Advanced search
Publication Cover
Acta Oncologica Volume 56, 2017 - Issue 12
Journal homepage
4,682
Views
29
CrossRef citations to date
0
Altmetric
ORIGINAL ARTICLES: SARCOMA

Treatment patterns and clinical outcomes with pazopanib in patients with advanced soft tissue sarcomas in a compassionate use setting: results of the SPIRE study*

Hans GelderblomDepartment of Medical Oncology, Leiden University Medical Centre, Leiden, the Netherlands; Correspondence[email protected]
View further author information
,
Ian R. JudsonSarcoma Unit, The Royal Marsden NHS Foundation Trust, London, UK; View further author information
,
Charlotte BensonSarcoma Unit, The Royal Marsden NHS Foundation Trust, London, UK; View further author information
,
Ofer MerimskyUnit of Bone and Soft Tissue Oncology, Tel-Aviv Sourasky Medical Center and Tel-Aviv University Sackler School of Medicine, Tel-Aviv, Israel; View further author information
,
Giovanni GrignaniDivisione Oncologia Medica, Candiolo Cancer Institute – FPO I.R.C.C.S., Candiolo, Italy; View further author information
,
Daniela KatzHadassah-Hebrew University Medical Center, Jerusalem, Israel; View further author information
,
Klaus W. FreivogelUnited BioSource (Germany) GmbH, Loerrach, Germany; View further author information
,
Dara SteinUnited BioSource Corporation, Quebec, Canada; View further author information
,
Minesh Jobanputrabluebird bio, London, UK; View further author information
,
Arron MungulBristol-Myers Squibb, Uxbridge, UK; View further author information
,
Stephanie C. MansonNovartis Oncology, East Hanover, NJ, USA; View further author information
&
Roberta SanfilippoAdult Mesenchymal Tumor Medical Oncology Unit, Fondazione IRCCS Istituto Nazionale Tumori, Milan, ItalyView further author information
 show all
Pages 1769-1775 | Received 14 Dec 2016, Accepted 15 May 2017, Published online: 19 Jul 2017

Citations (29)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (5)

Nashita Patel, Shibani Pokras, Jane Ferma, Vicky Casey, Fil Manuguid, Ken Culver & Sebastian Bauer. (2023) Treatment Patterns and Outcomes in Patients with Metastatic Synovial Sarcoma in France, Germany, Italy, Spain and the UK. Future Oncology 19:18, pages 1261-1275.
Read now
Charlotte Carroll, Nashita Patel, Necdet B Gunsoy, Heide A Stirnadel-Farrant & Shibani Pokras. (2022) Meta-analysis of pazopanib and trabectedin effectiveness in previously treated metastatic synovial sarcoma (second-line setting and beyond). Future Oncology 18:32, pages 3651-3665.
Read now
Yitian Wang, Minxun Lu, Yong Zhou, Sisi Zhou, Xinzhu Yu, Fan Tang, Yi Luo, Wenli Zhang, Hong Duan, Li Min & Chongqi Tu. (2020) The Efficacy and Safety of Apatinib in Advanced Synovial Sarcoma: A Case Series of Twenty-One Patients in One Single Institution. Cancer Management and Research 12, pages 5255-5264.
Read now
Florence E Chamberlain, Chris Wilding, Robin L Jones & Paul Huang. (2019) Pazopanib in patients with advanced intermediate-grade or high-grade liposarcoma. Expert Opinion on Investigational Drugs 28:6, pages 505-511.
Read now
Eytan Ben-Ami, Jason L. Hornick & Andrew J. Wagner. (2018) The potential of emerging new therapeutics for the treatment of perivascular epithelioid cell tumors (PEComa). Expert Opinion on Orphan Drugs 6:9, pages 537-543.
Read now

Articles from other publishers (24)

Sandra P D'Angelo, Dejka M Araujo, Albiruni R Abdul Razak, Mark Agulnik, Steven Attia, Jean-Yves Blay, Irene Carrasco Garcia, John A Charlson, Edwin Choy, George D Demetri, Mihaela Druta, Edouard Forcade, Kristen N Ganjoo, John Glod, Vicki L Keedy, Axel Le Cesne, David A Liebner, Victor Moreno, Seth M Pollack, Scott M Schuetze, Gary K Schwartz, Sandra J Strauss, William D Tap, Fiona Thistlethwaite, Claudia Maria Valverde Morales, Michael J Wagner, Breelyn A Wilky, Cheryl McAlpine, Laura Hudson, Jean-Marc Navenot, Tianjiao Wang, Jane Bai, Stavros Rafail, Ruoxi Wang, Amy Sun, Lilliam Fernandes, Erin Van Winkle, Erica Elefant, Colin Lunt, Elliot Norry, Dennis Williams, Swethajit Biswas & Brian A Van Tine. (2024) Afamitresgene autoleucel for advanced synovial sarcoma and myxoid round cell liposarcoma (SPEARHEAD-1): an international, open-label, phase 2 trial. The Lancet 403:10435, pages 1460-1471.
Crossref
Mara Mantiero, Marta Bini, Maggie Polignano, Luca Porcu, Roberta Sanfilippo, Chiara Fabbroni, Gabriella Parma, Mariateresa Lapresa, Carmelo Calidona, Cecilia Silvestri, Andrea Franza, Francesco Raspagliesi, Nicoletta Colombo & Monika Ducceschi. (2023) A Ten-Year Real-Life Experience with Pazopanib in Uterine Leyomiosarcoma in Two High-Specialized Centers in Italy: Effectiveness and Safety. Cancers 16:1, pages 192.
Crossref
Karolina Małgorzata Kapturska & Aleksandra Pawlak. (2023) New molecular targets in canine hemangiosarcoma—Comparative review and future of the precision medicine. Veterinary and Comparative Oncology 21:3, pages 357-377.
Crossref
Ahmet Bilici, Sinan Koca, Mustafa Karaagac, Sabin Goktas Aydin, Emrah Eraslan, Muhammed Ali Kaplan, Birol Ocak, Sema Sezgin Goksu, Semra Paydas, Fahri Akgul, Sumeyye Derin, Yakup Ergun, Emre Yekeduz, Cihan Erol, Deniz Tataroglu Ozyukseler, Atike Gokcen Demiray, Mustafa Karaca, Zeynep Gulsum Guc, Serkan Menekse, Havva Yesil Cinkir, Ozge Gumusay, Abdullah Sakin, Ozlem Ozkul, Hacer Demir, Dilek Erdem, Mehmet Besiroglu, Olcun Umit Unal, Ramazan Acar, Lokman Koral, Suleyman Sahin, Teoman Sakalar, Aykut Bahceci, Ahmet Ozveren, Ulug Mutlu Gunaydin, Mehmet Metin Seker, Veli Sunar, Pinar Dal, Mehmet Artac & Serdar Turhal. (2023) Real-world outcomes of pazopanib in metastatic soft tissue sarcoma: a retrospective Turkish oncology group (TOG) study. Journal of Cancer Research and Clinical Oncology 149:11, pages 8243-8253.
Crossref
Iqra Ijaz, Muhammad Naveed Shahzad, Hossein Hosseinifard, Shuya Liu, Masoud Ostadi Sefidan, Lubna Ejaz Kahloon, Saber Imani, Zhong Hua & Yu Qin Zhang. (2023) Evaluation of the efficacy of systemic therapy for advanced uterine leiomyosarcoma: A systematic review, meta‐analysis, and meta‐regression analysis. Cancer Medicine 12:13, pages 13894-13911.
Crossref
Mia C. Weiss & Brian A. Van Tine. (2023) Relapsed Synovial Sarcoma: Treatment Options. Current Treatment Options in Oncology 24:3, pages 229-239.
Crossref
Christoph E. Heilig, Andreas Laßmann, Sadaf S. Mughal, Andreas Mock, Sebastian Pirmann, Veronica Teleanu, Marcus Renner, Carolin Andresen, Bruno C. Köhler, Bogac Aybey, Sebastian Bauer, Jens T. Siveke, Rainer Hamacher, Gunnar Folprecht, Stephan Richter, Evelin Schröck, Christian H. Brandts, Marit Ahrens, Peter Hohenberger, Gerlinde Egerer, Thomas Kindler, Melanie Boerries, Anna L. Illert, Nikolas von Bubnoff, Leonidas Apostolidis, Philipp J. Jost, C. Benedikt Westphalen, Wilko Weichert, Ulrich Keilholz, Frederick Klauschen, Katja Beck, Ulrike Winter, Daniela Richter, Lino Möhrmann, Michael Bitzer, Klaus Schulze-Osthoff, Benedikt Brors, Gunhild Mechtersheimer, Simon Kreutzfeldt, Christoph Heining, Daniel B. Lipka, Albrecht Stenzinger, Richard F. Schlenk, Peter Horak, Hanno Glimm, Daniel Hübschmann & Stefan Fröhling. (2022) Gene expression-based prediction of pazopanib efficacy in sarcoma. European Journal of Cancer 172, pages 107-118.
Crossref
Anastasios Kyriazoglou, Lydia Gkaralea, Ioannis Kotsantis, Maria Anastasiou, Anastasios Pantazopoulos, Maria Prevezanou, Ioannis Chatzidakis, Georgios Kavourakis, Panagiota Economopoulou, Ioanna Nixon & Amanda Psyrri. (2022) Tyrosine kinase inhibitors in sarcoma treatment (Review). Oncology Letters 23:6.
Crossref
Aparna Sharma, Babita Kataria, Bivas Biswas, Sameer Bakhshi & Deepam Pushpam. (2021) Oral metronomic chemotherapy is a cost effective alternative to pazopanib in advanced soft tissue sarcoma. Journal of Oncology Pharmacy Practice 28:3, pages 560-568.
Crossref
Sinan Koca, Mehmet Beşiroğlu, Melike Özçelik, Mustafa Karaca, Mehmet Bilici, Bekir Hacıoğlu, Gamze G Doğu, Nihal B Kaplan, Zeynep Oruç, Dinçer Aydın & Faysal Dane. (2020) Pazopanib for metastatic soft-tissue sarcoma: A multicenter retrospective study. Journal of Oncology Pharmacy Practice 27:3, pages 541-546.
Crossref
Yasutomo Teshima, Satoshi Nomura & Nobuaki Fukasawa. (2021) Postmarketing observational study of pazopanib in patients with metastatic soft tissue sarcoma in Japan. Japanese Journal of Clinical Oncology 51:4, pages 612-621.
Crossref
Aikaterini Liapi, Patrice Mathevet, Fernanda G. Herrera, Delfyne Hastir & Apostolos Sarivalasis. (2021) VEGFR Inhibitors for Uterine Metastatic Perivascular Epithelioid Tumors (PEComa) Resistant to mTOR Inhibitors. A Case Report and Review of Literature. Frontiers in Oncology 11.
Crossref
Anastasios Kyriazoglou, Michalis Liontos, Ioannis Ntanasis-Stathopoulos & Maria Gavriatopoulou. (2021) The systemic treatment of uterine leiomyosarcomas. Medicine 100:13, pages e25309.
Crossref
Nour Abdul Halim, Rola El Sayed, Ibrahim A. Alameh, Jessica Khoury, Clara El Nakib, Maroun Bou Zerdan, Maya Charafeddine, Fadi Farhat, Fadi El Karak & Hazem I. Assi. (2021) Safety and efficacy of pazopanib as a second-line treatment and beyond for soft tissue sarcomas: A real-life tertiary-center experience in the MENA region. Cancer Treatment and Research Communications 26, pages 100275.
Crossref
Yoshihiro Nishida, Hiroshi Urakawa, Robert Nakayama, Eisuke Kobayashi, Toshifumi Ozaki, Keisuke Ae, Yoshihiro Matsumoto, Hiroyuki Tsuchiya, Takahiro Goto, Hiroaki Hiraga, Norifumi Naka, Shunji Takahashi, Yuichi Ando, Masahiko Ando, Yachiyo Kuwatsuka, Shunsuke Hamada, Takafumi Ueda & Akira Kawai. (2020) Phase II clinical trial of pazopanib for patients with unresectable or metastatic malignant peripheral nerve sheath tumors . International Journal of Cancer 148:1, pages 140-149.
Crossref
Jan Borysowski & Andrzej Górski. (2020) Ethics framework for treatment use of investigational drugs. BMC Medical Ethics 21:1.
Crossref
Chung Ryul Oh, Jung Yong Hong, Jee Hung Kim, Ji Sung Lee, Hyo Song Kim, Tae Won Kim, Jin-Hee Ahn & Jeong Eun Kim. (2020) Real-World Outcomes of Pazopanib Treatment in Korean Patients with Advanced Soft Tissue Sarcoma: A Multicenter Retrospective Cohort Study. Targeted Oncology 15:4, pages 485-493.
Crossref
Ameer Hamza, Paul W. Gidley, Kim O. Learned, Ehab Y. Hanna & Diana Bell. (2020) Uncommon tumors of temporomandibular joint: An institutional experience and review. Head & Neck 42:8, pages 1859-1873.
Crossref
Rongfei Jia, Ling Jiang, Yuhong Zhou, Yan Wang, Xi Guo, Yuan Ji, Xiang Ni & Xiaoyan Yang. (2020) Clinical features of 18 perivascular epithelioid cell tumor cases. Medicine 99:34, pages e21659.
Crossref
Alex T. J. Lee, Robin L. Jones & Paul H. Huang. (2019) Pazopanib in advanced soft tissue sarcomas. Signal Transduction and Targeted Therapy 4:1.
Crossref
Julia F. SlejkoJuan-David RuedaJames A. TrovatoEmily F. GormanGail BetzStephen ArconaChristopher ZackerBruce Stuart. (2019) A Comprehensive Review of Methods to Measure Oral Oncolytic Dose Intensity Using Retrospective Data. Journal of Managed Care & Specialty Pharmacy 25:10, pages 1125-1132.
Crossref
Kenji Nakano, Yuki Funauchi, Keiko Hayakawa, Taisuke Tanizawa, Keisuke Ae, Seiichi Matsumoto & Shunji Takahashi. (2019) Relative Dose Intensity of Induction-Phase Pazopanib Treatment of Soft Tissue Sarcoma: Its Relationship with Prognoses of Pazopanib Responders. Journal of Clinical Medicine 8:1, pages 60.
Crossref
Aparna Sharma, Ilavarasi Vanidassane, Aditi Aggarwal, AsitRanjan Mridha, Rambha Pandey, Ekta Dhamija, Adarsh Barwad & Sameer Rastogi. (2019) Pazopanib efficacy and toxicity in a metastatic sarcoma cohort: Are Indian patients different?. Indian Journal of Cancer 56:3, pages 207.
Crossref
Ingrid M. E. Desar, Emmy D. G. Fleuren & Winette T. A. van der Graaf. (2018) Systemic Treatment for Adults with Synovial Sarcoma. Current Treatment Options in Oncology 19:2.
Crossref

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.