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Research Article

Cytochrome P450 Inactivation by Pharmaceuticals and Phytochemicals: Therapeutic Relevance

Pages 101-147 | Published online: 09 Oct 2008

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Hui-dan Zhu, Ni Gu, Meng Wang, Hong-ru Kong & Meng-tao Zhou. (2015) Effects of capsicine on rat cytochrome P450 isoforms CYP1A2, CYP2C19, and CYP3A4. Drug Development and Industrial Pharmacy 41:11, pages 1824-1828.
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Ying Peng, Hui Wu, Xueyuan Zhang, Fengyi Zhang, Huanhuan Qi, Yunxi Zhong, Yu Wang, Hua Sang, Guangji Wang & Jianguo Sun. (2015) A comprehensive assay for nine major cytochrome P450 enzymes activities with 16 probe reactions on human liver microsomes by a single LC/MS/MS run to support reliable in vitro inhibitory drug–drug interaction evaluation. Xenobiotica 45:11, pages 961-977.
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Alan Boobis, Jean-Baptiste Watelet, Rhys Whomsley, Margherita Strolin Benedetti, Pascal Demoly & Keith Tipton. (2009) Drug interactions. Drug Metabolism Reviews 41:3, pages 486-527.
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Margherita Strolin Benedetti, Rhys Whomsley, Italo Poggesi, Willi Cawello, François-Xavier Mathy, Marie-Laure Delporte, Peggy Papeleu & Jean-Baptiste Watelet. (2009) Drug metabolism and pharmacokinetics. Drug Metabolism Reviews 41:3, pages 344-390.
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Kazumasa Kozakai, Yasuhiro Yamada, Motoji Oshikata, Taiji Kawase, Etsuko Suzuki, Yukari Haramaki & Hideki Taniguchi. (2012) Reliable High-throughput Method for Inhibition Assay of 8 Cytochrome P450 Isoforms Using Cocktail of Probe Substrates and Stable Isotope-labeled Internal Standards. Drug Metabolism and Pharmacokinetics 27:5, pages 520-529.
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S. Genovese, F. Epifano, M. Curini, D. Menger, N.C.L. Zembruski & J. Weiss. (2011) In vitro effects of natural prenyloxycinnamic acids on human cytochrome P450 isozyme activity and expression. Phytomedicine 18:7, pages 586-591.
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Hsia-lien Lin, Haoming Zhang, Christine Medower, Paul F. Hollenberg & William W. Johnson. (2011) Inactivation of Cytochrome P450 (P450) 3A4 but not P450 3A5 by OSI-930, a Thiophene-Containing Anticancer Drug. Drug Metabolism and Disposition 39:2, pages 345-350.
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Michael D. Coleman. 2010. Human Drug Metabolism. Human Drug Metabolism 319 327 .
Thomas M. Polasek, Janani S. Sadagopal, David J. Elliot & John O. Miners. (2009) In vitro-in vivo extrapolation of zolpidem as a perpetrator of metabolic interactions involving CYP3A. European Journal of Clinical Pharmacology 66:3, pages 275-283.
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Shobana Ganesan, Babu L. Tekwani, Rajnish Sahu, Lalit M. Tripathi & Larry A. Walker. (2009) Cytochrome P450-dependent toxic effects of primaquine on human erythrocytes. Toxicology and Applied Pharmacology 241:1, pages 14-22.
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Chambers C. Hughes, Yu-Liang Yang, Wei-Ting Liu, Pieter C. Dorrestein, James J. La Clair & William Fenical. (2009) Marinopyrrole A Target Elucidation by Acyl Dye Transfer. Journal of the American Chemical Society 131:34, pages 12094-12096.
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Scott W. Grimm, Heidi J. Einolf, Steven D. Hall, Kan He, Heng-Keang Lim, Kah-Hiing John Ling, Chuang Lu, Amin A. Nomeir, Eleanore Seibert, Konstantine W. Skordos, George R. Tonn, Robert Van Horn, Regina W. Wang, Y. Nancy Wong, Tian J. Yang & R. Scott Obach. (2009) The Conduct of in Vitro Studies to Address Time-Dependent Inhibition of Drug-Metabolizing Enzymes: A Perspective of the Pharmaceutical Research and Manufacturers of America. Drug Metabolism and Disposition 37:7, pages 1355-1370.
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K. N. Woodward. 2009. Veterinary Pharmacovigilance. Veterinary Pharmacovigilance 423 452 .
Vincent O. Dezentjé, Henk-Jan Guchelaar, Johan W.R. Nortier, Cornelis J.H. van de Velde & Hans Gelderblom. (2009) Clinical Implications of CYP2D6 Genotyping in Tamoxifen Treatment for Breast Cancer . Clinical Cancer Research 15:1, pages 15-21.
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Dil M. Ramanathan & Richard M. Lelacheur. 2008. Mass Spectrometry in Drug Metabolism and Pharmacokinetics. Mass Spectrometry in Drug Metabolism and Pharmacokinetics 1 85 .
Melissa M. Yatzeck, Luke D. Lavis, Tzu-Yuan Chao, Sunil S. Chandran & Ronald T. Raines. (2008) A highly sensitive fluorogenic probe for cytochrome P450 activity in live cells. Bioorganic & Medicinal Chemistry Letters 18:22, pages 5864-5866.
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