108
Views
10
CrossRef citations to date
0
Altmetric
Research Article

Effect of the Drug–Excipient Ratio in Matrix-Type-Controlled Release Systems: Computer Simulation Study

, , , &
Pages 535-543 | Published online: 26 Sep 2008

References

  • Bonny, J. D., & Leuenberger, H. (1991). Matrix type controlled release systems: I. Effect of percolation on drug dissolution kinetics.Pharmaceutica Acta Helvetiae, 66(5–6), 160–164., [PUBMED], [INFOTRIEVE]
  • Bonny, J. D., & Leuenberger, H. (1993). Matrix type controlled release systems. II. Percolation effects in non-swellable matrices.Pharmaceutica Acta Helvetiae, 68, 25–33., [CROSSREF]
  • Bunde, A., Havlin, S., Nossal, R., Stanley, H. E., & Weiss, G. H. (1985). On controlled diffusion-limited drug release from a leaky matrix.Journal of Chemical Physics, 83(11), 5909–5913., [CROSSREF]
  • Caraballo, I.F.., Fernández-Arévalo, Holgado, M. A., Rabasco, A. M., & Leuenberger, H. (1994). Study of the release mechanism of carteolol inert matrix tablets on the basis of percolation theory.International Journal of Pharmaceutics, 109, 229–236., [CROSSREF]
  • Caraballo, I., Millan, M., & Rabasco, A. M. (1996). Relationship between drug percolation threshold and particle size in matrix tablets.Pharmaceutical Research, 13(3), 387–390., [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
  • Caraballo, I., Melgoza, L. M., Alvarez-Fuentes, J., Soriano, M. C., & Rabasco, A. M. (1999). Design of controlled release inert matrices of naltrexone hydrochloride based on percolation concepts.International Journal of Pharmaceutics, 181(1), 23–30., [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
  • Costa, P., & Sousa, L. J. (2001). Modeling and comparison of dissolution profiles.European Journal of Pharmaceutical Sciences, 13, 123–133., [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
  • Crank, J. (1975). The Mathematics of Diffusion (2nd ed.). Oxford: Oxford University Press.
  • Ehtezazi, T., & Washington, C. (2000). Controlled release macromolecules from PLA microspheres: using porous structure topology.Journal of Controlled Release, 68, 361–372., [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
  • Fernandez-Hervas, M. J., Vela, M. T., Cerro del, J., & Rabasco, A. M. (1995). Determination of percolation threshold in matrix-type controlled release systems: application of a resistance analysis technique.International Journal of Pharmaceutics, 113, 39–45., [CROSSREF]
  • Higuchi, T. (1963). Mechanism of sustained-action medication. Theoretical analysis of rate released of solid drugs dispersed in solid matrices.Journal of Pharmaceutical Sciences, 52, 1145–1148., [PUBMED], [INFOTRIEVE]
  • Kosmidis, K., Argyrakis, P., & Macheras, P. (2003a). Fractal kinetics in drug release from finite fractal matrices.Journal of Chemical Physics, 119(12), 6373–6377., [CROSSREF]
  • Kosmidis, K., Argyrakis, P., & Macheras, P. (2003b). A reappraisal of drug release laws using Monte Carlo simulations: the prevalence of the Weibull function.Pharmaceutical Research, 20(7), 988–995., [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
  • Leu, R., & Leuenberger, H. (1993). Application of percolation theory to the compaction of pharmaceutical powders.International Journal of Pharmaceutics, 90, 213–219., [CROSSREF]
  • Leuenberger, H., Leu, R., & Bonny, J. D. (1992). Application of percolation theory and fractal geometry to tablet compaction.Drug Development and Industrial Pharmacy, 18, 723–766.
  • Leuenberger, H., Bonny, J. D., & Kolb, M. (1995). Percolation effects in matrix-type controlled drug release system.International Journal of Pharmaceutics, 115, 217–224., [CROSSREF]
  • Millan, M., Caraballo, I., & Rabasco, A. M. (1998). The role of the drug/excipient particle size ratio in the percolation model for tablets.Pharmaceutical Research, 15(2), 216–220., [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
  • Peppas, N. (1985). Analysis of Fickian and non-Fickian drug release from polymers.Pharmaceutica Acta Helvetiae, 60(4), 110–111., [PUBMED], [INFOTRIEVE]
  • Sahimi, M. (1994). Connectivity as the essential physics of disordered systems. Applications of Percolation Theory. London: Taylor and Francis.
  • Sales, J. L., Uñac, R. O., Gargiulo, M. V., Bustos, V., & Zgrablich, G. (1996). Monte Carlo simulation of temperature programmed desorption spectra: a guide through the forest for monomolecular adsorption on a square lattice.Langmuir, 12, 95–100., [CROSSREF]
  • Siegmund, C., & Leuenberger, H. (1999). Percolation theory, conductivity and dissolution of hydrophilic suppository bases (PEG systems).International Journal of Pharmaceutics, 189(2), 187–196., [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
  • Stauffer, D., & Aharony, A. (1994). Introduction to Percolation Theory 2nd ed. (revised). London: Taylor and Francis.
  • Takada, K., & Yoshikawa, H. (1999). Oral drug delivery, traditional. In: Mathiowitz, E. (Ed.). Encyclopedia of Controlled Drug Delivery, Vol. 2. New York: John Wiley & Sons, 728–742.
  • Yamane, S., Takayama, K., Nagai, T. (1998). Effect of fractal dimension on drug permeation through porous ethylcellulose films.Journal of Controlled Release, 50, 103–109., [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.