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Research Article

Enhanced Oral Bioavailability and Intestinal Lymphatic Transport of a Hydrophilic Drug Using Liposomes

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Pages 335-345 | Published online: 25 Sep 2008

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Nidhi Singh, Mayank Handa, Vanshikha Singh, Prashant Kesharwani & Rahul Shukla. (2022) Lymphatic targeting for therapeutic application using nanoparticulate systems. Journal of Drug Targeting 30:10, pages 1017-1033.
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Swapna Poudwal, Ambikanandan Misra & Pravin Shende. (2021) Role of lipid nanocarriers for enhancing oral absorption and bioavailability of insulin and GLP-1 receptor agonists. Journal of Drug Targeting 29:8, pages 834-847.
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Mitali H. Patel, Veenu P. Mundada & Krutika K. Sawant. (2019) Fabrication of solid lipid nanoparticles of lurasidone HCl for oral delivery: optimization, in vitro characterization, cell line studies and in vivo efficacy in schizophrenia. Drug Development and Industrial Pharmacy 45:8, pages 1242-1257.
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Jin Ren, Zhengjie Fang, Liqun Jiang & Qian Du. (2017) Quercetin-containing self-assemble proliposome preparation and evaluation. Journal of Liposome Research 27:4, pages 335-342.
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Yue Yuan Luo, Xiang Yuan Xiong, Yuan Tian, Zi Ling Li, Yan Chun Gong & Yu Ping Li. (2016) A review of biodegradable polymeric systems for oral insulin delivery. Drug Delivery 23:6, pages 1882-1891.
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Krutika K. Sawant, Mitali H. Patel & Krishna Patel. (2016) Cefdinir nanosuspension for improved oral bioavailability by media milling technique: formulation, characterization and in vitro–in vivo evaluations. Drug Development and Industrial Pharmacy 42:5, pages 758-768.
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Qingqing Cai, Xinxian Deng, Zhongdong Li, Dianyun An, Teng Shen & Mingkang Zhong. (2016) Effects of lipid vehicle and P-glycoprotein inhibition on the mesenteric lymphatic transport of paclitaxel in unconscious, lymph duct-cannulated rats. Drug Delivery 23:1, pages 147-153.
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Neha N Parayath, Hayley Nehoff, Philipp Müller, Sebastien Taurin & Khaled Greish. (2015) Styrene maleic acid micelles as a nanocarrier system for oral anticancer drug delivery – dual uptake through enterocytes and M-cells. International Journal of Nanomedicine 10, pages 4653-4667.
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Vijaykumar Nekkanti, Natarajan Venkatesan, Zhijun Wang & Guru V. Betageri. (2015) Improved oral bioavailability of valsartan using proliposomes: design, characterization and in vivo pharmacokinetics. Drug Development and Industrial Pharmacy 41:12, pages 2077-2088.
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Hyeongmin Kim, Ilkyeong Seong, Jieun Ro, Seong-Ha Hwang, Gyiae Yun & Jaehwi Lee. (2015) Enhanced association of probucol with chylomicron by pharmaceutical excipients: an in vitro study. Drug Development and Industrial Pharmacy 41:7, pages 1073-1079.
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Shilpa Chaudhary, Tarun Garg, R. S. R. Murthy, Goutam Rath & Amit K. Goyal. (2014) Recent approaches of lipid-based delivery system for lymphatic targeting via oral route. Journal of Drug Targeting 22:10, pages 871-882.
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Indu Singh, Rajan Swami, Wahid Khan & Ramakrishna Sistla. (2014) Lymphatic system: a prospective area for advanced targeting of particulate drug carriers. Expert Opinion on Drug Delivery 11:2, pages 211-229.
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Yaw-Bin Huang, Ming-Jun Tsai, Pao-Chu Wu, Yi-Hung Tsai, Yi-Hsin Wu & Jia-You Fang. (2011) Elastic liposomes as carriers for oral delivery and the brain distribution of (+)-catechin. Journal of Drug Targeting 19:8, pages 709-718.
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Ceyda T. Sengel-Turk, Mehmet Gumustas, Bengi Uslu & Sibel A. Ozkan. 2017. Nano- and Microscale Drug Delivery Systems. Nano- and Microscale Drug Delivery Systems 165 195 .
Hyeji Ahn & Ji-Ho Park. (2016) Liposomal delivery systems for intestinal lymphatic drug transport. Biomaterials Research 20:1.
Crossref
Sandy Ong, Long Ming, Kah Lee & Kah Yuen. (2016) Influence of the Encapsulation Efficiency and Size of Liposome on the Oral Bioavailability of Griseofulvin-Loaded Liposomes. Pharmaceutics 8:3, pages 25.
Crossref
Qiuhong Yang & Laird Forrest. 2016. Drug Delivery. Drug Delivery 503 548 .
Arvind Thakkar, Sushma Chenreddy, Jeffrey Wang & Sunil Prabhu. (2015) Ferulic acid combined with aspirin demonstrates chemopreventive potential towards pancreatic cancer when delivered using chitosan-coated solid-lipid nanoparticles. Cell & Bioscience 5:1.
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Sophia Yui Kau Fong, Martin Brandl & Annette Bauer-Brandl. (2015) Phospholipid-based solid drug formulations for oral bioavailability enhancement: A meta-analysis. European Journal of Pharmaceutical Sciences 80, pages 89-110.
Crossref
Indu Singh, Rajan Swami, Wahid Khan & Ramakrishna Sistla. 2014. Focal Controlled Drug Delivery. Focal Controlled Drug Delivery 429 458 .
Deepa Mishra, Justin R. Hubenak & Anshu B. Mathur. (2013) Nanoparticle systems as tools to improve drug delivery and therapeutic efficacy. Journal of Biomedical Materials Research Part A 101:12, pages 3646-3660.
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Frank BoehmMisagh Alipour, Abdelwahab Omri & Zacharias Suntres. 2013. Nanomedical Device and Systems Design. Nanomedical Device and Systems Design 455 490 .
Kaushik Thanki, Rahul P. Gangwal, Abhay T. Sangamwar & Sanyog Jain. (2013) Oral delivery of anticancer drugs: Challenges and opportunities. Journal of Controlled Release 170:1, pages 15-40.
Crossref
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Crossref
Hyeongmin Kim, Yeongseok Kim & Jaehwi Lee. (2013) Liposomal formulations for enhanced lymphatic drug delivery. Asian Journal of Pharmaceutical Sciences 8:2, pages 96-103.
Crossref
Hyo-Kyung Han, Hyun-Jae Shin & Dong Hoon Ha. (2012) Improved oral bioavailability of alendronate via the mucoadhesive liposomal delivery system. European Journal of Pharmaceutical Sciences 46:5, pages 500-507.
Crossref
Shih-Pin Hsu & I-Ming Chu. (2012) Design of polyanionic nanocarriers based on modified poly (aspartic acid)s for oral administration: synthesis and characterization. Journal of Polymer Research 19:7.
Crossref
Shuang Cai, Qiuhong Yang, Taryn R. Bagby & M. Laird Forrest. (2011) Lymphatic drug delivery using engineered liposomes and solid lipid nanoparticles. Advanced Drug Delivery Reviews 63:10-11, pages 901-908.
Crossref
Sravan Penchala, Anh‐Nhan Pham, Ying Huang & Jeffrey Wang. 2011. Oral Bioavailability. Oral Bioavailability 343 354 .
Ji-Hoon Choi & Yong-Bok Lee. (2010) Nano-sized Drug Carriers and Key Factors for Lymphatic Delivery. Journal of Pharmaceutical Investigation 40:spc, pages 75-82.
Crossref
Emilie Roger, Frederic Lagarce, Emmanuel Garcion & Jean-Pierre Benoit. (2010) Biopharmaceutical parameters to consider in order to alter the fate of nanocarriers after oral delivery. Nanomedicine 5:2, pages 287-306.
Crossref
Abu Bakar Abdul Majeed, Rosa E. V. Pereira, Tommy B. Julianto & Kah H. Yuen. (2010) Enhanced oral cefotaxime sodium bioavailability after administration of cefotaxime-loaded Eudragit S100 nanoparticles and its influence on the lymphatic transport. Enhanced oral cefotaxime sodium bioavailability after administration of cefotaxime-loaded Eudragit S100 nanoparticles and its influence on the lymphatic transport.
Sharon Sheue Nee Ling, Kah Hay Yuen, Enrico Magosso & Susan Anne Barker. (2009) Oral bioavailability enhancement of a hydrophilic drug delivered via folic acid-coupled liposomes in rats. Journal of Pharmacy and Pharmacology 61:4, pages 445-449.
Crossref
Svetlana Golocorbin-Kon, Momir Mikov, Mousab Arafat, Zika Lepojevic, Ivan Mikov, Majda Sahman-Zaimovic & Zdenko Tomic. (2009) Cefotaxime pharmacokinetics after oral application in the form of 3α,7α-dihydroxy-12-keto-5β-cholanate microvesicles in rat. European Journal of Drug Metabolism and Pharmacokinetics 34:1, pages 31-36.
Crossref
Xiang Yuan Xiong, Yu Ping Li, Zi Ling Li, Chun Li Zhou, Kam Chiu Tam, Zhi Yong Liu & Guo Xiu Xie. (2007) Vesicles from Pluronic/poly(lactic acid) block copolymers as new carriers for oral insulin delivery. Journal of Controlled Release 120:1-2, pages 11-17.
Crossref

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