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Original Articles

Comparison of basal cytotoxicity of seven carbamates in CHO-K1 cells

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Pages 345-354 | Received 04 Nov 2005, Accepted 09 Mar 2006, Published online: 01 Feb 2007

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Mercedes Taroncher, Yelko Rodríguez-Carrasco, Francisco J. Barba & María José Ruiz. (2023) Evaluation of cytotoxicity, analysis of metals and cumulative risk assessment in microalgae. Toxicology Mechanisms and Methods 33:5, pages 388-400.
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Cristina Rossi, Pier Paolo Danieli & Bruno Ronchi. (2014) In Vitro Effects of the Organochlorine Pesticide β-Hexachlorocyclohexane on Bovine Peripheral Blood Mononuclear Cells. Italian Journal of Animal Science 13:3.
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G. Lombardi, A. Prosperini, G. Font & M. J. Ruiz. (2012) Effect of polyphenols on enniatins-induced cytotoxic effects in mammalian cells. Toxicology Mechanisms and Methods 22:9, pages 687-695.
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Giuseppe Meca, Isabel Sospedra, María Adela Valero, Jordi Mañes, Guillermina Font & María José Ruiz. (2011) Antibacterial activity of the enniatin B, produced by Fusarium tricinctum in liquid culture, and cytotoxic effects on Caco-2 cells. Toxicology Mechanisms and Methods 21:7, pages 503-512.
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Giuseppe Meca, José Miguel Soriano, Guillermina Font, Jordi Mañes & María José Ruiz. (2011) Production, purification, and mass spectrometry characterization of the cyclohexadepsipeptide enniatin J3 and study of the cytoxicity on differentiated and undifferentiated Caco-2 cells. Toxicological & Environmental Chemistry 93:2, pages 383-395.
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Dharm Paul Garg, Punita Bhalla, Ravi Kiran, Anil Bansal & D.K. Dhawan. (2009) Vitamin E-mediated protection on methomyl-induced alterations in rat liver. Toxicological & Environmental Chemistry 91:4, pages 685-698.
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Mercedes Taroncher, Yelko Rodríguez-Carrasco, Francisco J. Barba & María-José Ruiz. (2023) Enhancement of the Antioxidant Effect of Natural Products on the Proliferation of Caco-2 Cells Produced by Fish Protein Hydrolysates and Collagen. International Journal of Molecular Sciences 24:7, pages 6871.
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Marialuce Giorgini, Mercedes Taroncher, Josefa Tolosa, María-José Ruiz & Yelko Rodríguez-Carrasco. (2023) Amitraz and Its Metabolites: Oxidative Stress-Mediated Cytotoxicity in HepG2 Cells and Study of Their Stability and Characterization in Honey. Antioxidants 12:4, pages 885.
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Marialuce Giorgini, Mercedes Taroncher, María-José Ruiz, Yelko Rodríguez-Carrasco & Josefa Tolosa. (2023) In Vitro and Predictive Computational Toxicology Methods for the Neurotoxic Pesticide Amitraz and Its Metabolites. Brain Sciences 13:2, pages 252.
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Mercedes Taroncher, Fiona Halbig, Yelko Rodríguez-Carrasco & María-José Ruiz. (2022) Stressful Effects of T-2 Metabolites and Defense Capability of HepG2 Cells. Toxins 14:12, pages 841.
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Andre Luis Dias Araujo Mazzari, Mariella Guimarães Lacerda, Flora Aparecida Milton, João Augusto Mulin Montechiari Machado, Simone Batista Pires Sinoti, Anne-Soulene Toullec, Patricia Marquez Rodrigues, Francisco de Assis Rocha Neves, Luiz Alberto Simeoni, Dâmaris Silveira & Jose Maria Prieto. (2022) In vitro effects of European and Latin-American medicinal plants in CYP3A4 gene expression, glutathione levels, and P-glycoprotein activity. Frontiers in Pharmacology 13.
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Carmen Martínez-Alonso, Mercedes Taroncher, Luigi Castaldo, Luana Izzo, Yelko Rodríguez-Carrasco, Alberto Ritieni & María-José Ruiz. (2022) Effect of Phenolic Extract from Red Beans (Phaseolus vulgaris L.) on T-2 Toxin-Induced Cytotoxicity in HepG2 Cells. Foods 11:7, pages 1033.
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Fojan Agahi, Raquel Penalva-Olcina, Guillermina Font, Ana Juan-García & Cristina Juan. (2022) Effects of Voghiera garlic extracts in neuronal human cell line against zearalenone's derivates and beauvericin. Food and Chemical Toxicology 162, pages 112905.
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Veronica Zingales, M. Salome Sirerol-Piquer, Mónica Fernández-Franzón & Maria-José Ruiz. (2021) Role of quercetin on sterigmatocystin-induced oxidative stress-mediated toxicity. Food and Chemical Toxicology 156, pages 112498.
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Harshit Malhotra, Sukhjeet Kaur & Prashant S. Phale. (2021) Conserved Metabolic and Evolutionary Themes in Microbial Degradation of Carbamate Pesticides. Frontiers in Microbiology 12.
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Mercedes Taroncher, Yelko Rodríguez-Carrasco, Tone Aspevik, Katerina Kousoulaki, Francisco J. Barba & María-José Ruiz. (2021) Cytoprotective Effects of Fish Protein Hydrolysates against H2O2-Induced Oxidative Stress and Mycotoxins in Caco-2/TC7 Cells. Antioxidants 10:6, pages 975.
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Mercedes Taroncher, Yelko Rodríguez-Carrasco & María-José Ruiz. (2021) Interactions between T-2 toxin and its metabolites in HepG2 cells and in silico approach. Food and Chemical Toxicology 148, pages 111942.
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Zeba Khan & Sharique A Ali. (2021) A preliminary study assessing the effect of isocyanate in neuroblastoma brain cells in vitro. Acta Neurobiologiae Experimentalis 81:2, pages 1-5.
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Cristina Fuentes, María Ruiz-Rico, Ana Fuentes, José Manuel Barat & María José Ruiz. (2021) Comparative cytotoxic study of silica materials functionalised with essential oil components in HepG2 cells. Food and Chemical Toxicology 147, pages 111858.
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Mercedes Taroncher, Yelko Rodríguez-Carrasco & María-José Ruiz. (2020) T-2 toxin and its metabolites: Characterization, cytotoxic mechanisms and adaptive cellular response in human hepatocarcinoma (HepG2) cells. Food and Chemical Toxicology 145, pages 111654.
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Veronica Zingales, Clarissa Fedeli, Mónica Fernández-Franzón & Maria-José Ruiz. (2020) Cytotoxic effects of individual and combined sterigmatocystin and nivalenol on liver hepatocellular carcinoma cells. Food and Chemical Toxicology 143, pages 111473.
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Veronica Zingales, Mónica Fernández-Franzón & Maria-José Ruiz. (2020) The role of mitochondria in sterigmatocystin-induced apoptosis on SH-SY5Y cells. Food and Chemical Toxicology 142, pages 111493.
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Fojan Agahi, Guillermina Font, Cristina Juan & Ana Juan-García. (2020) Individual and Combined Effect of Zearalenone Derivates and Beauvericin Mycotoxins on SH-SY5Y Cells. Toxins 12:4, pages 212.
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Elsa T. Rodrigues, Ana T. Varela, Miguel A. Pardal & Vilma A. Sardão. (2019) Cell-based assays as an alternative for the study of aquatic toxicity of pharmaceuticals. Environmental Science and Pollution Research 27:7, pages 7145-7155.
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Veronica Zingales, Mónica Fernández-Franzón & Maria-José Ruiz. (2020) Sterigmatocystin-induced cytotoxicity via oxidative stress induction in human neuroblastoma cells. Food and Chemical Toxicology 136, pages 110956.
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Ana Juan-García, Domenico Montesano, Jordi Mañes & Cristina Juan. (2019) Cytoprotective effects of carotenoids-rich extract from Lycium barbarum L. on the beauvericin-induced cytotoxicity on Caco-2 cells. Food and Chemical Toxicology 133, pages 110798.
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Elsa T. Rodrigues, Ana T. Varela, Miguel A. Pardal & Paulo J. Oliveira. (2019) Cell-based assays seem not to accurately predict fish short-term toxicity of pesticides. Environmental Pollution 252, pages 476-482.
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Ana Juan-García, Josefa Tolosa, Cristina Juan & María-José Ruiz. (2019) Cytotoxicity, Genotoxicity and Disturbance of Cell Cycle in HepG2 Cells Exposed to OTA and BEA: Single and Combined Actions. Toxins 11:6, pages 341.
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Celia Fernández-Blanco, Luigi Elmo, Thomas Waldner & Maria-Jose Ruiz. (2018) Cytotoxic effects induced by patulin, deoxynivalenol and toxin T2 individually and in combination in hepatic cells (HepG2). Food and Chemical Toxicology 120, pages 12-23.
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Sara Maisanaba, Federica Saladino, Guillermina Font, Ángeles Jos, Ana M. Cameán & Giuseppe Meca. (2017) Bioaccesibility of Cylindrospermopsin from cooked fish muscle after the application of an in vitro digestion model and its bioavailability. Food and Chemical Toxicology 110, pages 360-370.
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K. Bordin, F. Saladino, C. Fernández-Blanco, M.J. Ruiz, J. Mañes, M. Fernández-Franzón, G. Meca & F.B. Luciano. (2017) Reaction of zearalenone and α-zearalenol with allyl isothiocyanate, characterization of reaction products, their bioaccessibility and bioavailability in vitro. Food Chemistry 217, pages 648-654.
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Andre L. D. A. Mazzari, Flora Milton, Samantha Frangos, Ana C. B. Carvalho, Dâmaris Silveira, Francisco de Assis Rocha Neves & Jose M. Prieto. (2016) In vitro Effects of Four Native Brazilian Medicinal Plants in CYP3A4 mRNA Gene Expression, Glutathione Levels, and P-Glycoprotein Activity. Frontiers in Pharmacology 7.
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Ana Juan-García, Cristina Juan, Lara Manyes & María-José Ruiz. (2016) Binary and tertiary combination of alternariol, 3-acetyl-deoxynivalenol and 15-acetyl-deoxynivalenol on HepG2 cells: Toxic effects and evaluation of degradation products. Toxicology in Vitro 34, pages 264-273.
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Yasin Eren, Sevim Feyza Erdoğmuş, Dilek Akyıl & Arzu Özkara. (2014) Mutagenic and cytotoxic activities of benfuracarb insecticide. Cytotechnology 68:4, pages 637-643.
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Beatriz Mallebrera, Ana Juan-Garcia, Guillermina Font & Maria-Jose Ruiz. (2016) Mechanisms of beauvericin toxicity and antioxidant cellular defense. Toxicology Letters 246, pages 28-34.
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Celia Fernández-Blanco, Guillermina Font & Maria-Jose Ruiz. (2016) Role of quercetin on Caco-2 cells against cytotoxic effects of alternariol and alternariol monomethyl ether. Food and Chemical Toxicology 89, pages 60-66.
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Nidhal Zouaoui, Beatriz Mallebrera, Houda Berrada, Salwa Abid-Essefi, Hassen Bacha & Maria-Jose Ruiz. (2016) Cytotoxic effects induced by patulin, sterigmatocystin and beauvericin on CHO–K1 cells. Food and Chemical Toxicology 89, pages 92-103.
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Celia Fernández-Blanco, Guillermina Font & Maria-Jose Ruiz. (2016) Interaction effects of enniatin B, deoxinivalenol and alternariol in Caco-2 cells. Toxicology Letters 241, pages 38-48.
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B. Mallebrera, V. Brandolini, G. Font & M.J. Ruiz. (2015) Cytoprotective effect of resveratrol diastereomers in CHO-K1 cells exposed to beauvericin. Food and Chemical Toxicology 80, pages 319-327.
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Ana Juan-García, Cristina Juan, Stefanie König & María-José Ruiz. (2015) Cytotoxic effects and degradation products of three mycotoxins: Alternariol, 3-acetyl-deoxynivalenol and 15-acetyl-deoxynivalenol in liver hepatocellular carcinoma cells. Toxicology Letters 235:1, pages 8-16.
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Pilar Vila-Donat, Celia Fernández-Blanco, Gianni Sagratini, Guillermina Font & María-José Ruiz. (2015) Effects of soyasaponin I and soyasaponins-rich extract on the Alternariol-induced cytotoxicity on Caco-2 cells. Food and Chemical Toxicology 77, pages 44-49.
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C. Chiesi, C. Fernandez-Blanco, L. Cossignani, G. Font & M.J. Ruiz. (2015) Alternariol-induced cytotoxicity in Caco-2 cells. Protective effect of the phenolic fraction from virgin olive oil. Toxicon 93, pages 103-111.
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Rachel Clarke, Lisa Connolly, Caroline Frizzell & Christopher T. Elliott. (2014) Cytotoxic assessment of the regulated, co-existing mycotoxins aflatoxin B1, fumonisin B1 and ochratoxin, in single, binary and tertiary mixtures. Toxicon 90, pages 70-81.
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Celia Fernández-Blanco, Guillermina Font & Maria-Jose Ruiz. (2014) Oxidative stress of alternariol in Caco-2 cells. Toxicology Letters 229:3, pages 458-464.
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Elena Tatay, Giuseppe Meca, Guillermina Font & Maria-Jose Ruiz. (2014) Interactive effects of zearalenone and its metabolites on cytotoxicity and metabolization in ovarian CHO-K1 cells. Toxicology in Vitro 28:1, pages 95-103.
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A. Prosperini, G. Font & M.J. Ruiz. (2014) Interaction effects of Fusarium enniatins (A, A1, B and B1) combinations on in vitro cytotoxicity of Caco-2 cells. Toxicology in Vitro 28:1, pages 88-94.
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Mingyan Lei, Niya Zhang & Desheng Qi. (2013) In vitro investigation of individual and combined cytotoxic effects of aflatoxin B1 and other selected mycotoxins on the cell line porcine kidney 15. Experimental and Toxicologic Pathology 65:7-8, pages 1149-1157.
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A. Prosperini, A. Juan-García, G. Font & M.J. Ruiz. (2013) Beauvericin-induced cytotoxicity via ROS production and mitochondrial damage in Caco-2 cells. Toxicology Letters 222:2, pages 204-211.
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A. Prosperini, A. Juan-García, G. Font & M.J. Ruiz. (2013) Reactive oxygen species involvement in apoptosis and mitochondrial damage in Caco-2 cells induced by enniatins A, A1, B and B1. Toxicology Letters 222:1, pages 36-44.
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H. Lu, M. Fernández-Franzón, G. Font & M.J. Ruiz. (2013) Toxicity evaluation of individual and mixed enniatins using an in vitro method with CHO-K1 cells. Toxicology in Vitro 27:2, pages 672-680.
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A. Prosperini, Giuseppe Meca, G. Font & M.J. Ruiz. (2012) Study of the cytotoxic activity of beauvericin and fusaproliferin and bioavailability in vitro on Caco-2 cells. Food and Chemical Toxicology 50:7, pages 2356-2361.
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María-José Ruiz, Petra Macáková, Ana Juan-García & Guillermina Font. (2011) Cytotoxic effects of mycotoxin combinations in mammalian kidney cells. Food and Chemical Toxicology 49:10, pages 2718-2724.
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M.J. Ruiz, P. Franzova, A. Juan-García & G. Font. (2011) Toxicological interactions between the mycotoxins beauvericin, deoxynivalenol and T-2 toxin in CHO-K1 cells in vitro. Toxicon 58:4, pages 315-326.
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G. Meca, G. Font & M.J. Ruiz. (2011) Comparative cytotoxicity study of enniatins A, A1, A2, B, B1, B4 and J3 on Caco-2 cells, Hep-G2 and HT-29. Food and Chemical Toxicology 49:9, pages 2464-2469.
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G. Meca, M.J. Ruiz, J.M. Soriano, A. Ritieni, A. Moretti, G. Font & J. Mañes. (2010) Isolation and purification of enniatins A, A1, B, B1, produced by Fusarium tricinctum in solid culture, and cytotoxicity effects on Caco-2 cells. Toxicon 56:3, pages 418-424.
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E. Maran, M. Fernández-Franzón, G. Font & M.J. Ruiz. (2010) Effects of aldicarb and propoxur on cytotoxicity and lipid peroxidation in CHO-K1 cells. Food and Chemical Toxicology 48:6, pages 1592-1596.
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E. Ferrer, A. Juan-García, G. Font & M.J. Ruiz. (2009) Reactive oxygen species induced by beauvericin, patulin and zearalenone in CHO-K1 cells. Toxicology in Vitro 23:8, pages 1504-1509.
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Dharm Paul Garg, Anil K. Bansal, Anshoo Malhotra, Ravi Kiran & D.K. Dhawan. (2009) Methomyl induced hematological and biochemical alterations – protection by vitamin E. Pesticide Biochemistry and Physiology 93:3, pages 127-132.
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Elisa Maran, Mónica Fernández, Pierluigi Barbieri, Guillermina Font & María José Ruiz. (2009) Effects of four carbamate compounds on antioxidant parameters. Ecotoxicology and Environmental Safety 72:3, pages 922-930.
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