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International Journal of Hyperthermia Volume 39, 2022 - Issue 1
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First-in-man histotripsy of hepatic tumors: the THERESA trial, a feasibility study

Joan Vidal-Jovea Institute Khuab for Interventional Oncology, Comprehensive Tumor Center, Barcelona, SpainCorrespondence[email protected]
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Xavier Serresb Department of Interventional Ultrasound, Vall d’Hebron University Hospital, Barcelona, SpainView further author information
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Eli Vlaisavljevichc Department of Biomedical Engineering, Virginia Polytechnic University, Blacksburg, VirginiaView further author information
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Jon Cannatad Research and Development, Histosonics, Inc, Ann Arbor, MI, USAView further author information
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Alex Duryead Research and Development, Histosonics, Inc, Ann Arbor, MI, USAView further author information
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Ryan Millerd Research and Development, Histosonics, Inc, Ann Arbor, MI, USAView further author information
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Xavier Merinob Department of Interventional Ultrasound, Vall d’Hebron University Hospital, Barcelona, SpainView further author information
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Manuela Velata Institute Khuab for Interventional Oncology, Comprehensive Tumor Center, Barcelona, SpainView further author information
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Yossi Kame R&D Clinical Excellence, Philips Healthcare, Haifa, IsraelView further author information
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Ryan Bolduanf Clinical Research and Medical Affairs, Histosonics, Inc, Ann Arbor, MI, USAView further author information
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Joseph Amaralf Clinical Research and Medical Affairs, Histosonics, Inc, Ann Arbor, MI, USAView further author information
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Timothy Hallg Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI, USAView further author information
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Zhen Xug Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI, USAView further author information
,
Fred T. Lee Jr.h Department of Radiology, University of Wisconsin, Madison, WI, USAView further author information
&
Timothy J. Ziemlewiczh Department of Radiology, University of Wisconsin, Madison, WI, USAView further author information
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Pages 1115-1123 | Received 06 Jun 2022, Accepted 07 Aug 2022, Published online: 24 Aug 2022

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Suzanne LeBlang & Timothy J. Ziemlewicz. (2024) The art of histotripsy: a focused ultrasound application that has the potential to treat from head to toe!. International Journal of Hyperthermia 41:1.
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Tejaswi Worlikar, Timothy Hall, Man Zhang, Mishal Mendiratta-Lala, Michael Green, Clifford S. Cho & Zhen Xu. (2024) Insights from in vivo preclinical cancer studies with histotripsy. International Journal of Hyperthermia 41:1.
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Alayna N. Hay, Lauren Ruger, Andy Hsueh, Elliana Vickers, Shawna Klahn, Eli Vlaisavljevich & Joanne Tuohy. (2023) A review of the development of histotripsy for extremity tumor ablation with a canine comparative oncology model to inform human treatments. International Journal of Hyperthermia 40:1.
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Ellen Yeats & Timothy L. Hall. (2023) Aberration correction in abdominal histotripsy. International Journal of Hyperthermia 40:1.
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Takuya Osada, Xiaoning Jiang, Yuhang Zhao, Mengyue Chen, Benjamin C. Kreager, Huaiyu Wu, Howuk Kim, Jun Ren, Joshua Snyder, Pei Zhong, Michael A. Morse & H. Kim Lyerly. (2023) The use of histotripsy as intratumoral immunotherapy beyond tissue ablation—the rationale for exploring the immune effects of histotripsy. International Journal of Hyperthermia 40:1.
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Jessica Gannon, Khan Mohammad Imran, Alissa Hendricks-Wenger, Michael Edwards, Hannah Covell, Lauren Ruger, Neha Singh, Margaret Nagai-Singer, Benjamin Tintera, Kristin Eden, Mishal Mendiratta-Lala, Joan Vidal-Jove, David Luyimbazi, Martha Larson, Sherrie Clark-Deener, Sheryl Coutermarsh-Ott, Irving C. Allen & Eli Vlaisavljevich. (2023) Ultrasound-guided noninvasive pancreas ablation using histotripsy: feasibility study in an in vivo porcine model. International Journal of Hyperthermia 40:1.
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Khan M. Imran, Anutosh Ganguly, Tamalika Paul, Manali Powar, Eli Vlaisavljevich, Clifford S. Cho & Irving C. Allen. (2023) Magic bubbles: utilizing histotripsy to modulate the tumor microenvironment and improve systemic anti-tumor immune responses. International Journal of Hyperthermia 40:1.
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Randall P. Williams, Julianna C. Simon, Vera A. Khokhlova, Oleg A. Sapozhnikov & Tatiana D. Khokhlova. (2023) The histotripsy spectrum: differences and similarities in techniques and instrumentation. International Journal of Hyperthermia 40:1.
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Isabella Iwanicki, Lydia L. Wu, Fernando Flores-Guzman, Rachael Sundland, Paula Viza-Gomes, Rachel Nordgren, Connor S. Centner, Jessica J. Kandel, Mark A. Applebaum, Kenneth B. Bader & Sonia L. Hernandez. (2023) Histotripsy induces apoptosis and reduces hypoxia in a neuroblastoma xenograft model. International Journal of Hyperthermia 40:1.
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Lauren Ruger, Ester Yang, Sheryl Coutermarsh-Ott, Elliana Vickers, Jessica Gannon, Marlie Nightengale, Andy Hsueh, Brittany Ciepluch, Nikolaos Dervisis, Eli Vlaisavljevich & Shawna Klahn. (2023) Histotripsy ablation for the treatment of feline injection site sarcomas: a first-in-cat in vivo feasibility study. International Journal of Hyperthermia 40:1.
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Adam D Maxwell & Eli Vlaisavljevich. (2024) Cavitation-induced pressure saturation: a mechanism governing bubble nucleation density in histotripsy. Physics in Medicine & Biology 69:9, pages 095012.
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Yash VermaArosh S. Perera Molligoda Arachchige. (2024) Advances in Tumor Management: Harnessing the Potential of Histotripsy. Radiology: Imaging Cancer 6:3.
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Grace M. Minesinger, Paul F. Laeseke, Ayca Z. Kutlu, Michael A. Speidel & Martin G. Wagner. (2024) FEM deformable liver registration to facilitate CBCT guided histotripsy. FEM deformable liver registration to facilitate CBCT guided histotripsy.
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Raul N Uppot, Tze Min Wah & Peter R Mueller. (2023) Percutaneous treatment of renal tumours. Journal of Medical Imaging and Radiation Oncology 67:8, pages 853-861.
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Connor Edsall, Laura Huynh, Timothy L Hall & Eli Vlaisavljevich. (2023) Bubble cloud characteristics and ablation efficiency in dual-frequency intrinsic threshold histotripsy. Physics in Medicine & Biology 68:22, pages 225006.
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Khan Mohammad Imran, Jessica Gannon, Holly A. Morrison, Juselyn D. Tupik, Benjamin Tintera, Margaret A. Nagai-Singer, Hannah Ivester, Justin Markov Madanick, Alissa Hendricks-Wenger, Kyungjun Uh, David T. Luyimbazi, Michael Edwards, Sheryl Coutermarsh-Ott, Kristin Eden, Christopher Byron, Sherrie Clark-Deener, Kiho Lee, Eli Vlaisavljevich & Irving C. Allen. (2023) Successful In Situ Targeting of Pancreatic Tumors in a Novel Orthotopic Porcine Model Using Histotripsy. Ultrasound in Medicine & Biology 49:11, pages 2361-2370.
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Allison B. Couillard, Annie M. Zlevor, Timothy J. Ziemlewicz, Meridith A. Kisting, Emily Knott, Annika E. Rossebo, Jim White, Meghan G. Lubner, Lori Mankowski Gettle, J. Louis Hinshaw, Lu Mao, William Stoffregen, John F. Swietlik, Erica Knavel-Koepsel, Lindsay Stratchko, E. Jason Abel, Zhen Xu, Fred T. LeeJr.Jr. & Paul F. Laeseke. (2023) A Comparison of Histotripsy and Percutaneous Cryoablation in a Chronic Healthy Swine Kidney Model. Journal of Vascular and Interventional Radiology 34:11, pages 1986-1996.
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Vishwas V. Trivedi, Emily L. Wallach, Kenneth B. Bader & Himanshu Shekhar. (2023) Contrast-Enhanced Imaging of Histotripsy Bubble Clouds Using Chirp-Coded Excitation and Volterra Filtering. IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control 70:9, pages 989-998.
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Ellen Yeats, Ning Lu, Jonathan R. Sukovich, Zhen Xu & Timothy L. Hall. (2023) Soft Tissue Aberration Correction for Histotripsy Using Acoustic Emissions From Cavitation Cloud Nucleation and Collapse. Ultrasound in Medicine & Biology 49:5, pages 1182-1193.
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