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Journal of Asthma Volume 46, 2009 - Issue 4
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ORIGINAL ARTICLE

The FEF25–75 and its Decline as a Predictor of Methacholine Responsiveness in Children

Rupali Drewek Departments of Pediatric Pulmonology, Medical College of Wisconsin, Milwaukee, Wisconsin
, M.D.,
Elfriede Garber Children's Hospital of Wisconsin, Milwaukee, Wisconsin
, R.P.F.T.,
Sheryl Stanclik Children's Hospital of Wisconsin, Milwaukee, Wisconsin
, R.P.F.T., R.R.T.,
Pippa Simpson Departments of Pediatric Quantitative Health Sciences, Medical College of Wisconsin, Milwaukee, Wisconsin
, PH.D,
Melodee Nugent Departments of Pediatric Quantitative Health Sciences, Medical College of Wisconsin, Milwaukee, Wisconsin
, M.A. &
William Gershan Departments of Pediatric Pulmonology, Medical College of Wisconsin, Milwaukee, Wisconsin
, M.D.
Pages 375-381 | Published online: 21 Jul 2009

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Wuping Bao, Xue Zhang, Junfeng Yin, Lei Han, Zhixuan Huang, Luhong Bao, Chengjian Lv, Huijuan Hao, Yishu Xue, Xin Zhou & Min Zhang. (2021) Small-Airway Function Variables in Spirometry, Fractional Exhaled Nitric Oxide, and Circulating Eosinophils Predicted Airway Hyperresponsiveness in Patients with Mild Asthma. Journal of Asthma and Allergy 14, pages 415-426.
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Xun Chen$suffix/text()$suffix/text(), Ke Wang$suffix/text()$suffix/text(), Min Jiang$suffix/text()$suffix/text() & Guang-Min Nong$suffix/text()$suffix/text(). (2013) Leukotriene receptor antagonists for small-airway abnormalities in asthmatics: a systematic review and meta-analysis. Journal of Asthma 50:7, pages 695-704.
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Articles from other publishers (19)

靖溢 杨. (2024) The Application of Pulmonary Ventilation Function Testing of Small Airway Function Parameters in the Diagnosis and Evaluation of Asthma. Advances in Clinical Medicine 14:04, pages 1813-1818.
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Javad Enayat, Sayed Alireza Mahdaviani, Mahsa Rekabi, Mehdi Ghaini, Golnaz Eslamian, Mazdak Fallahi, Sepideh Ghazvineh, Niusha Sharifinejad, Mohammad Reza Raoufy & Ali Akbar Velayati. (2022) Respiratory pattern complexity in newly-diagnosed asthmatic patients. Respiratory Physiology & Neurobiology 300, pages 103873.
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Irfan Shafiq, Mateen Haider Uzbeck, Zaid Zoumot, Mohamed Abuzakouk, Niyas Parappurath & Ali Saeed Wahla. (2021) Correlation between Reduced FEF25-75% and a Positive Methacholine Challenge Test in Adults with Nonobstructive Baseline Spirometry. Pulmonary Medicine 2021, pages 1-5.
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Rundong Qin, Jiaying An, Jiaxing Xie, Renbin Huang, Yanqing Xie, Li He, Hui Xv, Geng Qian & Jing Li. (2021) FEF25-75% Is a More Sensitive Measure Reflecting Airway Dysfunction in Patients with Asthma: A Comparison Study Using FEF25-75% and FEV1%. The Journal of Allergy and Clinical Immunology: In Practice 9:10, pages 3649-3659.e6.
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Fang Yi, Lina Han, Baojuan Liu, Xu Zhang, Yongxin Xue, Wei Luo, Qiaoli Chen & Kefang Lai. (2020) Determinants of response to bronchodilator in patients with cough variant asthma- A randomized, single-blinded, placebo-controlled study. Pulmonary Pharmacology & Therapeutics 61, pages 101903.
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Kefang Lai, Fang Yi, Lina Han, Baojuan Liu, Xu Zhang, Yongxin Xue, Wei Luo & Qiaoli Chen. (2019) Response to bronchodilator and clinical, pathophysiological features in patients with nonasthmatic eosinophilic bronchitis. The Clinical Respiratory Journal 14:3, pages 242-249.
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Valérie Lévesque, Claude Poirier & Bruno-Pierre Dubé. (2018) Dose omission to shorten methacholine challenge testing: clinical consequences of the use of a 10% fall in FEV1 threshold. Allergy, Asthma & Clinical Immunology 14:1.
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Wuping Bao, Xue Zhang, Chengjian Lv, Luhong Bao, Junfeng Yin, Zhixuan Huang, Bing Wang, Xin Zhou & Min Zhang. (2018) The Value of Fractional Exhaled Nitric Oxide and Forced Mid-Expiratory Flow as Predictive Markers of Bronchial Hyperresponsiveness in Adults with Chronic Cough. The Journal of Allergy and Clinical Immunology: In Practice 6:4, pages 1313-1320.
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L. Garcia‐Marcos, J. Edwards, E. Kennington, P. Aurora, E. Baraldi, S. Carraro, M. Gappa, R. Louis, A. Moreno‐Galdo, D. G. Peroni, M. Pijnenburg, K. N. Priftis, M. Sanchez‐Solis, A. Schuster & S. Walker. (2018) Priorities for future research into asthma diagnostic tools: A PAN ‐ EU consensus exercise from the European asthma research innovation partnership ( EARIP ) . Clinical & Experimental Allergy 48:2, pages 104-120.
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Xiujuan Yao & Yongchang Sun. (2014) The sounds of small airways: emerging role in pathogenesis and clinical expression of asthma. Chinese Medical Journal 127:1, pages 173-179.
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Constantine Saadeh, Blake Cross, Charles Saadeh & Michael Gaylor. (2014) Retrospective Observations on the Ability to Diagnose and Manage Patients with Asthma through the Use of Impulse Oscillometry: Comparison with Spirometry and Overview of the Literature. Pulmonary Medicine 2014, pages 1-9.
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Shiwan Shah & Gulshan Sharma. 2014. Heterogeneity in Asthma. Heterogeneity in Asthma 75 80 .
Elizabeth R. GibbShannon M. ThyneDaniel N. KaplanNgoc P. Ly. (2013) Asthma, FEF 25–75 , and Hospitalizations in Children . Pediatric Allergy, Immunology, and Pulmonology 26:3, pages 115-121.
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Erica van der Wiel, Nick H.T. ten Hacken, Dirkje S. Postma & Maarten van den Berge. (2013) Small-airways dysfunction associates with respiratory symptoms and clinical features of asthma: A systematic review. Journal of Allergy and Clinical Immunology 131:3, pages 646-657.
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F. Muñoz-López & M. Ríos-Alcolea. (2012) The interest of FEF25–75 in evaluating bronchial hyperresponsiveness with the methacholine test. Allergologia et Immunopathologia 40:6, pages 352-356.
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Eric W. AltonHomer A. BousheyHolger GarnFrancis H. GreenMichael HodgesRichard J. MartinRobert D. MurdochHarald RenzStephen B. ShrewsburyRosanne SeguinGraham JohnsonJoel D. ParryJeff TepperPaolo RenziJoy CavagnaroNicolay Ferrari. (2012) Clinical Expert Panel on Monitoring Potential Lung Toxicity of Inhaled Oligonucleotides: Consensus Points and Recommendations. Nucleic Acid Therapeutics 22:4, pages 246-254.
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Akihiko Ohwada & Kazuhisa Takahashi. (2012) Concave Pattern of a Maximal Expiratory Flow-Volume Curve: A Sign of Airflow Limitation in Adult Bronchial Asthma. Pulmonary Medicine 2012, pages 1-6.
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Nemr Eid & Ronald Morton. (2011) Lung function changes in asthmatic children treated with HFA‐BDP. Pediatric Pulmonology 46:9, pages 837-841.
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Nicola P. Consilvio, Sabrina Di Pillo, Marcello Verini, Tommaso de Giorgis, Anna Cingolani, Valentina Chiavaroli, Francesco Chiarelli & Angelika Mohn. (2010) The reciprocal influences of asthma and obesity on lung function testing, ahr, and airway inflammation in prepubertal children. Pediatric Pulmonology 45:11, pages 1103-1110.
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