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Original Articles

Optimizing Response to Methadone Maintenance Treatment: Use of Higher-Dose Methadone

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Pages 95-102 | Published online: 23 Jan 2012

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (19)

Ruzmayuddin Mamat, Nor Afiqah Ahmad Nasrulddin & Nursazreen Amalina Mohamad Yusoff. (2020) Continued Use of Illicit Substance among Methadone Treatment Patients in Primary Health Care Clinics in East Coast Region of Malaysia. Alcoholism Treatment Quarterly 38:2, pages 184-198.
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Maurice Dematteis, Marc Auriacombe, Oscar D’Agnone, Lorenzo Somaini, Néstor Szerman, Richard Littlewood, Farrukh Alam, Hannu Alho, Amine Benyamina, Julio Bobes, Jean Pierre Daulouede, Claudio Leonardi, Icro Maremmani, Marta Torrens, Stephan Walcher & Michael Soyka. (2017) Recommendations for buprenorphine and methadone therapy in opioid use disorder: a European consensus. Expert Opinion on Pharmacotherapy 18:18, pages 1987-1999.
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Rui Luo, Xingyuan Li, Shasha Qin, Zhenzhou Luo, Xi Luo, Peiwu Hu, Zhisheng Liu, Xiangling Feng & Xingli Li. (2017) Impact of SNP–SNP Interaction Among ABCB1, ARRB2, DRD1 and OPRD1 on Methadone Dosage Requirement in Han Chinese Patients. Pharmacogenomics 18:18, pages 1659-1670.
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Steven L. Proctor, Amy L. Copeland, Albert M. Kopak, Norman G. Hoffmann, Philip L. Herschman & Nadiya Polukhina. (2016) Outcome predictors for patients receiving methadone maintenance treatment: findings from a retrospective multi-site study. Journal of Substance Use 21:6, pages 601-613.
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Hui-Ju Tsai, Sheng-Chang Wang, Sheng-Wen Liu, Ing-Kang Ho, Yao-Sheng Chang, Yu-Ting Tsai, Keh-Ming Lin & Yu-Li Liu. (2014) Assessment of CYP450 Genetic Variability Effect on Methadone Dose and Tolerance. Pharmacogenomics 15:7, pages 977-986.
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Natalie M. Latuga & Robert G. Wahler. (2013) Very-High-Dose Methadone With Minimal Toxicity and Inadequate Pain Control in a Hospice Patient With Cancer. Journal of Pain & Palliative Care Pharmacotherapy 27:2, pages 143-149.
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Ayman Fareed, Sreedevi Vayalapalli, Steven Stout, Jennifer Casarella, Karen Drexler & StephenP. Bailey. (2010) Effect of Methadone Maintenance Treatment on Heroin Craving, a Literature Review. Journal of Addictive Diseases 30:1, pages 27-38.
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Mary Jeanne Kreek, Lisa Borg, Elizabeth Ducat & Brenda Ray. (2010) Pharmacotherapy in the Treatment of Addiction: Methadone. Journal of Addictive Diseases 29:2, pages 200-216.
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Ayman Fareed, Jennifer Casarella, Richard Amar, Sreedevi Vayalapalli & Karen Drexler. (2010) Methadone Maintenance Dosing Guideline for Opioid Dependence, a Literature Review. Journal of Addictive Diseases 29:1, pages 1-14.
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Debra F. Hobbins. (2010) Case Report: Methadone Maintenance Dose of 1200 mg/day in an Ultra-rapid Metabolizer. Journal of Addictions Nursing 21:1, pages 22-36.
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Ayman Fareed, Jennifer Casarella, Mary Roberts, Mary Sleboda, Richard Amar, Shreedevi Vayalapalli & Karen Drexler. (2009) High Dose versus Moderate Dose Methadone Maintenance: Is There a Better Outcome?. Journal of Addictive Diseases 28:4, pages 399-405.
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Angela L Stotts, Carrie L Dodrill & Thomas R Kosten. (2009) Opioid dependence treatment: options in pharmacotherapy. Expert Opinion on Pharmacotherapy 10:11, pages 1727-1740.
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Erin Cummins & Francesco Leri. (2009) Animal studies trigger new insights on the use of methadone maintenance. Expert Opinion on Drug Discovery 4:5, pages 577-586.
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Miriam Adelson, Einat Peles, Gershon Bodner & Mary Jeanne Kreek. (2007) Correlation Between High Methadone Doses and Methadone Serum Levels in Methadone Maintenance Treatment (MMT) Patients. Journal of Addictive Diseases 26:1, pages 15-26.
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Anne Pelet, Sebastien Doll, Thérèse Huissoud, Janine Resplendino, Jacques Besson & Bernard Favrat. (2007) Methadone Maintenance Treatment (MMT) in General Practice or in Specialized Centers: Profile of Patients in the Swiss Canton of Vaud. The American Journal of Drug and Alcohol Abuse 33:5, pages 665-674.
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PeterL. Tenore. (2005) DINO-VAMP. Journal of Maintenance in the Addictions 2:4, pages 29-44.
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C.B. Eap, C. Felder, K. Powell Golay & C. Uehlinger. (2003) Increase of Oral Methadone Dose in Methadone Injecting Patients. Journal of Addictive Diseases 22:3, pages 7-17.
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Sarz Maxwell & MarcS. Shinderman. (2002) Optimizing Long-Term Response to Methadone Maintenance Treatment. Journal of Addictive Diseases 21:3, pages 1-12.
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Richard Yoast, MichaelA. Williams, ScottD. Deitchman & HunterC. Champion. (2001) Report of the Council on Scientific Affairs. Journal of Addictive Diseases 20:2, pages 15-40.
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Articles from other publishers (33)

Aida Afghani, Emran M Razaghi, Reza Rastgoo Sisakht, Ali Farhoudian & Nasim Vousooghi. (2023) Serum Level of GDNF is Associated with Adherence to Methadone Maintenance Treatment. Archives of Neuroscience 10:3.
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Icro Maremmani, Matteo Pacini & Angelo G. I. MaremmaniIcro Maremmani, Matteo Pacini & Angelo G. I. Maremmani. 2023. Dual Disorder Heroin Addicts. Dual Disorder Heroin Addicts 183 195 .
En Chao, Chia-Chun Hung, Ching-Po Lin, Yi-Chien Jacob Ku, Qurat Ul Ain, David S. Metzger & Tony Szu-Hsien Lee. (2020) Adherence among HIV-positive injection drug users undergoing methadone treatment in Taiwan. BMC Psychiatry 20:1.
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Annabelle M Belcher, Thomas O Cole, Aaron D Greenblatt, Stephen W Hoag, David H Epstein, Michael Wagner, Amy S Billing, Ebonie Massey, Kristen R Hamilton, Zofia K Kozak, Christopher J Welsh, Eric Weintraub, Emerson M Wickwire, Eric D Wish, Ted J Kaptchuk & Luana Colloca. (2019) Open-label dose-extending placebos for opioid use disorder: a protocol for a randomised controlled clinical trial with methadone treatment. BMJ Open 9:6, pages e026604.
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Mehmet Sofuoglu, Elise E. DeVito & Kathleen M. Carroll. (2018) Pharmacological and Behavioral Treatment of Opioid Use Disorder. Psychiatric Research and Clinical Practice 1:1, pages 4-15.
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Sufang Peng, Haifeng Jiang, Jiang Du, Shuxing Lin, Shujun Pan, Shunying Yu & Min Zhao. (2018) Methadone Dosage and Plasma Levels, SNPs of OPRM1 Gene and Age of First Drug Use Were Associated With Outcomes of Methadone Maintenance Treatment. Frontiers in Genetics 9.
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Joan Trujols, Francisco González-Saiz, María José Manresa, Saul Alcaraz, Francesca Batlle, Santiago Duran-Sindreu & José Pérez de los Cobos. (2017) Patient perception of methadone dose adequacy in methadone maintenance treatment: The role of perceived participation in dosage decisions. Patient Education and Counseling 100:5, pages 981-986.
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Martha J. Bojko, Alyona Mazhnaya, Ruthanne Marcus, Iuliia Makarenko, Zahedul Islam, Sergey Filippovych, Sergii Dvoriak & Frederick L. Altice. (2016) The Future of Opioid Agonist Therapies in Ukraine: A Qualitative Assessment of Multilevel Barriers and Ways Forward to Promote Retention in Treatment. Journal of Substance Abuse Treatment 66, pages 37-47.
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Leslie Lappalainen, Seonaid Nolan, Sabina Dobrer, Cathy Puscas, Julio Montaner, Keith Ahamad, Huiru Dong, Thomas Kerr, Evan Wood & M.‐J. Milloy. (2015) Dose–response relationship between methadone dose and adherence to antiretroviral therapy among HIV‐positive people who use illicit opioids. Addiction 110:8, pages 1330-1339.
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Matteo Pacini, Angelo Giovanni Icro Maremmani, Mauro Ceccanti & Icro Maremmani. (2015) Former Heroin-Dependent Alcohol Use Disorder Patients. Prevalence, Addiction History and Clinical Features. Alcohol and Alcoholism 50:4, pages 451-457.
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Marcus Baumeister, Marc Vogel, Kenneth M Dürsteler-MacFarland, Urs Gerhard, Johannes Strasser, Marc Walter, Gerhard A Wiesbeck & Sylvie A Petitjean. (2014) Association between methadone dose and concomitant cocaine use in methadone maintenance treatment: a register-based study. Substance Abuse Treatment, Prevention, and Policy 9:1.
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Shiau Hui Diong, Nor Shuhadah Mohd Yusoff, Maw Shin Sim, Raja Elina Raja Aziddin, Zamri Chik, Poppy Rajan, Rusdi Abdul Rashid, Norliza Chemi & Zahurin Mohamed. (2014) Quantitation of Methadone and Metabolite in Patients under Maintenance Treatment. Journal of Analytical Toxicology 38:9, pages 660-666.
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Mohammad-Reza Shiran, Martin S. Lennard, Mohammad-Zafar Iqbal, Olawale Lagundoye, Nicholas Seivewright, Geoffrey T. Tucker & Amin Rostami-Hodjegan. (2012) Pharmacokinetic-Pharmacodynamic Modeling of Mood and Withdrawal Symptoms in Relation to Plasma Concentrations of Methadone in Patients Undergoing Methadone Maintenance Treatment. Journal of Clinical Psychopharmacology 32:5, pages 666-671.
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Shadi Nahvi, Alain H. Litwin, Moonseong Heo, Karina M. Berg, Xuan Li & Julia H. Arnsten. (2012) Directly observed antiretroviral therapy eliminates adverse effects of active drug use on adherence. Drug and Alcohol Dependence 120:1-3, pages 174-180.
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Francina Fonseca, Rafael de la Torre, Laura Díaz, Antonio Pastor, Elisabet Cuyàs, Nieves Pizarro, Olha Khymenets, Magí Farré & Marta Torrens. (2011) Contribution of Cytochrome P450 and ABCB1 Genetic Variability on Methadone Pharmacokinetics, Dose Requirements, and Response. PLoS ONE 6:5, pages e19527.
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Johannes Strasser, Gerhard A. Wiesbeck, Natalie Meier, Rudolf Stohler & Kenneth M. Dürsteler-MacFarland. (2010) Effects of a Single 50% Extra Dose of Methadone on Heroin Craving and Mood in Lower- Versus Higher-Dose Methadone Patients. Journal of Clinical Psychopharmacology 30:4, pages 450-454.
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Pertti Kalevi Heikman & Ilkka Antero Ojanperä. (2009) Inadequate Dose of Opioid-agonist Medication is Related to Misuse of Benzodiazepines. Addictive Disorders & Their Treatment 8:3, pages 145-153.
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Ayman Fareed, Jennifer Casarella, Richard Amar & Karen Drexler. (2009) Dose-Dependent Cognitive Impairment in an Elder Methadone-Maintained Patient. Journal of Addiction Medicine 3:2, pages 109-110.
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Ellen Tuchman & Ernest Drucker. (2008) Lessons Learned in OBOT: 3 Case Studies of Women who did not Succeed in Pharmacy-based Methadone Treatment. Addictive Disorders & Their Treatment 7:3, pages 129-141.
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Yongfang Li, Jean-Pierre Kantelip, Pauline Gerritsen-van Schieveen & Siamak Davani. (2012) Interindividual Variability of Methadone Response. Molecular Diagnosis & Therapy 12:2, pages 109-124.
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Francesco Leri, Robert E Sorge, Erin Cummins, David Woehrling, James G Pfaus & Jane Stewart. (2007) High-Dose Methadone Maintenance in Rats: Effects on Cocaine Self-Administration and Behavioral Side Effects. Neuropsychopharmacology 32:11, pages 2290-2300.
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Francesco Leri, Yan Zhou, Benjamin Goddard, Erin Cummins & Mary Jeanne Kreek. (2005) Effects of High-Dose Methadone Maintenance on Cocaine Place Conditioning, Cocaine Self-Administration, and Mu-Opioid Receptor mRNA Expression in the Rat Brain. Neuropsychopharmacology 31:7, pages 1462-1474.
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Jodie A Trafton, Jared Minkel & Keith Humphreys. (2006) Determining Effective Methadone Doses for Individual Opioid-Dependent Patients. PLoS Medicine 3:3, pages e80.
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Richard Hallinan, John Ray, Andrew Byrne, Kingsley Agho & John Attia. (2006) Therapeutic thresholds in methadone maintenance treatment: A receiver operating characteristic analysis. Drug and Alcohol Dependence 81:2, pages 129-136.
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Anja Dobler-Mikola, Josef Hättenschwiler, Daniel Meili, Thilo Beck, Edi Böni & Jiri Modestin. (2005) Patterns of heroin, cocaine, and alcohol abuse during long-term methadone maintenance treatment. Journal of Substance Abuse Treatment 29:4, pages 259-265.
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D.C. Lehotay, S. George, M.L. Etter, K. Graybiel, J.C. Eichhorst, B. Fern, W. Wildenboer, P. Selby & B. Kapur. (2005) Free and bound enantiomers of methadone and its metabolite, EDDP in methadone maintenance treatment: Relationship to dosage?. Clinical Biochemistry 38:12, pages 1088-1094.
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José Pérez de los Cobos, Joan Trujols, Juan Carlos Valderrama, Sergi Valero & Teresa Puig. (2005) Patient perspectives on methadone maintenance treatment in the Valencia Region: Dose adjustment, participation in dosage regulation, and satisfaction with treatment. Drug and Alcohol Dependence 79:3, pages 405-412.
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Richard Hallinan, Andrew Byrne, Janaki Amin & Gregory J. Dore. (2004) Hepatitis C virus incidence among injecting drug users on opioid replacement therapy. Australian and New Zealand Journal of Public Health 28:6, pages 576-578.
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Francesco Leri, Annie Tremblay, Robert E Sorge & Jane Stewart. (2004) Methadone Maintenance Reduces Heroin- and Cocaine-Induced Relapse without Affecting Stress-Induced Relapse in a Rodent Model of Poly-Drug Use. Neuropsychopharmacology 29:7, pages 1312-1320.
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Fabrizio Faggiano, Federica Vigna-Taglianti, Elisabetta Versino & Patrizia Lemma. (2003) Methadone maintenance at different dosages for opioid dependence. Cochrane Database of Systematic Reviews.
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Gilberto Gerra, Mila Ferri, Edoardo Polidori, Giovanna Santoro, Amir Zaimovic & Emilio Sternieri. (2003) Long-term methadone maintenance effectiveness: psychosocial and pharmacological variables. Journal of Substance Abuse Treatment 25:1, pages 1-8.
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Chin B. Eap, Thierry Buclin & Pierre Baumann. (2002) Interindividual Variability of the Clinical Pharmacokinetics of Methadone. Clinical Pharmacokinetics 41:14, pages 1153-1193.
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Chin B Eap, Michel Bourquin, Jean-Louis Martin, Jacques Spagnoli, Santino Livoti, Kerry Powell, Pierre Baumann & Jean-Jacques Déglon. (2000) Plasma concentrations of the enantiomers of methadone and therapeutic response in methadone maintenance treatment. Drug and Alcohol Dependence 61:1, pages 47-54.
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