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Original Articles

Lung Deposition and Clearance of Pharmaceutical Aerosols: What Can Be Learned from Inhalation Toxicology and Industrial Hygiene?

Pages 290-304 | Published online: 11 Jun 2007

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (5)

Mohammad A. M. Momin, Shubhra Sinha, Ian G. Tucker & Shyamal C. Das. (2019) Carrier-free combination dry powder inhaler formulation of ethionamide and moxifloxacin for treating drug-resistant tuberculosis. Drug Development and Industrial Pharmacy 45:8, pages 1321-1331.
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E.M. Littringer, S. Zellnitz, K. Hammernik, V. Adamer, H. Friedl & N.A. Urbanetz. (2013) Spray Drying of Aqueous Salbutamol Sulfate Solutions Using the Nano Spray Dryer B-90—The Impact of Process Parameters on Particle Size. Drying Technology 31:12, pages 1346-1353.
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Zhen Xu, HeidiM. Mansour & AnthonyJ. Hickey. (2011) Particle Interactions in Dry Powder Inhaler Unit Processes: A Review. Journal of Adhesion Science and Technology 25:4-5, pages 451-482.
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Heidi M Mansour, Yun-Seok Rhee & Xiao Wu. (2009) Nanomedicine in pulmonary delivery. International Journal of Nanomedicine 4, pages 299-319.
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Hao-Ying Li, Helen Neill, Rebecca Innocent, Peter Seville, Ian Williamson & James C. Birchall. (2003) Enhanced Dispersibility and Deposition of Spray-dried Powders for Pulmonary Gene Therapy. Journal of Drug Targeting 11:7, pages 425-432.
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Articles from other publishers (20)

Mahmoud H. Abu Elella, Arwa Omar Al Khatib & Hisham Al-Obaidi. (2024) Spray-Dried Nanolipid Powders for Pulmonary Drug Delivery: A Comprehensive Mini Review. Pharmaceutics 16:5, pages 680.
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Arwa Omar Al Khatib, Mohamed El-Tanani & Hisham Al-Obaidi. (2023) Inhaled Medicines for Targeting Non-Small Cell Lung Cancer. Pharmaceutics 15:12, pages 2777.
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Anthony J. Hickey. (2023) Dry Powder Inhalers: An Overview. Journal of Aerosol Medicine and Pulmonary Drug Delivery 36:6, pages 316-323.
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Barbara Rothen-Rutishauser, Matthew Gibb, Ruiwen He, Alke Petri-Fink & Christie M. Sayes. (2023) Human lung cell models to study aerosol delivery – considerations for model design and development. European Journal of Pharmaceutical Sciences 180, pages 106337.
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Mohammad A. M. Momin, Bishal Raj Adhikari, Shubhra Sinha, Ian Larson & Shyamal C. Das. (2021) Roflumilast Powders for Chronic Obstructive Pulmonary Disease: Formulation Design and the Influence of Device, Inhalation Flow Rate, and Storage Relative Humidity on Aerosolization. Pharmaceutics 13:8, pages 1254.
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S. Lakshmipriya, S. Bhuvaneswari & R. Rajiev. (2021) Survey on the anticipation of an industrial hygienist. Materials Today: Proceedings 45, pages 1446-1450.
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Mohammad A.M. Momin, Ian G. Tucker, Colin S. Doyle, John A. Denman & Shyamal C. Das. (2018) Manipulation of spray-drying conditions to develop dry powder particles with surfaces enriched in hydrophobic material to achieve high aerosolization of a hygroscopic drug. International Journal of Pharmaceutics 543:1-2, pages 318-327.
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Anthony J. Hickey. (2018) Complexity in Pharmaceutical Powders for Inhalation: A perspective. KONA Powder and Particle Journal 35:0, pages 3-13.
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Anthony J. Hickey. 2018. Inhaled Pharmaceutical Product Development Perspectives. Inhaled Pharmaceutical Product Development Perspectives 1 14 .
Anthony J. Hickey. 2018. Particles and Nanoparticles in Pharmaceutical Products. Particles and Nanoparticles in Pharmaceutical Products 213 232 .
Mohammad A.M. Momin, Shubhra Sinha, Ian G. Tucker, Colin Doyle & Shyamal C. Das. (2017) Dry powder formulation of kanamycin with enhanced aerosolization efficiency for drug-resistant tuberculosis. International Journal of Pharmaceutics 528:1-2, pages 107-117.
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Mathias Mönckedieck, Jens Kamplade, Eva Maria Littringer, Axel Mescher, Srikanth Gopireddy, Mats Hertel, Eva Gutheil, Peter Walzel, Nora Anne Urbanetz, Martin Köster, Hartwig Steckel & Regina Scherließ. 2016. Process-Spray. Process-Spray 517 566 .
Anita Pomázi, Francesca Buttini, Rita Ambrus, Paolo Colombo & Piroska Szabó-Révész. (2013) Effect of polymers for aerolization properties of mannitol-based microcomposites containing meloxicam. European Polymer Journal 49:9, pages 2518-2527.
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E.M. Littringer, R. Paus, A. Mescher, H. Schroettner, P. Walzel & N.A. Urbanetz. (2013) The morphology of spray dried mannitol particles — The vital importance of droplet size. Powder Technology 239, pages 162-174.
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E.M. Littringer, A. Mescher, H. Schroettner, L. Achelis, P. Walzel & N.A. Urbanetz. (2012) Spray dried mannitol carrier particles with tailored surface properties – The influence of carrier surface roughness and shape. European Journal of Pharmaceutics and Biopharmaceutics 82:1, pages 194-204.
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Kimberly A Foster, Mehran Yazdanian & Kenneth L Audus. (2001) Microparticulate uptake mechanisms of in-vitro cell culture models of the respiratory epithelium. Journal of Pharmacy and Pharmacology 53:1, pages 57-66.
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Anthony Hickey & Heidi Mansour. 2008. Modified-Release Drug Delivery Technology, Second Edition. Modified-Release Drug Delivery Technology, Second Edition 573 601 .
Ya-Ping SunPeter York, Srinivas Palakodaty, Andreas Kordikowski & Raymond Sloan. 2002. Supercritical Fluid Technology in Materials Science and Engineering. Supercritical Fluid Technology in Materials Science and Engineering.
Michael H. Peters & Sumanta K. Pal. (1997) Brownian Particle Adsorption in Unsteady-State Viscous Flows in Pores. Journal of Colloid and Interface Science 186:2, pages 477-492.
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Lwandiko E. Masinde & Anthony J. Hickey. (1993) Aerosolized aqueous suspensions of poly(L-lactic acid) microspheres. International Journal of Pharmaceutics 100:1-3, pages 123-131.
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