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Research Article

Cytochromes P450: A Structure-Based Summary of Biotransformations Using Representative Substrates

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Pages 1-100 | Published online: 09 Oct 2008

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Crossref
Souzan B. Yanni. 2015. Translational ADMET for Drug Therapy. Translational ADMET for Drug Therapy 63 110 .
Laura M. JonesAnthony J. FlemmingPeter E. Urwin. (2015) NHR-176 regulates cyp-35d1 to control hydroxylation-dependent metabolism of thiabendazole in Caenorhabditis elegans . Biochemical Journal 466:1, pages 37-44.
Crossref
LUCIA HIĽOVSKÁ, RASTISLAV JENDŽELOVSKÝ & PETER FEDOROČKO. (2015) Potency of non-steroidal anti-inflammatory drugs in chemotherapy. Molecular and Clinical Oncology 3:1, pages 3-12.
Crossref
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Gabriel V. Markov, Praveen Baskaran & Ralf J. Sommer. (2014) The Same or Not the Same: Lineage-Specific Gene Expansions and Homology Relationships in Multigene Families in Nematodes. Journal of Molecular Evolution 80:1, pages 18-36.
Crossref
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A. D. Bastiaan Vliegenthart, Carl S. Tucker, Jorge Del Pozo & James W. Dear. (2014) Zebrafish as model organisms for studying drug‐induced liver injury. British Journal of Clinical Pharmacology 78:6, pages 1217-1227.
Crossref
Bernard Testa. 2014. Drug Metabolism Prediction. Drug Metabolism Prediction 1 26 .
Anastasia V. Rudik, Alexander V. Dmitriev, Alexey A. Lagunin, Dmitry A. Filimonov & Vladimir V. Poroikov. (2014) Metabolism Site Prediction Based on Xenobiotic Structural Formulas and PASS Prediction Algorithm. Journal of Chemical Information and Modeling 54:2, pages 498-507.
Crossref
Nigel J. Waters & Michelle K. Dennehy. 2014. Handbook of Metabolic Pathways of Xenobiotics. Handbook of Metabolic Pathways of Xenobiotics 1 24 .
J.-H. Fuhrhop. (2013) Porphyrin Assemblies and Their Scaffolds. Langmuir 30:1, pages 1-12.
Crossref
Ji Eun Lee, Tae Hui Kwon, Su Jin Gu, Duck-Hyung Lee, B. Moon Kim, Jae Yeol Lee, Jae Kyun Lee, Seon Hee Seo, Ae Nim Pae, Gyochang Keum, Yong Seo Cho & Sun-Joon Min. (2014) Efficient synthesis of mibefradil analogues: an insight into in vitro stability. Organic & Biomolecular Chemistry 12:30, pages 5669.
Crossref
Armin H. Meyer, Agnieszka Dybala-Defratyka, Peter J. Alaimo, Inacrist Geronimo, Ariana D. Sanchez, Christopher J. Cramer & Martin Elsner. (2014) Cytochrome P450-catalyzed dealkylation of atrazine by Rhodococcus sp. strain NI86/21 involves hydrogen atom transfer rather than single electron transfer . Dalton Trans. 43:32, pages 12175-12186.
Crossref
R.W. Coppock & Margitta M. Dziwenka. 2014. Biomarkers in Toxicology. Biomarkers in Toxicology 647 654 .
Maria S. Zharkova, Boris N. Sobolev, Nina Yu. Oparina, Alexander V. Veselovsky & Alexander I. Archakov. (2013) Prediction of amino acid residues participated in substrate recognition by cytochrome P450 subfamilies with broad substrate specificity. Journal of Molecular Recognition 26:2, pages 86-91.
Crossref
Koichi Handa, Izumi Nakagome, Noriyuki Yamaotsu, Hiroaki Gouda & Shuichi Hirono. (2013) Three-dimensional Quantitative Structure–Activity Relationship Analysis of Inhibitors of Human and Rat Cytochrome P4503A Enzymes. Drug Metabolism and Pharmacokinetics 28:4, pages 345-355.
Crossref
Gisele Baraldi Messiano, Renan Augusto da Silva Santos, Leandro De Santis Ferreira, Rodrigo Almeida Simões, Valquíria Aparecida Polisel Jabor, Massuo Jorge Kato, Norberto Peporine Lopes, Mônica Tallarico Pupo & Anderson Rodrigo Moraes de Oliveira. (2013) In vitro metabolism study of the promising anticancer agent the lignan (−)-grandisin. Journal of Pharmaceutical and Biomedical Analysis 72, pages 240-244.
Crossref
Peter Hlavica. (2013) Evaluation of structural features in fungal cytochromes P450 predicted to rule catalytic diversification. Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics 1834:1, pages 205-220.
Crossref
Hans Matter & Wolfgang Schmider. 2013. Drug Discovery and Evaluation: Safety and Pharmacokinetic Assays. Drug Discovery and Evaluation: Safety and Pharmacokinetic Assays 1005 1052 .
Hongmao Sun, Henrike Veith, Menghang Xia, Christopher P. Austin, Raymond R. Tice & Ruili Huang. (2012) Prediction of Cytochrome P450 Profiles of Environmental Chemicals with QSAR Models Built from Drug‐Like Molecules. Molecular Informatics 31:11-12, pages 783-792.
Crossref
Alessandra Pirovano, Nicolò Borile & A. Jan Hendriks. (2012) A comparison of octanol–water partitioning between organic chemicals and their metabolites in mammals. Chemosphere 88:8, pages 1036-1041.
Crossref
Jed Zaretzki, Patrik Rydberg, Charles Bergeron, Kristin P. Bennett, Lars Olsen & Curt M. Breneman. (2012) RS-Predictor Models Augmented with SMARTCyp Reactivities: Robust Metabolic Regioselectivity Predictions for Nine CYP Isozymes. Journal of Chemical Information and Modeling 52:6, pages 1637-1659.
Crossref
C. Bergeron, G. Moore, J. Zaretzki, C. M. Breneman & K. P. Bennett. (2012) Fast Bundle Algorithm for Multiple-Instance Learning. IEEE Transactions on Pattern Analysis and Machine Intelligence 34:6, pages 1068-1079.
Crossref
Alexander V. LyubimovCurtis J. Omiecinski, Xi Yang & Elizabeth M. Laurenzana. 2011. Encyclopedia of Drug Metabolism and Interactions. Encyclopedia of Drug Metabolism and Interactions 1 30 .
Chun Li & Nataraj Kalyanaraman. 2012. ADME‐Enabling Technologies in Drug Design and Development. ADME‐Enabling Technologies in Drug Design and Development 189 212 .
Alexander V. LyubimovLin Xu, Biplab Das & Chandra Prakash. 2011. Encyclopedia of Drug Metabolism and Interactions. Encyclopedia of Drug Metabolism and Interactions 1 35 .
Katerina Cizkova, Anna Konieczna, Bela Erdosova, Radka Lichnovska & Jiri Ehrmann. (2012) Peroxisome Proliferator-Activated Receptors in Regulation of Cytochromes P450: New Way to Overcome Multidrug Resistance?. Journal of Biomedicine and Biotechnology 2012, pages 1-10.
Crossref
Tao Zhang, Hao Dai, Limin Angela Liu, David F. V. Lewis & Dongqing Wei. (2012) Classification Models for Predicting Cytochrome P450 Enzyme‐Substrate Selectivity. Molecular Informatics 31:1, pages 53-62.
Crossref
Peter Hlavica. (2011) Insect cytochromes P450: Topology of structural elements predicted to govern catalytic versatility. Journal of Inorganic Biochemistry 105:10, pages 1354-1364.
Crossref
Samuel L. C. Moors, Ann M. Vos, Maxwell D. Cummings, Herman Van Vlijmen & Arnout Ceulemans. (2011) Structure-Based Site of Metabolism Prediction for Cytochrome P450 2D6. Journal of Medicinal Chemistry 54:17, pages 6098-6105.
Crossref
Jed Zaretzki, Charles Bergeron, Patrik Rydberg, Tao-wei Huang, Kristin P. Bennett & Curt M. Breneman. (2011) RS-Predictor: A New Tool for Predicting Sites of Cytochrome P450-Mediated Metabolism Applied to CYP 3A4. Journal of Chemical Information and Modeling 51:7, pages 1667-1689.
Crossref
Tao Zhang, Limin Angela Liu, David F. V. LewisDong-Qing Wei. (2011) Long-Range Effects of a Peripheral Mutation on the Enzymatic Activity of Cytochrome P450 1A2. Journal of Chemical Information and Modeling 51:6, pages 1336-1346.
Crossref
Arthur N. Mayeno, Jonathan L. Robinson & Brad Reisfeld. (2010) Rapid estimation of activation enthalpies for cytochrome‐P450‐mediated hydroxylations. Journal of Computational Chemistry 32:4, pages 639-657.
Crossref
Melisa Clements & Liang Li. (2011) Strategy of using microsome-based metabolite production to facilitate the identification of endogenous metabolites by liquid chromatography mass spectrometry. Analytica Chimica Acta 685:1, pages 36-44.
Crossref
Johannes N. van den Anker, Matthias Schwab & Gregory L. Kearns. 2011. Pediatric Clinical Pharmacology. Pediatric Clinical Pharmacology 51 75 .
Vitor H. Teixeira, Vera Ribeiro & Paulo J. Martel. (2010) Analysis of binding modes of ligands to multiple conformations of CYP3A4. Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics 1804:10, pages 2036-2045.
Crossref
Austin Chen, Daniel Dubé, Laurence Dubé, Sébastien Gagné, Michel Gallant, Mireille Gaudreault, Erich Grimm, Robert Houle, Patrick Lacombe, Sébastien Laliberté, Suzanna Liu, Dwight MacDonald, Bruce Mackay, David Martin, Dan McKay, David Powell & Jean-François Lévesque. (2010) Addressing time-dependent CYP 3A4 inhibition observed in a novel series of substituted amino propanamide renin inhibitors, a case study. Bioorganic & Medicinal Chemistry Letters 20:17, pages 5074-5079.
Crossref
Harry B. Gray & Jay R. Winkler. (2010) Electron flow through metalloproteins. Biochimica et Biophysica Acta (BBA) - Bioenergetics 1797:9, pages 1563-1572.
Crossref
Patrik Rydberg, David E. Gloriam, Jed Zaretzki, Curt Breneman & Lars Olsen. (2010) SMARTCyp: A 2D Method for Prediction of Cytochrome P450-Mediated Drug Metabolism. ACS Medicinal Chemistry Letters 1:3, pages 96-100.
Crossref
Jos H.M. Lange, Martina A.W. van der Neut, Alice J.M. Borst, Mahmut Yildirim, Herman H. van Stuivenberg, Bernard J. van Vliet & Chris G. Kruse. (2010) Probing the cannabinoid CB1/CB2 receptor subtype selectivity limits of 1,2-diarylimidazole-4-carboxamides by fine-tuning their 5-substitution pattern. Bioorganic & Medicinal Chemistry Letters 20:9, pages 2770-2775.
Crossref
Elisabet Aranda, René Ullrich & Martin Hofrichter. (2009) Conversion of polycyclic aromatic hydrocarbons, methyl naphthalenes and dibenzofuran by two fungal peroxygenases. Biodegradation 21:2, pages 267-281.
Crossref
R.I. Sanchez & F.C. Kauffman. 2010. Comprehensive Toxicology. Comprehensive Toxicology 109 128 .
Jean-Pierre Gillet & Michael M. Gottesman. 2010. Multi-Drug Resistance in Cancer. Multi-Drug Resistance in Cancer 47 76 .
Lisa Michielan, Lothar Terfloth, Johann Gasteiger & Stefano Moro. (2009) Comparison of Multilabel and Single-Label Classification Applied to the Prediction of the Isoform Specificity of Cytochrome P450 Substrates. Journal of Chemical Information and Modeling 49:11, pages 2588-2605.
Crossref
Jean‐Pierre Gillet, Michael M. Gottesman & Mitsunori Okabe. 2009. The Liver. The Liver 1075 1090 .
Anderson Rodrigo Moraes de Oliveira, Patrícia da Fonseca, Carlos Curti, Roberto Santana da Silva & Pierina Sueli Bonato. (2009) In vitro metabolism study of a new nitrosyl ruthenium complex [Ru(NH·NHq)(terpy)NO]3+ nitric oxide donor using rat microsomes. Nitric Oxide 21:1, pages 14-19.
Crossref
Patrick Sch?fer, Martin M?ller, Angela Kr?ger, Christian E.W. Steinberg & Ralph Menzel. (2009) Cytochrome P450-dependent metabolism of PCB52 in the nematode Caenorhabditis elegans. Archives of Biochemistry and Biophysics 488:1, pages 60-68.
Crossref
Arthur N. Mayeno, Jonathan L. Robinson, Raymond S. H. Yang & Brad Reisfeld. (2009) Predicting Activation Enthalpies of Cytochrome-P450-Mediated Hydrogen Abstractions. 2. Comparison of Semiempirical PM3, SAM1, and AM1 with a Density Functional Theory Method. Journal of Chemical Information and Modeling 49:7, pages 1692-1703.
Crossref
Peter Hlavica. (2009) Assembly of non-natural electron transfer conduits in the cytochrome P450 system: A critical assessment and update of artificial redox constructs amenable to exploitation in biotechnological areas. Biotechnology Advances 27:2, pages 103-121.
Crossref
Nedeljka N. Rosic. (2008) Versatile capacity of shuffled cytochrome P450s for dye production. Applied Microbiology and Biotechnology 82:2, pages 203-210.
Crossref
Kiyoshi Nagata. (2009) Drug metabolism catalyzed by cytochrome P-450. Folia Pharmacologica Japonica 134:3, pages 146-148.
Crossref
Martin Kluge, René Ullrich, Christoph Dolge, Katrin Scheibner & Martin Hofrichter. (2008) Hydroxylation of naphthalene by aromatic peroxygenase from Agrocybe aegerita proceeds via oxygen transfer from H2O2 and intermediary epoxidation. Applied Microbiology and Biotechnology 81:6, pages 1071-1076.
Crossref
Andreas Luch. 2009. Molecular, Clinical and Environmental Toxicology. Molecular, Clinical and Environmental Toxicology 151 179 .
Wolfgang Dekant. 2009. Molecular, Clinical and Environmental Toxicology. Molecular, Clinical and Environmental Toxicology 57 86 .
Kersten S. Rabe, Valérie J. Gandubert, Mark Spengler, Michael Erkelenz & Christof M. Niemeyer. (2008) Engineering and assaying of cytochrome P450 biocatalysts. Analytical and Bioanalytical Chemistry 392:6, pages 1059-1073.
Crossref
Olavi Pelkonen, Miia Turpeinen, Jukka Hakkola, Paavo Honkakoski, Janne Hukkanen & Hannu Raunio. (2008) Inhibition and induction of human cytochrome P450 enzymes: current status. Archives of Toxicology 82:10, pages 667-715.
Crossref

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