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Aerosol Science and Technology Volume 46, 2012 - Issue 12
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Original Articles

Development of a Stochastic Individual Path (SIP) Model for Predicting the Deposition of Pharmaceutical Aerosols: Effects of Turbulence, Polydisperse Aerosol Size, and Evaluation of Multiple Lung Lobes

P. Worth Longest Department of Mechanical and Nuclear Engineering, Virginia Commonwealth University, Richmond, Virginia, USA; Department of Pharmaceutics, Virginia Commonwealth University, Richmond, Virginia, USA
,
Geng Tian Department of Mechanical and Nuclear Engineering, Virginia Commonwealth University, Richmond, Virginia, USA
,
Renishkumar Delvadia Department of Pharmaceutics, Virginia Commonwealth University, Richmond, Virginia, USA
&
Michael Hindle Department of Pharmaceutics, Virginia Commonwealth University, Richmond, Virginia, USA
Pages 1271-1285 | Received 31 Jan 2012, Accepted 25 Jun 2012, Published online: 25 Jul 2012

Citations (48)

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Karl Bass, Morgan L. Thomas, Mariette P. C. Kemner-van de Corput, Harm A. W. M. Tiddens & P. Worth Longest. (2021) Development of characteristic airway bifurcations in cystic fibrosis. Aerosol Science and Technology 55:10, pages 1143-1164.
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P. Worth Longest, Karl Bass, Rabijit Dutta, Vijaya Rani, Morgan L. Thomas, Ahmad El-Achwah & Michael Hindle. (2019) Use of computational fluid dynamics deposition modeling in respiratory drug delivery. Expert Opinion on Drug Delivery 16:1, pages 7-26.
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Andrew R. Martin, Charles P. Moore & Warren H. Finlay. (2018) Models of deposition, pharmacokinetics, and intersubject variability in respiratory drug delivery. Expert Opinion on Drug Delivery 15:12, pages 1175-1188.
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Morteza Yousefi, Kiao Inthavong & Jiyuan Tu. (2015) Microparticle Transport and Deposition in the Human Oral Airway: Toward the Smart Spacer. Aerosol Science and Technology 49:11, pages 1109-1120.
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Geng Tian, Michael Hindle & P. Worth Longest. (2014) Targeted Lung Delivery of Nasally Administered Aerosols. Aerosol Science and Technology 48:4, pages 434-449.
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Articles from other publishers (43)

G.H. Spasov, R. Rossi, A. Vanossi, C. Cottini & A. Benassi. (2024) A critical analysis of the CFD-DEM simulation of pharmaceutical aerosols deposition in upper intra-thoracic airways: Considerations on air flow. Computers in Biology and Medicine 170, pages 107948.
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Hasan Jubaer, Morgan Thomas, Dale Farkas, Arun V. Kolanjiyil, Mohammad A.M. Momin, Michael Hindle & Worth Longest. (2024) Development of an effective two-equation turbulence modeling approach for simulating aerosol deposition across a range of turbulence levels. Journal of Aerosol Science 175, pages 106262.
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Mahsa Jahed, Janusz Kozinski & Leila Pakzad. (2023) The impact of actuator nozzle and surroundings condition on drug delivery using pressurized-metered dose inhalers. Biomechanics and Modeling in Mechanobiology 22:6, pages 2117-2133.
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Ross L. Walenga, Clare Butler, Brent A. Craven, P. Worth Longest, Raja Mohamed, Bryan Newman, Bo Olsson, Günther Hochhaus, Bing V. Li, Markham C. Luke, Liang Zhao, Andrzej Przekwas & Robert Lionberger. (2022) Mechanistic modeling of generic orally inhaled drug products: A workshop summary report. CPT: Pharmacometrics & Systems Pharmacology 12:5, pages 560-574.
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G.H. Spasov, R. Rossi, A. Vanossi, C. Cottini & A. Benassi. (2022) A critical analysis of the CFD-DEM simulation of pharmaceutical aerosols deposition in extra-thoracic airways. International Journal of Pharmaceutics 629, pages 122331.
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Stefanie Gürzing, Anja L. ThiebesChristian G. CornelissenStefan JockenhoevelManuel A. Reddemann. (2022) Suitability of Bronchoscopic Spraying for Fluid Deposition in Lower Airway Regions: Fluorescence Analysis on a Transparent In Vitro Airway Model . Journal of Aerosol Medicine and Pulmonary Drug Delivery 35:5, pages 269-277.
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Mohamed Talaat, Xiuhua Si, Xiaofei Liu & Jinxiang Xi. (2022) Count- and mass-based dosimetry of MDI spray droplets with polydisperse and monodisperse size distributions. International Journal of Pharmaceutics 623, pages 121920.
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Juliet Rebello, Bill Brashier & Sharvari Shukla. (2022) Assessment of the predictive capability of modelling and simulation to determine bioequivalence of inhaled drugs: A systematic review. DARU Journal of Pharmaceutical Sciences 30:1, pages 229-243.
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Worth Longest, Amr Hassan, Dale Farkas & Michael Hindle. (2022) Computational Fluid Dynamics (CFD) Guided Spray Drying Recommendations for Improved Aerosol Performance of a Small-Particle Antibiotic Formulation. Pharmaceutical Research 39:2, pages 295-316.
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Morgan L. Thomas & P. Worth Longest. (2022) Evaluation of the polyhedral mesh style for predicting aerosol deposition in representative models of the conducting airways. Journal of Aerosol Science 159, pages 105851.
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Lukas Pichelstorfer, Renate Winkler-Heil, Michael Boy & Werner Hofmann. (2021) Aerosol dynamics simulations of the anatomical variability of e-cigarette particle and vapor deposition in a stochastic lung. Journal of Aerosol Science 158, pages 105706.
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Georg Möller, Malte Bieber, Stefanie Gürzing, Anja Lena Thiebes, Sarah Klein, Christian Gabriel Cornelissen & Manuel Armin Reddemann. (2021) Transparent 23-generation airway model for experimental investigation of aerosol flow and deposition within the human respiratory tract. Journal of Aerosol Science 156, pages 105782.
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Karl Bass, Dale Farkas, Amr Hassan, Serena Bonasera, Michael Hindle & P. Worth Longest. (2021) High-efficiency dry powder aerosol delivery to children: Review and application of new technologies. Journal of Aerosol Science 153, pages 105692.
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Fen Huang, Qixuan Zhu, Xudong Zhou, Dazhao Gou, Jiaqi Yu, Renjie Li, Zhenbo Tong & Runyu Yang. (2021) Role of CFD based in silico modelling in establishing an in vitro-in vivo correlation of aerosol deposition in the respiratory tract. Advanced Drug Delivery Reviews 170, pages 369-385.
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Yu Feng, Jianan Zhao, Hamideh Hayati, Ted Sperry & Hang Yi. (2021) Tutorial: Understanding the transport, deposition, and translocation of particles in human respiratory systems using Computational Fluid-Particle Dynamics and Physiologically Based Toxicokinetic models. Journal of Aerosol Science 151, pages 105672.
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Pantelis Koullapis, Fotos Stylianou, Ching-Long Lin, Stavros Kassinos & Josué Sznitman. 2021. Inhaled Medicines. Inhaled Medicines 167 195 .
Yu Feng, Hamideh Hayati, Alister J. Bates, Koch Walter, Lehner Matthias, Benda Odo, Ortiz Ramiro & Koch Gerda. 2021. Clinical and Biomedical Engineering in the Human Nose. Clinical and Biomedical Engineering in the Human Nose 225 253 .
P.G. Koullapis, F.S. Stylianou, J. Sznitman, B. Olsson & S.C. Kassinos. (2020) Towards whole-lung simulations of aerosol deposition: A model of the deep lung. Journal of Aerosol Science 144, pages 105541.
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P. Worth Longest, Dale Farkas, Amr Hassan & Michael Hindle. (2020) Computational Fluid Dynamics (CFD) Simulations of Spray Drying: Linking Drying Parameters with Experimental Aerosolization Performance. Pharmaceutical Research 37:6.
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Conor A. RuzyckiAndrew R. MartinWarren H. Finlay. (2019) An Exploration of Factors Affecting In Vitro Deposition of Pharmaceutical Aerosols in the Alberta Idealized Throat . Journal of Aerosol Medicine and Pulmonary Drug Delivery 32:6, pages 405-417.
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Worth LongestBenjamin SpenceMichael Hindle. (2019) Devices for Improved Delivery of Nebulized Pharmaceutical Aerosols to the Lungs. Journal of Aerosol Medicine and Pulmonary Drug Delivery 32:5, pages 317-339.
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Benjamin M. SpenceWorth LongestXiangyin WeiSneha DhapareMichael Hindle. (2019) Development of a High-Flow Nasal Cannula and Pharmaceutical Aerosol Combination Device. Journal of Aerosol Medicine and Pulmonary Drug Delivery 32:4, pages 224-241.
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Worth Longest, Dale Farkas, Karl Bass & Michael Hindle. (2019) Use of Computational Fluid Dynamics (CFD) Dispersion Parameters in the Development of a New DPI Actuated with Low Air Volumes. Pharmaceutical Research 36:8.
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Karl BassSusan BocMichael HindleKelley DodsonWorth Longest. (2019) High-Efficiency Nose-to-Lung Aerosol Delivery in an Infant: Development of a Validated Computational Fluid Dynamics Method. Journal of Aerosol Medicine and Pulmonary Drug Delivery 32:3, pages 132-148.
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Robert A. Lionberger. (2019) Innovation for Generic Drugs: Science and Research Under the Generic Drug User Fee Amendments of 2012. Clinical Pharmacology & Therapeutics 105:4, pages 878-885.
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Worth Longest & Dale Farkas. (2019) Development of a New Inhaler for High-Efficiency Dispersion of Spray-Dried Powders Using Computational Fluid Dynamics (CFD) Modeling. The AAPS Journal 21:2.
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Karl Bass & P. Worth Longest. (2018) Development of an infant complete-airway in vitro model for evaluating aerosol deposition. Medical Engineering & Physics 58, pages 47-55.
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Karl Bass & P. Worth Longest. (2018) Recommendations for simulating microparticle deposition at conditions similar to the upper airways with two-equation turbulence models. Journal of Aerosol Science 119, pages 31-50.
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P.G. Koullapis, P. Hofemeier, J. Sznitman & S.C. Kassinos. (2018) An efficient computational fluid-particle dynamics method to predict deposition in a simplified approximation of the deep lung. European Journal of Pharmaceutical Sciences 113, pages 132-144.
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Frantisek Lizal, Jan Jedelsky, Kaye Morgan, Katrin Bauer, Jordi Llop, Unai Cossio, Stavros Kassinos, Sylvia Verbanck, Jesús Ruiz-Cabello, Arnoldo Santos, Edmund Koch & Christian Schnabel. (2018) Experimental methods for flow and aerosol measurements in human airways and their replicas. European Journal of Pharmaceutical Sciences 113, pages 95-131.
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P. Worth Longest & Michael Hindle. (2017) Small Airway Absorption and Microdosimetry of Inhaled Corticosteroid Particles after Deposition. Pharmaceutical Research 34:10, pages 2049-2065.
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Andrey Golov, Sergey Simakov, Yan Soe, Roman Pryamonosov, Ospan Mynbaev & Alexander Kholodov. (2017) Multiscale CT-Based Computational Modeling of Alveolar Gas Exchange during Artificial Lung Ventilation, Cluster (Biot) and Periodic (Cheyne-Stokes) Breathings and Bronchial Asthma Attack. Computation 5:4, pages 11.
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P. Worth LongestGeng TianNavvab Khajeh-Hosseini-DalasmMichael Hindle. (2016) Validating Whole-Airway CFD Predictions of DPI Aerosol Deposition at Multiple Flow Rates. Journal of Aerosol Medicine and Pulmonary Drug Delivery 29:6, pages 461-481.
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Renishkumar R. DelvadiaXiangyin WeiP. Worth LongestJurgen VenitzPeter R. Byron. (2016) In Vitro Tests for Aerosol Deposition. IV: Simulating Variations in Human Breath Profiles for Realistic DPI Testing . Journal of Aerosol Medicine and Pulmonary Drug Delivery 29:2, pages 196-206.
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Ross L. Walenga & P. Worth Longest. (2016) Current Inhalers Deliver Very Small Doses to the Lower Tracheobronchial Airways: Assessment of Healthy and Constricted Lungs. Journal of Pharmaceutical Sciences 105:1, pages 147-159.
Crossref
Geng Tian, Michael Hindle, Sau Lee & P. Worth Longest. (2015) Validating CFD Predictions of Pharmaceutical Aerosol Deposition with In Vivo Data. Pharmaceutical Research 32:10, pages 3170-3187.
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Ana Fern?ndez Tena & Pere Casan Clar?. (2015) Aplicaciones de la din?mica de fluidos computacional a la neumolog?a. Archivos de Bronconeumolog?a 51:6, pages 293-298.
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Ana Fern?ndez Tena & Pere Casan Clar?. (2015) Use of Computational Fluid Dynamics in Respiratory Medicine. Archivos de Bronconeumolog?a (English Edition) 51:6, pages 293-298.
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Navvab Khajeh-Hosseini-Dalasm & P. Worth Longest. (2015) Deposition of particles in the alveolar airways: Inhalation and breath-hold with pharmaceutical aerosols. Journal of Aerosol Science 79, pages 15-30.
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P. Worth Longest & Geng Tian. (2014) Development of a New Technique for the Efficient Delivery of Aerosolized Medications to Infants on Mechanical Ventilation. Pharmaceutical Research 32:1, pages 321-336.
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Nicholas B. CarrigyConor A. RuzyckiLaleh GolshahiWarren H. Finlay. (2014) Pediatric In Vitro and In Silico Models of Deposition via Oral and Nasal Inhalation . Journal of Aerosol Medicine and Pulmonary Drug Delivery 27:3, pages 149-169.
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Geng TianP. Worth LongestXiang LiMichael Hindle. (2013) Targeting Aerosol Deposition to and Within the Lung Airways Using Excipient Enhanced Growth. Journal of Aerosol Medicine and Pulmonary Drug Delivery 26:5, pages 248-265.
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Landon T. Holbrook & P. Worth Longest. (2013) Validating CFD predictions of highly localized aerosol deposition in airway models: In vitro data and effects of surface properties. Journal of Aerosol Science 59, pages 6-21.
Crossref

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