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Original Articles

How LSD Originated

Pages 53-60 | Published online: 18 Jan 2012

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (4)

Rui Filipe Libânio Osório Marta. (2019) Metabolism of lysergic acid diethylamide (LSD): an update. Drug Metabolism Reviews 51:3, pages 378-387.
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David E. Smith. (2019) The Role of the Journal of Psychedelic Drugs in the Evolution of Psychedelic Medicine. Journal of Psychoactive Drugs 51:2, pages 98-101.
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Albert Garcia-Romeu & William A. Richards. (2018) Current perspectives on psychedelic therapy: use of serotonergic hallucinogens in clinical interventions. International Review of Psychiatry 30:4, pages 291-316.
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Simon L. Hill & Simon H. L. Thomas. (2011) Clinical toxicology of newer recreational drugs. Clinical Toxicology 49:8, pages 705-719.
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Articles from other publishers (60)

Adam Wojtas. (2023) The possible place for psychedelics in pharmacotherapy of mental disorders. Pharmacological Reports 75:6, pages 1313-1325.
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Agnieszka Wsół. (2023) Cardiovascular safety of psychedelic medicine: current status and future directions. Pharmacological Reports 75:6, pages 1362-1380.
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Andrew A. BolingerNoelle C. AnastasioKathryn A. CunninghamJia Zhou. 2023. 2023 Medicinal Chemistry Reviews. 2023 Medicinal Chemistry Reviews 53 81 .
Christiane Martins de Vasconcellos Silveira, Vanessa Farelo dos Santos, Isis Moraes Ornelas, Beatriz de Sá Carrilho, Matheus Antonio Vieira de Castro Ventura, Henrique Marcelo Gualberto Pereira, Stevens Kastrup Rehen & Magno Junqueira. (2023) Systematic characterization of Lysergic Acid Diethylamide metabolites in Caenorhabditis elegans by ultra-high performance liquid chromatography coupled with high-resolution tandem mass spectrometry. Journal of Chromatography A 1708, pages 464362.
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Rabeet Tariq. (2023) Using Psychedelics in Clinical Practice: Comparing Therapeutic Uses and Potential Harms. Current Reviews in Clinical and Experimental Pharmacology 18:2, pages 94-109.
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Gavin P. Schmitz & Bryan L. Roth. (2023) G protein-coupled receptors as targets for transformative neuropsychiatric therapeutics. American Journal of Physiology-Cell Physiology 325:1, pages C17-C28.
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Oliver G. Bosch, Simon Halm & Erich Seifritz. (2022) Psychedelics in the treatment of unipolar and bipolar depression. International Journal of Bipolar Disorders 10:1.
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Lauren Johansen, Paul Liknaitzky, Maja Nedeljkovic, Lisa Mastin-Purcell & Greg Murray. (2022) The psychological processes of classic psychedelics in the treatment of depression: a systematic review protocol. Systematic Reviews 11:1.
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Ayse Ceren Kaypak & Amir Raz. (2022) Macrodosing to microdosing with psychedelics: Clinical, social, and cultural perspectives. Transcultural Psychiatry 59:5, pages 665-674.
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Can Cao, Ximena Barros-Álvarez, Shicheng Zhang, Kuglae Kim, Marc A. Dämgen, Ouliana Panova, Carl-Mikael Suomivuori, Jonathan F. Fay, Xiaofang Zhong, Brian E. Krumm, Ryan H. Gumpper, Alpay B. Seven, Michael J. Robertson, Nevan J. Krogan, Ruth Hüttenhain, David E. Nichols, Ron O. Dror, Georgios Skiniotis & Bryan L. Roth. (2022) Signaling snapshots of a serotonin receptor activated by the prototypical psychedelic LSD. Neuron 110:19, pages 3154-3167.e7.
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Fúlvio Rieli Mendes, Cristiane dos Santos Costa, Victor Distefano Wiltenburg, Gabriela Morales-Lima, João Ariel Bonar Fernandes & Renato Filev. (2022) Classic and non‐classic psychedelics for substance use disorder: A review of their historic, past and current research. Addiction Neuroscience 3, pages 100025.
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Alaina M. Jaster, Mario de la Fuente Revenga & Javier González‐Maeso. (2021) Molecular targets of psychedelic‐induced plasticity. Journal of Neurochemistry 162:1, pages 80-88.
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V. L. Matrenitsky. (2022) РЕНЕСАНС ПСИХОДЕЛІЧНОЇ ТЕРАПІЇ ТА ЇЇ ЗНАЧЕННЯ ДЛЯ УКРАЇНИ. Likarska sprava:3-4, pages 37-59.
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Tristan D. McClure-Begley & Bryan L. Roth. (2022) The promises and perils of psychedelic pharmacology for psychiatry. Nature Reviews Drug Discovery 21:6, pages 463-473.
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Timothy Lawn, Ottavia Dipasquale, Alexandros Vamvakas, Ioannis Tsougos, Mitul A. Mehta & Matthew A. Howard. (2022) Differential contributions of serotonergic and dopaminergic functional connectivity to the phenomenology of LSD. Psychopharmacology 239:6, pages 1797-1808.
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Timothy Andrews & Katie Wright. (2022) The frontiers of new psychedelic therapies: A survey of sociological themes and issues. Sociology Compass 16:2.
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Wm Maurice Redden, Saif-Ur-Rahman Paracha & Quratulanne Sheheryar. (2022) Hallucinogen Use and Misuse in Older Adults. Clinics in Geriatric Medicine 38:1, pages 55-66.
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Kacper Lukasiewicz, Jacob J. Baker, Yi Zuo & Ju Lu. (2021) Serotonergic Psychedelics in Neural Plasticity. Frontiers in Molecular Neuroscience 14.
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Johannes G Ramaekers, Nadia Hutten, Natasha L Mason, Patrick Dolder, Eef L Theunissen, Friederike Holze, Matthias E Liechti, Amanda Feilding & Kim PC Kuypers. (2020) A low dose of lysergic acid diethylamide decreases pain perception in healthy volunteers. Journal of Psychopharmacology 35:4, pages 398-405.
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Nicole L. Galvão-Coelho, Wolfgang Marx, Maria Gonzalez, Justin Sinclair, Michael de Manincor, Daniel Perkins & Jerome Sarris. (2021) Classic serotonergic psychedelics for mood and depressive symptoms: a meta-analysis of mood disorder patients and healthy participants. Psychopharmacology 238:2, pages 341-354.
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Antonio Inserra, Danilo De Gregorio & Gabriella Gobbi. (2020) Psychedelics in Psychiatry: Neuroplastic, Immunomodulatory, and Neurotransmitter Mechanisms. Pharmacological Reviews 73:1, pages 202-277.
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Inés Ibarra-Lecue, Rebeca Diez-Alarcia & Leyre Urigüen. 2021. 5-HT Interaction with Other Neurotransmitters: Experimental Evidence and Therapeutic Relevance - Part A. 5-HT Interaction with Other Neurotransmitters: Experimental Evidence and Therapeutic Relevance - Part A 135 175 .
Fernanda Palhano-Fontes, Sérgio Mota-Rolim, Bruno Lobão-Soares, Nicole Galvão-Coelho, Joao Paulo Maia-Oliveira & Dráulio B. Araújo. 2021. Ayahuasca Healing and Science. Ayahuasca Healing and Science 21 41 .
Daniel Hoyer. (2020) Targeting the 5-HT system: Potential side effects. Neuropharmacology 179, pages 108233.
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Rachel A. Caplan, Jonah P. Zuflacht, Jed A. Barash & Corey R. Fehnel. (2020) Neurotoxicology Syndromes Associated with Drugs of Abuse. Neurologic Clinics 38:4, pages 983-996.
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Adam L. Halberstadt, Muhammad Chatha, Adam K. Klein, John D. McCorvy, Markus R. Meyer, Lea Wagmann, Alexander Stratford & Simon D. Brandt. (2020) Pharmacological and biotransformation studies of 1-acyl-substituted derivatives of -lysergic acid diethylamide (LSD). Neuropharmacology 172, pages 107856.
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Nurul Alyani Zainol Abidin, Faridah Kormin, Nurul Akhma Zainol Abidin, Nor Aini Fatihah Mohamed Anuar & Mohd Fadzelly Abu Bakar. (2020) The Potential of Insects as Alternative Sources of Chitin: An Overview on the Chemical Method of Extraction from Various Sources. International Journal of Molecular Sciences 21:14, pages 4978.
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David J. Heal, Jack Henningfield, Bruno G. Frenguelli, David J. Nutt & Sharon L. Smith. (2018) Psychedelics – Re-opening the doors of perception. Neuropharmacology 142, pages 1-6.
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Mark F. Bear, Barry W. Connors & Michael A. ParadisoMark F. Bear, Barry W. Connors & Michael A. Paradiso. 2018. Neurowissenschaften. Neurowissenschaften 559 589 .
José L. Moreno & Javier González-Maeso. 2018. 5-HT2A Receptors in the Central Nervous System. 5-HT2A Receptors in the Central Nervous System 147 189 .
Michael P. Bogenschutz & Alyssa A. Forcehimes. (2016) Development of a Psychotherapeutic Model for Psilocybin-Assisted Treatment of Alcoholism. Journal of Humanistic Psychology 57:4, pages 389-414.
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Qiuyan Chen & John J.G. Tesmer. (2017) A Receptor on Acid. Cell 168:3, pages 339-341.
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Daniel Wacker, Sheng Wang, John D. McCorvy, Robin M. Betz, A.J. Venkatakrishnan, Anat Levit, Katherine Lansu, Zachary L. Schools, Tao Che, David E. Nichols, Brian K. Shoichet, Ron O. Dror & Bryan L. Roth. (2017) Crystal Structure of an LSD-Bound Human Serotonin Receptor. Cell 168:3, pages 377-389.e12.
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Juan F. López-Giménez & Javier González-Maeso. 2018. Behavioral Neurobiology of Psychedelic Drugs. Behavioral Neurobiology of Psychedelic Drugs 45 73 .
Hermann A.M. Mucke. (2016) From Psychiatry to Flower Power and Back Again: The Amazing Story of Lysergic Acid Diethylamide. ASSAY and Drug Development Technologies 14:5, pages 276-281.
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David E. Nichols. (2016) Psychedelics. Pharmacological Reviews 68:2, pages 264-355.
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Monica F. Tomlinson, Matthew Brown & Peter N.S. Hoaken. (2016) Recreational drug use and human aggressive behavior: A comprehensive review since 2003. Aggression and Violent Behavior 27, pages 9-29.
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Michael P. Bogenschutz & Matthew W. Johnson. (2016) Classic hallucinogens in the treatment of addictions. Progress in Neuro-Psychopharmacology and Biological Psychiatry 64, pages 250-258.
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Charles D. Nichols. 2016. Neuropathology of Drug Addictions and Substance Misuse. Neuropathology of Drug Addictions and Substance Misuse 859 865 .
Mitsumasa Kurita, Aintzane García-Bea & Javier González-Maeso. 2016. The Medical Basis of Psychiatry. The Medical Basis of Psychiatry 601 654 .
Michael P. Bogenschutz & Stephen Ross. 2018. Behavioral Neurobiology of Psychedelic Drugs. Behavioral Neurobiology of Psychedelic Drugs 361 391 .
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Daniel Hoyer. 2015. Antitargets and Drug Safety. Antitargets and Drug Safety 57 80 .
Peter Gasser, Dominique Holstein, Yvonne Michel, Rick Doblin, Berra Yazar-Klosinski, Torsten Passie & Rudolf Brenneisen. (2014) Safety and Efficacy of Lysergic Acid Diethylamide-Assisted Psychotherapy for Anxiety Associated With Life-threatening Diseases. Journal of Nervous & Mental Disease 202:7, pages 513-520.
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Ryan H.A. Chan & John E. Mendelson. 2014. The Effects of Drug Abuse on the Human Nervous System. The Effects of Drug Abuse on the Human Nervous System 533 552 .
Warunya Arunotayanun, Jeffrey W. Dalley, Xi-Ping Huang, Vincent Setola, Ric Treble, Leslie Iversen, Bryan L. Roth & Simon Gibbons. (2013) An analysis of the synthetic tryptamines AMT and 5-MeO-DALT: Emerging ‘Novel Psychoactive Drugs’. Bioorganic & Medicinal Chemistry Letters 23:11, pages 3411-3415.
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Danuta Marona-Lewicka, Charles D. Nichols & David E. Nichols. (2011) An animal model of schizophrenia based on chronic LSD administration: Old idea, new results. Neuropharmacology 61:3, pages 503-512.
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Katherine M. Prevatt-Smith & Thomas E. Prisinzano. (2010) New therapeutic potential for psychoactive natural products. Nat. Prod. Rep. 27:1, pages 23-31.
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A R Green. (2008) Gaddum and LSD: the birth and growth of experimental and clinical neuropharmacology research on 5-HT in the UK. British Journal of Pharmacology 154:8, pages 1583-1599.
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Danuta Marona-Lewicka & David E. Nichols. (2007) Further evidence that the delayed temporal dopaminergic effects of LSD are mediated by a mechanism different than the first temporal phase of action. Pharmacology Biochemistry and Behavior 87:4, pages 453-461.
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John C.M. Brust. 2004. Neurological Aspects of Substance Abuse. Neurological Aspects of Substance Abuse 259 274 .
Can Cao, Ximena Barros-Álvarez, Shicheng Zhang, Kuglae Kim, Marc A. Dämgen, Ouliana Panova, Carl-Mikael Suomivuori, Jonathan Fay, Xiaofang Zhong, Brian E. Krumm, Ryan H. Gumpper, Alpay B. Seven, Michael J. Robertson, Nevan J. Krogan, Ruth Hüttenhain, David E. Nichols, Ron O. Dror, Georgios Skiniotis & Bryan Roth. (2022) Signaling Snapshots of 5-HT <sub>2B</sub>R Activated by the Prototypical Psychedelic LSD. SSRN Electronic Journal.
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