Targeting mast cell as a neuroprotective strategy

References

• Kitamura Y, Shimada M, Hatanaka K, Miyano Y. Development of mast cells from grafted bone marrow cells in irradiated mice. Nature. 1977;268(5619):442–43.
   PubMed Web of Science ®Google Scholar
• Beaven MA. Our perception of the mast cell from Paul Ehrlich to now. Eur J Immunol. 2009;39(1):11–25. doi:10.1002/eji.200838899.
   PubMed Web of Science ®Google Scholar
• Valent P, Horny HP, Escribano L, Longley BJ, Li CY, Schwartz LB, Marone G, Nunez R, Akin C, Sotlar K, et al. Diagnostic criteria and classification of mastocytosis: a consensus proposal. Leuk Res. 2001;25(7):603–25.
   PubMed Web of Science ®Google Scholar
• Silver RB, Reid AC, Mackins CJ, Askwith T, Schaefer U, Herzlinger D, Levi R. Mast cells: a unique source of renin. Proc Natl Acad Sci U S A. 2004;101(37):13607–12. doi:10.1073/pnas.0403208101.
   PubMed Web of Science ®Google Scholar
• Bot I, de Jager SC, Zernecke A, Lindstedt KA, van Berkel TJ, Weber C, Biessen EA. Perivascular mast cells promote atherogenesis and induce plaque destabilization in apolipoprotein E-deficient mice. Circulation. 2007;115(19):2516–25. doi:10.1161/CIRCULATIONAHA.106.660472.
   PubMed Web of Science ®Google Scholar
• Laine P, Kaartinen M, Penttila A, Panula P, Paavonen T, Kovanen PT. Association between myocardial infarction and the mast cells in the adventitia of the infarct-related coronary artery. Circulation. 1999;99(3):361–69.
   PubMed Web of Science ®Google Scholar
• Jonsson F, Daeron M. Mast cells and company. Front Immunol. 2012;3:16. doi:10.3389/fimmu.2012.00198.
   PubMed Web of Science ®Google Scholar
• Ibrahim MZ, Reder AT, Lawand R, Takash W, Sallouh-Khatib S. The mast cells of the multiple sclerosis brain. J Neuroimmunol. 1996;70(2):131–38.
   PubMed Web of Science ®Google Scholar
• Secor VH, Secor WE, Gutekunst CA, Brown MA. Mast cells are essential for early onset and severe disease in a murine model of multiple sclerosis. J Exp Med. 2000;191(5):813–22.
   PubMed Web of Science ®Google Scholar
• Piette F, Belmin J, Vincent H, Schmidt N, Pariel S, Verny M, Marquis C, Mely J, Hugonot-Diener L, Kinet JP, et al. Masitinib as an adjunct therapy for mild-to-moderate Alzheimer’s disease: a randomised, placebo-controlled phase 2 trial. Alzheimers Res Ther. 2011;3(2):16. doi:10.1186/alzrt75.
   PubMed Web of Science ®Google Scholar
• Kempuraj D, Selvakumar GP, Thangavel R, Ahmed ME, Zaheer S, Raikwar SP, Iyer SS, Bhagavan SM, Beladakere-Ramaswamy S, Zaheer A. Mast Cell Activation in Brain Injury, Stress, and Post-traumatic Stress Disorder and Alzheimer’s Disease Pathogenesis. Front Neurosci. 2017;11:703. doi:10.3389/fnins.2017.00703.
   PubMed Web of Science ®Google Scholar
• Kempuraj D, Thangavel R, Fattal R, Pattani S, Yang E, Zaheer S, Santillan DA, Santillan MK, Zaheer A. Mast cells release chemokine CCL2 in response to parkinsonian Toxin 1-Methyl-4-Phenyl-Pyridinium (MPP(+)). Neurochem Res. 2016;41(5):1042–49. doi:10.1007/s11064-015-1790-z.
   PubMed Web of Science ®Google Scholar
• Theoharides TC, Valent P, Akin C. Mast cells, mastocytosis, and related disorders. N Engl J Med. 2015;373(19):1885–86. doi:10.1056/NEJMc1510021.
   PubMed Web of Science ®Google Scholar
• Yoshida GJ. Mast cells, mastocytosis, and related disorders. N Engl J Med. 2015;373(19):1884–85. doi:10.1056/NEJMc1510021.
   PubMed Web of Science ®Google Scholar
• Ashman LK, Griffith R. Therapeutic targeting of c-KIT in cancer. Expert Opin Investig Drugs. 2013;22(1):103–15. doi:10.1517/13543784.2013.740010.
   PubMed Web of Science ®Google Scholar
• Erben P, Schwaab J, Metzgeroth G, Horny HP, Jawhar M, Sotlar K, Fabarius A, Teichmann M, Schneider S, Ernst T, et al. The KIT D816V expressed allele burden for diagnosis and disease monitoring of systemic mastocytosis. Ann Hematol. 2014;93(1):81–88. doi:10.1007/s00277-013-1964-1.
   PubMed Web of Science ®Google Scholar
• Longley BJ, Tyrrell L, Lu SZ, Ma YS, Langley K, Ding TG, Duffy T, Jacobs P, Tang LH, Modlin I. Somatic c-KIT activating mutation in urticaria pigmentosa and aggressive mastocytosis: establishment of clonality in a human mast cell neoplasm. Nat Genet. 1996;12(3):312–14. doi:10.1038/ng0396-312.
   PubMed Web of Science ®Google Scholar
• Boddaert N, Salvador A, Chandesris MO, Lemaitre H, Grevent D, Gauthier C, Naggara O, Georgin-Lavialle S, Moura DS, Munsch F, et al. Neuroimaging evidence of brain abnormalities in mastocytosis. Transl Psychiatry. 2017;7(8):e1197. doi:10.1038/tp.2017.160.
   PubMed Web of Science ®Google Scholar
• Moura DS, Georgin-Lavialle S, Gaillard R, Hermine O. Neuropsychological features of adult mastocytosis. Immunol Allergy Clin North Am. 2014;34(2):407–22. doi:10.1016/j.iac.2014.02.001.
   PubMed Web of Science ®Google Scholar
• Mattila OS, Strbian D, Saksi J, Pikkarainen TO, Rantanen V, Tatlisumak T, Lindsberg PJ. Cerebral mast cells mediate blood-brain barrier disruption in acute experimental ischemic stroke through perivascular gelatinase activation. Stroke. 2011;42(12):3600–05. doi:10.1161/STROKEAHA.111.632224.
   PubMed Web of Science ®Google Scholar
• Strbian D, Karjalainen-Lindsberg ML, Tatlisumak T, Lindsberg PJ. Cerebral mast cells regulate early ischemic brain swelling and neutrophil accumulation. J Cereb Blood Flow Metab. 2006;26(5):605–12. doi:10.1038/sj.jcbfm.9600228.
   PubMed Web of Science ®Google Scholar
• Strbian D, Kovanen PT, Karjalainen-Lindsberg ML, Tatlisumak T, Lindsberg PJ. An emerging role of mast cells in cerebral ischemia and hemorrhage. Ann Med. 2009;41(6):438–50. doi:10.1080/07853890902887303.
   PubMed Web of Science ®Google Scholar
• Dong H, Zhang X, Qian Y. Mast cells and neuroinflammation. Med Sci Monit Basic Res. 2014;20:200–06. doi:10.12659/MSMBR.893093.
   PubMedGoogle Scholar
• Hendrikus E, van Bergeijk DA, Oosting RS, Redegeld FA. Corrigendum to “Mast cells in neuroinflammation and brain disorders” [Neurosci. Biobehav. Rev. 79 (2017) 119-133]. Neurosci Biobehav Rev. 2017;83:774. doi:10.1016/j.neubiorev.2017.10.030.
   PubMed Web of Science ®Google Scholar
• Skaper SD, Facci L, Zusso M, Giusti P. Neuroinflammation, mast cells, and glia: dangerous liaisons. Neuroscientist. 2017;23(5):478–98. doi:10.1177/1073858416687249.
   PubMed Web of Science ®Google Scholar
• Medic N, Lorenzon P, Vita F, Trevisan E, Marchioli A, Soranzo MR, Fabbretti E, Zabucchi G. Mast cell adhesion induces cytoskeletal modifications and programmed cell death in oligodendrocytes. J Neuroimmunol. 2010;218(1–2):57–66. doi:10.1016/j.jneuroim.2009.10.011.
   PubMed Web of Science ®Google Scholar
• Zhang X, Dong H, Li N, Zhang S, Sun J, Zhang S, Qian Y. Activated brain mast cells contribute to postoperative cognitive dysfunction by evoking microglia activation and neuronal apoptosis. J Neuroinflammation. 2016;13(1):127. doi:10.1186/s12974-016-0592-9.
   PubMed Web of Science ®Google Scholar
• Hallgren J, Gurish MF. Pathways of murine mast cell development and trafficking: tracking the roots and routes of the mast cell. Immunol Rev. 2007;217:8–18. doi:10.1111/j.1600-065X.2007.00502.x.
   PubMed Web of Science ®Google Scholar
• Kitamura Y, Kasugai T, Arizono N, Matsuda H. Development of mast cells and basophils: processes and regulation mechanisms. Am J Med Sci. 1993;306(3):185–91.
   PubMed Web of Science ®Google Scholar
• Khalil M, Ronda J, Weintraub M, Jain K, Silver R, Silverman AJ. Brain mast cell relationship to neurovasculature during development. Brain Res. 2007;1171:18–29. doi:10.1016/j.brainres.2007.07.034.
   PubMed Web of Science ®Google Scholar
• Dimitriadou V, Lambracht-Hall M, Reichler J, Theoharides TC. Histochemical and ultrastructural characteristics of rat brain perivascular mast cells stimulated with compound 48/80 and carbachol. Neuroscience. 1990;39(1):209–24.
   PubMed Web of Science ®Google Scholar
• Dropp JJ. Mast cells in mammalian brain. Acta Anat (Basel). 1976;94(1):1–21.
   PubMedGoogle Scholar
• Edvinsson L, Cervos-Navarro J, Larsson LI, Owman C, Ronnberg AL. Regional distribution of mast cells containing histamine, dopamine, or 5-hydroxytryptamine in the mammalian brain. Neurology. 1977;27(9):878–83.
   PubMed Web of Science ®Google Scholar
• Goldschmidt RC, Hough LB, Glick SD, Padawer J. Mast cells in rat thalamus: nuclear localization, sex difference and left-right asymmetry. Brain Res. 1984;323(2):209–17.
   PubMed Web of Science ®Google Scholar
• Ibrahim MZ. The mast cells of the mammalian central nervous system. IX. Development of the mast cells in the brain of the young rat. Acta Anat (Basel). 1985;124(3–4):149–58.
   PubMedGoogle Scholar
• Ronnberg AL, Edvinsson L, Larsson LI, Nielsen KC, Owman C. Regional variation in the presence of mast cells in the mammalian brain. Agents Actions. 1973;3(3):191. doi:10.1007/BF01965748.
   PubMedGoogle Scholar
• Silver R, Silverman AJ, Vitkovic L, Lederhendler II. Mast cells in the brain: evidence and functional significance. Trends Neurosci. 1996;19(1):25–31.
   PubMed Web of Science ®Google Scholar
• Theoharides TC. Mast cells: the immune gate to the brain. Life Sci. 1990;46(9):607–17.
   PubMed Web of Science ®Google Scholar
• Shanas U, Bhasin R, Sutherland AK, Silverman AJ, Silver R. Brain mast cells lack the c-kit receptor: immunocytochemical evidence. J Neuroimmunol. 1998;90(2):207–11.
   PubMed Web of Science ®Google Scholar
• Moon TC, St Laurent CD, Morris KE, Marcet C, Yoshimura T, Sekar Y, Befus AD. Advances in mast cell biology: new understanding of heterogeneity and function. Mucosal Immunol. 2010;3(2):111–28. doi:10.1038/mi.2009.136.
   PubMed Web of Science ®Google Scholar
• Galli SJ, Kalesnikoff J, Grimbaldeston MA, Piliponsky AM, Williams CM, Tsai M. Mast cells as “tunable” effector and immunoregulatory cells: recent advances. Annu Rev Immunol. 2005;23:749–86. doi:10.1146/annurev.immunol.21.120601.141025.
   PubMed Web of Science ®Google Scholar
• Ottosson A, Edvinsson L. Release of histamine from dural mast cells by substance P and calcitonin gene-related peptide. Cephalalgia. 1997;17(3):166–74. doi:10.1046/j.1468-2982.1997.1703166.x.
   PubMed Web of Science ®Google Scholar
• Theoharides TC, Kempuraj D, Tagen M, Conti P, Kalogeromitros D. Differential release of mast cell mediators and the pathogenesis of inflammation. Immunol Rev. 2007;217:65–78. doi:10.1111/j.1600-065X.2007.00519.x.
   PubMed Web of Science ®Google Scholar
• Tore F, Tuncel N. Mast cells: target and source of neuropeptides. Curr Pharm Des. 2009;15(29):3433–45.
   PubMed Web of Science ®Google Scholar
• Orr EL, Pace KR. The significance of mast cells as a source of histamine in the mouse brain. J Neurochem. 1984;42(3):727–32.
   PubMed Web of Science ®Google Scholar
• Mannaioni PF, Masini E, Pistelli A, Salvemini D, Vane JR. Mast cells as a source of superoxide anions and nitric oxide-like factor: relevance to histamine release. Int J Tissue React. 1991;13(6):271–78.
   PubMedGoogle Scholar
• Galli SJ. New concepts about the mast cell. N Engl J Med. 1993;328(4):257–65. doi:10.1056/NEJM199301283280408.
   PubMed Web of Science ®Google Scholar
• Cutz E, Chan W, Track NS, Goth A, Said SI. Release of vasoactive intestinal polypeptide in mast cells by histamine liberators. Nature. 1978;275(5681):661–62.
   PubMed Web of Science ®Google Scholar
• Dux E, Joo F. Effects of histamine on brain capillaries. Fine structural and immunohistochemical studies after intracarotid infusion. Exp Brain Res. 1982;47(2):252–58.
   PubMed Web of Science ®Google Scholar
• Gross PM, Teasdale GM, Graham DI, Angerson WJ, Harper AM. Intra-arterial histamine increases blood-brain transport in rats. Am J Physiol. 1982;243(2):H307–17. doi:10.1152/ajpheart.1982.243.2.H307.
   PubMed Web of Science ®Google Scholar
• Goldschmidt RC, Hough LB, Glick SD. Rat brain mast cells: contribution to brain histamine levels. J Neurochem. 1985;44(6):1943–47.
   PubMed Web of Science ®Google Scholar
• Lindsberg PJ, Strbian D, Karjalainen-Lindsberg ML. Mast cells as early responders in the regulation of acute blood-brain barrier changes after cerebral ischemia and hemorrhage. J Cereb Blood Flow Metab. 2010;30(4):689–702. doi:10.1038/jcbfm.2009.282.
   PubMed Web of Science ®Google Scholar
• Nelissen S, Lemmens E, Geurts N, Kramer P, Maurer M, Hendriks J, Hendrix S. The role of mast cells in neuroinflammation. Acta Neuropathol. 2013;125(5):637–50. doi:10.1007/s00401-013-1092-y.
   PubMed Web of Science ®Google Scholar
• Skaper SD, Facci L, Giusti P. Mast cells, glia and neuroinflammation: partners in crime? Immunology. 2014;141(3):314–27. doi:10.1111/imm.12170.
   PubMed Web of Science ®Google Scholar
• Jin Y, Silverman AJ, Vannucci SJ. Mast cell stabilization limits hypoxic-ischemic brain damage in the immature rat. Dev Neurosci. 2007;29(4–5):373–84. doi:10.1159/000105478.
   PubMed Web of Science ®Google Scholar
• Jin Y, Silverman AJ, Vannucci SJ. Mast cells are early responders after hypoxia-ischemia in immature rat brain. Stroke. 2009;40(9):3107–12. doi:10.1161/STROKEAHA.109.549691.
   PubMed Web of Science ®Google Scholar
• Ganeshan K, Bryce PJ. Regulatory T cells enhance mast cell production of IL-6 via surface-bound TGF-beta. J Immunol. 2012;188(2):594–603. doi:10.4049/jimmunol.1102389.
   PubMed Web of Science ®Google Scholar
• Kim DY, Jeoung D, Ro JY. Signaling pathways in the activation of mast cells cocultured with astrocytes and colocalization of both cells in experimental allergic encephalomyelitis. J Immunol. 2010;185(1):273–83. doi:10.4049/jimmunol.1000991.
   PubMed Web of Science ®Google Scholar
• Skaper SD, Giusti P, Facci L. Microglia and mast cells: two tracks on the road to neuroinflammation. FASEB J. 2012;26(8):3103–17. doi:10.1096/fj.11-197194.
   PubMed Web of Science ®Google Scholar
• Kierdorf K, Erny D, Goldmann T, Sander V, Schulz C, Perdiguero EG, Wieghofer P, Heinrich A, Riemke P, Holscher C, et al. Microglia emerge from erythromyeloid precursors via Pu.1- and Irf8-dependent pathways. Nat Neurosci. 2013;16(3):273–80. doi:10.1038/nn.3318.
   PubMed Web of Science ®Google Scholar
• Denes A, Vidyasagar R, Feng J, Narvainen J, McColl BW, Kauppinen RA, Allan SM. Proliferating resident microglia after focal cerebral ischaemia in mice. J Cereb Blood Flow Metab. 2007;27(12):1941–53. doi:10.1038/sj.jcbfm.9600495.
   PubMed Web of Science ®Google Scholar
• Tanaka R, Komine-Kobayashi M, Mochizuki H, Yamada M, Furuya T, Migita M, Shimada T, Mizuno Y, Urabe T. Migration of enhanced green fluorescent protein expressing bone marrow-derived microglia/macrophage into the mouse brain following permanent focal ischemia. Neuroscience. 2003;117(3):531–39.
   PubMed Web of Science ®Google Scholar
• London A, Itskovich E, Benhar I, Kalchenko V, Mack M, Jung S, Schwartz M. Neuroprotection and progenitor cell renewal in the injured adult murine retina requires healing monocyte-derived macrophages. J Exp Med. 2011;208(1):23–39. doi:10.1084/jem.20101202.
   PubMed Web of Science ®Google Scholar
• Derecki NC, Cronk JC, Lu Z, Xu E, Abbott SB, Guyenet PG, Kipnis J. Wild-type microglia arrest pathology in a mouse model of Rett syndrome. Nature. 2012;484(7392):105–09. doi:10.1038/nature10907.
   PubMed Web of Science ®Google Scholar
• Kulka M, Fukuishi N, Metcalfe DD. Human mast cells synthesize and release angiogenin, a member of the ribonuclease A (RNase A) superfamily. J Leukoc Biol. 2009;86(5):1217–26. doi:10.1189/jlb.0908517.
   PubMed Web of Science ®Google Scholar
• Subramanian V, Crabtree B, Acharya KR. Human angiogenin is a neuroprotective factor and amyotrophic lateral sclerosis associated angiogenin variants affect neurite extension/pathfinding and survival of motor neurons. Hum Mol Genet. 2008;17(1):130–49. doi:10.1093/hmg/ddm290.
   PubMed Web of Science ®Google Scholar
• Nautiyal KM, Dailey CA, Jahn JL, Rodriquez E, Son NH, Sweedler JV, Silver R. Serotonin of mast cell origin contributes to hippocampal function. Eur J Neurosci. 2012;36(3):2347–59. doi:10.1111/j.1460-9568.2012.08138.x.
   PubMed Web of Science ®Google Scholar
• Theoharides TC. Neuroendocrinology of mast cells: challenges and controversies. Exp Dermatol. 2017;26(9):751–59. doi:10.1111/exd.13288.
   PubMed Web of Science ®Google Scholar
• van Gijn J, Kerr RS, Rinkel GJ. Subarachnoid haemorrhage. Lancet. 2007;369(9558):306–18. doi:10.1016/S0140-6736(07)60153-6.
   PubMed Web of Science ®Google Scholar
• Becker KJ. Epidemiology and clinical presentation of aneurysmal subarachnoid hemorrhage. Neurosurg Clin N Am. 1998;9(3):435–44.
   PubMed Web of Science ®Google Scholar
• Kaptain GJ, Lanzino G, Kassell NF. Subarachnoid haemorrhage: epidemiology, risk factors, and treatment options. Drugs Aging. 2000;17(3):183–99. doi:10.2165/00002512-200017030-00003.
   PubMed Web of Science ®Google Scholar
• King JT Jr. Epidemiology of aneurysmal subarachnoid hemorrhage. Neuroimaging Clin N Am. 1997;7(4):659–68.
   PubMed Web of Science ®Google Scholar
• Suzuki H, Nakano F. To improve translational research in subarachnoid hemorrhage. Transl Stroke Res. 2018;9(1):1–3. doi:10.1007/s12975-017-0546-2.
   PubMed Web of Science ®Google Scholar
• Aoki T, Kataoka H, Ishibashi R, Nakagami H, Nozaki K, Morishita R, Hashimoto N. Pitavastatin suppresses formation and progression of cerebral aneurysms through inhibition of the nuclear factor kappaB pathway. Neurosurgery. 2009;64(2):357–65. discussion 65-6. doi:10.1227/01.NEU.0000336764.92606.1D.
   PubMed Web of Science ®Google Scholar
• Aoki T, Kataoka H, Ishibashi R, Nozaki K, Egashira K, Hashimoto N. Impact of monocyte chemoattractant protein-1 deficiency on cerebral aneurysm formation. Stroke. 2009;40(3):942–51. doi:10.1161/STROKEAHA.108.532556.
   PubMed Web of Science ®Google Scholar
• Aoki T, Kataoka H, Ishibashi R, Nozaki K, Hashimoto N. Nifedipine inhibits the progression of an experimentally induced cerebral aneurysm in rats with associated down-regulation of NF-kappa B transcriptional activity. Curr Neurovasc Res. 2008;5(1):37–45.
   PubMed Web of Science ®Google Scholar
• Aoki T, Kataoka H, Shimamura M, Nakagami H, Wakayama K, Moriwaki T, Ishibashi R, Nozaki K, Morishita R, Hashimoto N. NF-kappaB is a key mediator of cerebral aneurysm formation. Circulation. 2007;116(24):2830–40. doi:10.1161/CIRCULATIONAHA.107.728303.
   PubMed Web of Science ®Google Scholar
• Chyatte D, Lewis I. Gelatinase activity and the occurrence of cerebral aneurysms. Stroke. 1997;28(4):799–804.
   PubMed Web of Science ®Google Scholar
• Fukuda S, Hashimoto N, Naritomi H, Nagata I, Nozaki K, Kondo S, Kurino M, Kikuchi H. Prevention of rat cerebral aneurysm formation by inhibition of nitric oxide synthase. Circulation. 2000;101(21):2532–38.
   PubMed Web of Science ®Google Scholar
• Moriwaki T, Takagi Y, Sadamasa N, Aoki T, Nozaki K, Hashimoto N. Impaired progression of cerebral aneurysms in interleukin-1beta-deficient mice. Stroke. 2006;37(3):900–05. doi:10.1161/01.STR.0000204028.39783.d9.
   PubMed Web of Science ®Google Scholar
• Sadamasa N, Nozaki K, Hashimoto N. Disruption of gene for inducible nitric oxide synthase reduces progression of cerebral aneurysms. Stroke. 2003;34(12):2980–84. doi:10.1161/01.STR.0000102556.55600.3B.
   PubMed Web of Science ®Google Scholar
• Aoki T, Kataoka H, Morimoto M, Nozaki K, Hashimoto N. Macrophage-derived matrix metalloproteinase-2 and −9 promote the progression of cerebral aneurysms in rats. Stroke. 2007;38(1):162–69. doi:10.1161/01.STR.0000252129.18605.c8.
   PubMed Web of Science ®Google Scholar
• Johnson JL, Jackson CL, Angelini GD, George SJ. Activation of matrix-degrading metalloproteinases by mast cell proteases in atherosclerotic plaques. Arterioscler Thromb Vasc Biol. 1998;18(11):1707–15.
   PubMed Web of Science ®Google Scholar
• Ishibashi R, Aoki T, Nishimura M, Hashimoto N, Miyamoto S. Contribution of mast cells to cerebral aneurysm formation. Curr Neurovasc Res. 2010;7(2):113–24.
   PubMed Web of Science ®Google Scholar
• Ollikainen E, Tulamo R, Frosen J, Lehti S, Honkanen P, Hernesniemi J, Niemela M, Kovanen PT. Mast cells, neovascularization, and microhemorrhages are associated with saccular intracranial artery aneurysm wall remodeling. J Neuropathol Exp Neurol. 2014;73(9):855–64.
   PubMed Web of Science ®Google Scholar
• Syvaranta S, Helske S, Laine M, Lappalainen J, Kupari M, Mayranpaa MI, Lindstedt KA, Kovanen PT. Vascular endothelial growth factor-secreting mast cells and myofibroblasts: a novel self-perpetuating angiogenic pathway in aortic valve stenosis. Arterioscler Thromb Vasc Biol. 2010;30(6):1220–27. doi:10.1161/ATVBAHA.109.198267.
   PubMed Web of Science ®Google Scholar
• Ribatti D, Levi-Schaffer F, Kovanen PT. Inflammatory angiogenesis in atherogenesis–a double-edged sword. Ann Med. 2008;40(8):606–21. doi:10.1080/07853890802186913.
   PubMed Web of Science ®Google Scholar
• Lappalainen H, Laine P, Pentikainen MO, Sajantila A, Kovanen PT. Mast cells in neovascularized human coronary plaques store and secrete basic fibroblast growth factor, a potent angiogenic mediator. Arterioscler Thromb Vasc Biol. 2004;24(10):1880–85. doi:10.1161/01.ATV.0000140820.51174.8d.
   PubMed Web of Science ®Google Scholar
• Kuwabara A, Liu J, Kamio Y, Liu A, Lawton MT, Lee JW, Hashimoto T. Protective effect of mesenchymal stem cells against the development of intracranial aneurysm rupture in mice. Neurosurgery. 2017;81(6):1021–28. doi:10.1093/neuros/nyx172.
   PubMed Web of Science ®Google Scholar
• Kassell NF, Sasaki T, Colohan AR, Nazar G. Cerebral vasospasm following aneurysmal subarachnoid hemorrhage. Stroke. 1985;16(4):562–72.
   PubMed Web of Science ®Google Scholar
• Sehba FA, Pluta RM, Zhang JH. Metamorphosis of subarachnoid hemorrhage research: from delayed vasospasm to early brain injury. Mol Neurobiol. 2011;43(1):27–40. doi:10.1007/s12035-010-8155-z.
   PubMed Web of Science ®Google Scholar
• Vergouwen MD, Vermeulen M, van Gijn J, Rinkel GJ, Wijdicks EF, Muizelaar JP, Mendelow AD, Juvela S, Yonas H, Terbrugge KG, et al. Definition of delayed cerebral ischemia after aneurysmal subarachnoid hemorrhage as an outcome event in clinical trials and observational studies: proposal of a multidisciplinary research group. Stroke. 2010;41(10):2391–95. doi:10.1161/STROKEAHA.110.589275.
   PubMed Web of Science ®Google Scholar
• Liszczak TM, Varsos VG, Black PM, Kistler JP, Zervas NT. Cerebral arterial constriction after experimental subarachnoid hemorrhage is associated with blood components within the arterial wall. J Neurosurg. 1983;58(1):18–26. doi:10.3171/jns.1983.58.1.0018.
   PubMed Web of Science ®Google Scholar
• Faleiro LC, Machado CR, Gripp A Jr., Resende RA, Rodrigues PA. Cerebral vasospasm: presence of mast cells in human cerebral arteries after aneurysm rupture. J Neurosurg. 1981;54(6):733–35. doi:10.3171/jns.1981.54.6.0733.
   PubMed Web of Science ®Google Scholar
• Doyle MP, Linden J, Duling BR. Nucleoside-induced arteriolar constriction: a mast cell-dependent response. Am J Physiol. 1994;266(5 Pt 2):H2042–50. doi:10.1152/ajpheart.1994.266.5.H2042.
   PubMed Web of Science ®Google Scholar
• Shepherd RK, Duling BR. Use of Ruthenium Red staining to detect mast cell degranulation in vivo. Microcirculation. 1995;2(4):363–70.
   PubMedGoogle Scholar
• Shepherd RK, Linden J, Duling BR. Adenosine-induced vasoconstriction in vivo. Role of the mast cell and A3 adenosine receptor. Circ Res. 1996;78(4):627–34.
   PubMed Web of Science ®Google Scholar
• Kusaka G, Ishikawa M, Nanda A, Granger DN, Zhang JH. Signaling pathways for early brain injury after subarachnoid hemorrhage. J Cereb Blood Flow Metab. 2004;24(8):916–25. doi:10.1097/01.WCB.0000125886.48838.7E.
   PubMed Web of Science ®Google Scholar
• Broderick JP, Brott TG, Duldner JE, Tomsick T, Leach A. Initial and recurrent bleeding are the major causes of death following subarachnoid hemorrhage. Stroke. 1994;25(7):1342–47.
   PubMed Web of Science ®Google Scholar
• Ostrowski RP, Colohan AR, Zhang JH. Molecular mechanisms of early brain injury after subarachnoid hemorrhage. Neurol Res. 2006;28(4):399–414. doi:10.1179/016164106X115008.
   PubMed Web of Science ®Google Scholar
• Chen S, Ma Q, Krafft PR, Hu Q, Rolland W 2nd, Sherchan P, Zhang J, Tang J, Zhang JH. P2X7R/cryopyrin inflammasome axis inhibition reduces neuroinflammation after SAH. Neurobiol Dis. 2013;58:296–307. doi:10.1016/j.nbd.2013.06.011.
   PubMed Web of Science ®Google Scholar
• Fujii M, Sherchan P, Krafft PR, Rolland WB, Soejima Y, Zhang JH. Cannabinoid type 2 receptor stimulation attenuates brain edema by reducing cerebral leukocyte infiltration following subarachnoid hemorrhage in rats. J Neurol Sci. 2014;342(1–2):101–06. doi:10.1016/j.jns.2014.04.034.
   PubMed Web of Science ®Google Scholar
• Liu F, Chen Y, Hu Q, Li B, Tang J, He Y, Guo Z, Feng H, Tang J, Zhang JH. MFGE8/Integrin beta3 pathway alleviates apoptosis and inflammation in early brain injury after subarachnoid hemorrhage in rats. Exp Neurol. 2015;272:120–27. doi:10.1016/j.expneurol.2015.04.016.
   PubMed Web of Science ®Google Scholar
• He Y, Xu L, Li B, Guo ZN, Hu Q, Guo Z, Tang J, Chen Y, Zhang Y, Tang J, et al. Macrophage-inducible C-Type lectin/spleen tyrosine kinase signaling pathway contributes to neuroinflammation after subarachnoid hemorrhage in rats. Stroke. 2015;46(8):2277–86. doi:10.1161/STROKEAHA.115.010088.
   PubMed Web of Science ®Google Scholar
• Guo Z, Hu Q, Xu L, Guo ZN, Ou Y, He Y, Yin C, Sun X, Tang J, Zhang JH. Lipoxin A4 reduces inflammation through formyl peptide receptor 2/p38 MAPK signaling pathway in subarachnoid hemorrhage rats. Stroke. 2016;47(2):490–97. doi:10.1161/STROKEAHA.115.011223.
   PubMed Web of Science ®Google Scholar
• Li JR, Xu HZ, Nie S, Peng YC, Fan LF, Wang ZJ, Wu C, Yan F, Chen JY, Gu C, et al. Fluoxetine-enhanced autophagy ameliorates early brain injury via inhibition of NLRP3 inflammasome activation following subrachnoid hemorrhage in rats. J Neuroinflammation. 2017;14(1):186. doi:10.1186/s12974-017-0959-6.
   PubMed Web of Science ®Google Scholar
• Xie Z, Huang L, Enkhjargal B, Reis C, Wan W, Tang J, Cheng Y, Zhang JH. Recombinant Netrin-1 binding UNC5B receptor attenuates neuroinflammation and brain injury via PPARgamma/NFkappaB signaling pathway after subarachnoid hemorrhage in rats. Brain Behav Immun. 2018;69:190–202. doi:10.1016/j.bbi.2017.11.012.
   PubMed Web of Science ®Google Scholar
• Huang XP, Peng JH, Pang JW, Tian XC, Li XS, Wu Y, Li Y, Jiang Y, Sun XC. Peli1 contributions in microglial activation, neuroinflammatory responses and neurological deficits following experimental subarachnoid hemorrhage. Front Mol Neurosci. 2017;10:398. doi:10.3389/fnmol.2017.00398.
   PubMed Web of Science ®Google Scholar
• Peng Y, Jin J, Fan L, Xu H, He P, Li J, Chen T, Ruan W, Chen G. Rolipram attenuates early brain injury following experimental subarachnoid hemorrhage in rats: possibly via regulating the SIRT1/NF-kappaB pathway. Neurochem Res. 2018;43(4):785–95. doi:10.1007/s11064-018-2480-4.
   PubMed Web of Science ®Google Scholar
• Li X, Peng J, Pang J, Wu Y, Huang X, Li Y, Zhou J, Gu L, Sun X, Chen L, et al. Apolipoprotein E-mimetic peptide COG1410 promotes autophagy by phosphorylating GSK-3beta in early brain injury following experimental subarachnoid hemorrhage. Front Neurosci. 2018;12:127.
   PubMed Web of Science ®Google Scholar
• Liu L, Fujimoto M, Nakano F, Nishikawa H, Okada T, Kawakita F, Imanaka-Yoshida K, Yoshida T, Suzuki H. Deficiency of tenascin-C alleviates neuronal apoptosis and neuroinflammation after experimental subarachnoid hemorrhage in mice. Mol Neurobiol. 2018. doi:10.1007/s12035-018-1006-z.
   Web of Science ®Google Scholar
• Yin J, Li R, Liu W, Chen Y, Zhang X, Li X, He X, Duan C. Neuroprotective effect of protein phosphatase 2A/tristetraprolin following subarachnoid hemorrhage in rats. Front Neurosci. 2018;12:96. doi:10.3389/fnins.2018.00044.
   PubMed Web of Science ®Google Scholar
• Berger R, Garnier Y. Pathophysiology of perinatal brain damage. Brain Res Brain Res Rev. 1999;30(2):107–34.
   PubMedGoogle Scholar
• Ferriero DM. Neonatal brain injury. N Engl J Med. 2004;351(19):1985–95. doi:10.1056/NEJMra041996.
   PubMed Web of Science ®Google Scholar
• Nelson KB, Lynch JK. Stroke in newborn infants. Lancet Neurol. 2004;3(3):150–58. doi:10.1016/S1474-4422(04)00679-9.
   PubMed Web of Science ®Google Scholar
• Vannucci RC. Hypoxic-ischemic encephalopathy. Am J Perinatol. 2000;17(3):113–20. doi:10.1055/s-2000-9293.
   PubMed Web of Science ®Google Scholar
• Volpe JJ. Perinatal brain injury: from pathogenesis to neuroprotection. Ment Retard Dev Disabil Res Rev. 2001;7(1):56–64. doi:10.1002/1098-2779(200102)7:1<56::AID-MRDD1008>3.0.CO;2-A.
   PubMedGoogle Scholar
• Bona E, Andersson AL, Blomgren K, Gilland E, Puka-Sundvall M, Gustafson K, Hagberg H. Chemokine and inflammatory cell response to hypoxia-ischemia in immature rats. Pediatr Res. 1999;45(4 Pt 1):500–09. doi:10.1203/00006450-199904010-00008.
   PubMed Web of Science ®Google Scholar
• Hagberg H, Mallard C, Ferriero DM, Vannucci SJ, Levison SW, Vexler ZS, Gressens P. The role of inflammation in perinatal brain injury. Nat Rev Neurol. 2015;11(4):192–208. doi:10.1038/nrneurol.2015.13.
   PubMed Web of Science ®Google Scholar
• Liu F, McCullough LD. Inflammatory responses in hypoxic ischemic encephalopathy. Acta Pharmacol Sin. 2013;34(9):1121–30. doi:10.1038/aps.2013.89.
   PubMed Web of Science ®Google Scholar
• Ferriero DM. Timing is everything–delaying therapy for delayed cell death. Dev Neurosci. 2002;24(5):349–51. doi:10.1159/000069048.
   PubMed Web of Science ®Google Scholar
• Vannucci SJ, Hagberg H. Hypoxia-ischemia in the immature brain. J Exp Biol. 2004;207(Pt 18):3149–54. doi:10.1242/jeb.01064.
   PubMed Web of Science ®Google Scholar
• Patkai J, Mesples B, Dommergues MA, Fromont G, Thornton EM, Renauld JC, Evrard P, Gressens P. Deleterious effects of IL-9-activated mast cells and neuroprotection by antihistamine drugs in the developing mouse brain. Pediatr Res. 2001;50(2):222–30. doi:10.1203/00006450-200108000-00010.
   PubMed Web of Science ®Google Scholar
• Hedtjarn M, Mallard C, Hagberg H. Inflammatory gene profiling in the developing mouse brain after hypoxia-ischemia. J Cereb Blood Flow Metab. 2004;24(12):1333–51. doi:10.1097/01.WCB.0000141559.17620.36.
   PubMed Web of Science ®Google Scholar
• Sacco S, Marini C, Toni D, Olivieri L, Carolei A. Incidence and 10-year survival of intracerebral hemorrhage in a population-based registry. Stroke. 2009;40(2):394–99. doi:10.1161/STROKEAHA.108.523209.
   PubMed Web of Science ®Google Scholar
• Feigin VL, Lawes CM, Bennett DA, Anderson CS. Stroke epidemiology: a review of population-based studies of incidence, prevalence, and case-fatality in the late 20th century. Lancet Neurol. 2003;2(1):43–53.
   PubMed Web of Science ®Google Scholar
• Lapchak PA, Zhang JH. The high cost of stroke and stroke cytoprotection research. Transl Stroke Res. 2017;8(4):307–17. doi:10.1007/s12975-016-0518-y.
   PubMed Web of Science ®Google Scholar
• Woo D, Broderick JP. Spontaneous intracerebral hemorrhage: epidemiology and clinical presentation. Neurosurg Clin N Am. 2002;13(3):265–79.
   PubMed Web of Science ®Google Scholar
• Li X, Feng D, Chen G. An Update On Medical Treatment for Intracerebral Hemorrhage. Transl Stroke Res. 2018. doi:10.1007/s12975-018-0664-5.
   Web of Science ®Google Scholar
• Lok J, Leung W, Murphy S, Butler W, Noviski N, Lo EH. Intracranial hemorrhage: mechanisms of secondary brain injury. Acta Neurochir Suppl. 2011;111:63–69. doi:10.1007/978-3-7091-0693-8_11.
   PubMedGoogle Scholar
• Sayed BA, Christy AL, Walker ME, Brown MA. Meningeal mast cells affect early T cell central nervous system infiltration and blood-brain barrier integrity through TNF: a role for neutrophil recruitment? J Immunol. 2010;184(12):6891–900. doi:10.4049/jimmunol.1000126.
   PubMed Web of Science ®Google Scholar
• Chen S, Yang Q, Chen G, Zhang JH. An update on inflammation in the acute phase of intracerebral hemorrhage. Transl Stroke Res. 2015;6(1):4–8. doi:10.1007/s12975-014-0384-4.
   PubMed Web of Science ®Google Scholar
• Xi G, Keep RF, Hoff JT. Mechanisms of brain injury after intracerebral haemorrhage. Lancet Neurol. 2006;5(1):53–63. doi:10.1016/S1474-4422(05)70283-0.
   PubMed Web of Science ®Google Scholar
• Keep RF, Hua Y, Xi G. Intracerebral haemorrhage: mechanisms of injury and therapeutic targets. Lancet Neurol. 2012;11(8):720–31. doi:10.1016/S1474-4422(12)70104-7.
   PubMed Web of Science ®Google Scholar
• Manaenko A, Lekic T, Ma Q, Zhang JH, Tang J. Hydrogen inhalation ameliorated mast cell-mediated brain injury after intracerebral hemorrhage in mice. Crit Care Med. 2013;41(5):1266–75. doi:10.1097/CCM.0b013e31827711c9.
   PubMed Web of Science ®Google Scholar
• Strbian D, Tatlisumak T, Ramadan UA, Lindsberg PJ. Mast cell blocking reduces brain edema and hematoma volume and improves outcome after experimental intracerebral hemorrhage. J Cereb Blood Flow Metab. 2007;27(4):795–802. doi:10.1038/sj.jcbfm.9600387.
   PubMed Web of Science ®Google Scholar
• Qureshi AI, Tuhrim S, Broderick JP, Batjer HH, Hondo H, Hanley DF. Spontaneous intracerebral hemorrhage. N Engl J Med. 2001;344(19):1450–60. doi:10.1056/NEJM200105103441907.
   PubMed Web of Science ®Google Scholar
• Akyol GY, Manaenko A, Akyol O, Solaroglu I, Ho WM, Ding Y, Flores J, Zhang JH, Tang J. IVIG activates FcgammaRIIB-SHIP1-PIP3 Pathway to stabilize mast cells and suppress inflammation after ICH in mice. Sci Rep. 2017;7(1):15583. doi:10.1038/s41598-017-15455-w.
   PubMed Web of Science ®Google Scholar
• Macrez R, Ali C, Toutirais O, Le Mauff B, Defer G, Dirnagl U, Vivien D. Stroke and the immune system: from pathophysiology to new therapeutic strategies. Lancet Neurol. 2011;10(5):471–80. doi:10.1016/S1474-4422(11)70066-7.
   PubMed Web of Science ®Google Scholar
• Iadecola C, Anrather J. The immunology of stroke: from mechanisms to translation. Nat Med. 2011;17(7):796–808. doi:10.1038/nm.2399.
   PubMed Web of Science ®Google Scholar
• Moskowitz MA, Lo EH, Iadecola C. The science of stroke: mechanisms in search of treatments. Neuron. 2010;67(2):181–98. doi:10.1016/j.neuron.2010.07.002.
   PubMed Web of Science ®Google Scholar
• Hellings WE, Moll FL, De Vries JP, Ackerstaff RG, Seldenrijk KA, Met R, Velema E, Derksen WJ, De Kleijn DP, Pasterkamp G. Atherosclerotic plaque composition and occurrence of restenosis after carotid endarterectomy. JAMA. 2008;299(5):547–54. doi:10.1001/jama.299.5.547.
   PubMed Web of Science ®Google Scholar
• Montecucco F, Lenglet S, Gayet-Ageron A, Bertolotto M, Pelli G, Palombo D, Pane B, Spinella G, Steffens S, Raffaghello L, et al. Systemic and intraplaque mediators of inflammation are increased in patients symptomatic for ischemic stroke. Stroke. 2010;41(7):1394–404. doi:10.1161/STROKEAHA.110.578369.
   PubMed Web of Science ®Google Scholar
• Naghavi M, Libby P, Falk E, Casscells SW, Litovsky S, Rumberger J, Badimon JJ, Stefanadis C, Moreno P, Pasterkamp G, et al. From vulnerable plaque to vulnerable patient: a call for new definitions and risk assessment strategies: part II. Circulation. 2003;108(15):1772–78. doi:10.1161/01.CIR.0000087481.55887.C9.
   PubMed Web of Science ®Google Scholar
• Montaner J, Salat D, Garcia-Berrocoso T, Molina CA, Chacon P, Ribo M, Alvarez-Sabin J, Rosell A. Reperfusion therapy for acute stroke improves outcome by decreasing neuroinflammation. Transl Stroke Res. 2010;1(4):261–67. doi:10.1007/s12975-010-0038-0.
   PubMed Web of Science ®Google Scholar
• Caltagirone C, Cisari C, Schievano C, Di Paola R, Cordaro M, Bruschetta G, Esposito E, Cuzzocrea S, Stroke Study G. Co-ultramicronized palmitoylethanolamide/luteolin in the treatment of cerebral ischemia: from rodent to man. Transl Stroke Res. 2016;7(1):54–69. doi:10.1007/s12975-015-0440-8.
   PubMed Web of Science ®Google Scholar
• Ayata C, Ropper AH. Ischaemic brain oedema. J Clin Neurosci. 2002;9(2):113–24. doi:10.1054/jocn.2001.1031.
   PubMed Web of Science ®Google Scholar
• von Kummer R, Bourquain H, Bastianello S, Bozzao L, Manelfe C, Meier D, Hacke W. Early prediction of irreversible brain damage after ischemic stroke at CT. Radiology. 2001;219(1):95–100. doi:10.1148/radiology.219.1.r01ap0695.
   PubMed Web of Science ®Google Scholar
• Kasner SE, Demchuk AM, Berrouschot J, Schmutzhard E, Harms L, Verro P, Chalela JA, Abbur R, McGrade H, Christou I, et al. Predictors of fatal brain edema in massive hemispheric ischemic stroke. Stroke. 2001;32(9):2117–23.
   PubMed Web of Science ®Google Scholar
• Tchougounova E, Lundequist A, Fajardo I, Winberg JO, Abrink M, Pejler G. A key role for mast cell chymase in the activation of pro-matrix metalloprotease-9 and pro-matrix metalloprotease-2. J Biol Chem. 2005;280(10):9291–96. doi:10.1074/jbc.M410396200.
   PubMed Web of Science ®Google Scholar
• Lohi J, Harvima I, Keski-Oja J. Pericellular substrates of human mast cell tryptase: 72,000 dalton gelatinase and fibronectin. J Cell Biochem. 1992;50(4):337–49. doi:10.1002/jcb.240500402.
   PubMed Web of Science ®Google Scholar
• Di Girolamo N, Indoh I, Jackson N, Wakefield D, McNeil HP, Yan W, Geczy C, Arm JP, Tedla N. Human mast cell-derived gelatinase B (matrix metalloproteinase-9) is regulated by inflammatory cytokines: role in cell migration. J Immunol. 2006;177(4):2638–50.
   PubMed Web of Science ®Google Scholar
• Frank BT, Rossall JC, Caughey GH, Fang KC. Mast cell tissue inhibitor of metalloproteinase-1 is cleaved and inactivated extracellularly by alpha-chymase. J Immunol. 2001;166(4):2783–92.
   PubMed Web of Science ®Google Scholar
• Rosenberg GA, Estrada EY, Dencoff JE, Stetler-Stevenson WG. Tumor necrosis factor-alpha-induced gelatinase B causes delayed opening of the blood-brain barrier: an expanded therapeutic window. Brain Res. 1995;703(1–2):151–55.
   PubMed Web of Science ®Google Scholar
• Rosenberg GA. Matrix metalloproteinases in neuroinflammation. Glia. 2002;39(3):279–91. doi:10.1002/glia.10108.
   PubMed Web of Science ®Google Scholar
• Valent P. Role of mast cells in endogenous fibrinolysis and related (patho)physiological processes. In: Marone GLL, Galli SJ, editors. Mast Cells and Basophils. Academic Press, Clifornia, USA; 2000. p. 497–505.
   Google Scholar
• Barone FC, Hillegass LM, Tzimas MN, Schmidt DB, Foley JJ, White RF, Price WJ, Feuerstein GZ, Clark RK, Griswold DE, et al. Time-related changes in myeloperoxidase activity and leukotriene B4 receptor binding reflect leukocyte influx in cerebral focal stroke. Mol Chem Neuropathol. 1995;24(1):13–30.
   PubMedGoogle Scholar
• Zhang RL, Chopp M, Chen H, Garcia JH. Temporal profile of ischemic tissue damage, neutrophil response, and vascular plugging following permanent and transient (2H) middle cerebral artery occlusion in the rat. J Neurol Sci. 1994;125(1):3–10.
   PubMed Web of Science ®Google Scholar
• Rosell A, Cuadrado E, Ortega-Aznar A, Hernandez-Guillamon M, Lo EH, Montaner J. MMP-9-positive neutrophil infiltration is associated to blood-brain barrier breakdown and basal lamina type IV collagen degradation during hemorrhagic transformation after human ischemic stroke. Stroke. 2008;39(4):1121–26. doi:10.1161/STROKEAHA.107.500868.
   PubMed Web of Science ®Google Scholar
• Strbian D, Karjalainen-Lindsberg ML, Kovanen PT, Tatlisumak T, Lindsberg PJ. Mast cell stabilization reduces hemorrhage formation and mortality after administration of thrombolytics in experimental ischemic stroke. Circulation. 2007;116(4):411–18. doi:10.1161/CIRCULATIONAHA.106.655423.
   PubMed Web of Science ®Google Scholar
• Hu W, Xu L, Pan J, Zheng X, Chen Z. Effect of cerebral ischemia on brain mast cells in rats. Brain Res. 2004;1019(1–2):275–80. doi:10.1016/j.brainres.2004.05.109.
   PubMed Web of Science ®Google Scholar
• Arac A, Grimbaldeston MA, Nepomuceno AR, Olayiwola O, Pereira MP, Nishiyama Y, Tsykin A, Goodall GJ, Schlecht U, Vogel H, et al. Evidence that meningeal mast cells can worsen stroke pathology in mice. Am J Pathol. 2014;184(9):2493–504. doi:10.1016/j.ajpath.2014.06.003.
   PubMed Web of Science ®Google Scholar
• Arsene D, Vasilescu F, Toader C, Balan A, Popa C, Ardeleanu C. Clinico-pathological correlations in fatal ischemic stroke. An immunohistochemical study of human brain penumbra. Rom J Morphol Embryol. 2011;52(1):29–38.
   PubMed Web of Science ®Google Scholar
• Beridze M, Sanikidze T, Shakarishvili R, Intskirveli N, Bornstein NM. Selected acute phase CSF factors in ischemic stroke: findings and prognostic value. BMC Neurol. 2011;11:41. doi:10.1186/1471-2377-11-41.
   PubMed Web of Science ®Google Scholar
• Foerch C, Rosidi NL, Schlunk F, Lauer A, Cianchetti FA, Mandeville E, Arai K, Yigitkanli K, Fan X, Wang X, et al. Intravenous tPA therapy does not worsen acute intracerebral hemorrhage in mice. PLoS One. 2013;8(2):e54203. doi:10.1371/journal.pone.0054203.
   PubMed Web of Science ®Google Scholar
• Marinkovic I, Mattila OS, Strbian D, Meretoja A, Shekhar S, Saksi J, Abo-Ramadan U, Rantanen V, Lindsberg PJ, Tatlisumak T. Evolution of intracerebral hemorrhage after intravenous tPA: reversal of harmful effects with mast cell stabilization. J Cereb Blood Flow Metab. 2014;34(1):176–81. doi:10.1038/jcbfm.2013.189.
   PubMed Web of Science ®Google Scholar
• Finnie JW, Blumbergs PC. Traumatic brain injury. Vet Pathol. 2002;39(6):679–89. doi:10.1354/vp.39-6-679.
   PubMed Web of Science ®Google Scholar
• Xiong Y, Mahmood A, Chopp M. Animal models of traumatic brain injury. Nat Rev Neurosci. 2013;14(2):128–42. doi:10.1038/nrn3407.
   PubMed Web of Science ®Google Scholar
• Levy D, Edut S, Baraz-Goldstein R, Rubovitch V, Defrin R, Bree D, Gariepy H, Zhao J, Pick CG. Responses of dural mast cells in concussive and blast models of mild traumatic brain injury in mice: potential implications for post-traumatic headache. Cephalalgia. 2016;36(10):915–23. doi:10.1177/0333102415617412.
   PubMed Web of Science ®Google Scholar
• Stokely ME, Orr EL. Acute effects of calvarial damage on dural mast cells, pial vascular permeability, and cerebral cortical histamine levels in rats and mice. J Neurotrauma. 2008;25(1):52–61. doi:10.1089/neu.2007.0397.
   PubMed Web of Science ®Google Scholar
• Lozada A, Maegele M, Stark H, Neugebauer EM, Panula P. Traumatic brain injury results in mast cell increase and changes in regulation of central histamine receptors. Neuropathol Appl Neurobiol. 2005;31(2):150–62. doi:10.1111/j.1365-2990.2004.00622.x.
   PubMed Web of Science ®Google Scholar
• Hendrix S, Kramer P, Pehl D, Warnke K, Boato F, Nelissen S, Lemmens E, Pejler G, Metz M, Siebenhaar F, et al. Mast cells protect from post-traumatic brain inflammation by the mast cell-specific chymase mouse mast cell protease-4. FASEB J. 2013;27(3):920–29. doi:10.1096/fj.12-204800.
   PubMed Web of Science ®Google Scholar
• Moretti R, Chhor V, Bettati D, Banino E, De Lucia S, Le Charpentier T, Lebon S, Schwendimann L, Pansiot J, Rasika S, et al. Contribution of mast cells to injury mechanisms in a mouse model of pediatric traumatic brain injury. J Neurosci Res. 2016;94(12):1546–60. doi:10.1002/jnr.23911.
   PubMed Web of Science ®Google Scholar
• Wu B, Ma Q, Suzuki H, Chen C, Liu W, Tang J, Zhang J. Recombinant osteopontin attenuates brain injury after intracerebral hemorrhage in mice. Neurocrit Care. 2011;14(1):109–17. doi:10.1007/s12028-010-9372-z.
   PubMed Web of Science ®Google Scholar
• Hall NC, Packard BA, Hall CL, de Courten-Myers G, Wagner KR. Protein oxidation and enzyme susceptibility in white and gray matter with in vitro oxidative stress: relevance to brain injury from intracerebral hemorrhage. Cell Mol Biol (Noisy-Le-Grand). 2000;46(3):673–83.
   PubMed Web of Science ®Google Scholar
• Chen CH, Manaenko A, Zhan Y, Liu WW, Ostrowki RP, Tang J, Zhang JH. Hydrogen gas reduced acute hyperglycemia-enhanced hemorrhagic transformation in a focal ischemia rat model. Neuroscience. 2010;169(1):402–14. doi:10.1016/j.neuroscience.2010.04.043.
   PubMed Web of Science ®Google Scholar
• Tashiro M, Mochizuki H, Sakurada Y, Ishii K, Oda K, Kimura Y, Sasaki T, Ishiwata K, Yanai K. Brain histamine H receptor occupancy of orally administered antihistamines measured by positron emission tomography with (11)C-doxepin in a placebo-controlled crossover study design in healthy subjects: a comparison of olopatadine and ketotifen. Br J Clin Pharmacol. 2006;61(1):16–26. doi:10.1111/j.1365-2125.2005.02514.x.
   PubMed Web of Science ®Google Scholar
• Parrella E, Porrini V, Iorio R, Benarese M, Lanzillotta A, Mota M, Fusco M, Tonin P, Spano P, Pizzi M. PEA and luteolin synergistically reduce mast cell-mediated toxicity and elicit neuroprotection in cell-based models of brain ischemia. Brain Res. 2016;1648(Pt A):409–17. doi:10.1016/j.brainres.2016.07.014.
   PubMed Web of Science ®Google Scholar
• Kocic I, Kowianski P, Rusiecka I, Lietzau G, Mansfield C, Moussy A, Hermine O, Dubreuil P. Neuroprotective effect of masitinib in rats with postischemic stroke. Naunyn Schmiedebergs Arch Pharmacol. 2015;388(1):79–86. doi:10.1007/s00210-014-1061-6.
   PubMed Web of Science ®Google Scholar
• Itoh T, Fujita Y, Ito M, Masuda A, Ohno K, Ichihara M, Kojima T, Nozawa Y, Ito M. Molecular hydrogen suppresses FcepsilonRI-mediated signal transduction and prevents degranulation of mast cells. Biochem Biophys Res Commun. 2009;389(4):651–56. doi:10.1016/j.bbrc.2009.09.047.
   PubMed Web of Science ®Google Scholar
• Ohsawa I, Ishikawa M, Takahashi K, Watanabe M, Nishimaki K, Yamagata K, Katsura K, Katayama Y, Asoh S, Ohta S. Hydrogen acts as a therapeutic antioxidant by selectively reducing cytotoxic oxygen radicals. Nat Med. 2007;13(6):688–94. doi:10.1038/nm1577.
   PubMed Web of Science ®Google Scholar
• Swindle EJ, Metcalfe DD, Coleman JW. Rodent and human mast cells produce functionally significant intracellular reactive oxygen species but not nitric oxide. J Biol Chem. 2004;279(47):48751–59. doi:10.1074/jbc.M409738200.
   PubMed Web of Science ®Google Scholar
• Baba A, Tachi M, Ejima Y, Endo Y, Toyama H, Matsubara M, Saito K, Yamauchi M, Miura C, Kazama I. Anti-allergic drugs tranilast and ketotifen dose-dependently exert mast cell-stabilizing properties. Cell Physiol Biochem. 2016;38(1):15–27. doi:10.1159/000438605.
   PubMed Web of Science ®Google Scholar
• Hei ZQ, Gan XL, Huang PJ, Wei J, Shen N, Gao WL. Influence of ketotifen, cromolyn sodium, and compound 48/80 on the survival rates after intestinal ischemia reperfusion injury in rats. BMC Gastroenterol. 2008;8:42. doi:10.1186/1471-230X-8-42.
   PubMed Web of Science ®Google Scholar
• Ahmad A, Genovese T, Impellizzeri D, Crupi R, Velardi E, Marino A, Esposito E, Cuzzocrea S. Reduction of ischemic brain injury by administration of palmitoylethanolamide after transient middle cerebral artery occlusion in rats. Brain Res. 2012;1477:45–58. doi:10.1016/j.brainres.2012.08.006.
   PubMed Web of Science ®Google Scholar
• Garg P, Duncan RS, Kaja S, Koulen P. Intracellular mechanisms of N-acylethanolamine-mediated neuroprotection in a rat model of stroke. Neuroscience. 2010;166(1):252–62. doi:10.1016/j.neuroscience.2009.11.069.
   PubMed Web of Science ®Google Scholar
• Qiao H, Dong L, Zhang X, Zhu C, Zhang X, Wang L, Liu Z, Chen L, Xing Y, Wang C, et al. Protective effect of luteolin in experimental ischemic stroke: upregulated SOD1, CAT, Bcl-2 and claudin-5, down-regulated MDA and Bax expression. Neurochem Res. 2012;37(9):2014–24. doi:10.1007/s11064-012-0822-1.
   PubMed Web of Science ®Google Scholar
• Qiao H, Zhang X, Zhu C, Dong L, Wang L, Zhang X, Xing Y, Wang C, Ji Y, Cao X. Luteolin downregulates TLR4, TLR5, NF-kappaB and p-p38MAPK expression, upregulates the p-ERK expression, and protects rat brains against focal ischemia. Brain Res. 2012;1448:71–81. doi:10.1016/j.brainres.2012.02.003.
   PubMed Web of Science ®Google Scholar
• De Filippis D, Luongo L, Cipriano M, Palazzo E, Cinelli MP, de Novellis V, Maione S, Iuvone T. Palmitoylethanolamide reduces granuloma-induced hyperalgesia by modulation of mast cell activation in rats. Mol Pain. 2011;7:3. doi:10.1186/1744-8069-7-3.
   PubMed Web of Science ®Google Scholar
• De Filippis D, Negro L, Vaia M, Cinelli MP, Iuvone T. New insights in mast cell modulation by palmitoylethanolamide. CNS Neurol Disord Drug Targets. 2013;12(1):78–83.
   PubMed Web of Science ®Google Scholar
• Esposito E, Cordaro M, Cuzzocrea S. Roles of fatty acid ethanolamides (FAE) in traumatic and ischemic brain injury. Pharmacol Res. 2014;86:26–31. doi:10.1016/j.phrs.2014.05.009.
   PubMed Web of Science ®Google Scholar
• Cordaro M, Impellizzeri D, Paterniti I, Bruschetta G, Siracusa R, De Stefano D, Cuzzocrea S, Esposito E. Neuroprotective effects of co-ultraPEALut on secondary inflammatory process and autophagy involved in traumatic brain injury. J Neurotrauma. 2016;33(1):132–46. doi:10.1089/neu.2014.3460.
   PubMed Web of Science ®Google Scholar
• Dubreuil P, Letard S, Ciufolini M, Gros L, Humbert M, Casteran N, Borge L, Hajem B, Lermet A, Sippl W, et al. Masitinib (AB1010), a potent and selective tyrosine kinase inhibitor targeting KIT. PLoS One. 2009;4(9):e7258. doi:10.1371/journal.pone.0007258.
   PubMed Web of Science ®Google Scholar
• Samuelsson A, Towers TL, Ravetch JV. Anti-inflammatory activity of IVIG mediated through the inhibitory Fc receptor. Science. 2001;291(5503):484–86. doi:10.1126/science.291.5503.484.
   PubMed Web of Science ®Google Scholar
• Arumugam TV, Selvaraj PK, Woodruff TM, Mattson MP. Targeting ischemic brain injury with intravenous immunoglobulin. Expert Opin Ther Targets. 2008;12(1):19–29. doi:10.1517/14728222.12.1.19.
   PubMed Web of Science ®Google Scholar
• Jeong S, Lei B, Wang H, Dawson HN, James ML. Intravenous immunoglobulin G improves neurobehavioral and histological outcomes after traumatic brain injury in mice. J Neuroimmunol. 2014;276(1–2):112–18. doi:10.1016/j.jneuroim.2014.08.626.
   PubMed Web of Science ®Google Scholar