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Aerosol Science and Technology Volume 48, 2014 - Issue 4
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Original Articles

Targeted Lung Delivery of Nasally Administered Aerosols

Geng Tian Department of Mechanical and Nuclear Engineering, Virginia Commonwealth University, Richmond, Virginia, USA
,
Michael Hindle Department of Pharmaceutics, Virginia Commonwealth University, Richmond, Virginia, USA
&
P. Worth Longest Department of Mechanical and Nuclear Engineering, Virginia Commonwealth University, Richmond, Virginia, USA; Department of Pharmaceutics, Virginia Commonwealth University, Richmond, Virginia, USA
Pages 434-449 | Received 15 Aug 2013, Accepted 07 Jan 2014, Published online: 24 Feb 2014

Citations (29)

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Read on this site (4)

Shantanu Vachhani & Clement Kleinstreuer. (2021) Numerical analysis of enhanced nano-drug delivery to the olfactory bulb. Aerosol Science and Technology 55:12, pages 1343-1358.
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P. Worth Longest, Karl Bass, Rabijit Dutta, Vijaya Rani, Morgan L. Thomas, Ahmad El-Achwah & Michael Hindle. (2019) Use of computational fluid dynamics deposition modeling in respiratory drug delivery. Expert Opinion on Drug Delivery 16:1, pages 7-26.
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Morteza Yousefi, Kiao Inthavong & Jiyuan Tu. (2015) Microparticle Transport and Deposition in the Human Oral Airway: Toward the Smart Spacer. Aerosol Science and Technology 49:11, pages 1109-1120.
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A.F. Tena, J.F. Francos, E. Álvarez & P. Casan. (2015) A three dimensional in SILICO model for the simulation of inspiratory and expiratory airflow in humans. Engineering Applications of Computational Fluid Mechanics 9:1, pages 187-198.
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Articles from other publishers (25)

Taha Sadeghi, Pedram Fatehi & Leila Pakzad. (2024) Effect of Nasal Inhalation on Drug Particle Deposition and Size Distribution in the Upper Airway: With Soft Mist Inhalers. Annals of Biomedical Engineering 52:5, pages 1195-1212.
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Marc Mac Giolla Eain & Ronan MacLoughlin. (2023) In-Line Aerosol Therapy via Nasal Cannula during Adult and Paediatric Normal, Obstructive, and Restrictive Breathing. Pharmaceutics 15:12, pages 2679.
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Ghali Aladwani, Mohammad A.M. Momin, Benjamin Spence, Dale R. Farkas, Serena Bonasera, Amr Hassan, Michael Hindle & Worth Longest. (2023) Effects of different mesh nebulizer sources on the dispersion of powder formulations produced with a new small-particle spray dryer. International Journal of Pharmaceutics 642, pages 123138.
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Cecilia Calabrese, Anna Annunziata, Domenica Francesca Mariniello, Valentino Allocca, Pasquale Imitazione, Rosa Cauteruccio, Francesca Simioli & Giuseppe Fiorentino. (2023) Aerosol delivery through high-flow nasal therapy: Technical issues and clinical benefits. Frontiers in Medicine 9.
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Benjamin M. Spence, Worth Longest, Rabijit Dutta, Mohammad A. M. Momin, Sarah Strickler & Michael Hindle. (2022) In Vitro Evaluation of Nebulized Pharmaceutical Aerosol Delivery to the Lungs Using a New Heated Dryer System (HDS). AAPS PharmSciTech 24:1.
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Vivek P. Chavda, Gargi Jogi, Nirav Shah, Mansi N. Athalye, Nirav Bamaniya, Lalitkumar K Vora & Ana Cláudia Paiva-Santos. (2022) Advanced particulate carrier-mediated technologies for nasal drug delivery. Journal of Drug Delivery Science and Technology 74, pages 103569.
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Connor Howe, Mohammad A.M. Momin, Dale R. Farkas, Serena Bonasera, Michael Hindle & P. Worth Longest. (2021) Advancement of the Infant Air-Jet Dry Powder Inhaler (DPI): Evaluation of Different Positive-Pressure Air Sources and Flow Rates. Pharmaceutical Research 38:9, pages 1615-1632.
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Karl Bass, Dale Farkas, Amr Hassan, Serena Bonasera, Michael Hindle & P. Worth Longest. (2021) High-efficiency dry powder aerosol delivery to children: Review and application of new technologies. Journal of Aerosol Science 153, pages 105692.
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Connor HoweMichael HindleSerena BonaseraVijaya RaniP. Worth Longest. (2021) Initial Development of an Air-Jet Dry Powder Inhaler for Rapid Delivery of Pharmaceutical Aerosols to Infants. Journal of Aerosol Medicine and Pulmonary Drug Delivery 34:1, pages 57-70.
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Frantisek Lizal, Jakub Elcner, Jan Jedelsky, Milan Maly, Miroslav Jicha, Árpád Farkas, Miloslav Belka, Zdenek Rehak, Jan Adam, Adam Brinek, Jakub Laznovsky, Tomas Zikmund & Jozef Kaiser. (2020) The effect of oral and nasal breathing on the deposition of inhaled particles in upper and tracheobronchial airways. Journal of Aerosol Science 150, pages 105649.
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Rabijit Dutta, Benjamin Spence, Xiangyin Wei, Sneha Dhapare, Michael Hindle & P. Worth Longest. (2020) CFD Guided Optimization of Nose-to-Lung Aerosol Delivery in Adults: Effects of Inhalation Waveforms and Synchronized Aerosol Delivery. Pharmaceutical Research 37:10.
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Dale FarkasMichael HindleSerena BonaseraKarl BassWorth Longest. (2020) Development of an Inline Dry Powder Inhaler for Oral or Trans-Nasal Aerosol Administration to Children. Journal of Aerosol Medicine and Pulmonary Drug Delivery 33:2, pages 83-98.
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Alexander Ishmatov. (2020) Influence of weather and seasonal variations in temperature and humidity on supersaturation and enhanced deposition of submicron aerosols in the human respiratory tract. Atmospheric Environment 223, pages 117226.
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Worth LongestBenjamin SpenceMichael Hindle. (2019) Devices for Improved Delivery of Nebulized Pharmaceutical Aerosols to the Lungs. Journal of Aerosol Medicine and Pulmonary Drug Delivery 32:5, pages 317-339.
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Benjamin M. SpenceWorth LongestXiangyin WeiSneha DhapareMichael Hindle. (2019) Development of a High-Flow Nasal Cannula and Pharmaceutical Aerosol Combination Device. Journal of Aerosol Medicine and Pulmonary Drug Delivery 32:4, pages 224-241.
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Mohamed E. A. Abdelrahim. (2018) Aerosol Delivery to a Critically Ill Patient: A Big Issue Easily Solved by Developing Guidelines. Pulmonary Therapy 4:2, pages 125-133.
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Dale Farkas, Michael Hindle & P. Worth Longest. (2018) Efficient Nose-to-Lung Aerosol Delivery with an Inline DPI Requiring Low Actuation Air Volume. Pharmaceutical Research 35:10.
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Dale Farkas, Michael Hindle & P. Worth Longest. (2018) Application of an inline dry powder inhaler to deliver high dose pharmaceutical aerosols during low flow nasal cannula therapy. International Journal of Pharmaceutics 546:1-2, pages 1-9.
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P. Worth Longest & Michael Hindle. (2017) Small Airway Absorption and Microdosimetry of Inhaled Corticosteroid Particles after Deposition. Pharmaceutical Research 34:10, pages 2049-2065.
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Arun V. Kolanjiyil, Clement Kleinstreuer & Ruxana T. Sadikot. (2017) Computationally efficient analysis of particle transport and deposition in a human whole-lung-airway model. Part II: Dry powder inhaler application. Computers in Biology and Medicine 84, pages 247-253.
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Xiaole Chen, Yu Feng, Wenqi Zhong & Clement Kleinstreuer. (2017) Numerical investigation of the interaction, transport and deposition of multicomponent droplets in a simple mouth-throat model. Journal of Aerosol Science 105, pages 108-127.
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P. Worth LongestGeng TianNavvab Khajeh-Hosseini-DalasmMichael Hindle. (2016) Validating Whole-Airway CFD Predictions of DPI Aerosol Deposition at Multiple Flow Rates. Journal of Aerosol Medicine and Pulmonary Drug Delivery 29:6, pages 461-481.
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Atul Nayak, Ololade Olatunji, Diganta Bhusan Das & Goran Vladisavljević. 2016. Natural Polymers. Natural Polymers 263 313 .
Geng Tian, Michael Hindle, Sau Lee & P. Worth Longest. (2015) Validating CFD Predictions of Pharmaceutical Aerosol Deposition with In Vivo Data. Pharmaceutical Research 32:10, pages 3170-3187.
Crossref
P. Worth LongestLaleh GolshahiSrinivas R.B. BeharaGeng TianDale R. FarkasMichael Hindle. (2015) Efficient Nose-to-Lung (N2L) Aerosol Delivery with a Dry Powder Inhaler. Journal of Aerosol Medicine and Pulmonary Drug Delivery 28:3, pages 189-201.
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