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Research Article

Multiphase versus Single Pot Granulation Process: Influence of Process and Granulation Parameters on Granules Properties

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Pages 509-530 | Published online: 25 Sep 2008

REFERENCES

  • Airaksinen S., Karjalainen M., Räsänen E., Rantanen J., Yliruusi J. Comparison of the effect of two drying methods on the polymorphism of theophylline. Int. J. Pharm. 2004; 276: 129–141, [INFOTRIEVE], [CSA]
  • Albertini B., Cavallari C., Passerini N., Gonzales-Rodriguez M. L., Rodriguez L. Evaluation of β-lactose, PVP K12, and PVP K90 as excipients to prepare piroxicam granules using two wet granulation techniques. Eur. J. Pharm. Biopharm. 2003; 56(3)479–487, [INFOTRIEVE], [CSA], [CROSSREF]
  • Ameye D., Keleb E., Vervaet C., Remon J. P., Adams E., Massart D. L. Scaling-up of a lactose wet granulation process in Mi-Pro high shear mixers. Eur. J. Pharm. Sci. 2002; 17: 247–251, [INFOTRIEVE], [CSA], [CROSSREF]
  • André F., Bouiller B., Adams S., Bagnaro M., Becourt P., Guyot J. C. Etude par plan d'expérience de l'influence de trois paramètres de fabrication sur la qualité de grains obtenus en turbo-sphère. STP Pharma Sci. 1990; 6(10)723–727, [CSA]
  • Authelin J. R., Lepinasse G., Leprince-Ringuet J., Quessada V. Phénomène d'attrition, d'amorphisation et de mécanochimie accompagnant le séchage agité sous vide des produits pharmaceutiques. 4ème journée de l'AFSIA. 1996; 7: 3–96, [CSA]
  • Badawy S. I. F., Menning M. M., Gorko M. A., Gilbert D. L. Effect of process parameters on compressibility of granulation manufactured in a high-shear mixer. Int. J. Pharm. 2000a; 198: 51–61, [INFOTRIEVE], [CSA], [CROSSREF]
  • Badawy S. I. F., Lee T. J., Menning M. M. Effect of drug substance particle size on the characteristics of granulation manufactured in a high-shear mixer. AAPS Pharm. Sci. Tech. 2000b; 1(4)33, [CSA], [CROSSREF]
  • Baillon, B. (1996). Séchage sous vide/micro-ondes combinés de granulés pharmaceutiques. Ph. D. Thesis, Université de Pau et des pays de l'Adour
  • Bardin M., Knight P. C., Seville J. P. K. On control of particle size distribution in granulation high-shear mixers. Powder Technol. 2004; 140: 169–175, [CSA], [CROSSREF]
  • Bashaiwoldu A. B., Podzeck F., Newton J. M. A study on the effect of drying techniques on mechanical properties of pellets and compacted pellets. Eur. J. Pharm. Sci. 2004; 21: 119–129, [INFOTRIEVE], [CSA], [CROSSREF]
  • Bauer K.H., Vadagnini M. New developments in wet granulation. Pharm. Technol. Eur. 1997; 9(3)27–34, [CSA]
  • Becker D., Rigassi T., Bauer-Brandl A. Effectiveness of binders in wet granulation: a comparison using a model formulation of different tabletability. Drug Dev. Ind. Pharm. 1997; 23(8)791–808, [CSA]
  • Benkerrour L., Puisieux F., Duchêne D. Influence de la nature du diluant, de la viscosité et de la concentration en liant du liquide de mouillage, sur les caractéristiques des grains et des comprimés. Pharm. Acta Helv. 1982; 57(11)301–308, [INFOTRIEVE], [CSA]
  • Betz G., Junker Bürgin P., Leuenberger H. Powder consumption measurement and temperature recording during granulation. Int. J. Pharm. 2004; 272: 137–149, [INFOTRIEVE], [CSA], [CROSSREF]
  • Biggs C. A., Sanders C., Willems A. W., Hoffman A. C., Instone T., Salman A. D., Hounslow M. J. Coupling granule properties and granulation rates in high-shear granulation. Powder Technol. 2003; 130: 162–168, [CSA], [CROSSREF]
  • Bock T. K., Kraas U. Experience with the Diosna mini-granulator and assessment of process scalability. Eur. J. Pharm. Biopharm. 2001; 52: 297–303, [INFOTRIEVE], [CSA], [CROSSREF]
  • http://www.lbbohle.de/deutsch/bosite_d/granu1_d.html Böhle
  • Bouwman A. M., Visser M. R., Eissens A. C., Wesselingh J. A., Frijlink H. W. The effect of vessel material on granules produced in a high-shear mixer. Eur. J. Pharm. Sci. 2004; 23: 169–179, [INFOTRIEVE], [CSA], [CROSSREF]
  • Carstensen J. T., Zoglio M. A. Tray drying of pharmaceutical wet granulations. J. Pharm. Sci. 1982; 71(1)35–39, [INFOTRIEVE], [CSA]
  • Castel B. Mise en forme des solides. Chimie—procédés. Opérations unitaires. Génie de la réaction chimique. In Techniques de l'ingénieur, J 3 382
  • Cavallari C., Abertini B., Gonzalez-Rodriguez M. L., Rodriguez L. Improved dissolution behavior of steam-granulated piroxicam. Eur. J. Pharm. Biopharm. 2002; 54: 65–73, [INFOTRIEVE], [CSA], [CROSSREF]
  • Chaplin G., Pugsley T., Winters C. Application of chaos analysis to pressure fluctuation data from a fluidized bed dryer containing pharmaceutical granules. Powder Technol. 2004; 142: 110–120, [CSA], [CROSSREF]
  • Chulia, D.(1990). In Compactage et granulation. Journée d’étude sur les poudres JEP 90: de la fabrication à la fonctionnalisation, Paris, March
  • http://www.collette Collette
  • Cruaud O., Puisieux F., Duchêne D. Influence des conditions opératoires sur les caractéristiques des grains obtenus par granulation humide. Labo-Pharma—Problème et techniques. 1980; 297: 281–287, [CSA]
  • Davis T. D., Peck G. E., Stowell J. G., Morris K. R., Byrn S. R. Modelling and monitoring of polymorphic transformation during the drying phase of wet granulation. Pharm. Res. 2004; 21(5)860–866, [INFOTRIEVE], [CSA], [CROSSREF]
  • Delacourte A., Saint Pol J. F., Guyot J. C., Dupas H., Delie B. Comparaison du pouvoir liant de divers excipients en granulation humide: mise au point d'une technique d’étude. Pharm. Acta Helv. 1992; 67(11)308–314, [CSA]
  • Deleuil M. Les mécanismes de croissance en granulation. STP Pharma. Sci. 1990; 6(5)310–315, [CSA]
  • Duschler G., Carius W., Bauer K. H. Single-step granulation with microwaves preliminary studies and pilot scale results. Drug Dev. Ind. Pharm. 1995; 21(14)1599–1610, [CSA]
  • Duschler G., Carius W., Bauer K. H. Single-step granulation: development of a vacuum-based IR drying method (pilot scale results). Drug Dev. Ind. Pharm. 1997; 23(2)119–126, [CSA]
  • Ennis B. J. Agglomeration and size enlargement. Powder Technol. 1996; 88: 203–225, [CSA], [CROSSREF]
  • Ertel K. D., Zoglio M. A., Ritschel W. A., Carstensen J. T. Physical aspects of wet granulation. IV. Effect of kneading time on dissolution rate and tablet properties. Drug Dev. Ind. Pharm. 1990; 16(6)963–981, [CSA]
  • Faure A., York P., Rowe RC. Process control and scale-up of pharmaceutical wet granulation processes: a review. Eur. J. Pharm. Biopharm. 2001; 52(3)269–277, [INFOTRIEVE], [CSA], [CROSSREF]
  • Faure A., Grimsey I. M., Rowe R. C., York P., Cliff M. J. Applicability of scale-up methodology for wet granulation processes in Collette Gral high shear mixer-granulators. Eur. J. Pharm. Sci. 1999; 8: 85–93, [INFOTRIEVE], [CSA], [CROSSREF]
  • Fu J. S., Cheong G. K., Reynolds G. K., Adams M. J., Salman A. D., Hounslow M. J. An experimental study of the variability in the properties and quality of wet granules. Powder Technol. 2004; 140(3)209–216, [CSA], [CROSSREF]
  • Gaillard C., Chulia D., Jeannin C., Ozil P., Paschos S. Granulation à l'aide d'un granulateur-séchoir à grande vitesse. Pharm. Acta Helv., 64. 1989; 5(6)168–176, [CSA]
  • Gaillard, C. (1990). Gélatine, pouvoir liant et granulation. Ph. D. Thesis, Université Joseph Fournier, Grenoble
  • Gao J. Z., Gray D. B., Motheram R., Hussain M. A. Importance of inlet air velocity in fluid bed drying of a granulation prepared in a high shear granulator. AAPS Pharm. Sci. Tech. 2000; 1(4), [CSA]
  • Gao J. Z., Jain A., Motheram R., Gray D. B., Hussain M. A. Fluid bed granulation of a poorly water soluble, low density, micronized drug: comparison with high shear granulation. Int. J. Pharm. 2001; 237(1–2)1–14, [CSA]
  • Gauthier, H. (1993). Validation d'un procédé industriel de granulation humide. Application à un mélangeur, granulateur, sécheur micro-onde: le Spectrum. Ph. D. Thesis, faculté de pharmacie de Limoges
  • Goldszal A., Bousquet J. Wet agglomeration process of powders: from physics toward process optimization. Powder Technol. 2001; 117: 221–231, [CSA], [CROSSREF]
  • http://www.gruenberg.com/gruenberg/brochures Gruenberg
  • Hausman D. S. Comparison of low shear, high shear, and fluid bed granulation during low dose tablet process development. Drug Dev. Ind. Pharm. 2004; 30(3)259–266, [INFOTRIEVE], [CSA], [CROSSREF]
  • Hlinak A. J., Salezi-Gerhardt A. An evaluation of fluid bed drying of aqueous granulations. Pharm. Dev. Technol. 2000; 5(1)11–17, [INFOTRIEVE], [CSA], [CROSSREF]
  • Holm P., Jungersen O., Schaefer T., Kristensen H. G. Granulation in high speed mixers. Part 1: Effect of process variables during kneading. Pharm. Ind. 1983; 45(8)806–811, [CSA]
  • Holm P., Jungersen O., Schaefer T., Kristensen H. G. Granulation in high speed mixers. Part 2: Effect of process variables during kneading. Pharm. Ind. 1984; 46(1)97–101, [CSA]
  • Holm P. Effect of impeller and chopper design on the granulation in a high speed mixer. Drug Dev. Ind. Pharm. 1987; 13(9–11)1675–1701, [CSA]
  • Hoornaert F., Wauters P. A. L., Meesters G. M. H., Pratsinis S. E., Scarlett B. Agglomeration behavior of powders in a Lödige mixer granulator. Powder Technol. 1998; 96: 116–128, [CSA], [CROSSREF]
  • Horisawa E., Danjo K., Hisakasu S. Influence of granulating method on physical and mechanical properties, compression behaviour, and compactibility of lactose and microcrystalline cellulose granules. Drug Dev. Ind. Pharm. 2000; 26(6)583–593, [INFOTRIEVE], [CSA], [CROSSREF]
  • Hunter B. N., Ganderton D. The influence on pharmaceutical granulation of the type and capacity of mixers. J. Pharm. Pharmacol. 1973; 25(Suppl)71P–78P, [INFOTRIEVE], [CSA]
  • Hunter B. A critical review on current options in granulation techniques. Interphex 1992; 82, 2A5–1–5–5[CSA]
  • Iveson S. M., Litster J. D., Ennis B. J. Fundamental studies of granule consolidation: Part 1. Effects of binder viscosity and binder content. Powder Technol. 1996; 88: 15–20, [CSA], [CROSSREF]
  • Iveson S. M., Litster J. D., Hapgood K., Ennis B. J. Nucleation, growth, and breakage phenomena in agitated wet granulation processes: a review. Powder Technol. 2001a; 117(1)3–39, [CSA], [CROSSREF]
  • Iveson S. M., Wauters P. A. L., Forrest S., Litster J. D., Meesters G. M. H., Scarlett B. Growth regime map for liquid-bound granules: further development and experimental validation. Powder Technol. 2001b; 117(2)83–97, [CSA], [CROSSREF]
  • Iveson S. M., Page N. W., Litster J. D. The importance of wet-powder dynamic mechanical properties in understanding granulation. Powder Technol. 2003; 130: 97–101, [CSA], [CROSSREF]
  • Jaiyeoba K. T., Spring M. S. The granulation of ternary mixtures: the effect of the solubility of the excipients. J. Pharm. Pharmacol. 1980; 32(1)1–5, [INFOTRIEVE], [CSA]
  • Johansen A., Schæfer T. Effect of interactions between powder particle size and binder viscosity on agglomeration growth mechanisms in a high shear mixer. Eur. J. Pharm. Sci. 2001; 12: 297–309, [INFOTRIEVE], [CSA], [CROSSREF]
  • Jørgensen A. C., Luukkonen P., Rantanen J., Schaefer T., Juppo A. M., Yliruusi J. Comparison of torque measurement and near-infrared spectroscopy in characterization of a wet granulation process. J. Pharm. Sci. 2004a; 93(9)2232–2243, [CSA], [CROSSREF]
  • Jørgensen A. C., Rantanen J., Luukkonen P., Laine S., Yliruusi J. Visualization of a pharmaceutical unit operation: wet granulation. Anal. Chem. 2004b; 76: 5331–5338, [CSA], [CROSSREF]
  • Joulié R. Chapter 8, Drying. Part 4: Fluid bed drying. Powder technology and pharmaceutical processes. Handbook of Powder Technology, D. Chulia, M. Deleuil, Y. Pourcelot. Informa UK Ltd, Amsterdam–London–New York–Tokyo 1994; 272–284
  • Kapsidou T., Nikolakakis I., Malamataris S. Agglomeration state and migration of drugs in wet granulations during drying. Int. J. Pharm. 2001; 227: 97–112, [INFOTRIEVE], [CSA]
  • Keningley S. T., Knight P. C., Marson A. D. An investigation into the effects of binder viscosity on agglomeration behaviour. Powder Technol. 1997; 91: 95–103, [CSA]
  • Kiekens F., Cordoba-Diaz M., Remon J. P. Influence of chopper and mixer speeds and microwave power level during the high-shear granulation process on the final granule characteristics. Drug Dev. Ind. Pharm. 1999; 25(12)1289–1293, [INFOTRIEVE], [CSA], [CROSSREF]
  • Kiekens F., Zelkó R., Remon J. P. Influence of drying temperature and granulation liquid viscosity on the inter- and intragranular drug migration in tray-died granules and compacts. Pharm. Dev. Technol. 2000; 5(1)131–137, [INFOTRIEVE], [CSA], [CROSSREF]
  • Killeen M. J. Comparison of granular and tablet properties for products produced by forced air and microwave/vacuum drying. Pharm. Eng. 1999; 19(2)48–63, [CSA]
  • Knight P. C., Instone T., Pearson J. M. K., Hounslow M. J. An investigation into the kinetics of liquid distribution and growth in high shear mixer agglomeration. Powder Technol. 1998; 97: 246–257, [CSA], [CROSSREF]
  • Knight P. C., Johansen A., Kristensen H. G., Schæfer T., Seville J. P. K. An investigation of the effect on agglomeration of changing the speed of a mechanical mixer. Powder Technol. 2000; 110: 204–209, [CSA], [CROSSREF]
  • Kokubo H., Sunada H. Effect of process variables on the properties and binder distribution of granules prepared by high-speed mixer. Chem. Pharm. Bull. 1996; 44(8)1546–1549, [CSA]
  • Konishi K., Sunada H., Yonezawa Y., Danjo K., Yamaguchi H. Relationship between the physical properties of granules and tablets made from crude drug powder and the physical properties of the binder solution. 15th, Pharm. Technol. Conference, OxfordUK, March, 19–21, 1996; 2: 225–239
  • Kristensen H. G., Schaefer T. Granulation, a review on pharmaceutical wet-granulation. Drug Dev. Ind. Pharm. 1987; 13(4–5)803–873, [CSA]
  • Laicher A., Profitlich T., Schwitzer K., Ahlert D. A modified signal analysis for end-point control during granulation. Eur. J. Pharm. Sci. 1997; 5: 7–14, [CSA], [CROSSREF]
  • Landin M., York P., Cliff M. J., Rowe R. C., Wigmore A. J. Scale-up of a pharmaceutical granulation in fixed bowl mixer-granulators. Int. J. Pharm. 1996a; 133: 127–131, [CSA], [CROSSREF]
  • Landin M., York P., Cliff M. J., Rowe R. C., Wigmore A. J. The effect of batch size on scale-up of a pharmaceutical granulation in a fixed bowl mixer granulator. Int. J. Pharm. 1996b; 134: 243–246, [CSA], [CROSSREF]
  • Le Lan A. Traitement mécanique des solides dans les mélangeurs à turbine—Influence de la géométrie d'agitation. In. Int. symposium on mixing 1978; 1978, D2–1–D2–30[CSA]
  • http://www.mcc-online.com/granulation.htm Levin, M. Granulation: endpoint determination and scale-up
  • Li J. Z., Rekhi S. G., Augsburger L. L., Shangraw R. F. The role of intra- and extragranular microcrystalline cellulose in tablet dissolution. Pharm. Dev. Technol. 1996; 1(4)343–355, [INFOTRIEVE], [CSA]
  • Li Y., Sanzgiri Y. D., Chen Y. A study on moisture isotherms of formulation: the use of polynomial equations to predict the moisture isotherms of tablets products. AAPS Pharm. Sci. Tech. 2003; 4(4)59, [CSA], [CROSSREF]
  • Lister J., Hapgood K. P., Michaels J. N., Sims A., Roberts M., Kameneni S. K., Hsu T. Liquid distribution in wet granulation: dimensionless spray flux. Powder Technol. 2001; 114: 32–39, [CSA], [CROSSREF]
  • Lister J., Ennis B., Lian L. The science and engineering of granulation processes, J. Lister, B. Ennis. Informa UK Ltd, London 2004
  • Mackaplow M. B., Rosen L. A., Mickaels J. N. Effect of primary particle size on granule growth and end point determination in high-shear wet granulation. Powder Technol. 2000; 108: 32–45, [CSA], [CROSSREF]
  • Magnet, T. (1996). Le séchage en lit fluidisé. 4ème journée de l'AFSIA, 50–57
  • Malamataris S., Kiortsis S. Wettability parameters and deformational behaviour of powder-liquid mixes in the funicular agglomeration phase. Int. J. Pharm. 1997; 154(1)9–17, [CSA], [CROSSREF]
  • Mandal T. K. Evaluation of microwave drying for pharmaceutical granulations. Drug Dev. Ind. Pharm. 1995; 21(14)1683–1688, [CSA]
  • Mbali-Pemba, C., Vignoles, P., & Chulia D. (1996). Séchage et qualités d'usage. 4ème journée de l'AFSIA, 59
  • Miyamoto Y., Ryu A., Sugawara S., Miyajima M., Ogawa S., Matsui M., Takayama K., Nagai T. Simultaneous optimization of wet granulation process involving factor of drug content dependency on granule size. Drug Dev. Ind. Pharm. 1998; 24(11)1055–1056, [INFOTRIEVE], [CSA]
  • Mort P. R., Tardos G. Scale-up of agglomeration processes using transformations. Kona. 1999; 17: 64–75, [CSA]
  • Newitt D. M., Conway-Jones J. M. A contribution to the theory and practice of granulation. Trans. I. Chem. Eng. 1958; 113: 422–441, [CSA]
  • http://www.niroinc.com/html/pharma/MicrowaveVacDrying.html Niro
  • www.niroinc.com/html/pharma/granulation_techniques/single_pot_granulator.htm Niro
  • Ormós Z. D. Chapter 11, Granulation and coating. Powder technology and pharmaceutical processes. Handbook of Powder Technology, D. Chulia, M. Deleuil, Y. Pourcelot. Informa UK Ltd, Amsterdam–London–New York–Tokyo 1994; 359–372
  • Oulahna D., Cordier F., Galet L., Dodds J. A. Wet granulation: the effect of shear on granule properties. Powder Technol. 2003; 130: 238–246, [CSA], [CROSSREF]
  • Parikh D. M. Handbook of Pharmaceutical Granulation Technology. Informa UK Ltd. 1997
  • Paschos, S. (1987). A propos de l'optimisation de la granulation des poudres en lit fluidisé et dans un mélangeur-granulateur-séchoir rapide. Ph. D. Thesis, Université scientifique technologique et médicale de Grenoble
  • Pearlswig D. M., Robin P., Lucisano L. J. Simulation modelling applied to the development of a single pot process using microwaves/vacuum drying. Pharm. Technol. 1994; 4: 44–60, [CSA]
  • Péré, C. (1999). Etude du séchage sous vide et sous micro-ondes de billes de verre et de granulés pharmaceutiques. Ph. D. Thesis, Ecole des mines de Paris
  • Péré C., Rodier E. Microwave vacuum drying of porous media: experimental study and qualitative considerations of internal transfers. Chem. Eng. Process. 2002; 41: 427–436, [CSA], [CROSSREF]
  • Perez J. P., Rabiškovà M. Influence of the drying technique on theophylline pellets prepared by extrusion-spheronization. Int. J. Pharm. 2002; 242: 349–351, [INFOTRIEVE], [CSA], [CROSSREF]
  • Plank R., Diehl B., Grinstead H., Zega J. Quantifying liquid coverage and powder flux in high-shear granulators. Powder Technol. 2003; 134: 223–234, [CSA], [CROSSREF]
  • Pont, V. (2000). Contribution à l’étude de la granulation des poudres en lit fluidisé: influence des paramètre du procédé et physico-chimiques sur la cinétique de granulation. Ph. D. Thesis, Institut national polytechnique de Toulouse
  • Poska R. Integrated mixing, granulating and microwave drying: a development experience. Pharm. Eng. 1991; 11(1)9–13, [CSA]
  • Ramaker, J. S. (2001). Fondamentals of the high shear pelletisation process. Ph. D thesis, Rijksuniversiteit Groningen
  • Reading S. J., Spring M. S. The effect of binder film characteristics on granule and tablet properties. J. Pharm. Pharmacol. 1984; 36(7)421–426, [INFOTRIEVE], [CSA]
  • Rekhi G. S., Caricofe R. B., Parikh D. M., Augsburger L. L. A new approach to scale-up of a high-shear granulation process. Pharm. Technol. 1996; 11: 2–10, [CSA]
  • Reynolds G. K., Biggs C. A., Salman A. D., Hounslow M. J. Non-uniformity of binder distribution in high shear granulation. Powder Technol. 2004; 140: 203–208, [CSA], [CROSSREF]
  • Ritala M., Virtanen S. The effect of binder solution quantity and lactose particle size on granules properties. Acta Pharm. Nord. 1991; 3(4)229–234, [CSA]
  • Robin P., Luciano L. J., Prealswig D. M. Rationale for selection of a single-pot manufacturing process using microwave/vacuum drying. Pharm. Technol. 1994; 18(5)28–36, [CSA]
  • Rosetto Y. φ 41 Pharmacotechnie industrielle, Y. Rosetto. Informa UK Ltd, France 1998
  • Schæfer T., Bak H. H., Jaegerskou A., Kristensen A., Svensson J. R., Holm P., Kristensen H. G. Granulation in different types of high speed mixers. Part 1: Effects of process variables and up-scaling. Pharm. Ind. 1986; 48(9)1083–1089, [CSA]
  • Schæfer T., Bak H. H., Jaegerskou A., Kristensen A., Svensson J. R., Holm P., Kristensen H. G. Granulation in different types of high speed mixers. Part 2: Comparison between mixers. Pharm. Ind. 1987; 49(3)297–304, [CSA]
  • Schæfer T. Equipment for wet granulation. Acta Pharm. Suec. 1988; 25: 205–228, [CSA]
  • Schæfer T., Johnsen D., Johansen A. Effect of powder particle size and binder viscosity on intergranular and intragranular particle size heterogeneity during high shear granulation. Eur. J. Pharm. Sci. 2004; 21: 525–531, [CSA], [CROSSREF]
  • Scott A. C., Hounslow M. J., Instone T. Direct evidence of heterogeneity during high-shear granulation. Powder Technol. 2000; 113: 205–213, [CSA], [CROSSREF]
  • Shi, L. K. (1996). Séchage sous vide avec/sans micro-onde en turbosphere. 4ème journée de l'AFSIA, 97–101
  • www.aeromatic-fielder.com/ndh_website/nps/cmsdvc.nsf/WebDoc/ndkw5lldt9?opendocument&Site=AF&Unique=ndkw5/nhtmw Smart, I. Microwave vacuum drying, 1996
  • Stahl H. Single-pot systems for drying pharmaceutical granules. Pharm. Technol. Eur. 2000; 12(5)23–34, [CSA]
  • Stahl H. Comparing different granulation techniques. Pharm. Technol. Eur. 2004; 11: 23–33, [CSA]
  • Steffens K. J., List K. NIR spectroscopy as a tool for in-process control in pharmaceutical production, an example. Procedings. 1st, World Meeting APGI/APV, Budapest, May, 9–11, 1995; 155–156
  • Tardos G. I., Khan M. I., Mort P. R. Critical parameters and limiting conditions in binder granulation of fine powders. Powder Technol. 1997; 94: 245–258, [CSA], [CROSSREF]
  • Timko RJ, Barret J. S., McHugh P. A., Chan S. T., Rosenberg H. A. Instrumentation of a vertical high shear mixer with a motor slip monitoring device. Drug Dev. Ind. Pharm. 1986; 12(10)1375–1393, [CSA]
  • Timko R. J., Barret J. S., McHugh P. A., Chan S. T., Rosenberg H. A. Use of a motor load analyzer to monitor the granulation process in a high intensity mixers. Drug Dev. Ind. Pharm. 1987; 13(3)405–435, [CSA]
  • Tobyn M. J., Staniforth J. N., Baichwal A. R., Mac Call T. W. Prediction of physical properties of a novel polysaccharide controlled release system I. Int. J. Pharm. 1996; 128: 113–122, [CSA], [CROSSREF]
  • Travers D. N. A comparison of solute migration in a test granulation dried by fluidization and other methods. J. Pharm. Pharmacol. 1975; 27: 516–522, [INFOTRIEVE], [CSA]
  • Uribarri E., Laguna A., Gonzalez M. Studies of wet granulation in a small scale high shear mixer of 20 mg tablets of polisanol. Boll. Chim. Farm. 2003; 142(8)343–346, [INFOTRIEVE], [CSA]
  • Van Den Dries K., Vromans H. Relationship between inhomogeneity phenomena and granule growth mechanisms in a high-shear mixer. Int. J. Pharm. 2002; 247: 17–177, [CSA], [CROSSREF]
  • Van Den Dries K., De Vegt O. M., Girard V., Vromans H. Granule breakage phenomena in a high shear mixer; influence of process and formulation variables and consequences on granule homogeneity. Powder Technol. 2003; 133: 228–236, [CSA], [CROSSREF]
  • Van Vaerenbergh G. The influence of a swinging bowl on granulate properties. Pharm. Technol. Eur. 2001; 13(3)36–43, [CSA]
  • Vialatte, L. (1998). Mécanismes de granulation. Application à la granulation par agitation mécanique. Ph. D. Thesis, Université technologique de Compiègne
  • Vromans H. Microwave drying of pharmaceutical excipients; comparison with conventional conductive drying. Eur. J. Pharm. Biopharm. 1994; 40(5)333–336, [CSA]
  • Warren J. W., Price J. C. Drug migration during drying of tablet granulations I: Effect of particle size of major diluent. J. Pharm. Sci. 1977a; 66(10)1406–1408, [INFOTRIEVE], [CSA]
  • Warren J. W., Price J. C. Drug migration during drying of tablet granulations II: Effect of binder solution viscosity and drying temperature. J. Pharm. Sci. 1977b; 66(10)1409–1412, [INFOTRIEVE], [CSA]
  • Waruters P. A. L., Jakobsen R. B., Litster J. D., Meesters G. M. H., Scarlett B. Liquid distribution as a means to describing the granule growth mechnism. Powder Technol. 2002; 123: 166–177, [CSA]
  • Wells J. I., Walker V. The influence of granulating fluids upon granule and tablet properties: the role of secondary binding. Int. J. Pharm. 1983; 15: 97–111, [CSA], [CROSSREF]
  • Westerhuis, J. A. (1997). Multivariate statistical modelling of pharmaceutical process. Ph. D. Thesis, Rijksuniversiteit Groningen
  • Westerhuis J. A., Coenegracht P. M. J., Lerk C. F. Multivariate modelling of the tablet manufacturing process with wet granulation tablet optimisation and in process control. Int. J. Pharm. 1997; 156: 109–117, [CSA], [CROSSREF]
  • White J. G. On-line moisture detection for a microwave vacuum dryer. Pharm. Res. 1994; 11(5)728–732, [INFOTRIEVE], [CSA], [CROSSREF]
  • York, P., Rowe, R. C. (1994). Monotoring granulation size enlargement process using mixer torque rheometry. First International Particle technology Forum, Denver, USA
  • Zanchetta A. Vacuum granulators dry faster with GA.ST. Pharm. Manuf. Review. 1992; 3, [CSA]
  • Zuurman K., Bolhuis G. K., Vromans H. Effect of binder on the relationship between bulk density and compactibility of lactose granulations. Int. J. Pharm. 1995; 119: 65–69, [CSA], [CROSSREF]

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