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Research Article

Multiphase versus Single Pot Granulation Process: Influence of Process and Granulation Parameters on Granules Properties

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Pages 509-530 | Published online: 25 Sep 2008

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Read on this site (6)

Preetanshu Pandey, Jing Tao, Anwesha Chaudhury, Rohit Ramachandran, Julia Z. Gao & Dilbir S. Bindra. (2013) A combined experimental and modeling approach to study the effects of high-shear wet granulation process parameters on granule characteristics. Pharmaceutical Development and Technology 18:1, pages 210-224.
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Firas Alshihabi, Thierry Vandamme & Gabriele Betz. (2013) Focused beam reflectance method as an innovative (PAT) tool to monitor in-line granulation process in fluidized bed. Pharmaceutical Development and Technology 18:1, pages 73-84.
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K. Giry, M. Viana, M. Genty, P. Wüthrich & D. Chulia. (2010) Surface responses and desirability functions to determine optimal granulation domains. Drug Development and Industrial Pharmacy 36:9, pages 1016-1026.
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K. Giry, M. Viana, M. Genty, F. Louvet, P. Wüthrich & D. Chulia. (2009) Comparison of single pot and multiphase granulation. Part 2: Effect of the drying process on granules manufactured in a single pot granulator and dried either in situ or in a fluid bed dryer. Pharmaceutical Development and Technology 14:2, pages 149-158.
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K. Giry, M. Viana, M. Genty, F. Louvet, P. Wüthrich & D. Chulia. (2009) Comparison of single pot and multiphase granulation. Part 1: Effect of the high shear granulator on granule properties according to the drug substance and its concentration. Pharmaceutical Development and Technology 14:2, pages 138-148.
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E. Chevalier, M. Viana, C. Pouget & D. Chulia. (2007) Influence of Process Parameters on Pellets Elaborated in a Mi-Pro High-Shear Granulator. Pharmaceutical Development and Technology 12:2, pages 133-144.
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Articles from other publishers (16)

Guolin Shi, Longfei Lin, Yuling Liu, Gongsen Chen, Yuting Luo, Yanqiu Wu & Hui Li. (2021) Pharmaceutical application of multivariate modelling techniques: a review on the manufacturing of tablets. RSC Advances 11:14, pages 8323-8345.
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Xingyu Lu, Daniel Skomski, Karen C. Thompson, Michael J. McNevin, Wei Xu & Yongchao Su. (2019) Three-Dimensional NMR Spectroscopy of Fluorinated Pharmaceutical Solids under Ultrafast Magic Angle Spinning. Analytical Chemistry 91:9, pages 6217-6224.
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Veronica De Simone, Annalisa Dalmoro, Gaetano Lamberti, Matteo d'Amore & Anna Angela Barba. (2017) Central composite design in HPMC granulation and correlations between product properties and process parameters. New Journal of Chemistry 41:14, pages 6504-6513.
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Anwesha Chaudhury, Dana Barrasso, Preetanshu Pandey, Huiquan Wu & Rohit Ramachandran. (2014) Population Balance Model Development, Validation, and Prediction of CQAs of a High-Shear Wet Granulation Process: Towards QbD in Drug Product Pharmaceutical Manufacturing. Journal of Pharmaceutical Innovation 9:1, pages 53-64.
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Bernice Mei Jin Tan, Zhi Hui Loh, Josephine Lay Peng Soh, Celine Valeria Liew & Paul Wan Sia Heng. (2014) Distribution of a viscous binder during high shear granulation—Sensitivity to the method of delivery and its impact on product properties. International Journal of Pharmaceutics 460:1-2, pages 255-263.
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F. Alshihabi, T. Vandamme & G. Betz. (2012) Predicting physical properties of pharmaceutical compacts using focused beam reflectance measurement (FBRM). Journal of Drug Delivery Science and Technology 22:6, pages 522-530.
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T.M. Chitu, D. Oulahna & M. Hemati. (2011) Wet granulation in laboratory scale high shear mixers: Effect of binder properties. Powder Technology 206:1-2, pages 25-33.
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K. Giry, M. Viana, M. Genty, F. Louvet, A. Désire, P. Wuthrich & D. Chulia. (2009) Comparison of Single Pot and Multiphase High Shear Wet Granulation Processes Related to Excipient Composition. Journal of Pharmaceutical Sciences 98:10, pages 3761-3775.
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K. Giry, M. Viana, M. Genty, P. Wüthrich & D. Chulia. (2009) Switch from single pot to multiphase high shear wet granulation process, influence of the volume of granulation liquid in a pilot scale study. Chemical Engineering and Processing: Process Intensification 48:8, pages 1293-1301.
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Sanni Matero, Sami Poutiainen, Jari Leskinen, Satu-Pia Reinikainen, Jarkko Ketolainen, Kristiina Järvinen & Antti Poso. (2009) Monitoring the wetting phase of fluidized bed granulation process using multi-way methods: The separation of successful from unsuccessful batches. Chemometrics and Intelligent Laboratory Systems 96:1, pages 88-93.
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Ajit S. Narang & Divyakant S. Desai. 2009. Pharmaceutical Perspectives of Cancer Therapeutics. Pharmaceutical Perspectives of Cancer Therapeutics 49 92 .
Z.H. Loh, C.V. Liew, C.C. Lee & P.W.S. Heng. (2008) Microwave-assisted drying of pharmaceutical granules and its impact on drug stability. International Journal of Pharmaceutics 359:1-2, pages 53-62.
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Stuart Cantor & Armin Gerhardt. 2008. Pharmaceutical Dosage Forms - Tablets. Pharmaceutical Dosage Forms - Tablets 261 301 .
Cecil Propst & Thomas Chirkot. 2008. Pharmaceutical Dosage Forms - Tablets. Pharmaceutical Dosage Forms - Tablets 195 225 .
Stuart Cantor, Larry Augsburger & Armin Gerhardt. 2008. Pharmaceutical Dosage Forms - Tablets, Third Edition. Pharmaceutical Dosage Forms - Tablets, Third Edition 261 301 .
Cecil Propst & Thomas Chirkot. 2008. Pharmaceutical Dosage Forms - Tablets, Third Edition. Pharmaceutical Dosage Forms - Tablets, Third Edition 195 225 .

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