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Hemoglobin
international journal for hemoglobin research
Volume 43, 2019 - Issue 1
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Original Article

Role of Genomic Biomarkers in Increasing Fetal Hemoglobin Levels Upon Hydroxyurea Therapy and in β-Thalassemia Intermedia: A Validation Cohort Study

Alexandra KolliopoulouUniversity of Patras, Medical Faculty, Laboratory of General Biology, Patras, Greece; View further author information
,
Stavroula SiamoglouSchool of Health Sciences, Department of Pharmacy, Laboratory of Pharmacogenomics and Individualized Therapy, University of Patras, Greece; View further author information
,
Anne JohnUnited Arab Emirates University, College of Medicine and Health Sciences, Department of Pathology, Al-Ain, United Arab Emirates; View further author information
,
Argyro SgourouSchool of Science and Technology, Biology Laboratory, Hellenic Open University, Patras, Greece; View further author information
,
Alexandra KourakliThalassemia and Hemoglobinopathies Unit, Hematology Division, Department of Internal Medicine, University of Patras Medical School, University Hospital, Patras, Greece; View further author information
,
Argiris SymeonidisMedical School, Hematology Division, Department of Internal Medicine, University of Patras, University of Patras, Greece; View further author information
,
Efthymia VlachakiAdults Thalassemia Unit, ‘Hippokration’ General Hospital of Thessaloniki, Greece; View further author information
,
Panagiota ChalkiaThalassemia and Sickle Cell Unit, University General Hospital of Thessaloniki, Greece; View further author information
,
Stamatia TheodoridouAdults Thalassemia Unit, ‘Hippokration’ General Hospital of Thessaloniki, Greece; View further author information
,
Bassam R. AliUnited Arab Emirates University, College of Medicine and Health Sciences, Department of Pathology, Al-Ain, United Arab Emirates; View further author information
,
Theodora KatsilaSchool of Health Sciences, Department of Pharmacy, Laboratory of Pharmacogenomics and Individualized Therapy, University of Patras, Greece; View further author information
,
George P. PatrinosSchool of Health Sciences, Department of Pharmacy, Laboratory of Pharmacogenomics and Individualized Therapy, University of Patras, Greece; ;United Arab Emirates University, College of Medicine and Health Sciences, Department of Pathology, Al-Ain, United Arab Emirates; ;United Arab Emirates University, Zayed Center of Health Sciences, Al-Ain, United Arab EmiratesView further author information
&
Adamantia PapachatzopoulouUniversity of Patras, Medical Faculty, Laboratory of General Biology, Patras, Greece; Correspondence[email protected]
View further author information
 show all
Pages 27-33 | Received 08 Feb 2019, Accepted 01 Mar 2019, Published online: 30 Apr 2019

Citations (7)

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Read on this site (2)

George P. Patrinos, David H. K Chui, Ross C. Hardison & Martin H. Steinberg. (2021) Strategies to improve pharmacogenomic-guided treatment options for patients with β-hemoglobinopathies. Expert Review of Hematology 14:10, pages 883-885.
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Ahmet Genc, Deniz Tastemir Korkmaz, Suleyman Bayram & Eyyup Rencuzogullari. (2020) The Effect of Five Single Nucleotide Polymorphisms on Hb F Variation of β-Thalassemia Traits and Hematologically Normal Individuals in Southeast Turkey. Hemoglobin 44:4, pages 231-239.
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Articles from other publishers (5)

Catarina Ginete, Mariana Delgadinho, Brígida Santos, Vera Pinto, Carina Silva, Armandina Miranda & Miguel Brito. (2023) Are Genetic Modifiers the Answer to Different Responses to Hydroxyurea Treatment?—A Pharmacogenetic Study in Sickle Cell Anemia Angolan Children. International Journal of Molecular Sciences 24:10, pages 8792.
Crossref
Mehran Karimi, Tahereh Zarei, Ardeshir Bahmanimehr, Azam Aramesh, Saeed Daryanoush & Sezaneh Haghpanah. (2021) Long-term safety and efficacy of hydroxyurea in patients with non-transfusion-dependent β-thalassemia: a comprehensive single-center experience. Annals of Hematology 100:12, pages 2901-2907.
Crossref
Kariofyllis Karamperis, Maria T. Tsoumpeli, Fotios Kounelis, Maria Koromina, Christina Mitropoulou, Catia Moutinho & George P. Patrinos. (2021) Genome-based therapeutic interventions for β-type hemoglobinopathies. Human Genomics 15:1.
Crossref
Nur Atikah Zakaria, Md Asiful Islam, Wan Zaidah Abdullah, Rosnah Bahar, Abdul Aziz Mohamed Yusoff, Ridhwan Abdul Wahab, Shaharum Shamsuddin & Muhammad Farid Johan. (2021) Epigenetic Insights and Potential Modifiers as Therapeutic Targets in β–Thalassemia. Biomolecules 11:5, pages 755.
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Apostolos Stratopoulos, Alexandra Kolliopoulou, Kariofyllis Karamperis, Anne John, Kyriaki Kydonopoulou, George Esftathiou, Argyro Sgourou, Alexandra Kourakli, Efthimia Vlachaki, Panagiota Chalkia, Stamatia Theodoridou, Manoussos N Papadakis, Spyridon Gerou, Argiris Symeonidis, Theodora Katsila, Bassam R Ali, Adamantia Papachatzopoulou & George P Patrinos. (2019) Genomic variants in members of the Krüppel-like factor gene family are associated with disease severity and hydroxyurea treatment efficacy in β-hemoglobinopathies patients. Pharmacogenomics 20:11, pages 791-801.
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