306
Views
35
CrossRef citations to date
0
Altmetric
Research Article

Radiation-Induced Apoptosis: The Ceramide-SAPK Signaling Pathway and Clinical Aspects

, &
Pages 575-581 | Published online: 08 Jul 2009

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (3)

Yixing Jiang, Nicole A. DiVittore, James M. Kaiser, Sriram S. Shanmugavelandy, Jennifer L. Fritz, Yasser Heakal, Hephzibah Rani S. Tagaram, Hua Cheng, Myles C. Cabot, Kevin F. Staveley-O'Carroll, Melissa A. Tran, Todd E. Fox, Brian M. Barth & Mark Kester. (2011) Combinatorial therapies improve the therapeutic efficacy of nanoliposomal ceramide for pancreatic cancer. Cancer Biology & Therapy 12:7, pages 574-585.
Read now
Thomas H Beckham, Saeed Elojeimy, Joseph C Cheng, Lorianne S Turner, Stanley R Hoffman, James S Norris & Xiang Liu. (2010) Targeting sphingolipid metabolism in head and neck cancer: rational therapeutic potentials. Expert Opinion on Therapeutic Targets 14:5, pages 529-539.
Read now
Xiang Liu, Joseph C Cheng, Lorianne S Turner, Saeed Elojeimy, Thomas H Beckham, Alicja Bielawska, Thomas E Keane, Yusuf A Hannun & James S Norris. (2009) Acid ceramidase upregulation in prostate cancer: role in tumor development and implications for therapy. Expert Opinion on Therapeutic Targets 13:12, pages 1449-1458.
Read now

Articles from other publishers (32)

Hui Cheng, Meng Wang, Jingjing Su, Yueyue Li, Jiao Long, Jing Chu, Xinyu Wan, Yu Cao & Qinglin Li. (2022) Lipid Metabolism and Cancer. Life 12:6, pages 784.
Crossref
Zhuang Sun, Xiaohui Wang, Jingyun Wang, Jing Wang, Xiao Liu, Runda Huang, Chunyan Chen, Meiling Deng, Hanyu Wang & Fei Han. (2021) Key radioresistance regulation models and marker genes identified by integrated transcriptome analysis in nasopharyngeal carcinoma. Cancer Medicine 10:20, pages 7404-7417.
Crossref
Emanuela Di Gregorio, Gianmaria Miolo, Asia Saorin, Elena Muraro, Michela Cangemi, Alberto Revelant, Emilio Minatel, Marco Trovò, Agostino Steffan & Giuseppe Corona. (2021) Radical Hemithoracic Radiotherapy Induces Systemic Metabolomics Changes That Are Associated with the Clinical Outcome of Malignant Pleural Mesothelioma Patients. Cancers 13:3, pages 508.
Crossref
Hecong Wang, Jiateng Wang, Mingyue Zhou, Yan Jia, Ming Yang & Congfen He. (2020) Prediction of neonatal acne based on maternal lipidomic profiling. Journal of Cosmetic Dermatology 19:10, pages 2759-2766.
Crossref
Falak Patel & Stefka D. Spassieva. 2018. Sphingolipids in Cancer. Sphingolipids in Cancer 367 388 .
LING CHEN, HUIXIA CHEN, YANTING LI, LEI LI, YAN QIU & JIE REN. (2015) Endocannabinoid and ceramide levels are altered in patients with colorectal cancer. Oncology Reports 34:1, pages 447-454.
Crossref
J.E. Nóbrega Jr., R. RossettoM.H.T. MatosR.N. ChavesD.M. MagalhãesI.B. Lima-VerdeS.N. Báo, C.C. CampelloJ.R. FigueiredoP.B.D. Gonçalves & J.F.C. Oliveira. (2014) Sphingosine 1-phosphate promotes activation of aprine preantral follicle in vitro. Arquivo Brasileiro de Medicina Veterinária e Zootecnia 66:4, pages 977-985.
Crossref
Adriana Haimovitz-Friedman, Tzu-I Jonathan Yang, Tin Htwe Thin & Marcel Verheij. (2012) Imaging Radiotherapy-Induced Apoptosis. Radiation Research 177:4, pages 467-482.
Crossref
Marcel Verheij, Conchita Vens & Baukelien van Triest. (2010) Novel therapeutics in combination with radiotherapy to improve cancer treatment: Rationale, mechanisms of action and clinical perspective. Drug Resistance Updates 13:1-2, pages 29-43.
Crossref
Aleksei V. Ermakov, Marina S. Konkova, Svetlana V. Kostyuk, Natalya A. Egolina, Liudmila V. Efremova & Natalya N. Veiko. (2009) Oxidative stress as a significant factor for development of an adaptive response in irradiated and nonirradiated human lymphocytes after inducing the bystander effect by low-dose X-radiation. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 669:1-2, pages 155-161.
Crossref
Marcel Verheij. (2008) Clinical biomarkers and imaging for radiotherapy-induced cell death. Cancer and Metastasis Reviews 27:3, pages 471-480.
Crossref
Marina Kartachova, Nico van Zandwijk, Sjaak Burgers, Harm van Tinteren, Marcel Verheij & Renato Alfredo Valdés Olmos. (2007) Prognostic Significance of 99m Tc Hynic-rh-Annexin V Scintigraphy During Platinum-Based Chemotherapy in Advanced Lung Cancer . Journal of Clinical Oncology 25:18, pages 2534-2539.
Crossref
Katharina Hancke, Oliver Strauch, Christine Kissel, Heike Göbel, Wolfgang Schäfer & Dominik Denschlag. (2007) Sphingosine 1-phosphate protects ovaries from chemotherapy-induced damage in vivo. Fertility and Sterility 87:1, pages 172-177.
Crossref
Debby Hwang, Rishi Popat, Christopher Bragdon, Kathryn E. O'Donnell & Stephen T. Sonis. (2005) Effects of ceramide inhibition on experimental radiation-induced oral mucositis. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology 100:3, pages 321-329.
Crossref
Z. Roth & P.J. Hansen. (2004) Sphingosine 1-Phosphate Protects Bovine Oocytes from Heat Shock During Maturation1. Biology of Reproduction 71:6, pages 2072-2078.
Crossref
Marco Macchia, Simone Bertini, Stefano Fogli, Elisa Giovannetti, Filippo Minutolo, Simona Rapposelli & Romano Danesi. (2003) Ceramide analogues in apoptosis: a new strategy for anticancer drug development. Il Farmaco 58:3, pages 205-211.
Crossref
Claire Rodriguez-Lafrasse, Gersende Alphonse, Marie-Thérèse Aloy, Dominique Ardail, Jean-Pierre Gérard, Pierre Louisot & Robert Rousson. (2002) Increasing endogenous ceramide using inhibitors of sphingolipid metabolism maximizes ionizing radiation-induced mitochondrial injury and apoptotic cell killing. International Journal of Cancer 101:6, pages 589-598.
Crossref
Patrick Swift. (2002) Novel techniques in the delivery of radiation in pediatric oncology. Pediatric Clinics of North America 49:5, pages 1107-1129.
Crossref
L MazurA Czyzewska & M Bochenek. (2016) Flow cytometric detection of apoptotic bone marrow cells with fractional DNA content after application of WR-2721, cyclophosphamide, cisplatin, and exposure of mice to gamma rays. Human & Experimental Toxicology 21:6, pages 335-341.
Crossref
Claus Rödel, Gerhard G Grabenbauer, Thomas Papadopoulos, Marc Bigalke, Klaus Günther, Christoph Schick, Andrea Peters, Rolf Sauer & Franz Rödel. (2002) Apoptosis as a cellular predictor for histopathologic response to neoadjuvant radiochemotherapy in patients with rectal cancer. International Journal of Radiation Oncology*Biology*Physics 52:2, pages 294-303.
Crossref
Mark Kester, Jong K. Yun, Tom Stover & Lakshman Sandirasegarane. 2002. Ceramide Signaling. Ceramide Signaling 149 160 .
Francisca Ong, Luc M.F Moonen, Maarten P.W Gallee, Cindy ten Bosch, Shuraila F Zerp, Augustinus A.M Hart, Harry Bartelink & Marcel Verheij. (2001) Prognostic factors in transitional cell cancer of the bladder: an emerging role for Bcl-2 and p53. Radiotherapy and Oncology 61:2, pages 169-175.
Crossref
Philippe P. Roux, Asha L. Bhakar, Timothy E. Kennedy & Philip A. Barker. (2001) The p75 Neurotrophin Receptor Activates Akt (Protein Kinase B) through a Phosphatidylinositol 3-Kinase-dependent Pathway. Journal of Biological Chemistry 276:25, pages 23097-23104.
Crossref
Conrad R Lewanski & William J Gullick. (2001) Radiotherapy and cellular signalling. The Lancet Oncology 2:6, pages 366-370.
Crossref
Gunnar C. E. Adell, Hong Zhang, Sofia Evertsson, Xiao-Feng Sun, Olle H. G. St�l & Bo A. Nordenskj�ld. (2001) Apoptosis in rectal carcinoma. Cancer 91:10, pages 1870-1875.
Crossref
Susan R Rose. (2001) Cranial irradiation and central hypothyroidism. Trends in Endocrinology & Metabolism 12:3, pages 97-104.
Crossref
Yuriy Sautin, Noboru Takamura, Stanislav Shklyaev, Yuji Nagayama, Akira Ohtsuru, Hiroyuki Namba & Shunichi Yamashita. (2000) Ceramide-Induced Apoptosis of Human Thyroid Cancer Cells Resistant to Apoptosis by Irradiation. Thyroid 10:9, pages 733-740.
Crossref
E. V. Dyatlovitskaya. (2000) The interrelation between the biological functions of sphingolipids and their chemical structure. Russian Journal of Bioorganic Chemistry 26:1, pages 9-15.
Crossref
Pothana Saikumar, Zheng Dong, Valery Mikhailov, Michael Denton, Joel M Weinberg & Manjeri A Venkatachalam. (1999) Apoptosis: definition, mechanisms, and relevance to disease. The American Journal of Medicine 107:5, pages 489-506.
Crossref
Yutaka Morita & Jonathan L. Tilly. (1999) Oocyte Apoptosis: Like Sand through an Hourglass. Developmental Biology 213:1, pages 1-17.
Crossref
Dianne Watters. (1999) Molecular mechanisms of ionizing radiation-induced apoptosis. Immunology and Cell Biology 77:3, pages 263-271.
Crossref
Harry Bartelink, Adrian Begg, José Coco Martin, Mariska van Dijk, Laura van ’t Veer, Paul van der Vaart & Marcel Verheij. (1999) Towards prediction and modulation of treatment response. Radiotherapy and Oncology 50:1, pages 1-11.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.