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Original Article

An ER activity profile including ER, PR, Bcl-2 and IGF-IR may have potential as selection criterion for letrozole or tamoxifen treatment of patients with advanced breast cancer

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Pages 522-531 | Received 30 Sep 2008, Published online: 08 Jul 2009

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Katrine L. H. Weischenfeldt, Tove Kirkegaard, Birgitte B. Rasmussen, Anita Giobbie-Hurder, Maj-Britt Jensen, Bent Ejlertsen & Anne E. Lykkesfeldt. (2017) A high level of estrogen-stimulated proteins selects breast cancer patients treated with adjuvant endocrine therapy with good prognosis. Acta Oncologica 56:9, pages 1161-1167.
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Ines Barone, Amanda Caruso, Luca Gelsomino, Cinzia Giordano, Daniela Bonofiglio, Stefania Catalano & Sebastiano Andò. (2021) Obesity and endocrine therapy resistance in breast cancer: Mechanistic insights and perspectives. Obesity Reviews 23:2.
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S Thrane, A M Pedersen, M B H Thomsen, T Kirkegaard, B B Rasmussen, A K Duun-Henriksen, A V Lænkholm, M Bak, A E Lykkesfeldt & C W Yde. (2014) A kinase inhibitor screen identifies Mcl-1 and Aurora kinase A as novel treatment targets in antiestrogen-resistant breast cancer cells. Oncogene 34:32, pages 4199-4210.
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D Elias, H Vever, A-V Lænkholm, M F Gjerstorff, C W Yde, A E Lykkesfeldt & H J Ditzel. (2014) Gene expression profiling identifies FYN as an important molecule in tamoxifen resistance and a predictor of early recurrence in patients treated with endocrine therapy. Oncogene 34:15, pages 1919-1927.
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Sarah L. Larsen, Anne-Vibeke Laenkholm, Anne Katrine Duun-Henriksen, Martin Bak, Anne E. Lykkesfeldt & Tove Kirkegaard. (2015) Src Drives Growth of Antiestrogen Resistant Breast Cancer Cell Lines and Is a Marker for Reduced Benefit of Tamoxifen Treatment. PLOS ONE 10:2, pages e0118346.
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Sarah A. Dabydeen, Keunsoo Kang, Edgar S. Díaz-Cruz, Ahmad Alamri, Margaret L. Axelrod, Kerrie B. Bouker, Rawan Al-Kharboosh, Robert Clarke, Lothar Hennighausen & Priscilla A. Furth. (2015) Comparison of tamoxifen and letrozole response in mammary preneoplasia of ER and aromatase overexpressing mice defines an immune-associated gene signature linked to tamoxifen resistance. Carcinogenesis 36:1, pages 122-132.
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Kristina E Aaltonen, Ann H Rosendahl, Hans Olsson, Per Malmström, Linda Hartman & Mårten Fernö. (2014) Association between insulin-like growth factor-1 receptor (IGF1R) negativity and poor prognosis in a cohort of women with primary breast cancer. BMC Cancer 14:1.
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Charlotte Levin Tykjær Jørgensen, Christina Bjerre, Bent Ejlertsen, Karsten D Bjerre, Eva Balslev, Annette Bartels, Nils Brünner & Dorte L Nielsen. (2014) TIMP-1 and responsiveness to gemcitabine in advanced breast cancer; results from a randomized phase III trial from the Danish breast cancer cooperative group. BMC Cancer 14:1.
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Karin Beelen, Mark Opdam, Tesa M Severson, Rutger HT Koornstra, Andrew D Vincent, Jelle Wesseling, Jettie J Muris, Els MJJ Berns, Jan B Vermorken, Paul J van Diest & Sabine C Linn. (2014) PIK3CA mutations, phosphatase and tensin homolog, human epidermal growth factor receptor 2, and insulin-like growth factor 1 receptor and adjuvant tamoxifen resistance in postmenopausal breast cancer patients. Breast Cancer Research 16:1.
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Arthur Adams, Aram SA van Brussel, Jeroen F Vermeulen, Willem PThM Mali, Elsken van der Wall, Paul J van Diest & Sjoerd G Elias. (2013) The potential of hypoxia markers as target for breast molecular imaging – a systematic review and meta-analysis of human marker expression. BMC Cancer 13:1.
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Guihua Zhai, Clinton J. Grubbs, Cecil R. Stockard, Heidi R. Umphrey, T. Mark Beasley & Hyunki Kim. (2013) Diffusion Weighted Imaging Evaluated the Early Therapy Effect of Tamoxifen in an MNU-Induced Mammary Cancer Rat Model. PLoS ONE 8:5, pages e64445.
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S Cutrupi, S Reineri, A Panetto, E Grosso, L Caizzi, L Ricci, O Friard, S Agati, M Scatolini, G Chiorino, A E Lykkesfeldt & M De Bortoli. (2012) Targeting of the adaptor protein Tab2 as a novel approach to revert tamoxifen resistance in breast cancer cells. Oncogene 31:40, pages 4353-4361.
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Karin Beelen, Wilbert Zwart & Sabine C. Linn. (2012) Can predictive biomarkers in breast cancer guide adjuvant endocrine therapy?. Nature Reviews Clinical Oncology 9:9, pages 529-541.
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Anne-Vibeke Laenkholm, Ann Knoop, Bent Ejlertsen, Tine Rudbeck, Maj-Britt Jensen, Sven Müller, Anne Elisabeth Lykkesfeldt, Birgitte Bruun Rasmussen & Kirsten Vang Nielsen. (2012) ESR1 gene status correlates with estrogen receptor protein levels measured by ligand binding assay and immunohistochemistry . Molecular Oncology 6:4, pages 428-436.
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Jeffrey D Altenburg, Andrew A Bieberich, Colin Terry, Kevin A Harvey, Justin F VanHorn, Zhidong Xu, V Jo Davisson & Rafat A Siddiqui. (2011) A synergistic antiproliferation effect of curcumin and docosahexaenoic acid in SK-BR-3 breast cancer cells: unique signaling not explained by the effects of either compound alone. BMC Cancer 11:1.
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H. Anderson, M. Hills, L. Zabaglo, R. A'Hern, A.F. Leary, B.P. Haynes, I.E. Smith & M. Dowsett. (2011) Relationship between estrogen receptor, progesterone receptor, HER-2 and Ki67 expression and efficacy of aromatase inhibitors in advanced breast cancer. Annals of Oncology 22:8, pages 1770-1776.
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A. C. Regierer, R. Wolters, C. Kurzeder, A. Wöckel, I. Novopashenny, K. Possinger, M. B. Wischnewsky & R. Kreienberg. (2011) High estrogen receptor expression in early breast cancer: chemotherapy needed to improve RFS?. Breast Cancer Research and Treatment 128:1, pages 273-281.
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Diana M. Cittelly, Partha M. Das, Virgilio A. Salvo, Juan P. Fonseca, Matthew E. Burow & Frank E. Jones. (2010) Oncogenic HER2Δ16 suppresses miR-15a/16 and deregulates BCL-2 to promote endocrine resistance of breast tumors. Carcinogenesis 31:12, pages 2049-2057.
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Angela M. Betancourt, Isam A. Eltoum, Renee A. Desmond, Jose Russo & Coral A. Lamartiniere. (2010) In Utero Exposure to Bisphenol A Shifts the Window of Susceptibility for Mammary Carcinogenesis in the Rat . Environmental Health Perspectives 118:11, pages 1614-1619.
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Anne E Lykkesfeldt, Katrine L Henriksen, Birgitte B Rasmussen, Hironobu Sasano, Dean B Evans, Susanne Møller, Bent Ejlertsen & Henning T Mouridsen. (2009) In situaromatase expression in primary tumor is associated with estrogen receptor expression but is not predictive of response to endocrine therapy in advanced breast cancer. BMC Cancer 9:1.
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