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Aerosol Science and Technology Volume 40, 2006 - Issue 5
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Original Articles

Experimental Measurement and Numerical Study of Particle Deposition in Highly Idealized Mouth-Throat Models

Yu Zhang Aerosol Research Laboratory of Alberta, Department of Mechanical Engineering, University of Alberta, Edmonton, Alberta, Canada
,
Tze Luck Chia Aerosol Research Laboratory of Alberta, Department of Mechanical Engineering, University of Alberta, Edmonton, Alberta, Canada
&
Warren H. Finlay Aerosol Research Laboratory of Alberta, Department of Mechanical Engineering, University of Alberta, Edmonton, Alberta, Canada
Pages 361-372 | Received 01 Sep 2005, Accepted 03 Feb 2006, Published online: 23 Feb 2007

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Xiaole Chen, Clement Kleinstreuer, Wenqi Zhong, Yu Feng & Xianguang Zhou. (2018) Effects of thermal airflow and mucus-layer interaction on hygroscopic droplet deposition in a simple mouth–throat model. Aerosol Science and Technology 52:8, pages 900-912.
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Morteza Yousefi, Kiao Inthavong & Jiyuan Tu. (2015) Microparticle Transport and Deposition in the Human Oral Airway: Toward the Smart Spacer. Aerosol Science and Technology 49:11, pages 1109-1120.
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Jolyon P Mitchell & Mark W Nagel. (2013) Improved Laboratory Test Methods for Orally Inhaled Products. Therapeutic Delivery 4:8, pages 1003-1026.
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Ahmed Fadl, Jinbo Wang & Zongqin Zhang. (2010) Metered-dose inhaler efficiency enhancement: A case study and novel design. Inhalation Toxicology 22:7, pages 601-609.
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P. Worth Longest, Michael Hindle, Suparna Das Choudhuri & PeterR. Byron. (2007) Numerical Simulations of Capillary Aerosol Generation: CFD Model Development and Comparisons with Experimental Data. Aerosol Science and Technology 41:10, pages 952-973.
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Ahmed Fadl, Jinbo Wang, Pao Yang, Zongqin Zhang & Yung Sung Cheng. (2007) Balloon-Based In Vitro MDI Aerosol Deposition Experiments on the Effects of Mouthpiece Diameter. Inhalation Toxicology 19:6-7, pages 505-515.
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Articles from other publishers (35)

Hao Jing & Xinguang Cui. (2024) A review on numerical studies of airflow dynamics and particle deposition in human respiratory system. Particuology 91, pages 351-377.
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Jianwei Wang, Yueyang Cai, Xiaole Chen, Baobin Sun & Feng Tao. (2024) The effects of aerosol concentration on the evolution, transport, and deposition of hygroscopic droplets in the highly idealized MT model: A numerical study. International Journal of Heat and Mass Transfer 219, pages 124916.
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Mahsa Jahed, Janusz Kozinski & Leila Pakzad. (2023) The impact of actuator nozzle and surroundings condition on drug delivery using pressurized-metered dose inhalers. Biomechanics and Modeling in Mechanobiology 22:6, pages 2117-2133.
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Pengcheng Yu, Chao Xue, Bella Boeckenstedt, Halli Olsen & Jack J. Jiang. (2023) Effects of vocal fold adduction on the particle deposition in the glottis: A numerical analysis and in vitro assessment. Computers in Biology and Medicine 166, pages 107537.
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Jenny Rissler, Madeleine Peterson Sjögren, Julia Linell, Amalia Larsson Hurtig, Per Wollmer & Jakob Löndahl. (2023) An experimental study on lung deposition of inhaled 2 μm particles in relation to lung characteristics and deposition models. Particle and Fibre Toxicology 20:1.
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Cong Liu, Hao Hu, Shuonv Zhou, Xiaole Chen, Yongtao Hu & Jianlin Hu. (2023) Change of Composition, Source Contribution, and Oxidative Effects of Environmental PM 2.5 in the Respiratory Tract . Environmental Science & Technology 57:31, pages 11605-11611.
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Yi Jin, Xiaole Chen, Yu Feng, Zhenning Jia, Jinan Zhang, Xiaojian Xie & Ya Zhang. (2023) A novel experimental approach to measure nebulized droplet deposition pattern and deposition fraction in an idealized mouth-to-throat model. Physics of Fluids 35:8.
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Huizhen Yang, Yan Wang, Xiaole Chen, Baobin Sun, Feng Tao, Xiaojian Xie & Yi Zhang. (2023) The effects of temperature and humidity on the deposition of nebulized droplet in an idealized mouth-throat model. Flow Measurement and Instrumentation 91, pages 102359.
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Xueying Xia, Ting Ding, Xiaole Chen, Feng Tao, Baobin Sun, Tong Lu, Jianwei Wang, Yu Huang & Yin Xu. (2022) Evaporation Affects the In Vitro Deposition of Nebulized Droplet in an Idealized Mouth-Throat Model. Atmosphere 14:1, pages 93.
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Zhaoqi Ma, Agisilaos Kourmatzis, Liam Milton-McGurk, Hak-Kim Chan, Dino Farina & Shaokoon Cheng. (2022) Simulating the effect of individual upper airway anatomical features on drug deposition. International Journal of Pharmaceutics 628, pages 122219.
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Jayachandran K Narayanan, Jie Lin, Yaning Feng & Xinguang Cui. (2022) Numerical study on the impact of mucus layer and inlet air-temperatures on the particle deposition in a highly idealized mouth-throat model using LES. Powder Technology 395, pages 455-475.
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Seng Han Lim, Sol Park, Chun Chuan Lee, Paul Chi Lui Ho, Philip Chi Lip Kwok & Lifeng Kang. (2021) A 3D printed human upper respiratory tract model for particulate deposition profiling. International Journal of Pharmaceutics 597, pages 120307.
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Fen Huang, Qixuan Zhu, Xudong Zhou, Dazhao Gou, Jiaqi Yu, Renjie Li, Zhenbo Tong & Runyu Yang. (2021) Role of CFD based in silico modelling in establishing an in vitro-in vivo correlation of aerosol deposition in the respiratory tract. Advanced Drug Delivery Reviews 170, pages 369-385.
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Tomás Sou & Christel A.S. Bergström. (2021) Contemporary Formulation Development for Inhaled Pharmaceuticals. Journal of Pharmaceutical Sciences 110:1, pages 66-86.
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F. Huang, Y. Zhang, Z.B. Tong, X.L. Chen, R.Y. Yang & A.B. Yu. (2021) Numerical investigation of deposition mechanism in three mouth–throat models. Powder Technology 378, pages 724-735.
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Xiaole Chen, Xianguang Zhou, Xueying Xia, Xiaojian Xie, Ping Lu & Yu Feng. (2021) Modeling of the transport, hygroscopic growth, and deposition of multi-component droplets in a simplified airway with realistic thermal boundary conditions. Journal of Aerosol Science 151, pages 105626.
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Adam H. Sonnenberg, Jacob Herrmann, Mark W. Grinstaff & Béla Suki. (2020) A Markov chain model of particle deposition in the lung. Scientific Reports 10:1.
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Kun Zhou, Ke Sun, Xiao Jiang, Shaojie Liu, Zhu He & Zhou Ding. (2018) Experimental Views of Tran-Bend Particle Deposition in Turbulent Flow with Nanoscale Effect. Journal of Nanotechnology 2018, pages 1-10.
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Xiaole Chen, Yu Feng, Wenqi Zhong, Baobin Sun & Feng Tao. (2018) Numerical investigation of particle deposition in a triple bifurcation airway due to gravitational sedimentation and inertial impaction. Powder Technology 323, pages 284-293.
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Anthony J. Hickey. 2018. Inhaled Pharmaceutical Product Development Perspectives. Inhaled Pharmaceutical Product Development Perspectives 53 71 .
Ravishekar (Ravi) Kannan, A.J. Przekwas, Narender Singh, Renishkumar Delvadia, Geng Tian & Ross Walenga. (2017) Pharmaceutical aerosols deposition patterns from a Dry Powder Inhaler: Euler Lagrangian prediction and validation. Medical Engineering & Physics 42, pages 35-47.
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Xiaole Chen, Yu Feng, Wenqi Zhong & Clement Kleinstreuer. (2017) Numerical investigation of the interaction, transport and deposition of multicomponent droplets in a simple mouth-throat model. Journal of Aerosol Science 105, pages 108-127.
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Ravishekar Kannan, Peng Guo & Andrzej Przekwas. (2015) Particle transport in the human respiratory tract: formulation of a nodal inverse distance weighted Eulerian–Lagrangian transport and implementation of the Wind–Kessel algorithm for an oral delivery. International Journal for Numerical Methods in Biomedical Engineering 32:6.
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Sharon Shui Yee Leung, Patricia Tang, Qi Zhou, Zhenbo Tong, Cassandra Leung, Janwit Decharaksa, Runyu Yang & Hak-Kim Chan. (2015) De-agglomeration Effect of the US Pharmacopeia and Alberta Throats on Carrier-Based Powders in Commercial Inhalation Products. The AAPS Journal 17:6, pages 1407-1416.
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Poonam Sheth, Matthew D. Bertsch, Carrie L. Knapp & Paul B. Myrdal. (2014) In vitro evaluation of nonconventional accessory devices for pressurized metered-dose inhalers. Annals of Allergy, Asthma & Immunology 113:1, pages 55-62.
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Ross L. Walenga, Geng Tian & P. Worth Longest. (2013) Development of Characteristic Upper Tracheobronchial Airway Models for Testing Pharmaceutical Aerosol Delivery. Journal of Biomechanical Engineering 135:9.
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Jianhua Huang, Hui Sun, Canjie Liu & Lianzhong Zhang. (2013) Moving boundary simulation of airflow and micro-particle deposition in the human extra-thoracic airway under steady inspiration. Part I: Airflow. European Journal of Mechanics - B/Fluids 37, pages 29-41.
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Nazrul Islam & Matthew J. Cleary. (2012) Developing an efficient and reliable dry powder inhaler for pulmonary drug delivery – A review for multidisciplinary researchers. Medical Engineering & Physics 34:4, pages 409-427.
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P. Worth Longest & Landon T. Holbrook. (2012) In silico models of aerosol delivery to the respiratory tract — Development and applications. Advanced Drug Delivery Reviews 64:4, pages 296-311.
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Mohammed AliMalay K. MazumderTed B. Martonen. (2009) Measurements of Electrodynamic Effects on the Deposition of MDI and DPI Aerosols in a Replica Cast of Human Oral–Pharyngeal–Laryngeal Airways. Journal of Aerosol Medicine and Pulmonary Drug Delivery 22:1, pages 35-44.
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P. Worth Longest, Michael Hindle, Suparna Das Choudhuri & Jinxiang Xi. (2008) Comparison of ambient and spray aerosol deposition in a standard induction port and more realistic mouth–throat geometry. Journal of Aerosol Science 39:7, pages 572-591.
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Warren H. FinlayAndrew R. Martin. (2008) Recent Advances in Predictive Understanding of Respiratory Tract Deposition. Journal of Aerosol Medicine and Pulmonary Drug Delivery 21:2, pages 189-206.
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Warren H. Finlay & Andrew R. Martin. (2008) Recent Advances in Predictive Understanding of Respiratory Tract Deposition. Journal of Aerosol Medicine 0:0, pages 080225123426385-18.
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A. F. Salleh, M. Izham, M. Tasyrif, S. Yaacob & K. Helmy. 2008. 4th Kuala Lumpur International Conference on Biomedical Engineering 2008. 4th Kuala Lumpur International Conference on Biomedical Engineering 2008 653 656 .
Ahmed Fadl, Jinbo Wang, Zongqin Zhang & Yung Sung Cheng. (2007) Effects of MDI spray angle on aerosol penetration efficiency through an oral airway cast. Journal of Aerosol Science 38:8, pages 853-864.
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