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Article

A novel murine model of orthopaedic wear‐debris associated osteolysis

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Pages 349-357 | Published online: 12 Jul 2009

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Read on this site (3)

Nianhu Li, Zhanwang Xu, Paul H Wooley, Jianxin Zhang & Shang-You Yang. (2014) Therapeutic potentials of naringin on polymethylmethacrylate induced osteoclastogenesis and osteolysis, in vitro and in vivo assessments. Drug Design, Development and Therapy 8, pages 1-11.
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Yang Wang, Ning-Ning Wu, Min Hu, Yu-Qin Mou, Rui-Dong Li, Liang Chen, Bai-Cheng He & Zhong-Liang Deng. (2012) Inhibitory Effect of Adenovirus-Mediated siRNA-Targeting BMPR-IB on UHMWPE-Induced Bone Destruction in the Murine Air Pouch Model. Connective Tissue Research 53:6, pages 528-534.
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Weiping Ren, Renwen Zhang, Bin Wu, Paul H Wooley, Monica Hawkins & David C Markel. (2011) Effects of SU5416 and a vascular endothelial growth factor neutralizing antibody on wear debris-induced inflammatory osteolysis in a mouse model. Journal of Inflammation Research 4, pages 29-38.
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Articles from other publishers (34)

Kewen Lei, Yang Wang, Xiaochun Peng, Lin Yu & Jiandong Ding. (2022) Long‐term delivery of etanercept mediated via a thermosensitive hydrogel for efficient inhibition of wear debris‐induced inflammatory osteolysis. Journal of Polymer Science 60:20, pages 2875-2888.
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Hui Li, Yihe Hu, Min Zeng, Junxiao Yang, Xiaolei Fan, Yinan Wang & Jie Xie. (2021) Exosomes From Human Urine-Derived Stem Cells Encapsulated Into PLGA Nanoparticles for Therapy in Mice With Particulate Polyethylene-Induced Osteolysis. Frontiers in Medicine 8.
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Lei Wang, Zhibiao Gao, Jie Zhang, Yulong Huo, Qiang Xu & Yusheng Qiu. (2021) Netrin‐1 regulates ERK1/2 signaling pathway and autophagy activation in wear particle‐induced osteoclastogenesis. Cell Biology International 45:3, pages 612-622.
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Meghan M. Moran, Brittany M. Wilson, Ryan D. Ross, Amarjit S. Virdi & Dale Rick Sumner. (2017) Arthrotomy‐based preclinical models of particle‐induced osteolysis: A systematic review. Journal of Orthopaedic Research 35:12, pages 2595-2605.
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Francesca Veronesi, Matilde Tschon & Milena Fini. (2017) Gene Expression in Osteolysis: Review on the Identification of Altered Molecular Pathways in Preclinical and Clinical Studies. International Journal of Molecular Sciences 18:3, pages 499.
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Jianhao Jiang, Tanghong Jia, Weiming Gong, Bin Ning, Paul H. Wooley & Shang-You Yang. (2016) Macrophage Polarization in IL-10 Treatment of Particle-Induced Inflammation and Osteolysis. The American Journal of Pathology 186:1, pages 57-66.
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David C. Markel, Nancy M. Jackson, Amanda O. Esquivel, Weiping Ren & Jeffrey C. Flynn. (2014) Immunological response to bolus versus multiple injections of hylan G‐F 20 (Synvisc ® ) in a murine biocompatibility model . Journal of Biomedical Materials Research Part B: Applied Biomaterials 102:7, pages 1375-1380.
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Luis Alberto Cordova, Verena Stresing, Bérengère Gobin, Philippe Rosset, Norbert Passuti, François Gouin, Valérie Trichet, Pierre Layrolle & Dominique Heymann. (2014) Orthopaedic implant failure: aseptic implant loosening–the contribution and future challenges of mouse models in translational research. Clinical Science 127:5, pages 277-293.
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Weiping Ren, Nancy Jackson, Wei Song, Tong Shi, Jeffrey C. Flynn & David C. Markel. (2014) Implant wear induced inflammation is mitigated in CX3CR1 −/− mice . Journal of Orthopaedic Research 32:8, pages 1037-1043.
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Weiping P. Ren, Wei Song, Amanda O. Esquivel, Nancy M. Jackson, Matthew Nelson, Jeffery C. Flynn & David C. Markel. (2013) Effect of erythromycin‐doped calcium polyphosphate scaffold composite in a mouse pouch infection model. Journal of Biomedical Materials Research Part B: Applied Biomaterials 102:6, pages 1140-1147.
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Chen Zhu, Jiaxing Wang, Tao Cheng, Qingtian Li, Hao Shen, Hui Qin, Mengqi Cheng & Xianlong Zhang. (2014) The Potential Role of Increasing the Release of Mouse β- Defensin-14 in the Treatment of Osteomyelitis in Mice: A Primary Study. PLoS ONE 9:1, pages e86874.
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Ruo-fan Ma, Jie Xu, Yan Chen, Deng Li, Max Daniel Kauther, Marcus Jäger & Christian Wedemeyer. (2013) An in vivo rat model of self-control continuous intramedullary infusion of ultra-high molecular weight polyethylene particles by osmotic pumps. Journal of Orthopaedic Translation 1:1, pages 49-56.
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Yang Wang, Ning-Ning Wu, Yu-Qin Mou, Liang Chen & Zhong-Liang Deng. (2013) Inhibitory effects of recombinant IL-4 and recombinant IL-13 on UHMWPE-induced bone destruction in the murine air pouch model. Journal of Surgical Research 180:2, pages e73-e81.
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Ke Ren, Anand Dusad, Yijia Zhang & Dong Wang. (2013) Therapeutic intervention for wear debris-induced aseptic implant loosening. Acta Pharmaceutica Sinica B 3:2, pages 76-85.
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Yang Wang, Ning-Ning Wu, Yu-Qin Mu, Ran-Xi Zhang, Min Hu, Rui-Dong Li, Liang Chen, Bai-Cheng He & Zhong-Liang Deng. (2013) The effect of adenovirus-mediated siRNA targeting BMPR-II on UHMWPE-induced osteoclast formation. Biomaterials 34:1, pages 150-159.
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DESHENG CHEN, XIANLONG ZHANG, YONGYUAN GUO, SIFENG SHI, XIN MAO, XIAOYUN PAN & TAO CHENG. (2012) MMP-9 inhibition suppresses wear debris-induced inflammatory osteolysis through downregulation of RANK/RANKL in a murine osteolysis model. International Journal of Molecular Medicine 30:6, pages 1417-1423.
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Desheng Chen, Yongyuan Guo, Xin Mao & Xianlong Zhang. (2012) Inhibition of p38 Mitogen-Activated Protein Kinase Down-regulates the Inflammatory Osteolysis Response to Titanium Particles in a Murine Osteolysis Model. Inflammation 35:6, pages 1798-1806.
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Weiping Ren, Otto Muzik, Nancy Jackson, Basma Khoury, Tong Shi, Jeffrey C. Flynn, Pulak Chakraborty & David C. Markel. (2012) Differentiation of septic and aseptic loosening by PET with both 11C-PK11195 and 18F-FDG in rat models. Nuclear Medicine Communications 33:7, pages 747-756.
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Shang‐You Yang, Kai Zhang, Ling Bai, Zheng Song, Haiying Yu, David A. McQueen & Paul H. Wooley. (2010) Polymethylmethacrylate and titanium alloy particles activate peripheral monocytes during periprosthetic inflammation and osteolysis. Journal of Orthopaedic Research 29:5, pages 781-786.
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Weiping Ren, Renwen Zhang, Monica Hawkins, Tong Shi & David C. Markel. (2010) Efficacy of periprosthetic erythromycin delivery for wear debris-induced inflammation and osteolysis. Inflammation Research 59:12, pages 1091-1097.
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Dechun Geng, Yaozeng Xu, Huilin Yang, Junhua Wang, Xuesong Zhu, Guangming Zhu & Xianbin Wang. (2010) Protection against titanium particle induced osteolysis by cannabinoid receptor 2 selective antagonist. Biomaterials 31:8, pages 1996-2000.
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Kai Zhang, Tang-Hong Jia, David McQueen, Wei-Ming Gong, David C. Markel, Paul H. Wooley & Shang-You Yang. (2009) Circulating blood monocytes traffic to and participate in the periprosthetic tissue inflammation. Inflammation Research 58:12, pages 837-844.
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Gerald J. Atkins, Katie J. Welldon, Christopher A. Holding, David R. Haynes, Donald W. Howie & David M. Findlay. (2009) The induction of a catabolic phenotype in human primary osteoblasts and osteocytes by polyethylene particles. Biomaterials 30:22, pages 3672-3681.
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David C. Markel, Renwen Zhang, Tong Shi, Monica Hawkins & Weiping Ren. (2009) Inhibitory effects of erythromycin on wear debris-induced VEGF/Flt-1 gene production and osteolysis. Inflammation Research 58:7, pages 413-421.
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Weiping Ren, David C. Markel, Reto Schwendener, Yunhong Ding, Bin Wu & Paul H. Wooley. (2007) Macrophage depletion diminishes implant‐wear‐induced inflammatory osteolysis in a mouse model. Journal of Biomedical Materials Research Part A 85A:4, pages 1043-1051.
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Mathias Bostrom & Regis OʼKeefe. (2008) What experimental approaches (eg, in vivo, in vitro, tissue retrieval) are effective in investigating the biologic effects of particles?. Journal of the American Academy of Orthopaedic Surgeons 16, pages S63-S67.
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Shang‐You Yang, Haiying Yu, Weiming Gong, Bin Wu, Lois Mayton, Richard Costello & Paul H. Wooley. (2007) Murine model of prosthesis failure for the long‐term study of aseptic loosening. Journal of Orthopaedic Research 25:5, pages 603-611.
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Bernd Baumann, Olaf Rolf, Franz Jakob, Sascha Goebel, Thomas Sterner, Jochen Eulert & Christof P. Rader. (2006) Synergistic effects of mixed TiAlV and polyethylene wear particles on TNFα response in THP-1 macrophages / Synergistische Effekte gemischter TiAlV- und Polyethylen-Abriebpartikel auf die TNFα-Antwort in THP-1 Makrophagen. Biomedizinische Technik/Biomedical Engineering 51:5_6, pages 360-366.
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Christopher A. Holding, David M. Findlay, Roumen Stamenkov, Susan D. Neale, Helen Lucas, A.S.S.K. Dharmapatni, Stuart A. Callary, Kush R. Shrestha, Gerald J. Atkins, Donald W. Howie & David R. Haynes. (2006) The correlation of RANK, RANKL and TNFα expression with bone loss volume and polyethylene wear debris around hip implants. Biomaterials 27:30, pages 5212-5219.
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Wei Ping Ren, David C. Markel, Renwen Zhang, Xin Peng, Bin Wu, Hawkins Monica & Paul H. Wooley. (2006) Association between UHMWPE particle-induced inflammatory osteoclastogenesis and expression of RANKL, VEGF, and Flt-1 in vivo. Biomaterials 27:30, pages 5161-5169.
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Weiping Ren, Bin Wu, Xin Peng, Jing Hua, Hsiao‐Nan Hao & Paul H. Wooley. (2006) Implant wear induces inflammation, but not osteoclastic bone resorption, in RANK –/– mice . Journal of Orthopaedic Research 24:8, pages 1575-1586.
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Bernd Baumann, Jochen Seufert, Franz Jakob, Ulrich Nöth, Olaf Rolf, Jochen Eulert & Christof P. Rader. (2005) Activation of NF-KB signalling and TNFα-expression in THP-1 macrophages by TiAlV- and polyethylene-wear particles. Journal of Orthopaedic Research 23:6, pages 1241-1248.
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Xuwei Liang, Jing Hua & Weiping Ren. (2005) Volumetric Histology Data Visualization and Quantitative Analysis. Volumetric Histology Data Visualization and Quantitative Analysis.
S-Y Yang, B Wu, L Mayton, P Mukherjee, PD Robbins, CH Evans & PH Wooley. (2004) Protective effects of IL-1Ra or vIL-10 gene transfer on a murine model of wear debris-induced osteolysis. Gene Therapy 11:5, pages 483-491.
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