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Research Article

Interaction Between Valproic Acid and Carbapenem Antibiotics

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Pages 647-657 | Published online: 09 Oct 2008

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Dan Zou, Rui Zhang, Lei Yu, Tingting Hu & Bin Wu. (2023) Seizures associated with antibiotics: a real-world disproportionality analysis of FAERS database. Expert Opinion on Drug Safety 22:11, pages 1143-1148.
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Pony Yee-Chee Chai, Chian-Ting Chang, Yi-Hua Chen, Hui-Yu Chen & Ka-Wai Tam. (2021) Effect of drug interactions between carbapenems and valproate on serum valproate concentration: a systematic review and meta-analysis. Expert Opinion on Drug Safety 20:2, pages 215-223.
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Toni A Campanella & Jason C Gallagher. (2020) A Clinical Review and Critical Evaluation of Imipenem-Relebactam: Evidence to Date. Infection and Drug Resistance 13, pages 4297-4308.
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Owen R. Albin, Twisha S. Patel & Keith S. Kaye. (2018) Meropenem–vaborbactam for adults with complicated urinary tract and other invasive infections. Expert Review of Anti-infective Therapy 16:12, pages 865-876.
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Eiko Suzuki, Daisuke Nakai, Hidenori Ikenaga, Keiichi Fusegawa, Ryoya Goda, Nobuhiro Kobayashi, Hiroshi Kuga & Takashi Izumi. (2016) In vivo inhibition of acylpeptide hydrolase by carbapenem antibiotics causes the decrease of plasma concentration of valproic acid in dogs. Xenobiotica 46:2, pages 126-131.
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Nick Petrucelli, Bryan D Hayes, Nidhi Shelat, Ramy H Elshaboury, Jeffrey C Pearson & Jennifer L Koehl. (2024) Evaluating Clinical Sequelae of the Carbapenem-Valproate Interaction: A Retrospective Analysis. Open Forum Infectious Diseases 11:3.
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Samantha Elledge, Kyle Klindworth, Jennifer Guy, Lindsey DeZotell & Ashley K. Holmes. (2022) Evaluating the Effects of Ertapenem and Meropenem on Tacrolimus. Journal of Pharmacy Practice 36:6, pages 1419-1423.
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Xin Y. Chu & Paul C.L. Ho. 2023. Oral Bioavailability and Drug Delivery. Oral Bioavailability and Drug Delivery 483 500 .
Andrew J. Fratoni, Jessica L. Colmerauer, Kristin E. Linder, David P. Nicolau & Joseph L. Kuti. (2021) A Retrospective Case Series of Concomitant Carbapenem and Valproic Acid Use: Are Best Practice Advisories Working?. Journal of Pharmacy Practice 36:3, pages 537-541.
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Xuping Yang, Zhenwei Jiang, Yan Jiang, Jing Ling, Lulu Dong, Sulan Zou, Rong Chen & Nan Hu. (2023) Determination of valproic acid and its six metabolites in human serum using LC–MS/MS and application to interaction with carbapenems in epileptic patients. Biomedical Chromatography 37:3.
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Elise J. Smolders, Rob Ter Heine, Stephanie Natsch & Kees Kramers. (2022) Meropenem to Treat Valproic Acid Intoxication. Therapeutic Drug Monitoring 44:3, pages 359-362.
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I-Ling Chen, Chen-Hsiang Lee, Shu-Chen Hsiao & Fu-Yuan Shih. (2020) Interactions between carbapenems and valproic acid among the patients in the intensive care units. Journal of Critical Care.
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Laurent M. Willems, Sebastian Bauer, Kolja Jahnke, Martin Voss, Felix Rosenow & Adam Strzelczyk. (2020) Therapeutic Options for Patients with Refractory Status Epilepticus in Palliative Settings or with a Limitation of Life-Sustaining Therapies: A Systematic Review. CNS Drugs 34:8, pages 801-826.
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Yumi Nishiya, Eiko Suzuki, Tomoko Ishizuka, Miho Kazui, Hidetaka Sakurai & Daisuke Nakai. (2020) Identification of non-P450 enzymes involved in the metabolism of new drugs: Their significance in drug interaction evaluation and prodrug disposition. Drug Metabolism and Pharmacokinetics 35:1, pages 45-55.
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M. A. Khobrani, S. W. Dudley, Y. C. Huckleberry, B. J. Kopp, A. D. Biggs, R. N. E. French, F. M. Shirazi & B. L. Erstad. (2018) Intentional use of carbapenem antibiotics for valproic acid toxicity: A case report. Journal of Clinical Pharmacy and Therapeutics 43:5, pages 723-725.
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Martin Holtkamp & William H. Theodore. (2018) Generic antiepileptic drugs—Safe or harmful in patients with epilepsy?. Epilepsia 59:7, pages 1273-1281.
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Larry H. Danziger & Karolyn S. Horn. 2018. Drug Interactions in Infectious Diseases: Antimicrobial Drug Interactions. Drug Interactions in Infectious Diseases: Antimicrobial Drug Interactions 1 56 .
Samuel Deshayes, Antoine Coquerel & Renaud Verdon. (2017) Neurological Adverse Effects Attributable to β-Lactam Antibiotics: A Literature Review. Drug Safety 40:12, pages 1171-1198.
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Z.-P. Wen, S.-S. Fan, C. Du, T. Yin, B.-T. Zhou, Z.-F. Peng, Y.-Y. Xie, W. Zhang, Y. Chen, J. Xiao & X.-P. Chen. (2017) Drug-drug interaction between valproic acid and meropenem: a retrospective analysis of electronic medical records from neurosurgery inpatients. Journal of Clinical Pharmacy and Therapeutics 42:2, pages 221-227.
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Chi‐Ren Huang, Chih‐Hsiang Lin, Shu‐Chen Hsiao, Nai‐Ching Chen, Wan‐Chen Tsai, Shang‐Der Chen, Yan‐Ting Lu & Yao‐Chung Chuang. (2017) Drug interaction between valproic acid and carbapenems in patients with epileptic seizures. The Kaohsiung Journal of Medical Sciences 33:3, pages 130-136.
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Peter Bede, Diane Lawlor, Damodar Solanki & Norman Delanty. (2016) Carbapenems and valproate: A consumptive relationship. Epilepsia Open 2:1, pages 107-111.
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Upendarrao Golla, Deepthi Joseph & Raghuvir Singh Tomar. (2016) Combined Transcriptomics and Chemical-Genetics Reveal Molecular Mode of Action of Valproic acid, an Anticancer Molecule using Budding Yeast Model. Scientific Reports 6:1.
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Elena S?nchez-Y??ez, Clara Esta?n-Mart?nez & Guillermo Ojeda Burgos. (2016) Meropenem y ?cido valproico: interacci?n farmacol?gica cl?nicamente relevante. Enfermedades Infecciosas y Microbiolog?a Cl?nica 34:8, pages 536-537.
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