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International Journal of Hyperthermia Volume 36, 2019 - Issue 1
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Original Articles

Targeting autophagy enhances heat stress-induced apoptosis via the ATP-AMPK-mTOR axis for hepatocellular carcinoma

Jiayun JiangInstitute of Hepatobiliary Surgery, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, P.R. ChinaORCID Iconhttp://orcid.org/0000-0002-0802-5750View further author information
ORCID Icon,
Shihan ChenInstitute of Hepatobiliary Surgery, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, P.R. ChinaView further author information
,
Kun LiInstitute of Hepatobiliary Surgery, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, P.R. ChinaView further author information
,
Chang ZhangInstitute of Hepatobiliary Surgery, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, P.R. ChinaView further author information
,
Yunhua TanInstitute of Hepatobiliary Surgery, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, P.R. ChinaView further author information
,
Qingsong DengInstitute of Hepatobiliary Surgery, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, P.R. ChinaView further author information
,
Yuelong ChaiInstitute of Hepatobiliary Surgery, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, P.R. ChinaView further author information
,
Xiaofei WangInstitute of Hepatobiliary Surgery, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, P.R. ChinaView further author information
,
Geng ChenInstitute of Hepatobiliary Surgery, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, P.R. ChinaView further author information
,
Kai FengInstitute of Hepatobiliary Surgery, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, P.R. ChinaView further author information
,
Leida ZhangInstitute of Hepatobiliary Surgery, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, P.R. ChinaView further author information
,
Chuan-Ming XieInstitute of Hepatobiliary Surgery, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, P.R. ChinaCorrespondence[email protected]
View further author information
&
Kuansheng MaInstitute of Hepatobiliary Surgery, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, P.R. ChinaCorrespondence[email protected]
View further author information
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Pages 498-509 | Received 26 Jan 2019, Accepted 21 Mar 2019, Published online: 22 Apr 2019

Citations (32)

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Yusheng Guo, Yanqiao Ren, Xiangjun Dong, Xuefeng Kan & Chuansheng Zheng. (2022) An Overview of Hepatocellular Carcinoma After Insufficient Radiofrequency Ablation. Journal of Hepatocellular Carcinoma 9, pages 343-355.
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Yunhua Tan, Xin Wang, Kuansheng Ma, Lin Zhang, Jing Li, Ping Chen & Ben Zhang. (2022) Risk factors for the recurrence of early hepatocellular carcinoma treated by percutaneous radiofrequency ablation with a multiple-electrode switching system: a multicenter prospective study. International Journal of Hyperthermia 39:1, pages 190-199.
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Chun Gao, Long Fang, Hui Zhang, Wei-Shuo Zhang, Xiao-Ou Li & Shi-Yu Du. (2020) Metformin Induces Autophagy via the AMPK-mTOR Signaling Pathway in Human Hepatocellular Carcinoma Cells. Cancer Management and Research 12, pages 5803-5811.
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Articles from other publishers (29)

Xuexia Liang, Qiaodan Liu, Shuqin Zhu, Zizi Li, Hui Chen & Zhongzhen Su. (2024) GSDME has prognostic and immunotherapeutic significance in residual hepatocellular carcinoma after insufficient radiofrequency ablation. Translational Oncology 39, pages 101796.
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Feilong Ye, Lulu Xie, Licong Liang, Zhimei Zhou, Siqin He, Rui Li, Liteng Lin & Kangshun Zhu. (2023) Mechanisms and therapeutic strategies to combat the recurrence and progression of hepatocellular carcinoma after thermal ablation. Journal of Interventional Medicine 6:4, pages 160-169.
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Shushan Zhang, Yongquan Huang, Songying Pi, Hui Chen, Feile Ye, Chaoqun Wu, Liujun Li, Qing Ye, Yuhong Lin & Zhongzhen Su. (2023) Autophagy-amplifying nanoparticles evoke immunogenic cell death combined with anti-PD-1/PD-L1 for residual tumors immunotherapy after RFA. Journal of Nanobiotechnology 21:1.
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Chunli Yang, Ziwei Deng, Qihang Zeng, Xiaoyu Chang, Xiaomin Wu & Guanghua Li. (2023) BMAL1 involved in autophagy and injury of thoracic aortic endothelial cells of rats induced by intermittent heat stress through the AMPK/mTOR/ULK1 pathway. Biochemical and Biophysical Research Communications 661, pages 34-41.
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Huaqiang Fang, Li Huang, Fanzhen Lv, Binbin Hu, Huijie Liu, Zhixin Huang, Yue Sun, Weimin Zhou & Xiaolei Wang. (2023) Dual-responsive targeted atherosclerosis therapy through a multi-effective nanoplatform with anti-inflammatory, lipid-regulating and autophagy. Chemical Engineering Journal 454, pages 140067.
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Zhennan Li, Cheng Lu, Fengliang Wang, Haowei Guo, Zhipeng Wang, Hong Yin & Jian Li. (2023) Heat treatment-induced autophagy promotes breast cancer cell invasion and metastasis via TGF- β 2-mediated epithelial-mesenchymal transitions . PeerJ 11, pages e14640.
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Shilun Wu, Zhuxin Li, Changyu Yao, Shuying Dong, Jun Gao, Shan Ke, Ruhang Zhu, Sen Huang, Shaohong Wang, Li Xu, Chen Ye, Jian Kong & Wenbing Sun. (2022) Progression of hepatocellular carcinoma after radiofrequency ablation: Current status of research. Frontiers in Oncology 12.
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Qiang Ding, Yue Wang, Shu-Wen Xia, Fang Zhao, Ji-Feng Zhong, Hui-Li Wang & Kun-Lin Chen. (2022) SIRT4 Expression Ameliorates the Detrimental Effect of Heat Stress via AMPK/mTOR Signaling Pathway in BMECs. International Journal of Molecular Sciences 23:21, pages 13307.
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Atsushi Enomoto & Takemichi Fukasawa. (2022) The role of calcium-calpain pathway in hyperthermia. Frontiers in Molecular Medicine 2.
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Jianquan Yang, Wen Guo & Man Lu. (2022) Recent Perspectives on the Mechanism of Recurrence After Ablation of Hepatocellular Carcinoma: A Mini-Review. Frontiers in Oncology 12.
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Alex T Von Schulze & Paige C Geiger. (2022) Heat and mitochondrial bioenergetics. Current Opinion in Physiology 27, pages 100553.
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Corey M. Summers & Rudy J. Valentine. (2022) Two hours of heat stress induces MAP-kinase signaling and autophagasome accumulation in C2C12 myotubes. Cell Biochemistry and Biophysics 80:2, pages 367-373.
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James J. McCormick, Kelli E. King, Maura M. Rutherford, Robert D. Meade, Sean R. Notley, Ashley P. Akerman, Karol Dokladny & Glen P. Kenny. (2022) Effect of extracellular hyperosmolality during normothermia and hyperthermia on the autophagic response in peripheral blood mononuclear cells from young men. Journal of Applied Physiology 132:4, pages 995-1004.
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Meng Li, Ping Zhang, Wenping Xu, Jianzhong Yuan, Qingfeng Li, Liming Tao, Zhong Li & Yang Zhang. (2021) Avermectin induces toxic effects in insect nontarget cells involves DNA damage and its associated programmed cell death. Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology 249, pages 109130.
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Junhua Li, Wei Zhou, Qiang Mao, Dandan Gao, Lin Xiong, Xinyao Hu, Yongfa Zheng & Ximing Xu. (2021) HMGB1 Promotes Resistance to Doxorubicin in Human Hepatocellular Carcinoma Cells by Inducing Autophagy via the AMPK/mTOR Signaling Pathway. Frontiers in Oncology 11.
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Chen Sun, Ming Bai, Weiwei Ke, Xiaoxun Wang, Xiangxuan Zhao & Zaiming Lu. (2021) The HSP90 inhibitor, XL888, enhanced cell apoptosis via downregulating STAT3 after insufficient radiofrequency ablation in hepatocellular carcinoma. Life Sciences 282, pages 119762.
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TAKASHI KONDO, ZHAO QING-LI, TATSUJI MIZUKAMI & JUN-ICHI SAITOH. (2021) Hyperthermia-induced Cell Death温熱誘発細胞死. Thermal Medicine 37:3, pages 63-77.
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Fan Shi, Dan Luo, Xuexiao Zhou, Qiaozhen Sun, Pei Shen & Shengzhi Wang. (2021) Combined effects of hyperthermia and chemotherapy on the regulate autophagy of oral squamous cell carcinoma cells under a hypoxic microenvironment. Cell Death Discovery 7:1.
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Ying Shan, Chuanyan Yang, Xiaoxiao Guo, Jiejie Sun, Zhaoyu He, Dongli Jiang, Wenwen Yang, Lingling Wang & Linsheng Song. (2021) The involvement of PyBeclin 1 and PyLC3 in regulating the activation of autophagy in scallop Patinopecten yessoensis after acute high temperature stress. Developmental & Comparative Immunology 121, pages 104093.
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Bao-Kang Wu, Qian-Hui Chen, Dan Pan, Bing Chang & Li-Xuan Sang. (2021) A novel therapeutic strategy for hepatocellular carcinoma: Immunomodulatory mechanisms of selenium and/or selenoproteins on a shift towards anti-cancer. International Immunopharmacology 96, pages 107790.
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Sarah Kassis, Mélanie Grondin & Diana A. Averill-Bates. (2021) Heat shock increases levels of reactive oxygen species, autophagy and apoptosis. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1868:3, pages 118924.
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Jianli Zhang, Erhao Wang, Lei Zhang & Bo Zhou. (2020) PSPH induces cell autophagy and promotes cell proliferation and invasion in the hepatocellular carcinoma cell line Huh7 via the AMPK/mTOR/ULK1 signaling pathway. Cell Biology International 45:2, pages 305-319.
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James J. McCormick, Karol Dokladny, Pope L. Moseley & Glen P. Kenny. (2021) Autophagy and heat: a potential role for heat therapy to improve autophagic function in health and disease. Journal of Applied Physiology 130:1, pages 1-9.
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Liming Hu, Jia Guo, Li Zhou, Sen Zhu, Chunming Wang, Jiawei Liu, Shanshan Hu, Mulin Yang & Changjun Lin. (2020) Hydrogen Sulfide Protects Retinal Pigment Epithelial Cells from Oxidative Stress-Induced Apoptosis and Affects Autophagy. Oxidative Medicine and Cellular Longevity 2020, pages 1-15.
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Michael N. Moore. (2020) Lysosomes, Autophagy, and Hormesis in Cell Physiology, Pathology, and Age-Related Disease. Dose-Response 18:3, pages 155932582093422.
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James J. McCormick, Kelli E. King, Melissa D. Côté, Morgan K. McManus, Serena M. Topshee, Hung-Sheng Hsu, Naoto Fujii & Glen P. Kenny. (2020) Regulation of autophagy following ex vivo heating in peripheral blood mononuclear cells from young adults. Journal of Thermal Biology 91, pages 102643.
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Kanwal Ahmed, Syed Faisal Zaidi, Mati-ur-Rehman, Rafey Rehman & Takashi Kondo. (2020) Hyperthermia and protein homeostasis: Cytoprotection and cell death. Journal of Thermal Biology 91, pages 102615.
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Yonglian Zeng, Zhenya Guo, Zhigao Hu, Mingjiang Liu, Yubing Chen, Shilian Chen, Bo Peng, Peng Zhang, Zhan Wu, Hongliang Luo, Fudi Zhong, Keqing Jiang, Yi Lu, Guandou Yuan & Songqing He. (2020) FGD1 exhibits oncogenic properties in hepatocellular carcinoma through regulating cell morphology, autophagy and mitochondrial function. Biomedicine & Pharmacotherapy 125, pages 110029.
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Ruina Zhai, Xusheng Dong, Lei Feng, Shengli Li & Zhiyong Hu. (2019) The Effect of Heat Stress on Autophagy and Apoptosis of Rumen, Abomasum, Duodenum, Liver and Kidney Cells in Calves. Animals 9:10, pages 854.
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