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Drug Development and Industrial Pharmacy Volume 31, 2005 - Issue 6
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Research Article

Effect of the Drug–Excipient Ratio in Matrix-Type-Controlled Release Systems: Computer Simulation Study

Rafael Villalobos UAM-Iztapalapa, Departamento de Química, Mexico City, Mexico; División de Estudios de Posgrado (Tecnología Farmacéutica), Facultad de Estudios Superiores Cuautitlán/UNAM, Cuautitlán Izcalli, Estado de México, Mexico
,
Adriana Ganem División de Estudios de Posgrado (Tecnología Farmacéutica), Facultad de Estudios Superiores Cuautitlán/UNAM, Cuautitlán Izcalli, Estado de México, Mexico
,
Salomón Cordero UAM-Iztapalapa, Departamento de Química, Mexico City, Mexico
,
Ana Maria Vidales Departamento de Física, CONICET, Universidad Nacional de San Luis, San Luis, Argentina
&
Armando Domínguez UAM-Iztapalapa, Departamento de Química, Mexico City, Mexico
Pages 535-543 | Published online: 26 Sep 2008

Citations (10)

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Read on this site (3)

Lizbeth Martínez, Gabriele Betz, Rafael Villalobos, Luz Melgoza & Paul M. Young. (2013) Correlation between compactibility values and excipient cluster size using an in silico approach. Drug Development and Industrial Pharmacy 39:2, pages 374-381.
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Rafael Villalobos, Hugo Viquez, Beatriz Hernández, Adriana Ganem, Luz María Melgoza & Paul M. Young. (2012) Parameters affecting drug release from inert matrices. 1: Monte Carlo simulation. Pharmaceutical Development and Technology 17:3, pages 344-352.
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S Dean Allison. (2008) Analysis of initial burst in PLGA microparticles. Expert Opinion on Drug Delivery 5:6, pages 615-628.
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Peter Hinow & Ami E. Radunskaya. 2014. Mathematical Models of Tumor-Immune System Dynamics. Mathematical Models of Tumor-Immune System Dynamics 109 123 .
Amalia Hadjitheodorou & George Kalosakas. (2013) Quantifying diffusion-controlled drug release from spherical devices using Monte Carlo simulations. Materials Science and Engineering: C 33:2, pages 763-768.
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Hadi Mohammadi & Walter Herzog. (2011) A novel model for diffusion based release kinetics using an inverse numerical method. Medical Engineering & Physics 33:8, pages 893-899.
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Lizbeth Mart?nez, Rafael Villalobos, Marisol S?nchez, Jeny Cruz, Adriana Ganem & Luz Mar?a Melgoza. (2009) Monte Carlo simulations for the study of drug release from cylindrical matrix systems with an inert nucleus. International Journal of Pharmaceutics 369:1-2, pages 38-46.
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A. Dokoumetzidis & P. Macheras. (2008) IVIVC of controlled release formulations: Physiological–dynamical reasons for their failure. Journal of Controlled Release 129:2, pages 76-78.
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Kosmas Kosmidis & Panos Macheras. (2008) Monte Carlo simulations of drug release from matrices with periodic layers of high and low diffusivity. International Journal of Pharmaceutics 354:1-2, pages 111-116.
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K. Sandy Pang, Michael Weiss & Panos Macheras. (2007) Advanced pharmacokinetic models based on organ clearance, circulatory, and fractal concepts. The AAPS Journal 9:2, pages E268-E283.
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