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Research Article

Pharmacogenetics of Uridine Diphosphoglucuronosyltransferase (UGT) 1A Family Members and its Role in Patient Response to Irinotecan

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Pages 393-409 | Published online: 09 Oct 2008

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Xiaoqin Zhu, Jia Zhu, Feifei Sun, Zijun Zhen, Dalei Zhou, Suying Lu, Junting Huang, Yi Que, Lian Zhang, Ruiqing Cai, Juan Wang & Yizhuo Zhang. (2021) Influence of UGT1A1 *6/*28 Polymorphisms on Irinotecan-Related Toxicity and Survival in Pediatric Patients with Relapsed/Refractory Solid Tumors Treated with the VIT Regimen. Pharmacogenomics and Personalized Medicine 14, pages 369-377.
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Yang-Liu Xia, Tong-Yi Dou, Xia Lv & Guang-Bo Ge. (2019) In vitro characterization of the glucuronidation pathways of licochalcone A mediated by human UDP-glucuronosyltransferases. Xenobiotica 49:6, pages 671-677.
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Li Wang, Xiaodan Hong, Zhihong Yao, Yi Dai, Guoping Zhao, Zifei Qin, Baojian Wu, Frank J. Gonzalez & Xinsheng Yao. (2018) Glucuronidation of icaritin by human liver microsomes, human intestine microsomes and expressed UDP-glucuronosyltransferase enzymes: identification of UGT1A3, 1A9 and 2B7 as the main contributing enzymes. Xenobiotica 48:4, pages 357-367.
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Guangyi Yang, Shufan Ge, Rashim Singh, Sumit Basu, Katherine Shatzer, Ming Zen, Jiong Liu, Yifan Tu, Chenning Zhang, Jinbao Wei, Jian Shi, Lijun Zhu, Zhongqiu Liu, Yuan Wang, Song Gao & Ming Hu. (2017) Glucuronidation: driving factors and their impact on glucuronide disposition. Drug Metabolism Reviews 49:2, pages 105-138.
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Chen Yang, Ying Liu, Wen-qi Xi, Chen-fei Zhou, Jin-ling Jiang, Tao Ma, Zheng-bao Ye, Jun Zhang & Zheng-gang Zhu. (2015) Relationship between UGT1A1*6/*28 polymorphisms and severe toxicities in Chinese patients with pancreatic or biliary tract cancer treated with irinotecan-containing regimens. Drug Design, Development and Therapy 9, pages 3677-3683.
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Hua Sun, Huan Wang, Hongming Liu, Xingwang Zhang & Baojian Wu. (2014) Glucuronidation of capsaicin by liver microsomes and expressed UGT enzymes: reaction kinetics, contribution of individual enzymes and marked species differences. Expert Opinion on Drug Metabolism & Toxicology 10:10, pages 1325-1336.
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Antonio Gonzalez, Jesse Stombaugh, Catherine Lozupone, Peter J. Turnbaugh, Jeffrey I. Gordon & Rob Knight. (2011) The mind-body-microbial continuum. Dialogues in Clinical Neuroscience 13:1, pages 55-62.
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Upendra A Argikar, Otito F Iwuchukwu & Swati Nagar. (2008) Update on tools for evaluation of uridine diphosphoglucuronosyltransferase polymorphisms. Expert Opinion on Drug Metabolism & Toxicology 4:7, pages 879-894.
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