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International Journal of Hyperthermia Volume 34, 2018 - Issue 3
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Original Articles

Hyperthermia-enhanced targeted drug delivery using magnetic resonance-guided focussed ultrasound: a pre-clinical study in a genetic model of pancreatic cancer

Navid FarrDepartment of Bioengineering, University of Washington, Seattle, WA, USA; View further author information
,
Yak-Nam WangApplied Physics Laboratory, University of Washington, Seattle, WA, USA; View further author information
,
Samantha D’AndreaDepartment of Medicine, University of Washington, Seattle, WA, USA; View further author information
,
Frank StarrApplied Physics Laboratory, University of Washington, Seattle, WA, USA; View further author information
,
Ari PartanenPhilips, Clinical Science MR Therapy, Andover, MA, USA; View further author information
,
Kayla M. GravelleDepartment of Medicine, University of Washington, Seattle, WA, USA; View further author information
,
Jeannine S. McCunePharmacokinetics Laboratory, University of Washington, Seattle, WA, USA; View further author information
,
Linda J. RislerPharmacokinetics Laboratory, University of Washington, Seattle, WA, USA; View further author information
,
Stella G. WhangDepartment of Medicine, University of Washington, Seattle, WA, USA; View further author information
,
Amy ChangFred Hutchinson Cancer Research Center, Seattle, WA, USA; View further author information
,
Sunil R. HingoraniDepartment of Medicine, University of Washington, Seattle, WA, USA; ;Fred Hutchinson Cancer Research Center, Seattle, WA, USA; View further author information
,
Donghoon LeeDepartment of Radiology, University of Washington, Seattle, WA, USAView further author information
&
Joo Ha HwangDepartment of Medicine, University of Washington, Seattle, WA, USA; Correspondence[email protected]
View further author information
 show all
Pages 284-291 | Received 31 Dec 2016, Accepted 27 May 2017, Published online: 17 Jul 2017

Citations (35)

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Sha Chen, Hao Bian & Jingyu Duan. (2022) High-Intensity Focused Ultrasound Enhanced Anti-Tumor Activities of Paclitaxel in Breast Cancer in vitro and in vivo. Cancer Management and Research 14, pages 1303-1312.
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Jacek Calik, Monika Migdal, Tomasz Zawada & Torsten Bove. (2022) Treatment of Seborrheic Keratosis by High Frequency Focused Ultrasound – An Early Experience with 11 Consecutive Cases. Clinical, Cosmetic and Investigational Dermatology 15, pages 145-156.
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Michael Gray, Laura Spiers & Constantin Coussios. (2022) Effects of human tissue acoustic properties, abdominal wall shape, and respiratory motion on ultrasound-mediated hyperthermia for targeted drug delivery to pancreatic tumors. International Journal of Hyperthermia 39:1, pages 918-934.
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Lukas Christian Sebeke, Pia Rademann, Alexandra Claudia Maul, Sin Yuin Yeo, Juan Daniel Castillo Gómez, Daniel A. Deenen, Patrick Schmidt, Bram de Jager, W. P. M. H. Heemels, Holger Grüll & Edwin Heijman. (2021) Visualization of thermal washout due to spatiotemporally heterogenous perfusion in the application of a model-based control algorithm for MR-HIFU mediated hyperthermia. International Journal of Hyperthermia 38:1, pages 1174-1187.
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H. Petra Kok, Erik N. K. Cressman, Wim Ceelen, Christopher L. Brace, Robert Ivkov, Holger Grüll, Gail ter Haar, Peter Wust & Johannes Crezee. (2020) Heating technology for malignant tumors: a review. International Journal of Hyperthermia 37:1, pages 711-741.
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Tomasz Zawada & Torsten Bove. (2024) Analytical modeling of harmonically driven focused acoustic sources with experimental verification. Applied Acoustics 221, pages 109989.
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Michael D. Gray, Laura Spiers & Constantin C. Coussios. (2023) Sound speed and attenuation of human pancreas and pancreatic tumors and their influence on focused ultrasound thermal and mechanical therapies. Medical Physics 51:2, pages 809-825.
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Rezvan Yazdian-Robati, Seyedeh Melika Ahmadi, Faranak Mavandadnejad, Pedram Ebrahimnejad, Shervin Amirkhanloo & Amin Shad. 2024. Recent Advances in Nanocarriers for Pancreatic Cancer Therapy. Recent Advances in Nanocarriers for Pancreatic Cancer Therapy 95 114 .
Andrea Coppola, Dario Grasso, Federico Fontana, Filippo Piacentino, Roberto Minici, Domenico Laganà, Anna Maria Ierardi, Gianpaolo Carrafiello, Fabio D’Angelo, Giulio Carcano & Massimo Venturini. (2023) Innovative Experimental Ultrasound and US-Related Techniques Using the Murine Model in Pancreatic Ductal Adenocarcinoma: A Systematic Review. Journal of Clinical Medicine 12:24, pages 7677.
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Sofia Gereta, Judith Stangl‐Kremser, Tenny R. Zhang & Jim C. Hu. 2023. The Application of Heat in Oncology. The Application of Heat in Oncology 425 458 .
Na Tang, Yi Zhu, Ziwei Lu, Jiali Deng, Jiajing Guo, Xinyi Ding, Jingyi Wang, Rong Cao, An Chen, Zhongyi Huang, Hongwei Lu & Zhongling Wang. (2023) pH-Responsive doxorubicin-loaded magnetosomes for magnetic resonance-guided focused ultrasound real-time monitoring and ablation of breast cancer. Biomaterials Science 11:21, pages 7158-7168.
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Laura Spiers, Michael Gray, Paul Lyon, Shivan Sivakumar, Noor Bekkali, Shaun Scott, Linda Collins, Robert Carlisle, Feng Wu, Mark Middleton & Constantin Coussios. (2023) Clinical trial protocol for PanDox: a phase I study of targeted chemotherapy delivery to non-resectable primary pancreatic tumours using thermosensitive liposomal doxorubicin (ThermoDox®) and focused ultrasound. BMC Cancer 23:1.
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Peipei Yang, Xin Zhi, Yunxue Xu, Linxue Qian & Zhifei Dai. (2023) Nanomedicines enhance minimally invasive therapy of pancreatic cancer. Nano Today 51, pages 101891.
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Farshad Moradi Kashkooli, Anshuman Jakhmola, Tyler K. Hornsby, Jahangir (Jahan) Tavakkoli & Michael C. Kolios. (2023) Ultrasound-mediated nano drug delivery for treating cancer: Fundamental physics to future directions. Journal of Controlled Release 355, pages 552-578.
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Mahua Sarkar, Yang Wang, Oscar Ekpenyong, Dong Liang & Huan Xie. (2022) Pharmacokinetic behaviors of soft nanoparticulate formulations of chemotherapeutics. WIREs Nanomedicine and Nanobiotechnology 15:2.
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Faraz Chamani, Marla M. Pyle, Tej B. Shrestha, Jan Sebek, Stefan H. Bossmann, Matthew T. Basel, Rahul A. Sheth & Punit Prakash. (2023) In Vitro Measurement and Mathematical Modeling of Thermally-Induced Injury in Pancreatic Cancer Cells. Cancers 15:3, pages 655.
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Pouya Namakshenas & Afsaneh Mojra. (2023) Efficient drug delivery to hypoxic tumors using thermosensitive liposomes with encapsulated anti-cancer drug under high intensity pulsed ultrasound. International Journal of Mechanical Sciences 237, pages 107818.
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Marjolein I. Priester & Timo L.M. ten Hagen. (2023) Image-guided drug delivery in nanosystem-based cancer therapies. Advanced Drug Delivery Reviews 192, pages 114621.
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Tomasz Zawada, Torsten Bove, Konstantin Astafiev, Erling Ringgaard & Rasmus Lou-Moeller. (2022) Lead-Free HIFU Transducers. Ultrasound in Medicine & Biology 48:12, pages 2530-2543.
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Pauline Jeanjean, Dounia El Hamrani, Coralie Genevois, Bruno Quesson & Franck Couillaud. (2022) Combination of MRI‐Guided High‐Intensity Focused Ultrasound and Bioluminescent Biological Systems to Assess Thermal Therapies for Tumor and Tumor Microenvironment. Advanced Materials Technologies 7:7.
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Maxime Lafond, Thomas Lambin, Robert Andrew Drainville, Aurélien Dupré, Mathieu Pioche, David Melodelima & Cyril Lafon. (2022) Pancreatic Ductal Adenocarcinoma: Current and Emerging Therapeutic Uses of Focused Ultrasound. Cancers 14:11, pages 2577.
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Diana Andrés, Jonathan Vappou, Noé Jiménez & Francisco Camarena. (2022) Thermal holographic patterns for ultrasound hyperthermia. Applied Physics Letters 120:8.
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Petros X. E. Mouratidis & Gail ter Haar. (2022) Latest Advances in the Use of Therapeutic Focused Ultrasound in the Treatment of Pancreatic Cancer. Cancers 14:3, pages 638.
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Toshihiro Yamaguchi, Shuji Kitahara, Kaori Kusuda, Jun Okamoto, Yuki Horise, Ken Masamune & Yoshihiro Muragaki. (2021) Current Landscape of Sonodynamic Therapy for Treating Cancer. Cancers 13:24, pages 6184.
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Ahmaduddin Khan & Niroj Kumar Sahu. (2021) Hydrazone conjugated and DOX loaded PEGylated-Fe 3 O 4 mesoporous magnetic nanoclusters (MNCs): hyperthermia and in vitro chemotherapy . New Journal of Chemistry 45:46, pages 21646-21656.
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Marjolein I. Priester, Sergio Curto, Gerard C. van Rhoon & Timo L. M. ten Hagen. (2021) External Basic Hyperthermia Devices for Preclinical Studies in Small Animals. Cancers 13:18, pages 4628.
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Nahid S. Awad, Vinod Paul, Nour M. AlSawaftah, Gail ter HaarTheresa M. Allen, William G. Pitt & Ghaleb A. Husseini. (2021) Ultrasound-Responsive Nanocarriers in Cancer Treatment: A Review. ACS Pharmacology & Translational Science 4:2, pages 589-612.
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L. Duarte, J. López-Saucedo, E. Vázquez, G. G. Flores-Rojas, F. Lopéz-Saucedo & E. Bucio. 2021. Advanced Antimicrobial Materials and Applications. Advanced Antimicrobial Materials and Applications 285 319 .
Hyo-Jin Kang, Jae Young Lee, Eun-Joo Park, Hak Jong Lee, Shin-Woo Ha, Yun Deok Ahn, Yuri Cheon & Joon Koo Han. (2020) Synergistic Effects of Pulsed Focused Ultrasound and a Doxorubicin-Loaded Microparticle–Microbubble Complex in a Pancreatic Cancer Xenograft Mouse Model. Ultrasound in Medicine & Biology 46:11, pages 3046-3058.
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Guillaume Maimbourg, Alexandre Houdouin, Thomas Deffieux, Mickael Tanter & Jean-Francois Aubry. (2020) Steering Capabilities of an Acoustic Lens for Transcranial Therapy: Numerical and Experimental Studies. IEEE Transactions on Biomedical Engineering 67:1, pages 27-37.
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Michael Dunne, Maximilian Regenold & Christine Allen. (2020) Hyperthermia can alter tumor physiology and improve chemo- and radio-therapy efficacy. Advanced Drug Delivery Reviews 163-164, pages 98-124.
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Tao Sun, Anshuman Dasgupta, Zongmin Zhao, Md Nurunnabi & Samir Mitragotri. (2020) Physical triggering strategies for drug delivery. Advanced Drug Delivery Reviews 158, pages 36-62.
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Pegah Faridi, Stefan H Bossmann & Punit Prakash. (2019) Simulation-based design and characterization of a microwave applicator for MR-guided hyperthermia experimental studies in small animals. Biomedical Physics & Engineering Express 6:1, pages 015001.
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Shorooq Khader, Anita Thyagarajan & Ravi P. Sahu. (2019) Exploring Signaling Pathways and Pancreatic Cancer Treatment Approaches Using Genetic Models. Mini-Reviews in Medicinal Chemistry 19:14, pages 1112-1125.
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Torsten Bove, Tomasz Zawada, Jørgen Serup, Alexander Jessen & Mattia Poli. (2019) High‐frequency (20‐MHz) high‐intensity focused ultrasound ( HIFU ) system for dermal intervention: Preclinical evaluation in skin equivalents . Skin Research and Technology 25:2, pages 217-228.
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