Advanced search
Publication Cover
Drug Metabolism Reviews Volume 49, 2017 - Issue 2
Submit an article Journal homepage
2,250
Views
79
CrossRef citations to date
0
Altmetric
Review Article

Glucuronidation: driving factors and their impact on glucuronide disposition

Guangyi YangDepartment of Pharmacy, Institute of Wudang Herbal Medicine Research, Taihe Hospital, Hubei University of Medicine, Shiyan, Hubei, China; ;Hubei Provincial Technology and Research Center for Comprehensive Development of Medicinal Herbs, Hubei University of Medicine, Shiyan, Hubei, China; View further author information
,
Shufan GeDepartment of Pharmacological and Pharmaceutical Sciences, College of Pharmacy, University of Houston, Houston, TX, USA; View further author information
,
Rashim SinghDepartment of Pharmacological and Pharmaceutical Sciences, College of Pharmacy, University of Houston, Houston, TX, USA; View further author information
,
Sumit BasuDepartment of Pharmacological and Pharmaceutical Sciences, College of Pharmacy, University of Houston, Houston, TX, USA; View further author information
,
Katherine ShatzerDepartment of Pharmacological and Pharmaceutical Sciences, College of Pharmacy, University of Houston, Houston, TX, USA; View further author information
,
Ming ZenDepartment of Thoracic and Cardiomacrovascular Surgery, Taihe Hospital, Hubei University of Medicine, Shiyan, Hubei, China; View further author information
,
Jiong LiuDepartment of Digestive Diseases Surgery, Taihe Hospital, Hubei University of Medicine, Shiyan, Hubei, China; View further author information
,
Yifan TuDepartment of Pharmacological and Pharmaceutical Sciences, College of Pharmacy, University of Houston, Houston, TX, USA; View further author information
,
Chenning ZhangDepartment of Pharmacy, Institute of Wudang Herbal Medicine Research, Taihe Hospital, Hubei University of Medicine, Shiyan, Hubei, China; View further author information
,
Jinbao WeiDepartment of Pharmacy, Institute of Wudang Herbal Medicine Research, Taihe Hospital, Hubei University of Medicine, Shiyan, Hubei, China; View further author information
,
Jian ShiDepartment of Pharmacy, Institute of Translational Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China; View further author information
,
Lijun ZhuDepartment of Pharmacy, Institute of Translational Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China; View further author information
,
Zhongqiu LiuDepartment of Pharmacy, Institute of Translational Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China; View further author information
,
Yuan WangDepartment of Pharmacy, College of Pharmacy, Hubei University of Medicine, Shiyan, Hubei, ChinaView further author information
,
Song GaoDepartment of Pharmacological and Pharmaceutical Sciences, College of Pharmacy, University of Houston, Houston, TX, USA; ;Department of Pharmacy, College of Pharmacy, Hubei University of Medicine, Shiyan, Hubei, ChinaView further author information
&
Ming HuDepartment of Pharmacological and Pharmaceutical Sciences, College of Pharmacy, University of Houston, Houston, TX, USA; ;Department of Pharmacy, College of Pharmacy, Hubei University of Medicine, Shiyan, Hubei, ChinaCorrespondence[email protected]
View further author information
 show all
Pages 105-138 | Received 14 Sep 2016, Accepted 30 Jan 2017, Published online: 22 May 2017

Citations (79)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (7)

Daniel Merenstein, Bruno Pot, Gregory Leyer, Arthur C. Ouwehand, Geoffrey A. Preidis, Christopher A. Elkins, Colin Hill, Zachery T. Lewis, Andi L. Shane, Niv Zmora, Mariya I. Petrova, Maria Carmen Collado, Lorenzo Morelli, Gina A. Montoya, Hania Szajewska, Daniel J. Tancredi & Mary Ellen Sanders. (2023) Emerging issues in probiotic safety: 2023 perspectives. Gut Microbes 15:1.
Read now
Camden Ellis, Keita Inaba, Christine Van de Vuurst, Atheel Ghrayeb & Theodore James Cory. (2023) Drug–drug interactions between COVID-19 therapeutics and antiretroviral treatment: the evidence to date. Expert Opinion on Drug Metabolism & Toxicology 19:11, pages 795-806.
Read now
Yujie Yuan, Shuang Zhang, Yangyang Yuan, Xinjing Yan, Linlin Zhang & Yun Wei Ran. (2023) Pharmacogenomics of Oxcarbazepine in the Treatment of Epilepsy. Pharmacogenomics 24:6, pages 335-343.
Read now
Xinyu Ge, Sheng Ma, Shu Yan, Yali Wu, Chong Chen, Chongzhuang Tang, Yan Zhan, Yi-cong Bian, Kai Shen, Sheng Feng, Xuehu Gao, Dafang Zhong, Hua Zhang, Li-yan Miao & Xing-xing Diao. (2023) Mass balance study of [14C]SHR0302, a selective and potent JAK1 inhibitor in humans. Xenobiotica 53:2, pages 69-83.
Read now
Gabriel Bernardes & Ed S. Krol. (2023) In vitro hepatic metabolism of the natural product quebecol. Xenobiotica 53:1, pages 1-11.
Read now
Lu Zhang, Bill Poland, Michelle Green, Shekman Wong & J. Greg Slatter. (2022) A population pharmacokinetic-pharmacodynamic model of navtemadlin, its glucuronide metabolite (M1) and serum macrophage inhibitory cykokine-1 (MIC-1). Xenobiotica 52:6, pages 555-566.
Read now
Amin Sayyari, Christiane Kruse Fæste, Ulrik Hansen, Silvio Uhlig, Tore Framstad, Dian Schatzmayr & Tore Sivertsen. (2018) Effects and biotransformation of the mycotoxin deoxynivalenol in growing pigs fed with naturally contaminated pelleted grains with and without the addition of Coriobacteriaceum DSM 11798. Food Additives & Contaminants: Part A 35:7, pages 1394-1409.
Read now

Articles from other publishers (72)

Alan Wayne Jones. (2023) Brief history of the alcohol biomarkers CDT, EtG, EtS, 5‐HTOL, and PEth. Drug Testing and Analysis 16:6, pages 570-587.
Crossref
Robert Papp, Laird Trimble, Adrian J. Fretland, Ravi Manohar, Richard Phipps, Lisbet Kvaerno, Alexander L. Perryman, Gregory Reynolds & W. Cameron Black. (2024) Identification and Biosynthesis of an N -Glucuronide Metabolite of Camonsertib . Drug Metabolism and Disposition 52:5, pages 368-376.
Crossref
Zhi Hao Chi, Lan Liu, Jingyun Zheng, Lei Tian, Jonathan Chevrier, Riana Bornman, Muvhulawa Obida, Cynthia Gates Goodyer, Barbara F. Hales & Stéphane Bayen. (2024) Biomonitoring of bisphenol A (BPA) and bisphenol analogues in human milk from South Africa and Canada using a modified QuEChERS extraction method. Environmental Pollution 348, pages 123730.
Crossref
Rayudu Gopalakrishna, Jennifer Aguilar, Andrew Oh, Emily Lee, Lucas Hou, Tammy Lee, Eric Xu, James Nguyen & William J. Mack. (2024) Resveratrol and its metabolites elicit neuroprotection via high‐affinity binding to the laminin receptor at low nanomolar concentrations . FEBS Letters 598:9, pages 995-1007.
Crossref
Thibaut Rosay, Angel G. Jimenez & Vanessa Sperandio. (2024) Glucuronic acid confers colonization advantage to enteric pathogens. Proceedings of the National Academy of Sciences 121:13.
Crossref
Wan-Yu Lin. (2024) Searching for gene-gene interactions through variance quantitative trait loci of 29 continuous Taiwan Biobank phenotypes. Frontiers in Genetics 15.
Crossref
Jieyu Dai, Tao Chen, Ryan Meng, Ferran Jardi, Stephanie Kourula, Ly Pham, Sandra De Jonghe, Ann De Smedt, Anna‐Lena Frisk & Jianxun Xie. (2023) Species differences in small intestinal exposure‐related epithelial vacuolation in rats and dogs treated with a heteroaryldihydropyrimidine molecule. Journal of Applied Toxicology 44:3, pages 400-414.
Crossref
Bruno Pereira Dos Santos, Letícia Birk, Patrícia Schwarz, Viviane Cristina Sebben, Ângela Malysz Sgaravatti, Giovanna Cristiano de Gouveia, Adriana Ubirajara Silva Petry, Francisco Paz de Menezes, Alexsandro Pinto Gonzaga, Paula Flores Schlickmann, Marcelo Dutra Arbo, Tiago Franco de Oliveira & Sarah Eller. (2024) A validated dilute-and-shoot LC–MS-MS urine screening for the analysis of 95 illicit drugs and medicines: Insights from clinical and forensic Brazilian cases. Journal of Analytical Toxicology.
Crossref
Inês Maximiano, Catarina Henriques, Ricardo G. Teixeira, Fernanda Marques, Andreia Valente & Alexandra M.M. Antunes. (2024) Lead to hit ruthenium-cyclopentadienyl anticancer compounds: Cytotoxicity against breast cancer cells, metabolic stability and metabolite profiling. Journal of Inorganic Biochemistry 251, pages 112436.
Crossref
Amal Khalifa, Rebecca Palu, Amy E. Perkins & Avery Volz. (2024) Prenatal alcohol exposure alters expression of genes involved in cell adhesion, immune response, and toxin metabolism in adolescent rat hippocampus. PLOS ONE 19:1, pages e0293425.
Crossref
Shuaiqi Wang, Dianwen Ju & Xian Zeng. (2024) Mechanisms and Clinical Implications of Human Gut Microbiota-Drug Interactions in the Precision Medicine Era. Biomedicines 12:1, pages 194.
Crossref
Matthias J. A. Vink, Jimmy Alarcan, Jonathan Martens, Wybren Jan Buma, Albert Braeuning, Giel Berden & Jos Oomens. (2023) Structural Elucidation of Agrochemical Metabolic Transformation Products Based on Infrared Ion Spectroscopy to Improve In Silico Toxicity Assessment. Chemical Research in Toxicology 37:1, pages 81-97.
Crossref
Sonja A. Wrobel, Daniel Bury, Stephan Koslitz, Heiko Hayen, Holger M. Koch, Thomas Brüning & Heiko U. Käfferlein. (2023) Quantitative Metabolism and Urinary Elimination Kinetics of Seven Neonicotinoids and Neonicotinoid-Like Compounds in Humans. Environmental Science & Technology 57:48, pages 19285-19294.
Crossref
S Z Elkhateeb, M O Ebraheem, S M Abdulateef & I A Ahmed. (2023) Constraints Affecting the Welfare of Domestic Sheep Grazing in the Natural Pasture. IOP Conference Series: Earth and Environmental Science 1252:1, pages 012144.
Crossref
Vick Kostrubsky, Ying Liu, Cathy Muste, Chungang Gu, Melissa Kirkland, Naoko Nishimura, Keiko Hasegawa, Keiji Hasumi & Long Yuan. (2023) Preclinical safety, toxicokinetics and metabolism of BIIB131, a novel prothrombolytic agent for acute stroke. Regulatory Toxicology and Pharmacology 145, pages 105498.
Crossref
Lia Visintin, María García Nicolás, Pablo Vangeenderhuysen, Tess Goessens, Eugenio Alladio, Beata Pomian, Lynn Vanhaecke, Sarah De Saeger & Marthe De Boevre. (2023) Unraveling biomarkers of exposure for tenuazonic acid through urinary metabolomics. Food and Chemical Toxicology 182, pages 114183.
Crossref
Marco Pepe, Mohsen Hesami, Karla A. de la Cerda, Melissa L. Perreault, Tom Hsiang & Andrew Maxwell Phineas Jones. (2023) A journey with psychedelic mushrooms: From historical relevance to biology, cultivation, medicinal uses, biotechnology, and beyond. Biotechnology Advances 69, pages 108247.
Crossref
Abdel-Rahim S. Ibrahim, Mai K. Mansour, Mohammed M.A. Ahmed, Roland Ulber & Ahmed Zayed. (2023) Metabolism of natural and synthetic bioactive compounds in Cunninghamella fungi and their applications in drug discovery. Bioorganic Chemistry 140, pages 106801.
Crossref
Brooke Langevin, Jogarao V.S. Gobburu & Mathangi Gopalakrishnan. (2023) Is There a Need for a Dedicated Pharmacokinetic Trial for a Drug in Obese Populations? A Drug Prioritization Decision Tree Framework. The Journal of Clinical Pharmacology 63:S2.
Crossref
Song Gao, Imoh Etim, Robin Sunsong, Christabel Ebuzoeme, Ting Du & Dinh Bui. 2023. Oral Bioavailability and Drug Delivery. Oral Bioavailability and Drug Delivery 233 266 .
Rashim Singh, Dinh Bui & Ming Hu. 2023. Oral Bioavailability and Drug Delivery. Oral Bioavailability and Drug Delivery 155 188 .
Lin Han & Pamela V. Chang. (2023) Activity-based protein profiling in microbes and the gut microbiome. Current Opinion in Chemical Biology 76, pages 102351.
Crossref
Jie Wang, Xu Li, Fang‐Fang Wang, Meng‐Ting Cheng, Yao‐Xu Mao, Shu‐Cheng Fang, Liang Wang, Cong‐Zhao Zhou, Wen‐Tao Hou & Yuxing Chen. (2023) Placing steroid hormones within the human ABCC3 transporter reveals a compatible amphiphilic substrate‐binding pocket . The EMBO Journal 42:17.
Crossref
Yiqing Hu, Yongchao Zhao, Peng Li, Hao Lu, Hua Li & Junbo Ge. (2023) Hypoxia and panvascular diseases: exploring the role of hypoxia-inducible factors in vascular smooth muscle cells under panvascular pathologies. Science Bulletin 68:17, pages 1954-1974.
Crossref
Rayudu Gopalakrishna, Andrew Oh, Lucas Hou, Emily Lee, Jennifer Aguilar, Andrew Li & William J. Mack. (2023) Flavonoid quercetin and its glucuronide and sulfate conjugates bind to 67-kDa laminin receptor and prevent neuronal cell death induced by serum starvation. Biochemical and Biophysical Research Communications 671, pages 116-123.
Crossref
Tabasum Ali, Sheikh Tahir Majeed, Rabiya Majeed, Rabiah Bashir, Suhail Ahmad Mir, Ifat Jan, Ghulam Nabi Bader & Khurshid Iqbal Andrabi. (2023) Recent Advances in the Pharmacological Properties and Molecular Mechanisms of Carvacrol. Revista Brasileira de Farmacognosia 34:1, pages 35-47.
Crossref
Urs Duthaler, Fabio Bachmann, Agustos C. Ozbey, Kenichi Umehara, Neil Parrott, Stephen Fowler & Stephan Krähenbühl. (2023) The Activity of Members of the UDP-Glucuronosyltransferase Subfamilies UGT1A and UGT2B is Impaired in Patients with Liver Cirrhosis. Clinical Pharmacokinetics 62:8, pages 1141-1155.
Crossref
Nicole Prince, Meryl Stav, Margaret Cote, Su H. Chu, Chirag M. Vyas, Olivia I. Okereke, Natalia Palacios, Augusto A Litonjua, Pantel Vokonas, David Sparrow, Avron SpiroIIIIII, Jessica A. Lasky-Su & Rachel S. Kelly. (2023) Metabolomics and Self-Reported Depression, Anxiety, and Phobic Symptoms in the VA Normative Aging Study. Metabolites 13:7, pages 851.
Crossref
Xiaoqing Yuan, Hong Wang, Shuyi Song, Lili Qiu, Xianming Lan, Pingping Dong & Jiayu Zhang. (2023) Stepwise Targeted Matching Strategy for Comprehensive Profiling of Xanthohumol Metabolites In Vivo and In Vitro Using UHPLC-Q-Exactive Orbitrap Mass Spectrometer. Molecules 28:13, pages 5168.
Crossref
Zheng-Yuan Su, Jen-Chun Chien, Yen-Chen Tung, Tien-Yuan Wu, Jie-An Liao & Guor-Jien Wei. (2023) Tangeretin and 4′-demethyltangeretin prevent damage to mouse hepatocytes from oxidative stress by activating the Nrf2-related antioxidant pathway via an epigenetic mechanism. Chemico-Biological Interactions, pages 110650.
Crossref
Kien P. Malarney & Pamela V. Chang. (2023) Chemoproteomic Approaches for Unraveling Prokaryotic Biology. Israel Journal of Chemistry 63:3-4.
Crossref
Xiao Zhai, Jieying Liu, Miao Yu, Qian Zhang, Ming Li, Nan Zhao, Juntao Liu, Yingna Song, Liangkun Ma, Rongrong Li, Zongxu Qiao, Guifen Zhao, Ruiping Wang & Xinhua Xiao. (2023) Nontargeted metabolomics reveals the potential mechanism underlying the association between birthweight and metabolic disturbances. BMC Pregnancy and Childbirth 23:1.
Crossref
Samar Ballabha Mohapatra & Narayanan Manoj. 2023. Glycoside Hydrolases. Glycoside Hydrolases 255 278 .
Akhila D S, Priyanka Ashwath, Kavitha Guladahalli Manjunatha, Sadanand Dangari Aksahy, Raghvendra Rao, DeviPrasadh Reddy & Rajeshwari Vittal. 2023. Xenobiotics in Aquatic Animals. Xenobiotics in Aquatic Animals 1 66 .
Tamara Božina, Ena Karačić, Lana Ganoci, Silvija Čuković-Čavka, Jozefina Palić, Nada Božina & Livija Šimičević. (2022) UGT2B7 c.-161C>T polymorphism frequency in Croatian population . Archives of Industrial Hygiene and Toxicology 73:4, pages 303-307.
Crossref
Miyu Nishikawa, Yuriko Kada, Mirai Kimata, Toshiyuki Sakaki & Shinichi Ikushiro. (2022) Comparison of metabolism and biological properties among positional isomers of quercetin glucuronide in LPS- and RANKL-challenged RAW264.7 cells. Bioscience, Biotechnology, and Biochemistry 86:12, pages 1670-1679.
Crossref
Yiqing Hu, Hao Lu, Hua Li & Junbo Ge. (2022) Molecular basis and clinical implications of HIFs in cardiovascular diseases. Trends in Molecular Medicine 28:11, pages 916-938.
Crossref
Takuya Kikuchi, Akane Hayashi, Naohiro Ikeda, Osamu Morita & Junichi Tasaki. (2022) Multidrug resistance-associated protein 2 (MRP2) is an efflux transporter of EGCG and its metabolites in the human small intestine. The Journal of Nutritional Biochemistry 107, pages 109071.
Crossref
Pierre-Alain Burnouf, Steve R. Roffler, Chia-Ching Wu & Yu-Cheng Su. (2022) Glucuronides: From biological waste to bio-nanomedical applications. Journal of Controlled Release 349, pages 765-782.
Crossref
Yueru Lian, Liyun Niu, Zhiyun Meng, Xiaoxia Zhu, Ruolan Gu, Zhuona Wu, Jian Li, Peng Han, Taoyun Liu, Hui Gan & Guifang Dou. (2022) A rapid quantitative method by liquid chromatography–tandem mass spectrometry for the measurement of anthocyanins and their metabolic characteristics in Sprague–Dawley rats. European Food Research and Technology 248:8, pages 2109-2124.
Crossref
Yurong Lai, Xiaoyan Chu, Li Di, Wei Gao, Yingying Guo, Xingrong Liu, Chuang Lu, Jialin Mao, Hong Shen, Huaping Tang, Cindy Q. Xia, Lei Zhang & Xinxin Ding. (2022) Recent advances in the translation of drug metabolism and pharmacokinetics science for drug discovery and development. Acta Pharmaceutica Sinica B 12:6, pages 2751-2777.
Crossref
Carolin Huber, Martin Krauss, Vera Reinstadler, Sara Denicolò, Gert Mayer, Tobias Schulze, Werner Brack & Herbert Oberacher. (2022) In silico deconjugation of glucuronide conjugates enhances tandem mass spectra library annotation of human samples. Analytical and Bioanalytical Chemistry 414:8, pages 2629-2640.
Crossref
Rajendra K. Wanare. (2022) Design, Synthesis and Evaluation of Novel Thiopyrimidine-Glucuronide Compounds with Promising Biological Activities. Asian Journal of Organic & Medicinal Chemistry 7:3, pages 239-244.
Crossref
Alan Talevi & Carolina L. Bellera. 2022. The ADME Encyclopedia. The ADME Encyclopedia 394 400 .
Xiao-Jing Zhang, Yan-Xiao Ji, Xu Cheng, Yanjie Cheng, Hailong YangJunyong Wang, Ling-Ping ZhaoYong-Ping Huang, Dating Sun, Hui Xiang, Li-Jun Shen, Peng-Long Li, Jun-Peng Ma, Rui-Feng Tian, Juan YangXinxin YaoHaibo Xu, Rufang LiaoLi XiaoPeng ZhangXin ZhangGuang-Nian Zhao, Xi WangMan-Li Hu, Song Tian, Juan Wan, Jingjing Cai, Xinliang Ma, Qingbo Xu, Yibin Wang, Rhian M. Touyz, Peter P. Liu, Rohit Loomba, Zhi-Gang She & Hongliang Li. (2021) A small molecule targeting ALOX12-ACC1 ameliorates nonalcoholic steatohepatitis in mice and macaques. Science Translational Medicine 13:624.
Crossref
Jia Zhu, Wenpei Liu, Meiling Zhang, Lihuan Lu, Hongqiu Pan, Xiaomin He, Nannan Wang, Miaomiao Yang, Honggang Yi & Shaowen Tang. (2021) A validation study of the UGT1A4 rs2011404 variant and the risk of anti‐tuberculosis drug‐induced hepatotoxicity in an Eastern Chinese Han population. Journal of Clinical Pharmacy and Therapeutics 46:5, pages 1288-1294.
Crossref
Song Gao, Nyma Siddiqui, Imoh Etim, Ting Du, Yun Zhang & Dong Liang. (2021) Developing nutritional component chrysin as a therapeutic agent: Bioavailability and pharmacokinetics consideration, and ADME mechanisms. Biomedicine & Pharmacotherapy 142, pages 112080.
Crossref
Michal Weitman, Corina Bejar, Michal Melamed, Tehilla Weill, Inessa Yanovsky, Shani Zeeli, Abraham Nudelman & Marta Weinstock. (2021) Comparison of the tissue distribution and metabolism of AN1284, a potent anti-inflammatory agent, after subcutaneous and oral administration in mice. Naunyn-Schmiedeberg's Archives of Pharmacology 394:10, pages 2077-2089.
Crossref
Huan Long, Xiaolong Hu, Baolin Wang, Quan Wang, Rong Wang, Shumeng Liu, Fei Xiong, Zhenzhou Jiang, Xiao-Qi Zhang, Wen-Cai Ye & Hao Wang. (2021) Discovery of Novel Apigenin–Piperazine Hybrids as Potent and Selective Poly (ADP-Ribose) Polymerase-1 (PARP-1) Inhibitors for the Treatment of Cancer. Journal of Medicinal Chemistry 64:16, pages 12089-12108.
Crossref
Ting Du, Rongjin Sun, Imoh Etim, Zicong Zheng, Dong Liang, Ming Hu & Song Gao. (2021) Age-and Region-Dependent Disposition of Raloxifene in Rats. Pharmaceutical Research 38:8, pages 1357-1367.
Crossref
Christabel Ebuzoeme, Imoh Etim, Autumn Ikimi, Jamie Song, Ting Du, Ming Hu, Dong Liang & Song Gao. (2021) Glucuronides Hydrolysis by Intestinal Microbial β-Glucuronidases (GUS) Is Affected by Sampling, Enzyme Preparation, Buffer pH, and Species. Pharmaceutics 13:7, pages 1043.
Crossref
G. Schuler. (2021) Steroid sulfates in domestic mammals and laboratory rodents. Domestic Animal Endocrinology 76, pages 106622.
Crossref
Donglu Zhang, Cong WeiCornelis E. C. A. HopMatthew R. WrightMing HuYurong Lai, S. Cyrus KhojastehW. Griff Humphreys. (2021) Intestinal Excretion, Intestinal Recirculation, and Renal Tubule Reabsorption Are Underappreciated Mechanisms That Drive the Distribution and Pharmacokinetic Behavior of Small Molecule Drugs. Journal of Medicinal Chemistry 64:11, pages 7045-7059.
Crossref
Anallely López-Yerena, Maria Pérez, Anna Vallverdú-Queralt, Eleftherios Miliarakis, Rosa M. Lamuela-Raventós & Elvira Escribano-Ferrer. (2021) Oleacein Intestinal Permeation and Metabolism in Rats Using an In Situ Perfusion Technique. Pharmaceutics 13:5, pages 719.
Crossref
Herana Kamal SeneviratneJoseph TillotsonJulie M. LadeLinda-Gail BekkerSue LiSubash PathakJessica JustmanNyaradzo MgodiShobha SwaminathanNirupama SistaJennifer FarriorPaul RichardsonCraig W. HendrixNamandje N. Bumpus. (2021) Metabolism of Long-Acting Rilpivirine After Intramuscular Injection: HIV Prevention Trials Network Study 076 (HPTN 076). AIDS Research and Human Retroviruses 37:3, pages 173-183.
Crossref
Herana Kamal Seneviratne, Allyson N. Hamlin, Sue Li, Beatriz Grinsztejn, Halima Dawood, Albert Y. Liu, Irene Kuo, Mina C. Hosseinipour, Ravindre Panchia, Leslie Cottle, Gordon Chau, Adeola Adeyeye, Alex R. Rinehart, Marybeth McCauley, Joseph S. Eron, Myron S. Cohen, Raphael J. Landovitz, Craig W. Hendrix & Namandjé N. Bumpus. (2021) Identification of Novel UGT1A1 Variants Including UGT1A1 454C>A through the Genotyping of Healthy Participants of the HPTN 077 Study. ACS Pharmacology & Translational Science 4:1, pages 226-239.
Crossref
Lu-lu Pan, Yong Yang, Min Hui, Shuo Wang, Cui-yun Li, Hong Zhang, Yan-hua Ding, Li Fu, Xing-xing Diao & Da-fang Zhong. (2020) Sulfation predominates the pharmacokinetics, metabolism, and excretion of forsythin in humans: major enzymes and transporters identified. Acta Pharmacologica Sinica 42:2, pages 311-322.
Crossref
Alan Talevi & Carolina L. Bellera. 2021. The ADME Encyclopedia. The ADME Encyclopedia 1 8 .
Toni K. Choueiri & William G. KaelinJrJr. (2020) Targeting the HIF2–VEGF axis in renal cell carcinoma. Nature Medicine 26:10, pages 1519-1530.
Crossref
Lijie Xu, Rongyao Zheng, Peng Xie, Qianqian Guo, Hui Ji & Tingting Li. (2020) Dysregulation of UDP-glucuronosyltransferases in CCl4 induced liver injury rats. Chemico-Biological Interactions 325, pages 109115.
Crossref
Dinh Bui, Li Li, Taijun Yin, Xinli Wang, Song Gao, Ming You, Rashim Singh & Ming Hu. (2020) Pharmacokinetic and Metabolic Profiling of Key Active Components of Dietary Supplement Magnolia officinalis Extract for Prevention against Oral Carcinoma . Journal of Agricultural and Food Chemistry 68:24, pages 6576-6587.
Crossref
Thomas Bachmann, Christian Schnurr, Laura Zainer & Michael Rychlik. (2020) Chemical synthesis of 5’-β-glycoconjugates of vitamin B6. Carbohydrate Research 489, pages 107940.
Crossref
Meghan E. Whalen, Richard Kajubi, Nona Chamankhah, Liusheng Huang, Francis Orukan, Erika Wallender, Moses R. Kamya, Grant Dorsey, Prasanna Jagannathan, Philip J. Rosenthal, Norah Mwebaza & Francesca T. Aweeka. (2019) Reduced Exposure to Piperaquine, Compared to Adults, in Young Children Receiving Dihydroartemisinin‐Piperaquine as Malaria Chemoprevention. Clinical Pharmacology & Therapeutics 106:6, pages 1310-1318.
Crossref
Robert Ancuceanu, Mihaela Dinu, Cristina Dinu-Pirvu, Valentina Anuţa & Vlad Negulescu. (2019) Pharmacokinetics of B-Ring Unsubstituted Flavones. Pharmaceutics 11:8, pages 370.
Crossref
Mitesh Patel, H. Christian Eberl, Andrea Wolf, Esaie Pierre, Joseph W. Polli & Maciej J. Zamek-Gliszczynski. (2019) Mechanistic Basis of Cabotegravir–Glucuronide Disposition in Humans. Journal of Pharmacology and Experimental Therapeutics 370:2, pages 269-277.
Crossref
Bo Lan, Fei Ma, Mei Han, Shanshan Chen, Wenna Wang, Qiao Li, Ying Fan, Yang Luo, Ruigang Cai, Jiayu Wang, Peng Yuan, Pin Zhang, Qing Li & Binghe Xu. (2019) The Effect of Polymorphism in UGT1A4 on Clinical Outcomes of Adjuvant Tamoxifen Therapy for Patients With Breast Cancer in China. Clinical Breast Cancer 19:2, pages e370-e375.
Crossref
Jun-ling Ren, Hui Sun, Hui Dong, Le Yang, Ai-hua Zhang, Ying Han, Li Wang, Liang Liu & Xi-jun Wang. (2019) A UPLC-MS-based metabolomics approach to reveal the attenuation mechanism of Caowu compatibility with Yunnan Baiyao. RSC Advances 9:16, pages 8926-8933.
Crossref
Yuhuan Li, Wenjie Song, Xiaojun Ou, Guangkuo Luo, Yushan Xie, Rongjin Sun, Ying Wang, Xiaoxiao Qi, Ming Hu, Zhongqiu Liu & Lijun Zhu. (2019) Breast Cancer Resistance Protein and Multidrug Resistance Protein 2 Determine the Disposition of Esculetin-7-O-Glucuronide and 4-Methylesculetin-7-O-Glucuronide. Drug Metabolism and Disposition 47:3, pages 203-214.
Crossref
Nuria Elizabeth Rocha-Guzmán, Rubén Francisco González-Laredo, Blanca Denis Vázquez-Cabral, Martha Rocío Moreno-Jiménez, José Alberto Gallegos-Infante, Claudia Ivette Gamboa-Gómez & Ana Gabriela Flores-Rueda. 2019. Functional and Medicinal Beverages. Functional and Medicinal Beverages 381 411 .
Yuhuan Li, Linlin Lu, Liping Wang, Wei Qu, Wenqin Liu, Yushan Xie, Hongming Zheng, Ying Wang, Xiaoxiao Qi, Ming Hu, Lijun Zhu & Zhongqiu Liu. (2018) Interplay of Efflux Transporters with Glucuronidation and Its Impact on Subcellular Aglycone and Glucuronide Disposition: A Case Study with Kaempferol. Molecular Pharmaceutics 15:12, pages 5602-5614.
Crossref
Adebanjo Adegbola, Rana Abutaima, Adeniyi Olagunju, Omotade Ijarotimi, Marco Siccardi, Andrew Owen, Julius Soyinka & Oluseye Bolaji. (2018) Effect of Pregnancy on the Pharmacokinetic Interaction between Efavirenz and Lumefantrine in HIV-Malaria Coinfection. Antimicrobial Agents and Chemotherapy 62:10.
Crossref
Miguel Toribio-Mateas. (2018) Harnessing the Power of Microbiome Assessment Tools as Part of Neuroprotective Nutrition and Lifestyle Medicine Interventions. Microorganisms 6:2, pages 35.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.