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Effect of long‐term depletion of plasma methionine on the growth and survival of human brain tumor xenografts in athymic mice

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Pages 195-204 | Received 15 Jul 1997, Accepted 16 Sep 1997, Published online: 04 Aug 2009

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Kei Kawaguchi, Qinghong Han, Shukuan Li, Yuying Tan, Kentaro Igarashi, Tasuku Kiyuna, Kentaro Miyake, Masuyo Miyake, Bartosz Chmielowski, Scott D. Nelson, Tara A. Russell, Sarah M. Dry, Yunfeng Li, Arun S. Singh, Mark A. Eckardt, Michiaki Unno, Fritz C. Eilber & Robert M. Hoffman. (2018) Targeting methionine with oral recombinant methioninase (o-rMETase) arrests a patient-derived orthotopic xenograft (PDOX) model of BRAF-V600E mutant melanoma: implications for chronic clinical cancer therapy and prevention. Cell Cycle 17:3, pages 356-361.
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Robert M. Hoffman. (2017) The wayward methyl group and the cascade to cancer. Cell Cycle 16:9, pages 825-829.
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AthanassiosP. Kyritsis, MelissaL. Bondy & VictorA. Levin. (2011) Modulation of Glioma Risk and Progression by Dietary Nutrients and Antiinflammatory Agents. Nutrition and Cancer 63:2, pages 174-184.
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Xavier Durando, Emilie Thivat, Marie-Chantal Farges, Eric Cellarier, Michel D'Incan, Aïcha Demidem, Marie-Paule Vasson, Chantal Barthomeuf & Philippe Chollet. (2007) Optimal Methionine-Free Diet Duration for Nitrourea Treatment: A Phase I Clinical Trial. Nutrition and Cancer 60:1, pages 23-30.
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Despina Komninou, Yvonne Leutzinger, Bandaru S. Reddy & John P. Richie Jr.. (2006) Methionine Restriction Inhibits Colon Carcinogenesis. Nutrition and Cancer 54:2, pages 202-208.
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Daniel E. Epner, Sydney Morrow, Mandi Wilcox & Jennifer L. Houghton. (2002) Nutrient Intake and Nutritional Indexes in Adults With Metastatic Cancer on a Phase I Clinical Trial of Dietary Methionine Restriction. Nutrition and Cancer 42:2, pages 158-166.
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Daniel E. Epner. (2001) Can Dietary Methionine Restriction Increase the Effectiveness of Chemotherapy in Treatment of Advanced Cancer?. Journal of the American College of Nutrition 20:sup5, pages 443S-449S.
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Shan Lu & Daniel E. Epner. (2000) Molecular Mechanisms of Cell Cycle Block by Methionine Restriction in Human Prostate Cancer Cells. Nutrition and Cancer 38:1, pages 123-130.
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Mengxue Sun, Meichen Yang, Shanshan Li, Chaohui Wang, Fengrong Zhang, Bolong Xu, Yulian Zhang, Xinxiao Sun, Qipeng Yuan & Huiyu Liu. (2023) Photothermal Lysis of Engineered Bacteria to Modulate Amino Acid Metabolism against Tumors. Advanced Functional Materials 33:13.
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Vadim S. Pokrovsky, Louay Abo Qoura, Elena Morozova & Victoria I. Bunik. (2022) Predictive markers for efficiency of the amino-acid deprivation therapies in cancer. Frontiers in Medicine 9.
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Despina Komninou, Virginia L. Malloy, Jay A. Zimmerman, Raghu Sinha & John P. RichieJrJr. (2019) Methionine restriction delays aging-related urogenital diseases in male Fischer 344 rats. GeroScience 42:1, pages 287-297.
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Evan C. Lien & Matthew G. Vander Heiden. (2019) A framework for examining how diet impacts tumour metabolism. Nature Reviews Cancer 19:11, pages 651-661.
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V. S. Pokrovsky, N. Yu Anisimova, D. Zh Davydov, S. V. Bazhenov, N. V. Bulushova, G. B. Zavilgelsky, V. Y. Kotova & I. V. Manukhov. (2018) Methionine gamma lyase from Clostridium sporogenes increases the anticancer effect of doxorubicin in A549 cells and human cancer xenografts. Investigational New Drugs 37:2, pages 201-209.
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Robert M. Hoffman, Qinghong Han, Kei Kawaguchi, Shukuan Li & Yuying Tan. 2019. Methionine Dependence of Cancer and Aging. Methionine Dependence of Cancer and Aging 311 322 .
V. S. Pokrovsky, N. Yu. Anisimova, D. Zh. Davydov, S. V. Bazhenov, N. V. Bulushova, G. B. Zavilgelsky, V. Y. Kotova & I. V. Manukhov. 2019. Methionine Dependence of Cancer and Aging. Methionine Dependence of Cancer and Aging 243 261 .
Robert M. Hoffman, Zhijian Yang, Yuying Tan, Qinghong Han, Shukuan Li & Shigeo Yagi. 2019. Methionine Dependence of Cancer and Aging. Methionine Dependence of Cancer and Aging 211 229 .
Robert M. Hoffman, Demetrius M. Kokkinakis & Eugene P. Frenkel. 2019. Methionine Dependence of Cancer and Aging. Methionine Dependence of Cancer and Aging 163 171 .
Kentaro Igarashi, Kei Kawaguchi, Tasuku Kiyuna, Kentaro Miyake, Masuyo Miyaki, Norio Yamamoto, Katsuhiro Hayashi, Hiroaki Kimura, Shinji Miwa, Takashi Higuchi, Arun S. Singh, Bartosz Chmielowski, Scott D. Nelson, Tara A. Russell, Mark A. Eckardt, Sarah M. Dry, Yunfeng Li, Shree Ram Singh, Sant P. Chawla, Fritz C. Eilber, Hiroyuki Tsuchiya & Robert M. Hoffman. (2018) Metabolic targeting with recombinant methioninase combined with palbociclib regresses a doxorubicin-resistant dedifferentiated liposarcoma. Biochemical and Biophysical Research Communications 506:4, pages 912-917.
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Kei Kawaguchi, Kentaro Miyake, Qinghong Han, Shukuan Li, Yuying Tan, Kentaro Igarashi, Tasuku Kiyuna, Masuyo Miyake, Takashi Higuchi, Hiromichi Oshiro, Zhiying Zhang, Sahar Razmjooei, Sintawat Wangsiricharoen, Michael Bouvet, Shree Ram Singh, Michiaki Unno & Robert M. Hoffman. (2018) Oral recombinant methioninase (o-rMETase) is superior to injectable rMETase and overcomes acquired gemcitabine resistance in pancreatic cancer. Cancer Letters 432, pages 251-259.
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Kentaro Igarashi, Kei Kawaguchi, Shukuan Li, Qinghong Han, Yuying Tan, Takashi Murakami, Tasuku Kiyuna, Kentaro Miyake, Masuyo Miyake, Arun S. Singh, Mark A. Eckardt, Scott D. Nelson, Tara A. Russell, Sarah M. Dry, Yunfeng Li, Norio Yamamoto, Katsuhiro Hayashi, Hiroaki Kimura, Shinji Miwa, Hiroyuki Tsuchiya, Shree Ram Singh, Fritz C. Eilber & Robert M. Hoffman. (2018) Recombinant methioninase in combination with doxorubicin (DOX) overcomes first-line DOX resistance in a patient-derived orthotopic xenograft nude-mouse model of undifferentiated spindle-cell sarcoma. Cancer Letters 417, pages 168-173.
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Kei Kawaguchi, Qinghong Han, Shukuan Li, Yuying Tan, Kentaro Igarashi, Kentaro Miyake, Tasuku Kiyuna, Masuyo Miyake, Bartosz Chemielwski, Scott D. Nelson, Tara A. Russell, Sarah M. Dry, Yunfeng Li, Arun S. Singh, Mark A. Eckardt, Michiaki Unno, Fritz C. Eilber & Robert M. Hoffman. (2018) Intra-tumor L-methionine level highly correlates with tumor size in both pancreatic cancer and melanoma patient-derived orthotopic xenograft (PDOX) nude-mouse models. Oncotarget 9:13, pages 11119-11125.
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Beverly Teicher & Herbert B. Newton. 2018. Handbook of Brain Tumor Chemotherapy, Molecular Therapeutics, and Immunotherapy. Handbook of Brain Tumor Chemotherapy, Molecular Therapeutics, and Immunotherapy 59 73 .
Evan C. Lien, Laura Ghisolfi, Renee C. Geck, John M. AsaraAlex Toker. (2017) Oncogenic PI3K promotes methionine dependency in breast cancer cells through the cystine-glutamate antiporter xCT. Science Signaling 10:510.
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Robert M. Hoffman. (2017) Is DNA methylation the new guardian of the genome?. Molecular Cytogenetics 10:1.
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Kei Kawaguchi, Kentaro Igarashi, Shukuan Li, Qinghong Han, Yuying Tan, Tasuku Kiyuna, Kentaro Miyake, Takashi Murakami, Bartosz Chmielowski, Scott D. Nelson, Tara A. Russell, Sarah M. Dry, Yunfeng Li, Michiaki Unno, Fritz C. Eilber & Robert M. Hoffman. (2017) Combination treatment with recombinant methioninase enables temozolomide to arrest a BRAF V600E melanoma in a patient-derived orthotopic xenograft (PDOX) mouse model. Oncotarget 8:49, pages 85516-85525.
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Robert Hoffman. (2017) Patient-Derived Orthotopic Xenograft (PDOX) Models of Melanoma. International Journal of Molecular Sciences 18:9, pages 1875.
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Ashraf S. A. El-Sayed, Laura E. Ruff, Salah E. Abdel Ghany, Gul Shad Ali & Sadik Esener. (2016) Molecular and Spectroscopic Characterization of Aspergillus flavipes and Pseudomonas putida L-Methionine γ-Lyase in Vitro. Applied Biochemistry and Biotechnology 181:4, pages 1513-1532.
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Ashraf S.A. El-Sayed, Abdalla E.A. Hassan, Ahmed A. Shindia, Shaimaa G. Mohamed & Mahmoud Z. Sitohy. (2016) Aspergillus flavipes methionine γ-lyase-dextran conjugates with enhanced structural, proteolytic stability and anticancer efficiency. Journal of Molecular Catalysis B: Enzymatic 133, pages S15-S24.
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R. Hamed Shimaa, M. Abo Elsoud Mostafa, G. Mahmoud Manal & M. S. Asker Mohsen. (2016) Isolation, screening and statistical optimizing of L-methioninase production by Chaetomium globosum. African Journal of Microbiology Research 10:36, pages 1513-1523.
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M.M. Muharram. (2016) Recombinant Engineering of L-Methioninase Using Two Different Promoter and Expression Systems and in vitro Analysis of Its Anticancer Efficacy on Different Human Cancer Cell Lines. Pakistan Journal of Biological Sciences 19:3, pages 106-114.
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Everett Stone, Olga Paley, Jian Hu, Barbara Ekerdt, Nai-Kong Cheung & George Georgiou. (2012) De Novo Engineering of a Human Cystathionine-γ-Lyase for Systemic l -Methionine Depletion Cancer Therapy . ACS Chemical Biology 7:11, pages 1822-1829.
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