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ORIGINAL ARTICLES

Standardized assessment of tumor-infiltrating lymphocytes in breast cancer: an evaluation of inter-observer agreement between pathologists

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Pages 90-94 | Received 15 Sep 2017, Accepted 01 Nov 2017, Published online: 23 Nov 2017

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Crossref
Alhadi Almangush, Miia Ruuskanen, Jaana Hagström, Pasi Hirvikoski, Satu Tommola, Veli-Matti Kosma, Pentti Nieminen, Antti Mäkitie & Ilmo Leivo. (2018) Tumor-infiltrating lymphocytes associate with outcome in nonendemic nasopharyngeal carcinoma: a multicenter study. Human Pathology 81, pages 211-219.
Crossref
C. Denkert, S. Loibl, J. Budczies, S. Wienert & F. Klauschen. (2018) Standardisierte Bestimmung tumorinfiltrierender Lymphozyten beim MammakarzinomStandardized determination of tumor-infiltrating lymphocytes in breast cancer. Der Pathologe 39:6, pages 520-531.
Crossref
Thaer Khoury, Xuan Peng, Li Yan, Dan Wang & Vidya Nagrale. (2018) Tumor-Infiltrating Lymphocytes in Breast Cancer. American Journal of Clinical Pathology 150:5, pages 441-450.
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Yumi A. Kojima, Xiaohong Wang, Hongxia Sun, Frances Compton, Michael Covinsky & Songlin Zhang. (2018) Reproducible evaluation of tumor-infiltrating lymphocytes (TILs) using the recommendations of International TILs Working Group 2014. Annals of Diagnostic Pathology 35, pages 77-79.
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