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REVIEW ARTICLE

Mechanisms of Sublingual Immunotherapy

, M.A., M.B.B.S. &
Pages 322-334 | Published online: 21 Jul 2009

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Stephen A Schworer & Edwin H Kim. (2020) Sublingual Immunotherapy for Food Allergy and its Future Directions. Immunotherapy 12:12, pages 921-931.
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Lin Yang & Rongfei Zhu. (2017) Immunotherapy of house dust mite allergy. Human Vaccines & Immunotherapeutics 13:10, pages 2390-2396.
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David I. Bernstein, Jose A. Bardelas$suffix/text()$suffix/text(), Bodil Svanholm Fogh, Amarjot Kaur, Ziliang Li & Hendrik Nolte. (2017) A practical guide to the sublingual immunotherapy tablet adverse event profile: implications for clinical practice. Postgraduate Medicine 129:6, pages 590-597.
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Giorgio Walter Canonica, Johann Christian Virchow, Petra Zieglmayer, Christian Ljørring, Ida Mosbech Smith & Holger Mosbech. (2016) Efficacy and safety of SQ house dust mite (HDM) SLIT-tablet treatment of HDM allergic asthma. Expert Review of Clinical Immunology 12:8, pages 805-815.
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Ludger Klimek, Holger Mosbech, Petra Zieglmayer, Dorte Rehm, Brian Sonne Stage & Pascal Demoly. (2016) SQ house dust mite (HDM) SLIT-tablet provides clinical improvement in HDM-induced allergic rhinitis. Expert Review of Clinical Immunology 12:4, pages 369-377.
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Cheng-Jang Wu, Hou-Wen Chou, Chian-Jiun Liou, Jiann-Jong Shen, Lian-Chen Wang & Ming-Ling Kuo. (2013) Prophylactic Vaccination with Adjuvant Monophosphoryl Lipid A Prevents Th2-Mediated Murine Asthmatic Responses. Journal of Asthma 50:4, pages 327-333.
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Richard Warrington. (2010) Immunotherapy in asthma. Immunotherapy 2:5, pages 711-725.
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Mary Dell Railey & A Wesley Burks. (2010) Therapeutic approaches for the treatment of food allergy. Expert Opinion on Pharmacotherapy 11:7, pages 1045-1048.
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Articles from other publishers (53)

Edwin H. Kim, J. Andrew Bird, Corinne A. Keet, Yamini V. Virkud, Lauren Herlihy, Ping Ye, Johanna M. Smeekens, Rishu Guo, Xiaohong Yue, Anusha Penumarti, Bahjat Qaqish, Quefeng Li, Michael D. Kulis & A. Wesley Burks. (2024) Desensitization and remission after peanut sublingual immunotherapy in 1- to 4-year-old peanut-allergic children: A randomized, placebo-controlled trial. Journal of Allergy and Clinical Immunology 153:1, pages 173-181.e10.
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Takamasa Yoshizawa, Kenichi Kumagai, Ryota Matsubara, Keisuke Nasu, Kazutaka Kitaura, Motoaki Suzuki, Yoshiki Hamada & Ryuji Suzuki. (2023) Characterization of Metal-Specific T-Cells in Inflamed Oral Mucosa in a Novel Murine Model of Chromium-Induced Allergic Contact Dermatitis. International Journal of Molecular Sciences 24:3, pages 2807.
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Anne K. Ellis, Lori Connors, Marie-Josee Francoeur & Douglas P. Mack. (2021) Rupatadine to prevent local allergic reactions to sublingual allergy immunotherapy: a case series. Allergy, Asthma & Clinical Immunology 17:1.
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Arwa Abu Khweek, Eunsoo Kim, Marisa R. Joldrichsen, Amal O. Amer & Prosper N. Boyaka. (2020) Insights Into Mucosal Innate Immune Responses in House Dust Mite-Mediated Allergic Asthma. Frontiers in Immunology 11.
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Moisés A. Calderon, Susan Waserman, David I. Bernstein, Pascal Demoly, Jo Douglass, Remi Gagnon, Constance H. Katelaris, Harold Kim, Harold S. Nelson, Yoshitaka Okamoto, Kimihiro Okubo, J. Christian Virchow, Lawrence DuBuske, Thomas B. Casale, G. Walter Canonica & Hendrik Nolte. (2020) Clinical Practice of Allergen Immunotherapy for Allergic Rhinoconjunctivitis and Asthma: An Expert Panel Report. The Journal of Allergy and Clinical Immunology: In Practice 8:9, pages 2920-2936.e1.
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Sanaz Keshavarz Shahbaz, Abdol-Reza Varasteh, Khadijeh Koushki, Seyed Hasan Ayati, Kazem Mashayekhi, Mahvash Sadeghi, Malihe Moghadam & Mojtaba Sankian. (2020) Sublingual dendritic cells targeting by aptamer: Possible approach for improvement of sublingual immunotherapy efficacy. International Immunopharmacology 85, pages 106603.
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Yasunari Nakasone, Kenichi Kumagai, Ryota Matsubara, Hiroaki Shigematsu, Kazutaka Kitaura, Satsuki Suzuki, Masashi Satoh, Yoshiki Hamada & Ryuji Suzuki. (2018) Characterization of T cell receptors in a novel murine model of nickel-induced intraoral metal contact allergy. PLOS ONE 13:12, pages e0209248.
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M P Kostinov, A M Poddubikova, O O Magarshak & A V Poddubikov. (2018) Application of bacterial therapeutic vaccine Immunovac-VP4 in the treatment of pollinosis. Terapevticheskii arkhiv 90:3, pages 16-20.
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William R. Reisacher & Wesley Davison. (2017) Immunotherapy for food allergy. Current Opinion in Otolaryngology & Head & Neck Surgery 25:3, pages 235-241.
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Melina Makatsori, Stephen Durham & Moises A Calderon. (2017) Specific immunotherapy for latex allergy. Cochrane Database of Systematic Reviews.
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William R. Reisacher & Theresa Schwanke. (2016) New advances in allergy immunotherapy. Current Opinion in Otolaryngology & Head and Neck Surgery 24:3, pages 231-237.
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Deniz Hanci, Ethem Şahin, Nuray Bayar Muluk & Cemal Cingi. (2015) Immunotherapy in all aspects. European Archives of Oto-Rhino-Laryngology 273:6, pages 1347-1355.
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N M Nenasheva. (2015) Atopic asthma: the role of allergen-specific immunotherapy. Russian Journal of Allergy 12:6, pages 54-67.
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Anna Stelmaszczyk-Emmel. (2015) Regulatory T cells in children with allergy and asthma: It is time to act. Respiratory Physiology & Neurobiology 209, pages 59-63.
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Jiu-Yao Wang. 2015. Allergy Bioinformatics. Allergy Bioinformatics 139 146 .
Yu‐E Qin, Jing‐Ran Mao, Yue‐chan Sang & Wen‐Xiu Li. (2013) Clinical efficacy and compliance of sublingual immunotherapy with D ermatophagoides farinae drops in patients with atopic dermatitis . International Journal of Dermatology 53:5, pages 650-655.
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Lianqin Tao, Baoyu Shi, Guochao Shi & Huanying Wan. (2014) Efficacy of sublingual immunotherapy for allergic asthma: retrospective meta‐analysis of randomized, double‐blind and placebo‐controlled trials. The Clinical Respiratory Journal 8:2, pages 192-205.
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Giovanni Passalacqua. (2014) The use of single versus multiple antigens in specific allergen immunotherapy for allergic rhinitis. Current Opinion in Allergy & Clinical Immunology 14:1, pages 20-24.
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Giorgio Walter Canonica, Linda Cox, Ruby Pawankar, Carlos E. Baena-Cagnani, Michael Blaiss, Sergio Bonini, Jean Bousquet, Moises Calderón, Enrico Compalati, Stephen R. Durham, Roy Gerth van Wijk, Désirée Larenas-Linnemann, Harold Nelson, Giovanni Passalacqua, Oliver Pfaar, Nelson Rosário, Dermot Ryan, Lanny Rosenwasser, Peter Schmid-Grendelmeier, Gianenrico Senna, Erkka Valovirta, Hugo Van Bever, Pakit Vichyanond, Ulrich Wahn & Osman Yusuf. (2014) Sublingual immunotherapy: World Allergy Organization position paper 2013 update. World Allergy Organization Journal 7, pages 6.
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Enrico Compalati, Fulvio Braido & Giorgio W. Canonica. (2014) An update on allergen immunotherapy and asthma. Current Opinion in Pulmonary Medicine 20:1, pages 109-117.
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Marek Jutel, Małgorzata Bartkowiak-Emeryk, Anna Bręborowicz, Ewa Cichocka-Jarosz, Andrzej Emeryk, Radosław Gawlik, Paweł Gonerko, Barbara Rogala, Anna Nowak-Węgrzyn & Samoliński. (2014) Podjęzykowa immunoterapia alergenowa – stanowisko Sekcji Immunoterapii Polskiego Towarzystwa Alergologicznego. Alergologia Polska - Polish Journal of Allergology 1:1, pages 30-37.
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Atanaska I. Kostadinova, Linette E. M. Willemsen, Léon M. J. Knippels & Johan Garssen. (2013) Immunotherapy – risk/benefit in food allergy. Pediatric Allergy and Immunology 24:7, pages 633-644.
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M. Álvaro, J. Sancha, H. Larramona, J.M. Lucas, M. Mesa, A.I. Tabar & A. Martinez-Cañavate. (2013) Allergen-specific immunotherapy: Update on immunological mechanisms. Allergologia et Immunopathologia 41:4, pages 265-272.
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William R. Reisacher & Andrea Wang. (2013) Novel Strategies for Allergy Immunotherapy. Current Otorhinolaryngology Reports 1:2, pages 119-126.
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Philippe Moingeon. (2013) Update on Immune Mechanisms Associated with Sublingual Immunotherapy: Practical Implications for the Clinician. The Journal of Allergy and Clinical Immunology: In Practice 1:3, pages 228-241.
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A. Yuta, H. Ogihara, K. Yamanaka, Y. Ogawa, H. Mizutani & K. Okubo. (2012) Therapeutic outcomes and immunological effects of sublingual immunotherapy for Japanese cedar pollinosis. Clinical & Experimental Allergy Reviews 12:n2, pages 29-35.
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Antonio Cappella & Stephen Durham. (2014) Allergen immunotherapy for allergic respiratory diseases. Human Vaccines & Immunotherapeutics 8:10, pages 1499-1512.
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Rima Rachid & Dale T. Umetsu. (2012) Immunological mechanisms for desensitization and tolerance in food allergy. Seminars in Immunopathology 34:5, pages 689-702.
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Ravi S. Swamy, Neha Reshamwala, Tessa Hunter, Soujanya Vissamsetti, Carah B. Santos, Fuad M. Baroody, Peter H. Hwang, Elisabeth G. Hoyte, Marco A. Garcia & Kari C. Nadeau. (2012) Epigenetic modifications and improved regulatory T-cell function in subjects undergoing dual sublingual immunotherapy. Journal of Allergy and Clinical Immunology 130:1, pages 215-224.e7.
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Moises A Calderon, Martin Penagos, Aziz Sheikh, Giorgio W Canonica & Stephen Durham. (2012) Cochrane Review: Sublingual immunotherapy for treating allergic conjunctivitis. Evidence-Based Child Health: A Cochrane Review Journal 7:3, pages 1041-1154.
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I. Stelmach, I. Kaluzińska‐Parzyszek, J. Jerzynska, P. Stelmach, W. Stelmach & P. Majak. (2011) Comparative effect of pre‐coseasonal and continuous grass sublingual immunotherapy in children. Allergy 67:3, pages 312-320.
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Mary S. Morris, Amanda Lowery, Demetrios S. Theodoropoulos, R. Daniel Duquette & David L. Morris. (2012) Quality of Life Improvement with Sublingual Immunotherapy: A Prospective Study of Efficacy. Journal of Allergy 2012, pages 1-6.
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Kaori Okuyama, Soichiro Ide, Shinobu Sakurada, Kazumasu Sasaki, Ichiro Sora, Gen Tamura, Yuichi Ohkawara, Motoaki Takayanagi & Isao Ohno. (2012) μ-opioid Receptor-Mediated Alterations of Allergen-Induced Immune Responses of Bronchial Lymph Node Cells in a Murine Model of Stress Asthma. Allergology International 61:2, pages 245-258.
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Philippe Moingeon & Laurent Mascarell. (2012) Induction of Tolerance via the Sublingual Route: Mechanisms and Applications. Clinical and Developmental Immunology 2012, pages 1-8.
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Yi-Ling Ye, Ya-Hui Chuang & Bor-Luen Chiang. (2011) Strategies of mucosal immunotherapy for allergic diseases. Cellular & Molecular Immunology 8:6, pages 453-461.
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Giovanni Passalacqua. (2011) Specific immunotherapy: beyond the clinical scores. Annals of Allergy, Asthma & Immunology 107:5, pages 401-406.
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M. H. Shamji & S. R. Durham. (2011) Mechanisms of immunotherapy to aeroallergens. Clinical & Experimental Allergy 41:9, pages 1235-1246.
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Melina Makatsori, Stephen Durham & Moises A Calderon. 1996. Cochrane Database of Systematic Reviews. Cochrane Database of Systematic Reviews.
Moises A Calderon, Martin Penagos, Aziz Sheikh, Giorgio W Canonica & Stephen Durham. (2011) Sublingual immunotherapy for treating allergic conjunctivitis. Cochrane Database of Systematic Reviews.
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Deborah Gentile & David P. Skoner. (2011) Sublingual Immunotherapy in Patients with Allergic Rhinoconjunctivitis. Current Allergy and Asthma Reports 11:2, pages 131-138.
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Polly Matzinger & Tirumalai Kamala. (2011) Tissue-based class control: the other side of tolerance. Nature Reviews Immunology 11:3, pages 221-230.
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Sara R. Prickett, Astrid L. Voskamp, April Dacumos-Hill, Karen Symons, Jennifer M. Rolland & Robyn E. O'Hehir. (2011) Ara h 2 peptides containing dominant CD4+ T-cell epitopes: Candidates for a peanut allergy therapeutic. Journal of Allergy and Clinical Immunology 127:3, pages 608-615.e5.
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Stephen R. Durham & Donald Y.M. Leung. (2011) One hundred years of allergen immunotherapy: Time to ring the changes. Journal of Allergy and Clinical Immunology 127:1, pages 3-7.
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Stefania Piconi, Daria Trabattoni, Veronica Rainone, Linda Borgonovo, Simone Passerini, Giuliano Rizzardini, Franco Frati, Enrico Iemoli & Mario Clerici. (2010) Immunological Effects of Sublingual Immunotherapy: Clinical Efficacy Is Associated with Modulation of Programmed Cell Death Ligand 1, IL-10, and IgG4. The Journal of Immunology 185:12, pages 7723-7730.
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E. E. Ahlfors & T. Lyberg. (2010) Kinetics of Local Tissue and Regional Lymph Node IL‐2 and IFN‐γ Responses in Experimental Oral Mucosa and Skin Contact Sensitivity in Mice. Scandinavian Journal of Immunology 72:1, pages 8-14.
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N Novak, E Gros, T Bieber & J-P Allam. (2010) Human skin and oral mucosal dendritic cells as ‘good guys’ and ‘bad guys’ in allergic immune responses. Clinical and Experimental Immunology 161:1, pages 28-33.
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Manfred B Lutz, Anja Döhler & Hiroaki Azukizawa. (2010) Revisiting the tolerogenicity of epidermal Langerhans cells. Immunology & Cell Biology 88:4, pages 381-386.
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Sarah Dimeloe, Alexandra Nanzer, Kimuli Ryanna & Catherine Hawrylowicz. (2010) Regulatory T cells, inflammation and the allergic response—The role of glucocorticoids and Vitamin D. The Journal of Steroid Biochemistry and Molecular Biology 120:2-3, pages 86-95.
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Lisa M. Stutius, Itai Pessach, Joanne Lee, Mindy S. Lo, Sharon Levy, Patricia Schram, Miriam Schizer, Jackson Wong, Wanda Phipatanakul & Dale T. Umetsu. (2010) Sublingual desensitization for buprenorphine hypersensitivity. Journal of Allergy and Clinical Immunology 125:4, pages 938-939.
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J. Lloyd Spencer. (2010) Immunization via the anal mucosa and adjacent skin to protect against respiratory virus infections and allergic rhinitis: A hypothesis. Medical Hypotheses 74:3, pages 542-546.
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Elke O. Luger, Michael Wegmann, Gernot Achatz, Margitta Worm, Harald Renz & Andreas Radbruch. (2010) Allergy for a Lifetime?. Allergology International 59:1, pages 1-8.
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Jean-Pierre Allam, Thomas Bieber & Natalija Novak. (2009) Dendritic cells as potential targets for mucosal immunotherapy. Current Opinion in Allergy & Clinical Immunology 9:6, pages 554-557.
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Robyn E. O'Hehir, Leanne M. Gardner, Maria P. de Leon, Belinda J. Hales, Mark Biondo, Jo A. Douglass, Jennifer M. Rolland & Alessandra Sandrini. (2009) House Dust Mite Sublingual Immunotherapy. American Journal of Respiratory and Critical Care Medicine 180:10, pages 936-947.
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