, Sérgio Akira Uyemura & Denise Crispim Tavares. (2021) Styrax camporum, a typical species of the Brazilian cerrado, attenuates DNA damage, preneoplastic lesions and oxidative stress in experimental rat colon carcinogenesis. Journal of Toxicology and Environmental Health, Part A 84:14, pages 582-592.
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Shireen Chikara, Kaitlin Lindsey, Harsharan Dhillon, Sujan Mamidi, Jeffrey Kittilson, Melpo Christofidou-Solomidou & Katie M. Reindl. (2017) Enterolactone Induces G1-phase Cell Cycle Arrest in Nonsmall Cell Lung Cancer Cells by Downregulating Cyclins and Cyclin-dependent Kinases. Nutrition and Cancer 69:4, pages 652-662.
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Devora M. Delman, Carol J. Fabian, Bruce F. Kimler, Henry Yeh & Brian K. Petroff. (2015) Effects of Flaxseed Lignan Secoisolariciresinol Diglucosideon Preneoplastic Biomarkers of Cancer Progression in a Model of Simultaneous Breast and Ovarian Cancer Development. Nutrition and Cancer 67:5, pages 857-864.
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Ryszard M. Kozłowski, Agnieszka Kręgielczak, Dana G. Radu, Andreea I. Pag & Cecilia Sîrghie. (2014) Flax Seeds–Source of Biomedical and Food Products. Molecular Crystals and Liquid Crystals 603:1, pages 122-135.
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A. Durazzo, M. Carcea, H. Adlercreutz, E. Azzini, A. Polito, L. Olivieri, M. Zaccaria, C. Meneghini, F. Maiani, G. Bausano, F. Martiri, A. Samaletdin, A. Fumagalli, A. Raguzzini, E. Venneria, M. S. Foddai, D. Ciarapica, B. Mauro, F. Volpe & G. Maiani. (2014) Effects of consumption of whole grain foods rich in lignans in healthy postmenopausal women with moderate serum cholesterol: a pilot study. International Journal of Food Sciences and Nutrition 65:5, pages 637-645.
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Aida Karina Zaineddin, Katharina Buck, Alina Vrieling, Judith Heinz, Dieter Flesch-Janys, Jakob Linseisen & Jenny Chang-Claude. (2012) The Association Between Dietary Lignans, Phytoestrogen-Rich Foods, and Fiber Intake and Postmenopausal Breast Cancer Risk: A German Case-Control Study. Nutrition and Cancer 64:5, pages 652-665.
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Murali Krishnan & P. Prabhasankar. (2012) Health Based Pasta: Redefining the Concept of the Next Generation Convenience Food. Critical Reviews in Food Science and Nutrition 52:1, pages 9-20.
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K.K. Singh, D. Mridula, Jagbir Rehal & P. Barnwal. (2011) Flaxseed: A Potential Source of Food, Feed and Fiber. Critical Reviews in Food Science and Nutrition 51:3, pages 210-222.
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Jasdeep Kaur Saggar, Jianmin Chen, Paul Corey & LilianU. Thompson. (2010) The Effect of Secoisolariciresinol Diglucoside and Flaxseed Oil, Alone and in Combination, on MCF-7 Tumor Growth and Signaling Pathways. Nutrition and Cancer 62:4, pages 533-542.
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NiinaM. Saarinen, KristaA. Power, Jianmin Chen & LilianU. Thompson. (2008) Lignans are Accessible to Human Breast Cancer Xenografts in Athymic Mice. Nutrition and Cancer 60:2, pages 245-250.
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Juan Chen, Xia Liu, Yan‐Ping Shi & Chun‐Yan Ma. (2007) Determination of the Lignan Secoisolariciresinol Diglucoside from Flaxseed (Linum Usitatissimum L.) by HPLC. Journal of Liquid Chromatography & Related Technologies 30:4, pages 533-544.
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Karen D. Coulman, Zhen Liu, Winston Quan Hum, John Michaelides & Lilian U. Thompson. (2005) Whole Sesame Seed Is as Rich a Source of Mammalian Lignan Precursors as Whole Flaxseed. Nutrition and Cancer 52:2, pages 156-165.
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Belma Konuklugil, Elisabeth Fuss & Willi. Alfermann. (2005) Isolation of the Lignan 6-Methoxypodophyllotoxin from Linum boissieri. and Biosynthesis of Lignans in this Species. Pharmaceutical Biology 43:9, pages 737-739.
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Mirjam Luijten, Anni Ronfeldt Thomsen, Jolanda A. H. van den Berg, Piet W. Wester, Aart Verhoef, Nico J. D. Nagelkerke, Herman Adlercreutz, Henk J. van Kranen, Aldert H. Piersma, Ilona K. Sorensen, Ghanta N. Rao & Coen F. van Kreijl. (2004) Effects of Soy-Derived Isoflavones and a High-Fat Diet on Spontaneous Mammary Tumor Development in Tg.NK (MMTV/c-neu) Mice. Nutrition and Cancer 50:1, pages 46-54.
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Henk J. van Kranen, Alicja Mortensen, Ilona K. Sorensen, Jolanda van den Berg-Wijnands, Rudolf Beems, Tarja Nurmi, Herman Adlercreutz & Coen F. van Kreijl. (2003) Lignan Precursors From Flaxseed or Rye Bran Do Not Protect Against the Development of Intestinal Neoplasia in ApcMin Mice. Nutrition and Cancer 45:2, pages 203-210.
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Joanne L. Slavin. (2000) Mechanisms for the Impact of Whole Grain Foods on Cancer Risk. Journal of the American College of Nutrition 19:sup3, pages 300S-307S.
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N. M. Saarinen, A. Warri, S. I. Makela, C. Eckerman, M. Reunanen, M. Ahotupa, S. M. Salmi, A. A. Franke, L. Kangas & R. Santti. (2000) Hydroxymatairesinol, a Novel Enterolactone Precursor With Antitumor Properties From Coniferous Tree (Picea abies). Nutrition and Cancer 36:2, pages 207-216.
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JanetC. L. Tou, Jianmin Chen & LilianU. Thompson. (1999) Dose, Timing, and Duration of Flaxseed Exposure Affect Reproductive Indices and Sex Hormone Levels in Rats. Journal of Toxicology and Environmental Health, Part A 56:8, pages 555-570.
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Carol J. Haggans, Andrea M. Hutchins, B. Amy Olson, William Thomas, Margaret C. Martini & Joanne L. Slavin. (1999) Effect of Flaxseed Consumption on Urinary Estrogen Metabolites in Postmenopausal Women. Nutrition and Cancer 33:2, pages 188-195.
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Mazda Jenab, Sharon E. Rickard, Lindy J. Orcheson & Lilian U. Thompson. (1999) Flaxseed and Lignans Increase Cecal β-Glucuronidase Activity in Rats. Nutrition and Cancer 33:2, pages 154-158.
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Sheng-Xiang Qiu, Zhi-Zhen Lu, Lumonadio Luyengi, Sang Kook Lee, John M. Pezzuto, Norman R. Farnsworth, Lilian U. Thompson & Harry H.S. Fong. (1999) Isolation and Characterization of Flaxseed (Linum usitatissimum) Constituents. Pharmaceutical Biology 37:1, pages 1-7.
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BasilA. Stoll. (1998) Essential fatty acids, insulin resistance, and breast cancer risk. Nutrition and Cancer 31:1, pages 72-77.
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Herman Adlercreutz & Witold Mazur. (1997) Phyto-oestrogens and Western Diseases. Annals of Medicine 29:2, pages 95-120.
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PaulaD. Nesbitt & LilianU. Thompson. (1997) Lignans in homemade and commercial products containing flaxseed. Nutrition and Cancer 29:3, pages 222-227.
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LilianU. Thompson, SharonE. Rickard, Felicia Cheung, EdwardO. Kenaschuk & WilliamR. Obermeyer. (1997) Variability in anticancer lignan levels in flaxseed. Nutrition and Cancer 27:1, pages 26-30.
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