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Research Article

Comparative study of DNA encapsulation into PLGA microparticles using modified double emulsion methods and spray drying techniques

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Pages 235-244 | Received 12 Jul 2004, Accepted 23 Jul 2004, Published online: 03 Oct 2008

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Marco Antonio Salazar-Miranda, Francisco Cruz-Sosa, María Eva Rodríguez-Huezo, Ruben Jiménez-Alvarado & César Pérez-Alonso. (2016) Microencapsulation of chlorthalidone by spray-drying of double emulsion and melt granulation coating. Drying Technology 34:9, pages 1118-1128.
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S Dean Allison. (2008) Analysis of initial burst in PLGA microparticles. Expert Opinion on Drug Delivery 5:6, pages 615-628.
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Xue-Qing Zhang, Janjira Intra & Aliasger K. Salem. (2008) Comparative study of poly (lactic-co-glycolic acid)-poly ethyleneimine-plasmid DNA microparticles prepared using double emulsion methods. Journal of Microencapsulation 25:1, pages 1-12.
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Ying Zheng, JeffreyR. Kovacs, EllenS. Gawalt, Hongmei Shen & WilsonS. Meng. (2006) Characterization of particles fabricated with poly(D,L-lactic-co-glycolic acid) and an ornithine–histidine peptide as carriers of oligodeoxynucleotide for delivery into primary dendritic cells. Journal of Biomaterials Science, Polymer Edition 17:12, pages 1389-1403.
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Sukumar Uday Kumar, Arsenii V. Telichko, Huaijun Wang, Dongwoon Hyun, Eric G. Johnson, Michael S. Kent, Robert B. Rebhun, Jeremy J. Dahl, William T. N. Culp & Ramasamy Paulmurugan. (2020) Acoustically Driven Microbubbles Enable Targeted Delivery of microRNA‐Loaded Nanoparticles to Spontaneous Hepatocellular Neoplasia in Canines. Advanced Therapeutics 3:12.
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Muhammad Iqbal, Nadiah Zafar, Hatem Fessi & Abdelhamid Elaissari. (2015) Double emulsion solvent evaporation techniques used for drug encapsulation. International Journal of Pharmaceutics 496:2, pages 173-190.
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Mohd. Asif Sherwani, Saba Tufail, Aijaz Ahmed Khan & Mohammad Owais. (2015) Dendrimer-PLGA based multifunctional immuno-nanocomposite mediated synchronous and tumor selective delivery of siRNA and cisplatin: potential in treatment of hepatocellular carcinoma. RSC Advances 5:49, pages 39512-39531.
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Clark J. Needham, Sarita R. Shah, Paschalia M. Mountziaris, F. Kurtis Kasper & Antonios G. Mikos. (2013) Modulation of Polyplex Release from Biodegradable Microparticles through Poly(ethylenimine) Modification and Varying Loading Concentration. Pharmaceutical Research 31:1, pages 77-85.
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Tetty Kemala, Emil Budianto & Bambang Soegiyono. (2012) Preparation and characterization of microspheres based on blend of poly(lactic acid) and poly(ɛ-caprolactone) with poly(vinyl alcohol) as emulsifier. Arabian Journal of Chemistry 5:1, pages 103-108.
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Chunxi Liu & Na Zhang. 2011. Nanoparticles in Translational Science and Medicine. Nanoparticles in Translational Science and Medicine 509 562 .
Jigar Lalani & Ambikanandan Misra. 2011. Challenges in Delivery of Therapeutic Genomics and Proteomics. Challenges in Delivery of Therapeutic Genomics and Proteomics 127 206 .
Kristen Bowey & Ronald J. Neufeld. (2010) Systemic and Mucosal Delivery of Drugs within Polymeric Microparticles Produced by Spray Drying. BioDrugs 24:6, pages 359-377.
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Janjira Intra & Aliasger K. Salem. (2010) Fabrication, characterization and in vitro evaluation of poly(D,L-lactide-co-glycolide) microparticles loaded with polyamidoamine–plasmid DNA dendriplexes for applications in nonviral gene delivery. Journal of Pharmaceutical Sciences 99:1, pages 368-384.
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Tim Pearce, Jared Hierman & Chun Wang. 2009. Delivery Technologies for Biopharmaceuticals. Delivery Technologies for Biopharmaceuticals 245 267 .
Renata P. Raffin, Paolo Colombo, Fabio Sonvico, Alessandra Rossi, Denise S. Jornada, Adriana R. Pohlmann & Silvia S. Guterres. (2009) Agglomerates Containing Pantoprazole Microparticles: Modulating the Drug Release. AAPS PharmSciTech 10:2, pages 335-345.
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Shashank R Sirsi, Rebecca C Schray, Margaret A Wheatley & Gordon J Lutz. (2009) Formulation of polylactide-co-glycolic acid nanospheres for encapsulation and sustained release of poly(ethylene imine)-poly(ethylene glycol) copolymers complexed to oligonucleotides. Journal of Nanobiotechnology 7:1.
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David N. Nguyen, Jordan J. Green, Juliana M. Chan, Robert Langer & Daniel G. Anderson. (2009) Polymeric Materials for Gene Delivery and DNA Vaccination. Advanced Materials 21:8, pages 847-867.
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Aiman O. Abbas, Maureen D. Donovan & Aliasger K. Salem. (2008) Formulating Poly(Lactide-Co-Glycolide) Particles for Plasmid DNA Delivery. Journal of Pharmaceutical Sciences 97:7, pages 2448-2461.
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Jisun Lee, Saemi Oh, Min Kyung Joo & Byeongmoon Jeong. (2008) Solvent-free preparation of caprolactone oligomer microspheres. Journal of Physics and Chemistry of Solids 69:5-6, pages 1596-1599.
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Reinhard Vehring. (2007) Pharmaceutical Particle Engineering via Spray Drying. Pharmaceutical Research 25:5, pages 999-1022.
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Jordy Luten, Cornelus F. van Nostrum, Stefaan C. De Smedt & Wim E. Hennink. (2008) Biodegradable polymers as non-viral carriers for plasmid DNA delivery. Journal of Controlled Release 126:2, pages 97-110.
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Xue-Qing Zhang, Janjira Intra & Aliasger K. Salem. (2007) Conjugation of Polyamidoamine Dendrimers on Biodegradable Microparticles for Nonviral Gene Delivery. Bioconjugate Chemistry 18:6, pages 2068-2076.
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Céline Brunot, Laurence Ponsonnet, Christelle Lagneau, Pierre Farge, Catherine Picart & Brigitte Grosgogeat. (2007) Cytotoxicity of polyethyleneimine (PEI), precursor base layer of polyelectrolyte multilayer films. Biomaterials 28:4, pages 632-640.
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Renata P. Raffin, Denise S. Jornada, Maria Inês Ré, Adriana R. Pohlmann & Silvia S. Guterres. (2006) Sodium pantoprazole-loaded enteric microparticles prepared by spray drying: Effect of the scale of production and process validation. International Journal of Pharmaceutics 324:1, pages 10-18.
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Ana L. Gomes dos Santos, Amélie Bochot, Aoife Doyle, Nicolas Tsapis, Juergen Siepmann, Florence Siepmann, Jeannette Schmaler, Madeleine Besnard, Francine Behar-Cohen & Elias Fattal. (2006) Sustained release of nanosized complexes of polyethylenimine and anti-TGF-β2 oligonucleotide improves the outcome of glaucoma surgery. Journal of Controlled Release 112:3, pages 369-381.
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