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Original

Increasing the Dissolution Rate of a Low-Solubility Drug Through a Crystalline-Amorphous Transition: A Case Study with Indomethicin

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Pages 221-231 | Published online: 11 Aug 2009

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Shiqi Hong, Shoucang Shen, David Cheng Thiam Tan, Wai Kiong Ng, Xueming Liu, Leonard S. O. Chia, Anastasia W. Irwan, Reginald Tan, Steven A Nowak, Kennan Marsh & Rajeev Gokhale. (2016) High drug load, stable, manufacturable and bioavailable fenofibrate formulations in mesoporous silica: a comparison of spray drying versus solvent impregnation methods. Drug Delivery 23:1, pages 316-327.
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Carol A. McCarthy, Robert J. Ahern, Rakesh Dontireddy, Katie B. Ryan & Abina M. Crean. (2016) Mesoporous silica formulation strategies for drug dissolution enhancement: a review. Expert Opinion on Drug Delivery 13:1, pages 93-108.
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Marc Hugo, Klaus Kunath & Jennifer Dressman. (2013) Selection of excipient, solvent and packaging to optimize the performance of spray-dried formulations: case example fenofibrate. Drug Development and Industrial Pharmacy 39:2, pages 402-412.
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Maria A. Miller, James DiNunzio, Michal E. Matteucci, Baltej S. Ludher, Robert O. Williams & Keith P. Johnston. (2012) Flocculated amorphous itraconazole nanoparticles for enhanced in vitro supersaturation and in vivo bioavailability. Drug Development and Industrial Pharmacy 38:5, pages 557-570.
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Zhi-Liang Zhang, Yuan Le, Jie-Xin Wang & Jian-Feng Chen. (2011) Preparation of stable micron-sized crystalline irbesartan particles for the enhancement of dissolution rate. Drug Development and Industrial Pharmacy 37:11, pages 1357-1364.
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Eman Atef, Harsh Chauhan, Dev Prasad, Dunesh Kumari & Charles Pidgeon. (2012) Quantifying Solid-State Mixtures of Crystalline Indomethacin by Raman Spectroscopy Comparison with Thermal Analysis. ISRN Chromatography 2012, pages 1-6.
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Ken K. Qian, Steven L. Suib & Robin H. Bogner. (2011) Spontaneous crystalline?to?amorphous phase transformation of organic or medicinal compounds in the presence of porous media, part 2: Amorphization capacity and mechanisms of interaction. Journal of Pharmaceutical Sciences 100:11, pages 4674-4686.
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Zhen Guo, Mingxin Ma, Tianyi Wang, Di Chang, Tongying Jiang & Siling Wang. (2011) A Kinetic Study of the Polymorphic Transformation of Nimodipine and Indomethacin during High Shear Granulation. AAPS PharmSciTech 12:2, pages 610-619.
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Shumet A. Hailu & Robin H. Bogner. (2011) Complex Effects of Drug/Silicate Ratio, Solid-State Equivalent pH, and Moisture on Chemical Stability of Amorphous Quinapril Hydrochloride Coground with Silicates. Journal of Pharmaceutical Sciences 100:4, pages 1503-1515.
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