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Review Articles

Pharmacology of apocynin: a natural acetophenone

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Pages 542-562 | Received 27 Nov 2020, Accepted 22 Feb 2021, Published online: 10 Mar 2021

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Hamid Ahmadpourmir, Homayoun Attar, Javad Asili, Vahid Soheili, Seyedeh Faezeh Taghizadeh & Abolfazl Shakeri. (2024) Natural-derived acetophenones: chemistry and pharmacological activities. Natural Products and Bioprospecting 14:1.
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Mortimer Mamelak. (2024) The Alzheimer’s Disease Brain, Its Microvasculature, and NADPH Oxidase. Journal of Alzheimer's Disease 99:s1, pages S109-S118.
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Asger R. Bihlet, Inger Byrjalsen, Jeppe R. Andersen, Alan Reynolds, Nicholas Larkins, Peter Alexandersen, Helene Rovsing, Robert Moots & Philip G. Conaghan. (2024) The efficacy and safety of a fixed-dose combination of apocynin and paeonol, APPA, in symptomatic knee OA: A double-blind, randomized, placebo-controlled, clinical trial. Osteoarthritis and Cartilage.
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Saliha Beyza Sayar & Cristina Has. (2024) Strategy for the optimization of read-through therapy for junctional epidermolysis bullosa with COL17A1 nonsense mutation. Journal of Investigative Dermatology.
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Bo-Ram Jin, Hyo-Jung Kim, Jung-Hyun Na, Won-Kyu Lee & Hyo-Jin An. (2024) Targeting benign prostate hyperplasia treatments: AR/TGF-β/NOX4 inhibition by apocynin suppresses inflammation and proliferation. Journal of Advanced Research 57, pages 135-147.
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Qian-Ru Lin, Lian-Qun Jia, Ming Lei, Di Gao, Nan Zhang, Lei Sha, Xu-Han Liu & Yu-Dan Liu. (2024) Natural products as pharmacological modulators of mitochondrial dysfunctions for the treatment of diabetes and its complications: An update since 2010. Pharmacological Research 200, pages 107054.
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Vallamkondu Manasa, Sivathasan Shubangi, Anitta Jose, Rakshitha Rame Gowda, Muthukumar Serva Peddha & Krupashree Krishnaswamy. (2024) Nanoencapsulation of apocynin and vanillic acid extracted from Picrorhiza kurroa Royle ex Benth plant roots and its characterisation. Heliyon 10:4, pages e26156.
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Mercedes Fernández-Moreno, Tamara Hermida-Gómez, Nicholas Larkins, Alan Reynolds & Francisco J. Blanco. (2024) Anti-Inflammatory Activity of APPA (Apocynin and Paeonol) in Human Articular Chondrocytes. Pharmaceuticals 17:1, pages 118.
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A. A. Shvetsova, D. K. Gaynullina & O. S. Tarasova. (2023) The Role of Reactive Oxygen Species in the Regulation of Blood Vessel Tone in Perinatal and Early Postnatal Ontogenesis. Российский физиологический журнал им  И  М  Сеченова 109:12, pages 1742-1762.
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Xinglong Zhang, Ran Pang, Kai Zhang, Qian Xu, Chunlei Xu, Wei Shi, Xinyu Liang, Dong Li, Wenhao Cui, Shucai Bai, Zhijun Li, Hui Li & Huafeng Zhang. (2023) Apocynin exerts cytoprotective effects on dexamethasone‐induced osteoblasts by inhibiting oxidative stress through the Nrf2 signalling pathway. Journal of Cellular and Molecular Medicine 27:23, pages 3911-3927.
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Jinyu Chao, Yifei Lei, Yusran Yusran, Hui Wang, Dan-Wei Zhang & Zhan-Ting Li. (2023) Supramolecular organic framework for recyclable heterogeneous photocatalysis of the reductive dechlorination of α-Chloroacetophenones and acetylation of amines with thioacetate. Journal of Catalysis 428, pages 115146.
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Nurdan Bülbül Aycı, Büşra Ertaş, Rumeysa Keles Kaya, Sevgi Kocyigit Sevinc, Gökçe Güllü Amuran, Feriha Ercan, Göksel Şener, Oya Orun, Mustafa Akkiprik & Sule Cetinel. (2023) Apocynin exhibits an ameliorative effect on endothelial dysfunction/ atherosclerosis-related factors in high-fat diet-induced obesity in rats. Marmara Medical Journal.
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A. A. Shvetsova, D. K. Gaynullina & O. S. Tarasova. (2024) The Role of Reactive Oxygen Species in the Regulation of Blood Vessel Tone in Perinatal and Early Postnatal Ontogenesis. Journal of Evolutionary Biochemistry and Physiology 59:6, pages 2210-2227.
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Xue Han, Wenwei Zhou, Jiajia Zhang, Yu Tu, Jiajia Wei, Ruyi Zheng, Jian Zhu, Diyun Xu, Huazhong Ying, Gaojun Wu, Qiaojuan Shi & Guang Liang. (2023) Linderalactone mitigates diabetic cardiomyopathy in mice via suppressing the MAPK/ATF6 pathway. International Immunopharmacology 124, pages 110984.
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Paulina Kleniewska & Rafał Pawliczak. (2023) Alpha-lipoic acid, apocynin or probiotics influence glutathione status and selected inflammatory parameters in C57/BL6 mice when combined with a low-fat diet. Pharmacological Reports 75:5, pages 1166-1176.
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Marina Darenskaya, Sergey Kolesnikov, Natalya Semenova & Lyubov Kolesnikova. (2023) Diabetic Nephropathy: Significance of Determining Oxidative Stress and Opportunities for Antioxidant Therapies. International Journal of Molecular Sciences 24:15, pages 12378.
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Yea‐Jin Park, Tae‐Young Gil, Bo‐Ram Jin, Yun‐Yeop Cha & Hyo‐Jin An. (2023) Apocynin alleviates weight gain and obesity‐induced adipose tissue inflammation in high‐fat diet‐fed C57BL /6 mice . Phytotherapy Research 37:8, pages 3481-3494.
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Mohammad Mehdi Gravandi, Sadaf Abdian, Maedeh Tahvilian, Amin Iranpanah, Seyed Zachariah Moradi, Sajad Fakhri & Javier Echeverría. (2023) Therapeutic targeting of Ras/Raf/MAPK pathway by natural products: A systematic and mechanistic approach for neurodegeneration. Phytomedicine 115, pages 154821.
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Nagat Frara, Dania Giaddui, Alan S. Braverman, Kais Jawawdeh, Changhao Wu, Michael R. Ruggieri, Sr & Mary F. Barbe. (2023) Mechanisms involved in nicotinamide adenine dinucleotide phosphate (NADPH) oxidase (Nox)-derived reactive oxygen species (ROS) modulation of muscle function in human and dog bladders. PLOS ONE 18:6, pages e0287212.
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Christina Meyer, Nikhil S. Rao, Suraj S. Vasanthi, Beatriz Pereira, Meghan Gage, Marson Putra, Claire Holtkamp, Joselyn Huss & Thimmasettappa Thippeswamy. (2023) Peripheral and central effects of NADPH oxidase inhibitor, mitoapocynin, in a rat model of diisopropylfluorophosphate (DFP) toxicity. Frontiers in Cellular Neuroscience 17.
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Giovanni Tossetta, Sonia Fantone, Federica Piani, Caterina Crescimanno, Andrea Ciavattini, Stefano Raffaele Giannubilo & Daniela Marzioni. (2023) Modulation of NRF2/KEAP1 Signaling in Preeclampsia. Cells 12:11, pages 1545.
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Yan Shen, Shaoqin Zhang, Yingli Su, Zexing Qu & Haisheng Ren. (2023) Controlling the repair mechanisms of oxetanes through functional group substitution. Physical Chemistry Chemical Physics 25:20, pages 14511-14519.
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Mitko Mladenov, Lubomir Lubomirov, Olaf Grisk, Dimiter Avtanski, Vadim Mitrokhin, Iliyana Sazdova, Milena Keremidarska-Markova, Yana Danailova, Georgi Nikolaev, Rossitza Konakchieva & Hristo Gagov. (2023) Oxidative Stress, Reductive Stress and Antioxidants in Vascular Pathogenesis and Aging. Antioxidants 12:5, pages 1126.
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Matheus Vinicius Barbosa da Silva, Maria Alessandra da Silva Lima, Lizandra Henrique de Farias, Vanessa Maria dos Santos & Thyago Moreira de Queiroz. (2023) Isolated Natural Antioxidants as a new Possible Therapeutic Alternative for the Treatment of Hypertension. Current Hypertension Reviews 19:1, pages 7-18.
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Hend Mohamed Anter, Reham Mokhtar Aman, Dina Ibrahim Ali Othman, Khaled M. Elamin, Irhan Ibrahim Abu Hashim & Mahasen Mohamed Meshali. (2023) Apocynin-loaded PLGA nanomedicine tailored with galactosylated chitosan intrigue asialoglycoprotein receptor in hepatic carcinoma: Prospective targeted therapy. International Journal of Pharmaceutics 631, pages 122536.
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Hailong Tian, Tingting Zhang, Siyuan Qin, Zhao Huang, Li Zhou, Jiayan Shi, Edouard C. Nice, Na Xie, Canhua Huang & Zhisen Shen. (2022) Enhancing the therapeutic efficacy of nanoparticles for cancer treatment using versatile targeted strategies. Journal of Hematology & Oncology 15:1.
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Doğan Çakan, Sinem Eroğlu & Ekrem Ramazan Keskin. (2022) The Effect of Locally Delivered Apocynin on Fat Graft Survival in an Experimental Rat Animal Model. Facial Plastic Surgery 38:04, pages 419-427.
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Yanan Wang, Na Zhao, Ying Jian, Yao Liu, Lin Zhao, Lei He, Qian Liu & Min Li. (2022) The pro-inflammatory effect of Staphylokinase contributes to community-associated Staphylococcus aureus pneumonia. Communications Biology 5:1.
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Sarai Sánchez-Duarte, Rocío Montoya-Pérez, Sergio Márquez-Gamiño, Karla S. Vera-Delgado, Cipriana Caudillo-Cisneros, Fernando Sotelo-Barroso, Luis A. Sánchez-Briones & Elizabeth Sánchez-Duarte. (2022) Apocynin Attenuates Diabetes-Induced Skeletal Muscle Dysfunction by Mitigating ROS Generation and Boosting Antioxidant Defenses in Fast-Twitch and Slow-Twitch Muscles. Life 12:5, pages 674.
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Yun Heo, Sang-Woo Shin, Da-Seul Kim, Semi Lee, So-Yeon Park, Seung-Woon Baek, Jun-Kyu Lee, Jun Hyuk Kim & Dong Keun Han. (2022) Bioactive PCL microspheres with enhanced biocompatibility and collagen production for functional hyaluronic acid dermal fillers. Biomaterials Science 10:4, pages 947-959.
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Silvia S. Barbieri, Leonardo Sandrini, Laura Musazzi, Maurizio Popoli & Alessandro Ieraci. (2021) Apocynin Prevents Anxiety-Like Behavior and Histone Deacetylases Overexpression Induced by Sub-Chronic Stress in Mice. Biomolecules 11:6, pages 885.
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