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Brain Injury Volume 33, 2019 - Issue 6: Update on Medications and Promising Therapies for Central Nervous System Conditions
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Targeting mast cell as a neuroprotective strategy

Umut OcakDepartment of Basic Sciences, Division of Physiology, Loma Linda University School of Medicine, Loma Linda, CA, USAORCID Iconhttp://orcid.org/0000-0002-6549-4246View further author information
ORCID Icon,
Pinar Eser OcakDepartment of Basic Sciences, Division of Physiology, Loma Linda University School of Medicine, Loma Linda, CA, USAView further author information
,
Annie WangDepartment of Anesthesiology, Loma Linda University School of Medicine, Loma Linda, CA, USAView further author information
,
John H. ZhangDepartment of Basic Sciences, Division of Physiology, Loma Linda University School of Medicine, Loma Linda, CA, USA;Department of Anesthesiology, Loma Linda University School of Medicine, Loma Linda, CA, USA;Department of Neurosurgery, Loma Linda University School of Medicine, Loma Linda, CA, USAView further author information
,
Warren BolingDepartment of Neurosurgery, Loma Linda University School of Medicine, Loma Linda, CA, USAView further author information
,
Pei WuDepartment of Basic Sciences, Division of Physiology, Loma Linda University School of Medicine, Loma Linda, CA, USA;Department of Neurosurgery, The First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, ChinaView further author information
,
Jun MoDepartment of Basic Sciences, Division of Physiology, Loma Linda University School of Medicine, Loma Linda, CA, USA;Department of Neurosurgery, The Fourth Affiliated Hospital, School of Medicine, Zhejiang University, Yiwu, Zhejiang, ChinaView further author information
,
Tongyu ZhangDepartment of Basic Sciences, Division of Physiology, Loma Linda University School of Medicine, Loma Linda, CA, USA;Department of Neurosurgery, The First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, ChinaView further author information
&
Lei HuangDepartment of Basic Sciences, Division of Physiology, Loma Linda University School of Medicine, Loma Linda, CA, USA;Department of Neurosurgery, Loma Linda University School of Medicine, Loma Linda, CA, USACorrespondence[email protected]
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Pages 723-733 | Received 27 May 2018, Accepted 19 Nov 2018, Published online: 17 Dec 2018

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Pinar Eser, Seniha Corabay, Ali Imran Ozmarasali, Gokhan Ocakoglu & Mevlut Ozgur Taskapilioglu. (2022) The association between hematologic parameters and intracranial injuries in pediatric patients with traumatic brain injury. Brain Injury 36:6, pages 740-749.
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Cesar Reis, Sheng Chen & Jiping Tang. (2019) An update on promising therapies for CNS conditions. Brain Injury 33:6, pages 699-700.
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Articles from other publishers (20)

Nirbhay Kumar Prabhakar, Heena Khan, Amarjot Kaur Grewal & Thakur Gurjeet Singh. (2022) Intervention of neuroinflammation in the traumatic brain injury trajectory: In vivo and clinical approaches. International Immunopharmacology 108, pages 108902.
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Li Zhu, Leo Huang, Anh Le, Tom J. Wang, Jiewen Zhang, Xuemei Chen, Junmin Wang, Jian Wang & Chao Jiang. 2011. Comprehensive Physiology. Comprehensive Physiology 3665 3704 .
Jing Yang, Hong-Quan Dong, Yan-Hu Liu, Mu-Huo Ji, Xun Zhang, Hong-Yu Dai, Zhao-Chu Sun, Lu Liu, Jian Zhou, Huan-Huan Sha, Yan-Ning Qian, Qing-Guo Li, Hao Yao & Na-Na Li. (2022) Laparotomy-Induced Peripheral Inflammation Activates NR2B Receptors on the Brain Mast Cells and Results in Neuroinflammation in a Vagus Nerve-Dependent Manner. Frontiers in Cellular Neuroscience 16.
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Pablo Eliasib Martínez‐Gopar, Marian Jesabel Pérez‐Rodríguez, Gabriela Rodríguez‐Manzo, René Garduño‐Gutierrez, Luis Tristán‐López, Quetzalli Denisse Angeles‐López, Claudia González‐Espinosa & Francisca Pérez‐Severiano. (2021) Mast cells and histamine are involved in the neuronal damage observed in a quinolinic acid‐induced model of Huntington's disease. Journal of Neurochemistry 160:2, pages 256-270.
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Lijia Mai, Qing Liu, Fang Huang, Hongwen He & Wenguo Fan. (2021) Involvement of Mast Cells in the Pathophysiology of Pain. Frontiers in Cellular Neuroscience 15.
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Tongyu Zhang, Lei Huang, Jianhua Peng, John H. Zhang & Hongqi Zhang. (2021) LJ529 attenuates mast cell-related inflammation via A3R-PKCε-ALDH2 pathway after subarachnoid hemorrhage in rats. Experimental Neurology 340, pages 113686.
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Duraisamy Kempuraj, Mohammad Ejaz Ahmed, Govindhasamy Pushpavathi Selvakumar, Ramasamy Thangavel, Sudhanshu P. Raikwar, Smita A. Zaheer, Shankar S. Iyer, Raghav Govindarajan, Premkumar Nattanmai Chandrasekaran, Casey Burton, Donald James & Asgar Zaheer. (2020) Acute Traumatic Brain Injury-Induced Neuroinflammatory Response and Neurovascular Disorders in the Brain. Neurotoxicity Research 39:2, pages 359-368.
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Yi Yao, Yonggang Zhang, Xiaoyang Liao, Rong Yang, Yi Lei & Jianzhao Luo. (2021) Potential Therapies for Cerebral Edema After Ischemic Stroke: A Mini Review. Frontiers in Aging Neuroscience 12.
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Lei Huang, Cameron Lenahan, Warren Boling, Jiping Tang & John H. Zhang. (2021) Molecular Hydrogen Application in Stroke: Bench to Bedside. Current Pharmaceutical Design 27:5, pages 703-712.
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Piplu Bhuiyan, Yi-Wei Wang, Huan-Huan Sha, Hong-Quan Dong & Yan-Ning Qian. (2021) Neuroimmune connections between corticotropin-releasing hormone and mast cells: novel strategies for the treatment of neurodegenerative diseases. Neural Regeneration Research 16:11, pages 2184.
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Umut Ocak, Pinar Eser Ocak, Lei Huang, Weilin Xu, Yuchun Zuo, Peng Li, Marcin Gamdzyk, Gang Zuo, Jun Mo, Guangyu Zhang & John H. Zhang. (2020) Inhibition of mast cell tryptase attenuates neuroinflammation via PAR-2/p38/NFκB pathway following asphyxial cardiac arrest in rats. Journal of Neuroinflammation 17:1.
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Umut Ocak, Pinar Eser Ocak, Lei Huang, Gang Zuo, Jun Yan, Xin Hu, Zhijun Song & John H. Zhang. (2020) Inhibition of PAR-2 Attenuates Neuroinflammation and Improves Short-Term Neurocognitive Functions Via ERK1/2 Signaling Following Asphyxia-Induced Cardiac Arrest in Rats. Shock 54:4, pages 539-547.
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Duraisamy Kempuraj, Mohammad Ejaz Ahmed, Govindhasamy Pushpavathi Selvakumar, Ramasamy Thangavel, Sudhanshu P. Raikwar, Smita A. Zaheer, Shankar S. Iyer, Casey Burton, Donald James & Asgar Zaheer. (2020) Mast Cell Activation, Neuroinflammation, and Tight Junction Protein Derangement in Acute Traumatic Brain Injury. Mediators of Inflammation 2020, pages 1-12.
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Iwona Jarocka-Karpowicz, Anna Syta-Krzyżanowska, Jan Kochanowicz & Zenon Dionizy Mariak. (2020) Clinical Prognosis for SAH Consistent with Redox Imbalance and Lipid Peroxidation. Molecules 25:8, pages 1921.
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Duraisamy Kempuraj, Mohammad Ejaz Ahmed, Govindhasamy Pushpavathi Selvakumar, Ramasamy Thangavel, Arshdeep S. Dhaliwal, Iuliia Dubova, Shireen Mentor, Keerthivaas Premkumar, Daniyal Saeed, Haris Zahoor, Sudhanshu P. Raikwar, Smita Zaheer, Shankar S. Iyer & Asgar Zaheer. (2019) Brain Injury–Mediated Neuroinflammatory Response and Alzheimer’s Disease. The Neuroscientist 26:2, pages 134-155.
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Karen Henriette Pinke, Sofia Fernanda Gonçalves Zorzella-Pezavento, Thais Fernanda de Campos Fraga-Silva, Luiza Ayumi Nishiyama Mimura, Larissa Ragozo Cardoso de Oliveira, Larissa Lumi Watanabe Ishikawa, Ana Angélica Henrique Fernandes, Vanessa Soares Lara & Alexandrina Sartori. (2020) Calming Down Mast Cells with Ketotifen: A Potential Strategy for Multiple Sclerosis Therapy?. Neurotherapeutics 17:1, pages 218-234.
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Edoardo Parrella, Vanessa Porrini, Marina Benarese & Marina Pizzi. (2019) The Role of Mast Cells in Stroke. Cells 8:5, pages 437.
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Ahmet Arac, Michele A. Grimbaldeston, Stephen J. Galli, Tonya M. Bliss & Gary K. Steinberg. (2019) Meningeal Mast Cells as Key Effectors of Stroke Pathology. Frontiers in Cellular Neuroscience 13.
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Elisa Landucci, Annunziatina Laurino, Lorenzo Cinci, Manuela Gencarelli & Laura Raimondi. (2019) Thyroid Hormone, Thyroid Hormone Metabolites and Mast Cells: A Less Explored Issue. Frontiers in Cellular Neuroscience 13.
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Duraisamy Kempuraj, Shireen Mentor, Ramasamy Thangavel, Mohammad E. Ahmed, Govindhasamy Pushpavathi Selvakumar, Sudhanshu P. Raikwar, Iuliia Dubova, Smita Zaheer, Shankar S. Iyer & Asgar Zaheer. (2019) Mast Cells in Stress, Pain, Blood-Brain Barrier, Neuroinflammation and Alzheimer’s Disease. Frontiers in Cellular Neuroscience 13.
Crossref

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