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Review Article

Pharmaceutical Applications of Hot-Melt Extrusion: Part I

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Pages 909-926 | Published online: 26 Sep 2008

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (43)

Ožbej Zupančič, Martin Spoerk & Amrit Paudel. (2022) Lipid-based solubilization technology via hot melt extrusion: promises and challenges. Expert Opinion on Drug Delivery 19:9, pages 1013-1032.
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Ukti Bhatt, Tushar Kanti Malakar, Upadhyayula Suryanarayana Murty & Subham Banerjee. (2021) 3D printing of immediate-release tablets containing olanzapine by filaments extrusion. Drug Development and Industrial Pharmacy 47:8, pages 1200-1208.
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Dnyaneshwar N. Kapote & Karl G. Wagner. (2021) Shellac- a natural carrier for colon targeting of indomethacin using hot melt extrusion. Drug Development and Industrial Pharmacy 47:5, pages 748-757.
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Maha F. Emam, Nesrin F. Taha, Nadia M. Mursi & Laila H. Emara. (2021) Preparation, characterization and in-Vitro/in-Vivo evaluation of meloxicam extruded pellets with enhanced bioavailability and stability. Drug Development and Industrial Pharmacy 47:1, pages 163-175.
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Arabella M. McLaughlin, John Robertson & Xiong-Wei Ni. (2020) Investigation of dissolution rate kinetics of bulk pharmaceutical feed streams within a stirred tank vessel and a twin screw extruder. Pharmaceutical Development and Technology 25:2, pages 219-226.
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Sultan Alshehri, Faiyaz Shakeel, Ehab Elzayat, Osaid Almeanazel, Mohammad Altamimi, Gamal Shazly, Mohsin Kazi, Bjad Almutairy, Bader Alsulays, Abdullah Alshetaili, Ahmed Alalaiwe & Michael Repka. (2019) Rat palatability, pharmacodynamics effect and bioavailability of mefenamic acid formulations utilizing hot-melt extrusion technology. Drug Development and Industrial Pharmacy 45:10, pages 1610-1616.
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Sandeep Sarabu, Suresh Bandari, Venkata Raman Kallakunta, Roshan Tiwari, Hemlata Patil & Michael A Repka. (2019) An update on the contribution of hot-melt extrusion technology to novel drug delivery in the twenty-first century: part II. Expert Opinion on Drug Delivery 16:6, pages 567-582.
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Venkata Raman Kallakunta, Sandeep Sarabu, Suresh Bandari, Roshan Tiwari, Hemlata Patil & Michael A Repka. (2019) An update on the contribution of hot-melt extrusion technology to novel drug delivery in the twenty-first century: part I. Expert Opinion on Drug Delivery 16:5, pages 539-550.
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A. L. Kelly, T. Gough, M. Isreb, R. Dhumal, J. W. Jones, S. Nicholson, A. B. Dennis & A. Paradkar. (2018) In-process rheometry as a PAT tool for hot melt extrusion. Drug Development and Industrial Pharmacy 44:4, pages 670-676.
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Sultan M. Alshehri, Roshan V. Tiwari, Bader B. Alsulays, Eman A. Ashour, Abdullah S. Alshetaili, Bjad Almutairy, Jun-Bom Park, Joseph Morott, Bhupinder Sandhu, Soumyajit Majumdar & Michael A. Repka. (2017) Investigation of the combined effect of MgO and PEG on the release profile of mefenamic acid prepared via hot-melt extrusion techniques. Pharmaceutical Development and Technology 22:6, pages 740-753.
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Mohammed Maniruzzaman, Steven A. Ross, Muhammad Tariqul Islam, Nikolaos Scoutaris, Arun Nair & Dennis Douroumis. (2017) Increased dissolution rates of tranilast solid dispersions extruded with inorganic excipients. Drug Development and Industrial Pharmacy 43:6, pages 947-957.
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Soraya Hengsawas Surasarang, Justin M. Keen, Siyuan Huang, Feng Zhang, James W. McGinity & Robert O. Williams$suffix/text()$suffix/text(). (2017) Hot melt extrusion versus spray drying: hot melt extrusion degrades albendazole. Drug Development and Industrial Pharmacy 43:5, pages 797-811.
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Bader B. Alsulays, Vijay Kulkarni, Sultan M. Alshehri, Bjad K. Almutairy, Eman A. Ashour, Joseph T. Morott, Abdullah S. Alshetaili, Jun-Bom Park, Roshan V. Tiwari & Michael A. Repka. (2017) Preparation and evaluation of enteric coated tablets of hot-melt extruded lansoprazole. Drug Development and Industrial Pharmacy 43:5, pages 789-796.
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Stavros N. Politis & Dimitrios M. Rekkas. (2017) Development of a fast, lean and agile direct pelletization process using experimental design techniques. Drug Development and Industrial Pharmacy 43:4, pages 545-557.
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Abdullah S. Alshetaili, Bjad K. Almutairy, Saad M. Alshahrani, Eman A. Ashour, Roshan V. Tiwari, Sultan M. Alshehri, Xin Feng, Bader B. Alsulays, Soumyajit Majumdar, Nigel Langley, Karl Kolter, Andreas Gryczke, Scott T. Martin & Michael A. Repka. (2016) Optimization of hot melt extrusion parameters for sphericity and hardness of polymeric face-cut pellets. Drug Development and Industrial Pharmacy 42:11, pages 1833-1841.
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Sai Sumana Penumetcha, Lakshmi Narayana Gutta, Harish Dhanala, Satyanarayana Yamili, Swetha Challa, Sneha Rudraraju, Soumya Rudraraju & Varma Rudraraju. (2016) Hot melt extruded Aprepitant–Soluplus solid dispersion: preformulation considerations, stability and in vitro study. Drug Development and Industrial Pharmacy 42:10, pages 1609-1620.
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Michał Teżyk, Bartłomiej Milanowski, Andrzej Ernst & Janina Lulek. (2016) Recent progress in continuous and semi-continuous processing of solid oral dosage forms: a review. Drug Development and Industrial Pharmacy 42:8, pages 1195-1214.
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Bart Claeys, Reinout Vandeputte, Bruno G. De Geest, Jean Paul Remon & Chris Vervaet. (2016) pH-independent immediate release polymethacrylate formulations – an observational study. Drug Development and Industrial Pharmacy 42:4, pages 578-583.
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Chinna Reddy Palem, Narendar Reddy Dudhipala, Sunil Kumar Battu, Michael A. Repka & Madhusudan Rao Yamsani. (2016) Development, optimization and in vivo characterization of domperidone-controlled release hot-melt-extruded films for buccal delivery. Drug Development and Industrial Pharmacy 42:3, pages 473-484.
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Eman A. Ashour, Vijay Kulkarni, Bjad Almutairy, Jun-Bom Park, Sejal P. Shah, Soumyajit Majumdar, Zhuoyang Lian, Elanor Pinto, Vivian Bi, Thomas Durig, Scott T. Martin & Michael A. Repka. (2016) Influence of pressurized carbon dioxide on ketoprofen-incorporated hot-melt extruded low molecular weight hydroxypropylcellulose. Drug Development and Industrial Pharmacy 42:1, pages 123-130.
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Natalia Castro, Vanessa Durrieu, Christine Raynaud, Antoine Rouilly, Luc Rigal & Christian Quellet. (2016) Melt Extrusion Encapsulation of Flavors: A Review. Polymer Reviews 56:1, pages 137-186.
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Jae-Young Lee, Wie-Soo Kang, Jingpei Piao, In-Soo Yoon, Dae-Duk Kim & Hyun-Jong Cho. (2015) Soluplus®/TPGS-based solid dispersions prepared by hot-melt extrusion equipped with twin-screw systems for enhancing oral bioavailability of valsartan. Drug Design, Development and Therapy 9, pages 2745-2756.
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Payal Sharma, Sameer R. Modi & Arvind K. Bansal. (2015) Co-processing as a tool to improve aqueous dispersibility of cellulose ethers. Drug Development and Industrial Pharmacy 41:11, pages 1745-1758.
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Justin R. Hughey, Justin M. Keen, Ryan C. Bennett, Sakae Obara & James W. McGinity. (2015) The incorporation of low-substituted hydroxypropyl cellulose into solid dispersion systems. Drug Development and Industrial Pharmacy 41:8, pages 1294-1301.
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Elena Ravina-Eirin, J. L. Gomez-Amoza & Ramón Martínez-Pacheco. (2015) Drug dispersion degree and drug dissolution rate in Hybrane S1200-based instant-release matricial particles prepared by hot melt extrusion. Drug Development and Industrial Pharmacy 41:6, pages 1000-1005.
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Nathan Boersen, Thomas Wai-Yip Lee, Xiaole (George) Shen & Ho-Wah Hui. (2014) A preliminary assessment of the impact of hot-melt extrusion on the physico-mechanical properties of a tablet. Drug Development and Industrial Pharmacy 40:10, pages 1386-1394.
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Bo Lang, James W. McGinity & Robert O. Williams$suffix/text()$suffix/text(). (2014) Hot-melt extrusion – basic principles and pharmaceutical applications. Drug Development and Industrial Pharmacy 40:9, pages 1133-1155.
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Elena Raviña-Eirín, Jose Luis Gómez-Amoza & Ramón Martínez-Pacheco. (2013) Utility of the hyperbranched polymer Hybrane S1200 for production of instant-release particles by hot melt extrusion. Drug Development and Industrial Pharmacy 39:7, pages 1107-1112.
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Gena Dalziel, Ewa Nauka, Feng Zhang, Sanjeev Kothari & Minli Xie. (2013) Assessment of granulation technologies for an API with poor physical properties. Drug Development and Industrial Pharmacy 39:7, pages 985-995.
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Chinna Reddy Palem, Sunil Kumar Battu, Sindhuri Maddineni, Ramesh Gannu, Michael A. Repka & Madhusudan Rao Yamsani. (2013) Oral transmucosal delivery of domperidone from immediate release films produced via hot-melt extrusion technology. Pharmaceutical Development and Technology 18:1, pages 186-195.
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Weibin Deng, Soumyajit Majumdar, Abhilasha Singh, Sejal Shah, Noorullah Naqvi Mohammed, Seongbong Jo, Elanor Pinto, Divya Tewari, Thomas Durig & Michael A. Repka. (2013) Stabilization of fenofibrate in low molecular weight hydroxypropylcellulose matrices produced by hot-melt extrusion. Drug Development and Industrial Pharmacy 39:2, pages 290-298.
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Seema Thakral, Naveen K Thakral & Dipak K Majumdar. (2013) Eudragit®: a technology evaluation. Expert Opinion on Drug Delivery 10:1, pages 131-149.
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Indrajit Ghosh, Radha Vippagunta, Shoufeng Li & Sudha Vippagunta. (2012) Key considerations for optimization of formulation and melt-extrusion process parameters for developing thermosensitive compound. Pharmaceutical Development and Technology 17:4, pages 502-510.
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Michael A Repka, Sejal Shah, Jiannan Lu, Sindhuri Maddineni, Joe Morott, Ketaki Patwardhan & Noorullah Naqvi Mohammed. (2012) Melt extrusion: process to product. Expert Opinion on Drug Delivery 9:1, pages 105-125.
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Jingwen Hou, Changyan Li, Liang Cheng, Shengrong Guo, Yaqiong Zhang & Tingting Tang. (2011) Study on hydrophilic 5-fluorouracil release from hydrophobic poly(ϵ-caprolactone) cylindrical implants. Drug Development and Industrial Pharmacy 37:9, pages 1068-1075.
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Parinda Srinarong, Hans de Waard, Henderik W Frijlink & Wouter LJ Hinrichs. (2011) Improved dissolution behavior of lipophilic drugs by solid dispersions: the production process as starting point for formulation considerations. Expert Opinion on Drug Delivery 8:9, pages 1121-1140.
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Fu Jijun, Xu Lishuang, Wang Xiaoli, Zhang Shu, Tao Xiaoguang, Zhao Xingna, He Haibing & Tang Xing. (2011) Nimodipine (NM) tablets with high dissolution containing NM solid dispersions prepared by hot-melt extrusion. Drug Development and Industrial Pharmacy 37:8, pages 934-944.
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L.S. Ranzani, J. Font, F. Galimany, A. Santanach, A.M. Gomez-Gomar, G. Casadevall & A. Gryczke. (2011) Enhanced in vivo absorption of CB-1 antagonist in rats via solid solutions prepared by hot-melt extrusion. Drug Development and Industrial Pharmacy 37:6, pages 694-701.
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Dennis Douroumis. (2011) Orally disintegrating dosage forms and taste-masking technologies; 2010. Expert Opinion on Drug Delivery 8:5, pages 665-675.
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T. Quinten, T. De Beer, A. Almeida, J. Vlassenbroeck, L. Van Hoorebeke, J.P. Remon & C. Vervaet. (2011) Development and evaluation of injection-molded sustained-release tablets containing ethylcellulose and polyethylene oxide. Drug Development and Industrial Pharmacy 37:2, pages 149-159.
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Dali Shukla, Subhashis Chakraborty, Sanjay Singh & Brahmeshwar Mishra. (2011) Lipid-based oral multiparticulate formulations – advantages, technological advances and industrial applications. Expert Opinion on Drug Delivery 8:2, pages 207-224.
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Michael A Repka, Soumyajit Majumdar, Sunil Kumar Battu, Ramesh Srirangam & Sampada B Upadhye. (2008) Applications of hot-melt extrusion for drug delivery. Expert Opinion on Drug Delivery 5:12, pages 1357-1376.
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