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Genistein‐induced upregulation of p21WAF1, downregulation of cyclin B, and induction of apoptosis in prostate cancer cells

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Pages 123-131 | Published online: 04 Aug 2009

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Tayyaba Nawaz, Sundus Nawaz, Waseem Khalid & Khalid Abdelsamea Mohamedahmed. (2023) Dietary phytochemicals beneficial to obesity and cancer management: a review. International Journal of Food Properties 26:1, pages 2006-2024.
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AhmedQ. Haddad, Neil Fleshner, Colleen Nelson, Basil Saour, Mireia Musquera, Vasundara Venkateswaran & Laurence Klotz. (2010) Antiproliferative Mechanisms of the Flavonoids 2,2′-Dihydroxychalcone and Fisetin in Human Prostate Cancer Cells. Nutrition and Cancer 62:5, pages 668-681.
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ElizabethA. Clubbs & JoshuaA. Bomser. (2009) Basal Cell Induced Differentiation of Noncancerous Prostate Epithelial Cells (RWPE-1) by Glycitein. Nutrition and Cancer 61:3, pages 390-396.
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Genoveva Murillo, WendyH. Hirschelman, Aiko Ito, RobertM. Moriarty, A. Douglas Kinghorn, JohnM. Pezzuto & RajendraG. Mehta. (2007) Zapotin, a Phytochemical Present in a Mexican Fruit, Prevents Colon Carcinogenesis. Nutrition and Cancer 57:1, pages 28-37.
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Debra L Bemis, Aaron E Katz & Ralph Buttyan. (2006) Clinical trials of natural products as chemopreventive agents for prostate cancer. Expert Opinion on Investigational Drugs 15:10, pages 1191-1200.
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Fazlul H. Sarkar & Yiwei Li. (2003) Soy Isoflavones and Cancer Prevention. Cancer Investigation 21:5, pages 744-757.
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Kwai Fung Hui, Yvonne Y. Leung, Po L. Yeung, Jaap M. Middeldorp & Alan K.S. Chiang. (2014) Combination of SAHA and bortezomib up‐regulates CDKN2A and CDKN1A and induces apoptosis of Epstein‐Barr virus‐positive Wp‐restricted Burkitt lymphoma and lymphoblastoid cell lines . British Journal of Haematology 167:5, pages 639-650.
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Yuji Nakayama, Youhei Saito, Shuhei Soeda, Erika Iwamoto, Sayuri Ogawa, Nobuyuki Yamagishi, Takahisa Kuga & Naoto Yamaguchi. (2014) Genistein Induces Cytokinesis Failure Through RhoA Delocalization and Anaphase Chromosome Bridging. Journal of Cellular Biochemistry 115:4, pages 763-771.
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Aamir Ahmad, Bernhard Biersack, Yiwei Li, Bin Bao, Dejuan Kong, Shadan Ali, Sanjeev Banerjee & Fazlul H. Sarkar. (2013) Perspectives on the Role of Isoflavones in Prostate Cancer. The AAPS Journal 15:4, pages 991-1000.
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Xiao Lin & Li Yu. (2013) Effects of Natural Compound Genistein on the Proliferation and Apoptosis in Ovarian Carcinoma Cell Lines 3AO. Advanced Materials Research 781-784, pages 726-730.
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Ganji Purnachandra Nagaraju, Syed F Zafar & Bassel F El-Rayes. (2013) Pleiotropic effects of genistein in metabolic, inflammatory, and malignant diseases. Nutrition Reviews 71:8, pages 562-572.
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K. Sahin, M. Tuzcu, N. Basak, B. Caglayan, U. Kilic, F. Sahin & O. Kucuk. (2012) Sensitization of Cervical Cancer Cells to Cisplatin by Genistein: The Role of NFB and Akt/mTOR Signaling Pathways. Journal of Oncology 2012, pages 1-6.
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Gilda G. Hillman & Vinita Singh-Gupta. (2011) Soy isoflavones sensitize cancer cells to radiotherapy. Free Radical Biology and Medicine 51:2, pages 289-298.
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Hisae Nakamura, Yuwei Wang, Takeshi Kurita, Hans Adomat, Gerald R. Cunha & Yuzhuo Wang. (2011) Genistein Increases Epidermal Growth Factor Receptor Signaling and Promotes Tumor Progression in Advanced Human Prostate Cancer. PLoS ONE 6:5, pages e20034.
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Jonathan Friedman & Cheryl Frye. (2011) Anti-anxiety, cognitive, and steroid biosynthetic effects of an isoflavone-based dietary supplement are gonad and sex-dependent in rats. Brain Research 1379, pages 164-175.
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Labanyamoy Kole, Biplab Giri, Sunil Kumar Manna, Biswajit Pal & Sajalendu Ghosh. (2011) Biochanin-A, an isoflavon, showed anti-proliferative and anti-inflammatory activities through the inhibition of iNOS expression, p38-MAPK and ATF-2 phosphorylation and blocking NFκB nuclear translocation. European Journal of Pharmacology 653:1-3, pages 8-15.
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Wanyeon KimKi Moon SeongBuHyun Youn. (2011) Phenylpropanoids in radioregulation: double edged sword. Experimental and Molecular Medicine 43:6, pages 323.
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Paul L De Souza, Pamela J Russell, John H Kearsley & Laurence G Howes. (2010) Clinical pharmacology of isoflavones and its relevance for potential prevention of prostate cancer. Nutrition Reviews 68:9, pages 542-555.
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Janet M. Pavese, Rebecca L. Farmer & Raymond C. Bergan. (2010) Inhibition of cancer cell invasion and metastasis by genistein. Cancer and Metastasis Reviews 29:3, pages 465-482.
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Subash C. Gupta, Ji Hye Kim, Sahdeo Prasad & Bharat B. Aggarwal. (2010) Regulation of survival, proliferation, invasion, angiogenesis, and metastasis of tumor cells through modulation of inflammatory pathways by nutraceuticals. Cancer and Metastasis Reviews 29:3, pages 405-434.
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Anna Hsu, Tammy M Bray & Emily Ho. (2010) Anti-inflammatory activity of soy and tea in prostate cancer prevention. Experimental Biology and Medicine 235:6, pages 659-667.
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Vinita Singh-Gupta, Hao Zhang, Christopher K. Yunker, Zahra Ahmad, Danielle Zwier, Fazlul H. Sarkar & Gilda G. Hillman. (2010) Daidzein Effect on Hormone Refractory Prostate Cancer In Vitro and In Vivo Compared to Genistein and Soy Extract: Potentiation of Radiotherapy. Pharmaceutical Research 27:6, pages 1115-1127.
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Sumita Mukherjee, Bipul Ranjan Acharya, Bhabatarak Bhattacharyya & Gopal Chakrabarti. (2010) Genistein Arrests Cell Cycle Progression of A549 Cells at the G 2 /M Phase and Depolymerizes Interphase Microtubules through Binding to a Unique Site of Tubulin . Biochemistry 49:8, pages 1702-1712.
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Tomoko Sonoda, Hiromu Suzuki, Mitsuru Mori, Taiji Tsukamoto, Akira Yokomizo, Seiji Naito, Kiyohide Fujimoto, Yoshihiko Hirao, Naoto Miyanaga & Hideyuki Akaza. (2010) Polymorphisms in estrogen related genes may modify the protective effect of isoflavones against prostate cancer risk in Japanese men. European Journal of Cancer Prevention 19:2, pages 131-137.
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Rihong Cong, Qingmin Sun, Li Yang, Haijuan Gu, Ying Zeng & Bin Wang. (2009) Effect of Genistein on vasculogenic mimicry formation by human uveal melanoma cells. Journal of Experimental & Clinical Cancer Research 28:1.
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K. Benthami, S. Ait Lyazidi, M. Haddad, M. Choukrad, B. Bennetau & S. Shinkaruk. (2009) Photophysics of Genistein isoflavone: Solvent and concentration effects studied by UV–visible spectroscopy and theoretical simulation. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy 74:2, pages 385-390.
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V. Alonso, F.C. Pérez-Martínez, F.J. Calahorra & P. Esbrit. (2009) Phytoestrogen modulation of bone-related cytokines and its impact on cell viability in human prostate cancer cells. Life Sciences 85:11-12, pages 421-430.
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Alicja Mortensen, Sabine E. Kulling, Heidi Schwartz, Ian Rowland, Corinna E. Ruefer, Gerald Rimbach, Aedin Cassidy, Pamela Magee, Julie Millar, Wendy L. Hall, Franziska Kramer Birkved, Ilona K. Sorensen & Gerhard Sontag. (2009) Analytical and compositional aspects of isoflavones in food and their biological effects. Molecular Nutrition & Food Research 53:S2.
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Nishant Mohan, Surajit Karmakar, Subhasree Roy Choudhury, Naren L. Banik & Swapan K. Ray. (2009) Bcl-2 inhibitor HA14-1 and genistein together adeptly down regulated survival factors and activated cysteine proteases for apoptosis in human malignant neuroblastoma SK-N-BE2 and SH-SY5Y cells. Brain Research 1283, pages 155-166.
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Srilatha Swami, Aruna V. Krishnan, Jacqueline Moreno, Rumi S. Bhattacharyya, Christopher Gardner, James D. Brooks, Donna M. Peehl & David Feldman. (2009) Inhibition of prostaglandin synthesis and actions by genistein in human prostate cancer cells and by soy isoflavones in prostate cancer patients. International Journal of Cancer 124:9, pages 2050-2059.
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Kee-Lung Chang, Hsiao-Ling Cheng, Li-Wen Huang, Bau-Shan Hsieh, Yu-Chen Hu, Tsai-Tung Chih, Huey-Wen Shyu & Shu-Jem Su. (2009) Combined effects of terazosin and genistein on a metastatic, hormone-independent human prostate cancer cell line. Cancer Letters 276:1, pages 14-20.
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F.G.E. Perabo, E.C. von Löw, R. Siener, J. Ellinger, S.C. Müller & P.J. Bastian. (2009) Eine kritische Bewertung der Phytotherapie des ProstatakarzinomsA critical assessment of phytotherapy for prostate cancer. Der Urologe 48:3, pages 270-283.
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S. Majid, A. A. Dar, A. E. Ahmad, H. Hirata, K. Kawakami, V. Shahryari, S. Saini, Y. Tanaka, A. V. Dahiya, G. Khatri & R. Dahiya. (2009) BTG3 tumor suppressor gene promoter demethylation, histone modification and cell cycle arrest by genistein in renal cancer. Carcinogenesis 30:4, pages 662-670.
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Robert Michael Hermann, Hendrik Andreas Wolff, Hubertus Jarry, Paul Thelen, Carsten Gruendker, Margret Rave-Fraenk, Heinz Schmidberger & Hans Christiansen. (2008) In vitro studies on the modification of low-dose hyper-radiosensitivity in prostate cancer cells by incubation with genistein and estradiol. Radiation Oncology 3:1.
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Shashwati Basak, Deepa Pookot, Emily J. Noonan & Rajvir Dahiya. (2008) Genistein down-regulates androgen receptor by modulating HDAC6-Hsp90 chaperone function. Molecular Cancer Therapeutics 7:10, pages 3195-3202.
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Sanjeev Banerjee, Yiwei Li, Zhiwei Wang & Fazlul H. Sarkar. (2008) Multi-targeted therapy of cancer by genistein. Cancer Letters 269:2, pages 226-242.
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Lin-lin ZHANG, Lei LI, Da-peng WU, Jin-hai FAN, Xiang LI, Kai-jie WU, Xin-yang WANG & Da-lin HE. (2008) A novel anti-cancer effect of genistein: reversal of epithelial mesenchymal transition in prostate cancer cells 1 . Acta Pharmacologica Sinica 29:9, pages 1060-1068.
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Daniel Peternac, Irena Klima, Marco G. Cecchini, Ruth Schwaninger, Urs E. Studer & George N. Thalmann. (2008) Agents used for chemoprevention of prostate cancer may influence PSA secretion independently of cell growth in the LNCaP model of human prostate cancer progression. The Prostate 68:12, pages 1307-1318.
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Jayakrishnan JayachandranStephen J. Freedland. (2008) Prevention of Prostate Cancer: What We Know and Where We Are Going. American Journal of Men's Health 2:2, pages 178-189.
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Claudia Steiner, Stéphanie Arnould, Augustin Scalbert & Claudine Manach. (2008) Isoflavones and the prevention of breast and prostate cancer: new perspectives opened by nutrigenomics. British Journal of Nutrition 99:E-S1, pages ES78-ES108.
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Shahana Majid, Nobuyuki Kikuno, Jason Nelles, Emily Noonan, Yuichiro Tanaka, Ken Kawamoto, Hiroshi Hirata, Long C. Li, Hong Zhao, Steve T. Okino, Robert F. Place, Deepa Pookot & Rajvir Dahiya. (2008) Genistein Induces the p21WAF1/CIP1 and p16INK4a Tumor Suppressor Genes in Prostate Cancer Cells by Epigenetic Mechanisms Involving Active Chromatin Modification . Cancer Research 68:8, pages 2736-2744.
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F G E Perabo, E C Von Löw, J Ellinger, A von Rücker, S C Müller & P J Bastian. (2007) Soy isoflavone genistein in prevention and treatment of prostate cancer. Prostate Cancer and Prostatic Diseases 11:1, pages 6-12.
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Hai-Bo Zhou, Jin-Ming Chen, Jian-Ting Cai, Qin Du & Chan-Ni Wu. (2008) Anticancer activity of genistein on implanted tumor of human SG7901 cells in nude mice. World Journal of Gastroenterology 14:4, pages 627.
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Gilda G Hillman, Yu Wang, Mingxin Che, Julian J Raffoul, Mark Yudelev, Omer Kucuk & Fazlul H Sarkar. (2007) Progression of renal cell carcinoma is inhibited by genistein and radiation in an orthotopic model. BMC Cancer 7:1.
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M A Goetzl, P J VanVeldhuizen & J B Thrasher. (2007) Effects of soy phytoestrogens on the prostate. Prostate Cancer and Prostatic Diseases 10:3, pages 216-223.
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Yoshie Nagata, Tomoko Sonoda, Mitsuru Mori, Naoto Miyanaga, Koji Okumura, Ken Goto, Seiji Naito, Kiyohide Fujimoto, Yoshihiko Hirao, Atsushi Takahashi, Taiji Tsukamoto & Hideyuki Akaza. (2007) Dietary Isoflavones May Protect against Prostate Cancer in Japanese Men ,. The Journal of Nutrition 137:8, pages 1974-1979.
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Elizabeth A. Clubbs & Joshua A. Bomser. (2007) Glycitein activates extracellular signal-regulated kinase via vascular endothelial growth factor receptor signaling in nontumorigenic (RWPE-1) prostate epithelial cells. The Journal of Nutritional Biochemistry 18:8, pages 525-532.
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Hye-Young Shim, Jong-Hwa Park, Hyun-Dong Paik, Seung-Yeol Nah, Darrick S.H.L. Kim & Ye Sun Han. (2007) Genistein-induced apoptosis of human breast cancer MCF-7 cells involves calpain–caspase and apoptosis signaling kinase 1–p38 mitogen-activated protein kinase activation cascades. Anti-Cancer Drugs 18:6, pages 649-657.
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MingXi Tang, Kumiko Ogawa, Makoto Asamoto, Naomi Hokaiwado, Azman Seeni, Shugo Suzuki, Satoru Takahashi, Takuji Tanaka, Kazuhito Ichikawa & Tomoyuki Shirai. (2007) Protective effects of citrus nobiletin and auraptene in transgenic rats developing adenocarcinoma of the prostate (TRAP) and human prostate carcinoma cells. Cancer Science 98:4, pages 471-477.
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Lori Rice, Renita Handayani, Yuehua Cui, Theresa Medrano, Von Samedi, Henry Baker, Nancy J. Szabo, Charles J. Rosser, Steve Goodison & Kathleen T. Shiverick. (2007) Soy Isoflavones Exert Differential Effects on Androgen Responsive Genes in LNCaP Human Prostate Cancer Cells. The Journal of Nutrition 137:4, pages 964-972.
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Jie Ma, Jie Wang, Ming Zhong & Zhao-yuan Wang. (2007) Effects of genistein on proliferation and cell cycle of salivary adenoid cystic carcinoma cells. Chinese Journal of Cancer Research 19:1, pages 64-67.
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