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Original

Toxicities associated with hyperthermic isolated limb perfusion and isolated limb infusion in the treatment of melanoma and sarcoma

, , & , MD
Pages 275-289 | Received 14 Sep 2007, Accepted 12 Nov 2007, Published online: 09 Jul 2009

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Shin-ichiro Masunaga, Yoshinori Sakurai, Hiroki Tanaka, Takushi Takata, Minoru Suzuki, Yu Sanada, Keizo Tano, Akira Maruhashi & Koji Ono. (2019) Usefulness of combination with both continuous administration of hypoxic cytotoxin and mild temperature hyperthermia in boron neutron capture therapy in terms of local tumor response and lung metastatic potential. International Journal of Radiation Biology 95:12, pages 1708-1717.
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N. Solari, F. Sucameli, M. Gipponi, F. De Cian & F. Cafiero. (2017) Laparoscopic hyperthermic isolated limb perfusion a new minimally invasive approach for HILP. International Journal of Hyperthermia 33:7, pages 862-866.
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Andreas Nyström Wendt, Jan Mattsson & Roger Olofsson Bagge. (2017) Myoglobin does not predict local toxicity in isolated limb perfusion. International Journal of Hyperthermia 33:6, pages 679-683.
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Nasreen A. Vohra, Kiran K. Turaga, Ricardo J. Gonzalez, Anthony Conley, Damon Reed, Marilyn M. Bui, David Cheong, Douglas G. Letson & Jonathan S. Zager. (2013) The use of isolated limb infusion in limb threatening extremity sarcomas. International Journal of Hyperthermia 29:1, pages 1-7.
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Philip C. W. Lui, Yuen Shan Fan, Guiyan Xu, C. Y. Ngai, Kwok Pui Fung, Gary M. K. Tse, Alex M. C. Yu & Jian Yi Li. (2010) Apoptotic and necrotic effects of tumour necrosis factor-alpha potentiated with hyperthermia on L929 and tumour necrosis factor-alpha-resistant L929. International Journal of Hyperthermia 26:6, pages 556-564.
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Alfredo A Santillan & Jonathan S Zager. (2010) Isolated limb infusion for melanoma: a less morbid alternative to hyperthermic isolated limb perfusion in the US. Expert Opinion on Drug Metabolism & Toxicology 6:9, pages 1033-1037.
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Mecker G Möller, Slawomir Salwa, Declan M Soden & Gerald C O’Sullivan. (2009) Electrochemotherapy as an adjunct or alternative to other treatments for unresectable or in-transit melanoma. Expert Review of Anticancer Therapy 9:11, pages 1611-1630.
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Articles from other publishers (35)

Danielle K. DePalo & Jonathan S. Zager. (2023) Isolated Limb Infusion for Limb-Threatening, Unresectable Sarcoma: Past Progress, Current Applications, and Future Directions. Journal of Clinical Medicine 12:12, pages 4036.
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Michael J. Carr, Justin M. Ko, Susan M. Swetter, Scott E. Woodman, Vernon K. Sondak, Kim A. Margolin & Jonathan S. Zager. 2016. Holland‐Frei Cancer Medicine. Holland‐Frei Cancer Medicine 1 27 .
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Ken Newcomer, Keenan J. Robbins, Jennifer Perone, Fernando Lambreton Hinojosa, David Chen, Susan Jones, Charles K. Kaufman, Roi Weiser, Ryan C. Fields & Douglas S. Tyler. (2022) Malignant melanoma: evolving practice management in an era of increasingly effective systemic therapies. Current Problems in Surgery 59:1, pages 101030.
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K.S. Martin-Tellez, W.J. van Houdt, F. van Coevorden, C. Colombo & M. Fiore. (2020) Isolated limb perfusion for soft tissue sarcoma: Current practices and future directions. A survey of experts and a review of literature. Cancer Treatment Reviews 88, pages 102058.
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Michael J. Carr, James Sun & Jonathan S. Zager. (2020) Isolated limb infusion: Institutional protocol and implementation. Journal of Surgical Oncology 122:1, pages 99-105.
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David T. PointerJr.Jr. & Jonathan S. Zager. (2020) Management of Locoregionally Advanced Melanoma. Surgical Clinics of North America 100:1, pages 109-125.
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Jüri Teras, Hidde M. Kroon, John F. Thompson, Marina Teras, Pille Pata, Andrus Mägi, Roland M. Teras & Sirje Rüütel Boudinot. (2020) First Eastern European experience of isolated limb infusion for in-transit metastatic melanoma confined to the limb: Is it still an effective treatment option in the modern era?. European Journal of Surgical Oncology 46:2, pages 272-276.
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Kristy K Broman & Jonathan S Zager. (2019) Intra-arterial perfusion-based therapies for regionally metastatic cutaneous and uveal melanoma. Melanoma Management 6:3, pages MMT26.
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Hidde M. Kroon & John F. Thompson. (2018) Isolated Limb Infusion and Isolated Limb Perfusion for Melanoma: Can the Outcomes of these Procedures be Compared?. Annals of Surgical Oncology 26:1, pages 8-9.
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Eelco de Bree, D. Michelakis, C. Ioannou, J. Romanos, K. Lasithiotakis & O. Zoras. (2019) Neoadjuvant Treatment of Locally Advanced Soft Tissue Sarcoma of the Extremities to Avoid Amputation. Isolated Limb Perfusion is a Valid Option. Hellenic Journal of Surgery 91:1, pages 22-32.
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Cristina O’Donoghue, Jonathan S. Zager & Vernon K. Sondak. 2019. Melanoma. Melanoma 515 534 .
Evan S. Weitman & Jonathan S. Zager. (2018) Regional therapies for locoregionally advanced and unresectable melanoma. Clinical & Experimental Metastasis 35:5-6, pages 495-502.
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Jennifer A. Perone, Nellie Farrow, Douglas S. Tyler & Georgia M. Beasley. (2018) Contemporary Approaches to In-Transit Melanoma. Journal of Oncology Practice 14:5, pages 292-300.
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Siming Li, Xinan Sheng, Lu Si, Chuanliang Cui, Yan Kong, Lili Mao, Bin Lian, Bixia Tang, Xieqiao Yan, Xuan Wang, Zhihong Chi & Jun Guo. (2017) Outcomes and Predictive Factors of Isolated Limb Infusion for Patients with In-transit Melanoma in China. Annals of Surgical Oncology 25:4, pages 885-893.
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Cristina O’Donoghue, Jonathan S. Zager & Vernon K. Sondak. 2018. Melanoma. Melanoma 1 20 .
Siavash Raigani, Sonia Cohen & Genevieve M. Boland. (2017) The Role of Surgery for Melanoma in an Era of Effective Systemic Therapy. Current Oncology Reports 19:3.
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Justin M. Ko, Susan M. Swetter, Jonathan S. Zager, Vernon K. Sondak, Scott E. Woodman & Kim A. Margolin. 2016. Holland‐Frei Cancer Medicine. Holland‐Frei Cancer Medicine 1 22 .
Maurice Matter, Antonia Digklia, Béatrice Gay, Berardino De Bari, Manuel Diezi & Eric Raymond. 2016. Induction Chemotherapy. Induction Chemotherapy 391 436 .
Andrea M. Abbott & Jonathan S. Zager. (2014) Locoregional Therapies in Melanoma. Surgical Clinics of North America 94:5, pages 1003-1015.
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SHIN-ICHIRO MASUNAGA, YOSHINORI SAKURAI, KEIZO TANO, HIROKI TANAKA, MINORU SUZUKI, NATSUKO KONDO, MASARU NARABAYASHI, TSUBASA WATANABE, YOSUKE NAKAGAWA, AKIRA MARUHASHI & KOJI ONO. (2014) Effect of bevacizumab combined with boron neutron capture therapy on local tumor response and lung metastasis. Experimental and Therapeutic Medicine 8:1, pages 291-301.
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John Thompson, Brendon J. Coventry, Douglas Tyler & Hidde M. Kroon. 2014. Breast, Endocrine and Surgical Oncology. Breast, Endocrine and Surgical Oncology 201 218 .
Maurice Matter, Beatrice Gay, Alexandre Christinat, Abderrahim Zouhair & Serge Leyvraz. 2013. Regionale Therapie maligner Tumoren. Regionale Therapie maligner Tumoren 327 357 .
Jeremiah L. Deneve & Jonathan S. Zager. (2012) Isolated Regional Therapy for Advanced Extremity Soft Tissue Sarcomas. Surgical Oncology Clinics of North America 21:2, pages 287-299.
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S Masunaga, Y Sakurai, H Tanaka, M Suzuki, Y Liu, N Kondo, A Maruhashi, Y Kinashi & K Ono. (2012) Effects of employing a 10 B-carrier and manipulating intratumour hypoxia on local tumour response and lung metastatic potential in boron neutron capture therapy . The British Journal of Radiology 85:1011, pages 249-258.
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S Masunaga, Y Liu, H Tanaka, Y Sakurai, M Suzuki, N Kondo, A Maruhashi & K Ono. (2011) Reducing intratumour acute hypoxia through bevacizumab treatment, referring to the response of quiescent tumour cells and metastatic potential. The British Journal of Radiology 84:1008, pages 1131-1138.
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Curtis J. Wray, Robert S. Benjamin, Kelly K. Hunt, Janice N. Cormier, Merrick I. Ross & Barry W. Feig. (2011) Isolated limb perfusion for unresectable extremity sarcoma. Cancer 117:14, pages 3235-3241.
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Maurice Matter, Beatrice Gay, Alexandre Christinat, Abderrahim Zouhair & Serge Leyvraz. 2011. Induction Chemotherapy. Induction Chemotherapy 267 301 .
S Masunaga, Y Matsumoto, G Kashino, R Hirayama, Y Liu, H Tanaka, Y Sakurai, M Suzuki, Y Kinashi, A Maruhashi & K Ono. (2010) Significance of manipulating tumour hypoxia and radiation dose rate in terms of local tumour response and lung metastatic potential, referring to the response of quiescent cell populations. The British Journal of Radiology 83:993, pages 776-784.
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Sylvie Bonvalot, Françoise Rimareix, Sylvain Causeret, Cécile Le Péchoux, Bérénice Boulet, Philippe Terrier, Axel Le Cesne & Jane Muret. (2009) Hyperthermic Isolated Limb Perfusion in Locally Advanced Soft Tissue Sarcoma and Progressive Desmoid-Type Fibromatosis with TNF 1 mg and Melphalan (T1-M HILP) Is Safe and Efficient. Annals of Surgical Oncology 16:12, pages 3350-3357.
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Shin-ichiro Masunaga, Yoshitaka Matsumoto, Ryoichi Hirayama, Genro Kashino, Hiroki Tanaka, Minoru Suzuki, Yuko Kinashi, Yong Liu, Koichi Ando & Koji Ono. (2009) Significance of manipulating intratumor hypoxia in the effect on lung metastases in radiotherapy, with reference to its effect on the sensitivity of intratumor quiescent cells. Clinical & Experimental Metastasis 26:7, pages 693-700.
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Alfredo A. Santillan, Keith A. Delman, Georgia M. Beasley, Paul J. Mosca, Steven N. Hochwald, Stephen R. Grobmyer, Robert H. Andtbacka, R. Dirk Noyes, John M. Kane, Merrick I. Ross, Douglas S. Tyler & Jonathan S. Zager. (2009) Predictive Factors of Regional Toxicity and Serum Creatine Phosphokinase Levels After Isolated Limb Infusion for Melanoma: A Multi-Institutional Analysis. Annals of Surgical Oncology 16:9, pages 2570-2578.
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Hidde M. Kroon & John F. Thompson. (2009) Isolated limb infusion: A review. Journal of Surgical Oncology 100:2, pages 169-177.
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Hidde M. Kroon, D‐Yin Lin, Peter C. A. Kam & John F. Thompson. (2009) Efficacy of repeat isolated limb infusion with melphalan and actinomycin D for recurrent melanoma. Cancer 115:9, pages 1932-1940.
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James M. Mcloughlin, Jonathan S. ZagerVernon K. SondakLawrence B. Berk. (2008) Treatment Options for Limited or Symptomatic Metastatic Melanoma. Cancer Control 15:3, pages 239-247.
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