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Research Article

Strategies to Overcome pH-Dependent Solubility of Weakly Basic Drugs by Using Different Types of Alginates

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Pages 1277-1284 | Published online: 20 Oct 2008

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Read on this site (8)

Natalia Veronica, Paul Wan Sia Heng & Celine Valeria Liew. (2023) Alginate-based matrix tablets for drug delivery. Expert Opinion on Drug Delivery 20:1, pages 115-130.
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A. B. Shreya, Renuka S. Managuli, Jyothsna Menon, Lavanya Kondapalli, Aswathi R. Hegde, Kiran Avadhani, Pallavi K. Shetty, Muthukumar Amirthalingam, Guruprasad Kalthur & Srinivas Mutalik. (2016) Nano-transfersomal formulations for transdermal delivery of asenapine maleate: in vitro and in vivo performance evaluations. Journal of Liposome Research 26:3, pages 221-232.
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Chika Taniguchi, Yohei Kawabata, Koichi Wada, Shizuo Yamada & Satomi Onoue. (2014) Microenvironmental pH-modification to improve dissolution behavior and oral absorption for drugs with pH-dependent solubility. Expert Opinion on Drug Delivery 11:4, pages 505-516.
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Elcin Aktas, Hakan Eroglu, Umit Kockan & Levent Oner. (2013) Systematic development of pH-independent controlled release tablets of carvedilol using central composite design and artificial neural networks. Drug Development and Industrial Pharmacy 39:8, pages 1207-1216.
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Nizar M. Al-Zoubi, Hatim S. AlKhatib & Wasfy M. Obeidat. (2011) Evaluation of hydrophilic matrix tablets based on Carbopol® 971P and low-viscosity sodium alginate for pH-independent controlled drug release. Drug Development and Industrial Pharmacy 37:7, pages 798-808.
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Antonio Moroni, William Drefko & Gerard Thone. (2011) Formulations of zero-order, pH-dependent, sustained release matrix systems by ionotropic gelation of alginate-containing mixtures. Drug Development and Industrial Pharmacy 37:2, pages 216-224.
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Fa-Qin Wang, Ping Li, Jun-Ping Zhang, Ai-Qin Wang & Qin Wei. (2010) A novel pH-sensitive magnetic alginate–chitosan beads for albendazole delivery. Drug Development and Industrial Pharmacy 36:7, pages 867-877.
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Phuong Ha-Lien Tran, Thao Truong-Dinh Tran, Kyoung-Ho Lee, Dong-Jin Kim & Beom-Jin Lee. (2010) Dissolution-modulating mechanism of pH modifiers in solid dispersion containing weakly acidic or basic drugs with poor water solubility. Expert Opinion on Drug Delivery 7:5, pages 647-661.
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Articles from other publishers (25)

Viviane Annisa, Teuku Nanda Saifullah Sulaiman, Akhmad Kharis Nugroho & Agung Endro Nugroho. (2023) A novel formulation of ketoconazole entrapped in alginate with anionic polymer beads for solubility enhancement: Preparation and characterization. Pharmacia 70:4, pages 1423-1438.
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Kaushika Patel, Vijay Kevlani & Shreeraj Shah. (2023) A novel Posaconazole oral formulation using spray dried solid dispersion technology: in-vitro and in-vivo study. Drug Delivery and Translational Research.
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Daniel Van Breda, Robert Lufu & Neill Jurgens Goosen. (2021) Optimisation of cellulase-assisted extraction of laminarin from the brown seaweed Ecklonia maxima, using response surface methodology. Biomass Conversion and Biorefinery 13:12, pages 10399-10412.
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John Rey Apostol Romal & Say Kee Ong. (2023) Marine polysaccharide-based hydrogels for critical materials selective removal and recovery: A review. Coordination Chemistry Reviews 482, pages 215054.
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Safwan Abdel Rahim, Nizar Al-Zoubi, Heba Khader, Rahaf Alwaraydat & Faisal Al-Akayleh. (2023) Ethanol-induced dose dumping from sodium alginate matrix tablets: Investigation of the effects of medium viscosity and pH. International Journal of Pharmaceutics 632, pages 122568.
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Ali Mujtaba, Arshiya Parveen, Nawaf M. Alotaibi, Mohammad Daud Ali & Munfis Patel. 2023. Alginate Biomaterial. Alginate Biomaterial 1 18 .
Tae Kyu Chung, Hyun A. Lee, Kyeong‐Ryoon Lee, Seong Bok Jang, Kyung‐Sang Yu & Howard Lee. (2022) A population PK–PD model of YH4808 , a novel P‐CAB , and intragastric pH that incorporated negative feedback by increased intragastric pH onto the systemic exposure to YH4808 . CPT: Pharmacometrics & Systems Pharmacology 11:9, pages 1223-1233.
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Maryam Hashemi, Khalil Abnous, Soudabeh Balarastaghi, Narges Hedayati, Zahra Salmasi & Rezvan Yazdian-Robati. (2021) Mitoxantrone-Loaded PLGA Nanoparticles for Increased Sensitivity of Glioblastoma Cancer Cell to TRAIL-Induced Apoptosis. Journal of Pharmaceutical Innovation 17:1, pages 207-214.
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Kamal Niaz, Muhammad Asif Nawaz, Sidra Pervez, Umair Younas, Ismail Shah & Fazlullah Khan. (2022) Total scale analysis of organic acids and their role to mitigate Alzheimer's disease. South African Journal of Botany 144, pages 437-447.
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Dyah H. Wardhani, Hana N. Ulya, Aulia Rahmawati, Thio V.K. Sugiarto, Andri C. Kumoro & Nita Aryanti. (2021) Preparation of degraded alginate as a pH-dependent release matrix for spray-dried iron and its encapsulation performances. Food Bioscience 41, pages 101002.
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Kunal Singha, Pintu Pandit & Subhankar Maity. 2021. Bionanocomposites in Tissue Engineering and Regenerative Medicine. Bionanocomposites in Tissue Engineering and Regenerative Medicine 399 416 .
Hemanth Gollavilli, Aswathi R. Hegde, Renuka S. Managuli, K. Vijay Bhaskar, Swapnil J. Dengale, Meka Sreenivasa Reddy, Guruprasad Kalthur & Srinivas Mutalik. (2020) Naringin nano-ethosomal novel sunscreen creams: Development and performance evaluation. Colloids and Surfaces B: Biointerfaces 193, pages 111122.
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Biswajit Bhattacharya, Susobhan Das, Garima Lal, Saundray Raj Soni, Animesh Ghosh, C. Malla Reddy & Soumyajit Ghosh. (2020) Screening, crystal structures and solubility studies of a series of multidrug salt hydrates and cocrystals of fenamic acids with trimethoprim and sulfamethazine. Journal of Molecular Structure 1199, pages 127028.
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Renuka S Managuli, Julie T Wang, Farid N Faruqu, Varun Kushwah, Sushil Y Raut, Ajjappla B Shreya, Khuloud T Al-Jamal, Sanyog Jain & Srinivas Mutalik. (2019) Asenapine maleate-loaded nanostructured lipid carriers: optimization and in vitro , ex vivo and in vivo evaluations . Nanomedicine 14:7, pages 889-910.
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Biswajit Bhattacharya, Amit Mondal, Saundray Raj Soni, Susobhan Das, Surojit Bhunia, K. Bal Raju, Animesh Ghosh & C. Malla Reddy. (2018) Multidrug salt forms of norfloxacin with non-steroidal anti-inflammatory drugs: solubility and membrane permeability studies. CrystEngComm 20:41, pages 6420-6429.
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Pratap Chandra Acharya, Clara Fernandes, Divya Suares, Saritha Shetty & Rakesh K. Tekade. 2018. Dosage Form Design Considerations. Dosage Form Design Considerations 513 547 .
Eliška Mašková, Kateřina Kubová, Jakub Vysloužil, Sylvie Pavloková & David Vetchý. (2016) Influence of pH Modulation on Dynamic Behavior of Gel Layer and Release of Weakly Basic Drug from HPMC/Wax Matrices, Controlled by Acidic Modifiers Evaluated by Multivariate Data Analysis. AAPS PharmSciTech 18:4, pages 1242-1253.
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Shanmukha Prasad Gopi, Manas Banik & Gautam R. Desiraju. (2016) New Cocrystals of Hydrochlorothiazide: Optimizing Solubility and Membrane Diffusivity. Crystal Growth & Design 17:1, pages 308-316.
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Nizar Al-Zoubi, Hatim S. Alkhatib, Ghadah Alobaidi, Safwan Abdel-Rahim, Wasfy Obeidat & Stavros Malamataris. (2015) Optimization of pH-independent chronotherapeutic release of verapamil HCl from three-layer matrix tablets. International Journal of Pharmaceutics 494:1, pages 296-303.
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Gaurav Tolia & S. Kevin Li. (2013) Silicone Adhesive Matrix of Verapamil Hydrochloride to Provide pH-Independent Sustained Release. AAPS PharmSciTech 15:1, pages 1-10.
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Peter Timmins & Samuel R. Pygall. 2014. Hydrophilic Matrix Tablets for Oral Controlled Release. Hydrophilic Matrix Tablets for Oral Controlled Release 257 280 .
Kateřina Dvořáčková, Petr Doležel, Eliška Mašková, Jan Muselík, Martina Kejdušová & David Vetchý. (2013) The Effect of Acid pH Modifiers on the Release Characteristics of Weakly Basic Drug from Hydrophlilic–Lipophilic Matrices. AAPS PharmSciTech 14:4, pages 1341-1348.
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Nikhil Malewar, Makarand Avachat, Varsha Pokharkar & Shirish Kulkarni. (2013) Controlled Release of Ropinirole Hydrochloride from a Multiple Barrier Layer Tablet Dosage Form: Effect of Polymer Type on Pharmacokinetics and IVIVC. AAPS PharmSciTech 14:3, pages 1178-1189.
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Sarah J. Nicholson, Peter Timmins, Randy C. Dockens, Alyson Connor, Robert Croop, Peter Ferrie, Jianing Zeng, Andrew B. Dennis & Ian Wilding. (2012) Development of oral extended release formulations of 6‐hydroxybuspirone. Biopharmaceutics & Drug Disposition 33:9, pages 522-535.
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Friederike Eisenächer, Andreas Schädlich & Karsten Mäder. (2011) Monitoring of internal pH gradients within multi-layer tablets by optical methods and EPR imaging. International Journal of Pharmaceutics 417:1-2, pages 204-215.
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